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Results for “Hemoglobin Level”

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At least 307 records · Page 17Linked to original sources
PubMed2001

Variability in hemoglobin levels: clinical implications. Case study of the anemic patient.

A historical, prospective, multicenter, observational study was conducted on data from October 1996 to December 1997 to determine the impact of hemoglobin (Hb) variability on the interpretation of maintenance anemia management outcomes in hemodialysis patients. Trends in mean Hb levels were retrospectively analyzed to determine whether there were any differences between 1-month Hb averages versus 3- or 6-month rolling averages. Results showed that: (a) Hb measurements exhibit wide variability between patients and within patients, regardless of the assessment method used, and (b) it is difficult to maintain patients within the 1 g/dL Hb spread recommended by NKF-K/DOQI. The largest variations in Hb readings were observed in 1-month readings, while 6-month rolling averages exhibited the least variability. These data illustrate the importance of assessing long-term trends in laboratory data before making incremental or decremental modifications in the anemia prescription.

Anemia, Iron-Deficiency↗
PubMed2005

Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock.

We have previously demonstrated that two wild-derived stocks of mice, Idaho and Majuro, are significantly longer-lived than mice of a control stock (DC) generated as a four-way cross of commonly used laboratory strains of mice. This study provides independent confirmation of this earlier finding, as well as examining serum glucose, insulin, leptin, glycated hemoglobin (GHb), cataract severity, and glucose tolerance levels in each of the stocks. Both the mean (+20%) and maximum (+13%) life span of the Idaho mice were significantly increased relative to the DC stock, while in the Majuro mice only maximum (+15%) life span was significantly increased. In addition, Majuro mice were hyperglycemic in both the fed and fasted states compared both to laboratory-derived and Idaho stocks, had significantly elevated GHb levels and cataract scores, and were glucose intolerant although serum insulin levels did not differ between stocks. Body weight and body mass index (BMI)-corrected leptin levels were also dramatically (1.5-3-fold) higher in the Majuro mice. The longevity of Id mice was not accompanied by changes in serum glucose and insulin levels, or glucose tolerance compared to DC controls, although GHb levels were significantly lower in the Idaho mice. Taken together, these findings suggest that neither a reduction of blood glucose levels nor an increase in glucose tolerance is necessary for life span extension in mice.

Animals↗
PubMed1983

[Physiological mechanisms for maintaining the body's energy requirements during reduced blood hemoglobin levels].

Energy expenditure and O2 consumption, the tidal volume of cardiac output (Q) and the respiration (VE), the arterio-venous difference in O2 content, the arterial and venous blood gases, and the survival of animals in graded decrease of the hemoglobin concentration in the vascular bed (hemodilution) were studied in anesthetized Wistar rats as well as the values of oxygen available in the brain tissue. The animals were shown to maintain the initial level of energy expenditure by means of the Q increase up to reducing the hemoglobin concentration from 16.2 g/dl to 4.9 g/dl (hematocrit 12.9%). The elements of oxygen insufficiency, however, as measured by the Q and VE responses as well as by changes in oxygen available in mixed venous blood and in brain tissue, become evident yet in early stages of the hemodilution.

Animals↗