Local analysis of 11th International Histocompatibility Workshop PCR oligonucleotides for HLA-DQ in a population of Inuits.
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PURPOSE: To follow the refraction values in an indigenous population group over the course of the past 50 years. METHOD: Case records from a population investigation carried out in Ammasalik, East Greeland, by Erik Skeller in 1950 were studied initially, a total of 1123 eyes were examined by sciascopy and 244 eyes could be followed sufficiently until about 1990-94. RESULT: The mean refraction was initially +0.08 D, while at the last examination the mean had increased to +0.69 D. Initially, there was no myopia, defined as at least -1.5 D, and at follow-up it was a maximum of 1%, and presumably due to immature cataract. A tendency to myopia (< -1.5 D) was found initially in 36%, but in only 22% at follow-up. CONCLUSION: The myopinizing factor in East Greenland has not affected persons born prior to 1942, even if they had a tendency to myopia (< -1.5 D).
In a Greenland municipality, slit-lamp biomicroscopy was performed in 44 individuals aged 70 or above. Two were found to have pseudoexfoliation corresponding to 4.5%. This is the first time pseudoexfoliation has been demonstrated in Eskimos.
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Three cases of spirit possession were studied to determine common underlying psychodynamic factors. The spirits were believed to represent culture bound defense mechanisms, and attempts at problem solving in individuals suffering from unresolved conflicts. These being anomic anxiety, dependency, sexual identity and aggression. The symptoms, therefore, were considered to be attempts at conflict resolution. Furthermore the psychodynamic process is described as a transition phase in psychic development between externalization and internalization of intrapsychic distress or collective versus individual ego solutions to life stress. As such, therapy will be facilitated by knowledge of myths and customs and culturally significant methods of healing.
OBJECTIVE: Recent studies indicate that persistent organohalogen pollutants (POPs) may contribute to sex ratio changes in offspring of exposed populations. Our aim in the present study was to investigate whether exposure to 2,2 ,4,4 ,5,5 -hexachlorobiphenyl (PCB-153) and dichlorodiphenyldichloroethene (p,p -DDE) affects sperm Y:X chromosome distribution. SUBJECTS AND METHODS: We obtained semen and blood for analysis of PCB-153 and p,p -DDE levels from 547 men from Sweden, Greenland, Poland (Warsaw), and Ukraine (Kharkiv), with regionally different levels of POP exposure. The proportion of Y- and X-chromosome-bearing sperm in the semen samples was determined by two-color fluorescence in situ hybridization analysis. RESULTS: Swedish and Greenlandic men had on average significantly higher proportions of Y sperm (in both cohorts, 51.2%) and correspondingly higher lipid-adjusted concentrations of PCB-153 (260 ng/g and 350 ng/g, respectively) compared with men from Warsaw (50.3% and 22 ng/g) and Kharkiv (50.7% and 54 ng/g). In the Swedish cohort, log-transformed PCB-153 and log-transformed p,p -DDE variables were significantly positively associated with Y-chromosome fractions (p-values 0.04 and <0.001, respectively). On the contrary, in the Polish cohort PCB-153 correlated negatively with the proportion of Y-bearing fraction of spermatozoa (p=0.008). CONCLUSIONS: The present study indicates that POP exposure might be involved in changing the proportion of ejaculated Y-bearing spermatozoa in human populations. Intercountry differences, with different exposure situations and doses, may contribute to varying Y:X chromosome ratios.
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OBJECTIVES: It is recognized that empowerment of Indigenous Peoples through training and education is a priority. The objective was to design a course that would provide an innovative training approach to targeted workers in remote communities and enhance learning related to the Nunavut Food Guide, traditional food and nutrition, and diabetes prevention. STUDY DESIGN: A steering committee was established at the outset of the project with representation from McGill University and the Government of Nunavut (including nutritionists, community nurses and community health representatives (CHRs), as well as with members of the target audience. Course content and implementation, as well as recruitment of the target audience, were carried out with guidance from the steering committee. METHODS: An 8-week long course was developed for delivery in January - March, 2004. Learning activities included presentation of the course content through stories, online self-assessment quizzes, time-independent online discussions and telephone-based discussions. Invitations were extended to all prenatal nutrition program workers, CHRs, CHR students, home-care workers, Aboriginal Diabetes Initiative workers and public health nurses in Nunavut. RESULTS: Ninety-six health-care workers registered for Healthy Living in Nunavut, with 44 actively participating, 23 with less active participation and 29 who did not participate. CONCLUSIONS: Despite having to overcome numerous technological, linguistic and cultural barriers, approximately 40% of registrants actively participated in the online nutrition course. The internet may be a useful medium for delivery of information to target audiences in the North.
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Thyroid hormones are important for metabolic regulation. A number of studies have dealt with the effect of arctic living on thyroid hormone secretion and metabolism in healthy animals and humans. Little is however known of the effect of arctic living on the occurrence of thyroid diseases. In a study from Upernavik, Greenland no cases of hyperthyroidism were observed over the 25 years period from 1950 to 1974. We present five cases of hyperthyroidism due to Graves' disease observed during a two month period in Nuuk Greenland. The discrepancy could be due to improved diagnostic methods and activity or to a real increase in incidence. Systematic studies of thyroid disorders in Greenland are warranted.
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