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Results for “Khellin”

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At least 307 records · Page 17Linked to original sources
PubMed1984

[Cromoglycic acid (disodium cromoglycate) and inhibitors of mast cell degranulation].

Cromoglycic acid (disodium cromoglycate) is a diacromone derived from khelline whose chief action in asthma is preventive, through inhibition of mastocyte degranulation. Since its digestive absorption is poor, it is given locally as a pulverulent aerosol. Cromoglycic acid is also used successfully in certain forms of ocular and nasal allergy. An oral preparation of cromoglycic acid is beginning to be used in food allergy and certain rectocolites. Trials are ongoing with several other substances, which have comparable properties and are active orally.

Animals↗
PubMed1983

The effect of sodium cromoglycate on the development of exercise-induced angina pectoris.

The effect of inhaling sodium cromoglycate on the development of chest pain in 8 patients with exercise-induced angina pectoris was studied in a double-blind cross-over placebo controlled trial. Blood levels of sodium cromoglycate of 24-136 ng/ml did not affect either the time to develop pain on exercise or the rate-pressure product at the time of pain. In view of the original observation that Khellin reduces angina, it is suggested that further studies should be performed to assess the effect of SCG at higher concentrations in the plasma.

Angina Pectoris↗
PubMed1993

[Vitiligo--an enigmatic disease. II. Therapy of vitiligo].

The work gives a review of therapeutic methods of vitiligo. PUVA therapy, application of cortisonoids, khellin (including UVA), phenylalanine (including UVA), melagenina, and laser therapy represent non-surgical methods. Surgical methods include application of fluorouracil following dermabrasion, of autologous epidermal grafting transplantation of in vitro cultured epidermis, in vitro cultured melanocytes and micropigmentation by pigment. Auxiliary methods are represented by administration of carotene, using sunscreens and if necessary cosmetic treatment. Entire depigmentation is done in accordance with the extent of vitiligo, unsuccessful repigmentation and the age of the patient. The conclusion points out psychosocial aspects and the necessity of mutual cooperation of both, physician and patient. (Ref. 53.)

Humans↗