Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “GINGIVECTOMY”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 307 records · Page 17Linked to original sources
PubMed2004

Decreased expressions of thrombospondin 2 in cyclosporin A-induced gingival overgrowth.

OBJECTIVES: Cyclosporin A (CsA) is known to elicit fibrous gingival overgrowth with changes of blood vessel profiles. In this study, we examined the expression of several angiogenic and angiostatic genes during the development of CsA-induced gingival overgrowth. METHODS: For the development of gingival overgrowth, Sprague-Dawley rats received subcutaneous injections of CsA in daily doses of 5, 10, 15 mg/kg body weight for 6 weeks, and another group received 10 mg/kg of CsA for 3, 6, and 12 weeks. Human gingival tissues were obtained from three CsA-treated patients following the gingivectomy procedure and from three healthy patients following the crown-lengthening procedure as a control. Gingival fibroblasts were isolated from the healthy gingival tissues of the rat or the human, and cultured with 250-1000 ng/ml of CsA. RESULTS: Reverse transcription-polymerase chain reaction (RT-PCR) analyses showed that expressions of some angiogenic genes such as angiopoietin 1, basic fibroblast growth factor, and vascular endothelial growth factor, and angiostatic genes such as angiopoietin 2, brain-specific angiogenesis inhibitor 1 and 2, and thrombospondin 1 were not changed significantly in both gingival tissues and cultured fibroblast cells under the CsA treatments. However, expression of thrombospondin 2 (TSP2) decreased dose- and time-dependently in rat and human gingival tissues. Western blot analyses showed that the expression of TSP2 protein was dose-dependently reduced by the CsA treatments in human cultured gingival fibroblasts. CONCLUSIONS: These results indicate that the decrease in angiostatic TSP2 expression may be attributed to the CsA-induced gingival vascularization rather than to the increased expression of angiogenic genes. It suggests that TSP2 is involved in the development of CsA-induced gingival overgrowth with the gingival vascularization.

Angiogenesis Inhibitors↗
PubMedDate not supplied

The apically repositioned flap in tooth exposure.

Methods of exposing impacted teeth in order to bring them into the line of the arch include gingivectomy, the apically repositioned flap and closed eruption techniques. These procedures aim to facilitate the eruption of the impacted tooth with a minimum of disruption or damage to the tooth itself or adjacent structures. The aim of this paper is to discuss the various surgical methods of exposing impacted teeth and to help to identify where the use of the apically repositioned flap is indicated. Clinical examples are presented and a surgical method for carrying out this procedure recommended.

Humans↗
PubMed1987

Removal of benign intraoral masses using the CO2 laser.

Benign soft tissue lesions of the mouth can be removed using the CO2 laser. This type of laser surgery is faster and offers less postoperative complication as compared with conventional surgery and electrosurgery. Presently, the CO2 laser can be used for intraoral biopsy of benign masses, gingivectomies, and frenectomies.

Adult↗
PubMed1980

Granulomatous gingivitis in Anderson-Fabry disease.

The patient is suffering from Anderson-Fabry disease. This was documented by family history, clinical findings, histochemical and electronmicroscopic demonstration of ceramide in the blood vessels, and enzyme studies. The patient, at age 17, developed a unique gingival enlargement, gingivitis granulomatosa, a cobbled tongue, glossitis granulomatosa, and a lip enlargement, cheilitis granulomatosa. This was not found in other members of the family. The clinical, histological, and electronmicroscopic findings were analogous to Melkersson-Rosenthal syndrome. The patient did not have sarcoidosis or other specific granulomatous diseases. These were ruled out by skin examination, chest films, histology, and skin sensitivity testing, nor did he have Dilantin associated gingival enlargement. The patient had only taken the drug for a brief period at age 11 when he had a generalized granulomatous lymphadenopathy which was not categorized with certainty. This could have been secondary to Anderson-Fabry disease aggravated by a minor infection, an idiosyncratic reaction to Dilantin, or the lymph node equivalent of the granulomatous response that later affected the gingiva. Although the gingival enlargement appeared to be a manifestation of an unusual syndrome, local therapy in the form of oral hygiene instruction, dental prophylaxis, gingivectomy, and regular maintenance therapy was successful in treatment and prevention of recurrence.

Adolescent↗
PubMed1981

Treatment of periodontal disease in a patient with Turner's syndrome. A case report.

This case report describes a patient with Turner's syndrome receiving systemic androgen therapy who experienced marked gingival enlargement, bleeding, and discomfort. Turner's syndrome and its treatment are discussed. The literature pertaining to sex hormones and their role in affecting periodontal disease is reviewed. The patient was treated with full mouth gingivectomy and 2-week recall visits for a period of 2 months consisting of oral physiotherapy instructions, scaling, and topical fluoride application. She was then placed on 1-month recall for the next 4 months. This mode of therapy was effective in treating severe gingival hyperplasia in a patient receiving systemic androgen therapy.

Adolescent↗
PubMed1984

Bilateral symmetrical lymphangiomas of the gingiva. A case report.

This is a report of a patient with bilateral symmetrical lymphangiomas of the mandibular gingiva which presented clinically as chronic localized gingivitis. The lesions were removed by conventional gingivectomy and have not recurred after 2 years. Both lesions were of the cavernous type and apparently confined to the gingiva. Their distribution indicates them to be developmental anomalies rather than tumors. For this reason it is felt that local excision is adequate even if the mass is incompletely removed. Anomalies should not recur in the same fashion as a tumor.

Adolescent↗
PubMed1992

Tuberous sclerosis with gingival overgrowth.

A case of tuberous sclerosis with gingival overgrowth is presented. A brief literature review and diagnostic criteria of tuberous sclerosis are discussed. The patient had a full-mouth gingivectomy with frequent post-operative maintenance visits. After 6 months, the overgrowth in conjunction with the tuberous sclerosis returned.

Adult↗
PubMed1995

Primary extramedullary plasmacytoma in cyclosporine-induced gingival overgrowth. A case report.

An unusual solitary extramedullary plasmacytoma developed in the gingiva of a 28 year-old male renal transplant patient with cyclosporine (CyA)-induced gingival overgrowth. On initial presentation, there was no suspicion of a tumor within the lesion. One year later, however, the lesion had increased progressively in size, and its surface was ulcerated. At this time, the lesion was excised by gingivectomy, and histopathological examination revealed plasmacytoma. CyA was discontinued and the patient has been closely observed for 4 years with no recurrence of the gingival lesion.

Adult↗
PubMed1999

Clinical effects of periodontal therapy on the severity of cyclosporin A-induced gingival hyperplasia.

BACKGROUND: Gingival hyperplasia (GH) is a major side effect associated with cyclosporin A (CsA) therapy. The condition is further augmented due to the gingival inflammation. In this study, the effects of initial periodontal therapy and gingival curettage are analyzed in a group of patients with clinically significant (>30%) CsA-induced gingival hyperplasia. METHODS: The test group of 15 patients received oral hygiene instructions, supra- and subgingival scaling, polishing, and gingival curettage only oral hygiene instructions were given to 16 control subjects. Plaque index (PI), gingival index (GI), calculus index (CI), periodontal probing depth (PD), and gingival hyperplasia were recorded at baseline and repeated 8 weeks after treatment. Current doses of immunosuppressive agents, serum concentrations of CsA, and duration of CsA therapy were recorded as the pharmacological parameters. RESULTS: Statistical evaluation revealed that all clinical variables showed statistical decreases compared to baseline in the treated patients, while none of the parameters changed significantly in the control group. Initial GH scores of 53.63% in controls and 53.40% in the treated patients were 52.83% and 32.13% following treatment, respectively. A difference of 21.27% in the severity of treated GH was accompanied by a 0.56 decrease in GI scores in the test group. CONCLUSIONS: Compared to the initial observations, the results suggested that nearly 60% of the condition could be of fibrotic origin. Initial periodontal therapy and curettage resulted in the resolution of the inflammation in CsA-induced GH. Further investigation of the treated patients has shown that 7 out of 15 patients (47%) in the test group responded well and their GH scores decreased below 30% at the end of the study. The treatment in this study was effective in eliminating the necessity of more extensive surgical modes of treatment, such as gingivectomy, in 47% of cases.

Adult↗
PubMed2003

A case of Zimmermann-Laband syndrome with supernumerary teeth.

BACKGROUND: Zimmermann-Laband syndrome is a rare autosomal dominant disorder that is characterized by gingival fibromatosis, ear, nose, bone, and nail defects, and hepatosplenomegaly. METHODS: This case report describes the clinical presentation and periodontal findings in a 13-year-old female patient with previously undiagnosed Zimmermann-Laband syndrome. RESULTS: Clinical and radiographic findings and genetic counseling confirmed the diagnosis of Zimmermann-Laband syndrome. The most striking oral findings were the presence of gingival enlargement involving both the maxillary and mandibular arches, anterior open bite, non-erupted teeth, and two supernumerary teeth. Periodontal treatment consisted of gingivectomy in four quadrants. Histopathologic evaluation of excised tissue supported the diagnosis of gingival fibromatosis. The patient was referred for appropriate orthodontic treatment and genetic counseling, and has been closely followed for the earliest signs of hepatosplenomegaly. CONCLUSIONS: Dental practitioners should be alert for developmental abnormalities that may occur in patients with gingival fibromatosis as this may indicate the presence of a rare disorder like Zimmermann-Laband syndrome. A comprehensive medical history and physical systemic evaluation are essential for correct diagnosis and treatment of these cases.

Abnormalities, Multiple↗
PubMed2005

Identification of the difference in extracellular matrix and adhesion molecules of cultured human gingival fibroblasts versus juvenile hyaline fibromatosis gingival fibroblasts using cDNA microarray analysis.

BACKGROUND: A difference from the normal range in collagen profile and perivascular hyaline deposition in the dermis and gingiva has been demonstrated histopathologically in juvenile hyaline fibromatosis (JHF), which is an autosomal recessive disease. The aim of this study was to understand the mechanism of gingival overgrowth in JHF, and to observe differences in the expression of genes regulating extracellular matrix organization. METHODS: Human gingival fibroblasts (GF) were obtained from individuals who have clinically healthy gingival tissue. JHF-GF were obtained from a patient who underwent a gingivectomy. Cultured fibroblast cells were examined visually using a phase contrast microscope. Total RNA from both cell types was isolated, and after biotin-deoxyuridine triphosphate (dUTP) labeling of cDNA, hybridization was performed with a pathway-specific gene expression profiling array membrane. Extracellular matrix (ECM) and adhesion molecule (AM) mRNA expressions in GF and JHF-GF were analyzed, and microarray data on genes modulating ECM remodeling were confirmed with reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Cell morphology differences were observed between fibroblast types. Although type I collagen gene expression levels were almost the same, decreased type IV collagen expression was noted in JHF-GF versus GF. Decreased matrix metalloproteinase (MMP) and increased tissue inhibitor of matrix metalloproteinase (TIMP) transcripts were noted in JHF-GF versus GF. Increased fibronectin and decreased laminin mRNA expression were observed in JHF-GF when compared to GF. The present findings suggest that GF and JHF-GF differ not only morphologically but also in the expression level of ECM and AM genes involving connective tissue turnover and remodeling. CONCLUSIONS: Results from these analyses may be helpful to clarify the nature of overgrowth mechanisms, especially regarding enzymes and their inhibitors. This information is important in understanding the remodeling of ECM. The gingival overgrowth that is observed in JHF patients may be explained by a decreased level of MMPs and increased blockage of MMPs with TIMPs.

Adult↗
PubMed1991

Gingival hyperplasia induced by nifedipine.

We describe 4 cases of gingival hyperplasia induced by nifedipine, together with clinical and histological findings. Hyperplasia of the interdental papillae was observed in all cases. Histologic examination showed multilayered epithelial parakeratosis with variations in the width, proliferation, reticulation and elongation of the rete pegs. Substitution of another drug and improvement of oral hygiene led to reduction of the gingival overgrowth without gingivectomy. These treatments are essential for gingival hyperplasia induced by nifedipine.

Aged↗
PubMed1996

Hydroxyproline and total protein levels in gingiva from patients treated with phenytoin and cyclosporine-A.

Hydroxyproline (Hyp) and total protein levels were studied in gingiva from patients treated with phenytoin (PHT) and cyclosporine-A (CSA). The study included 5 groups of subjects: PHT and CSA groups with and without gingival overgrowth (PHT-GO+), (PHT-GO-), (CSA-GO+), (CSA-GO-), and periodontally healthy controls (C). After taking clinical measurements, gingival samples were harvested by gingivectomy or excising one or two papillae from the posterior areas. The samples were analyzed biochemically. In the PHT groups, both Hyp and total protein levels were significantly higher than in the C group. The differences between the PHT-GO+ and PHT-GO- groups were not statistically significant. In the CSA groups, total protein levels were significantly higher than in controls while no significant difference was found in Hyp levels. The differences between the CSA-GO+ and CSA-GO- groups were not statistically significant. When the PHT and CSA groups were compared, Hyp levels were significantly higher in the PHT-GO+ group than in the CSA-GO+ group. Total protein level differences between the PHT and CSA groups were not statistically significant. Correlations between age, plaque index, gingival overgrowth index, Hyp and total protein levels were analyzed and most were found not to be statistically significant. PHT appears to stimulate both collagen and total protein synthesis in gingiva while CSA seems to have a stronger effect on total protein synthesis. This suggests that the mechanisms underlying PHT- and CSA-induced gingival overgrowth are different and further comparative studies are needed.

Adult↗
PubMed2004

Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients.

Phenytoin-induced gingival overgrowth is a well-known and frequently reported gingival lesion, which was first detected in 1939. However, there are conflicts in the literature about the agents which affect the severity of the lesion. Un-cooperative dental patients are one of the most unsuccessfully treated periodontal patient groups because of the difficulty in maintaining their oral hygiene. This case report consists of two cases with the same characteristics: phenytoin usage, comprehension and speech defects and poor oral hygiene, but each case differs in the duration of the phenytoin therapy. Both of the cases received scaling, root planning and a gingivectomy.

Adult↗
PubMed1976

Mucogingival repairs in periodontal surgery.

The utilization of partial thickness apically repositioned flaps, laterally repositioned flaps, and free mucosal autografts enable the clinician to repair most mucogingival problems. These techniques may be used separately or in combination to increase the zone of attached gingiva, deepen the vestibular fold, and eliminate muscle and frenum pulls. If basic surgical principles are adhered to, the possibilities of repair of mucogingival problems utilizing these procedures are unlimited. The most important step in mucogingival surgery is planning the surgical procedure prior to beginning surgery. In this way different techniques may be combined to achieve the desired result and minimize the number of surgical episodes that may be required. It is important to conserve tissue. For example, tissues from gingivectomy or flap surgery in one area may be utilized for a free gingival graft in another area (Fig. 21). There is one last but most important requirement for mucogingival surgery: there should be some evidence of periodontal pathology. The lack of a wide zone of attached gingiva, the lack of a deep vestibule or a frenum pull is not in itself an indication for surgical intervention ulness some periodontal pathology is evident. In some cases it may be determined by the clinician's judgment that it would be best to perform a mucogingival surgical procedure to prevent one of these areas from developing into a periodontal problem. This decision is often dictated by the patient's age. In older patients, areas of minimal attached gingiva and shallow vestibular depth that show no periodontal breakdown should be regarded as areas of health and no surgical intervention is indicated. On the other hand, if these areas are evident in a child, particularly when orthodontic therapy is anticipated, then surgical intervention may be advisable to prevent serious damage to the gingival tissues.

Gingiva↗
PubMed1976

[Report of a case of idiopathic gingival hyperplasia].

The clinical and histological picture of a rare gingival disease, i.e. idiopathic gingival hyperplasia, is discussed in detail on the basis of a case of our own Comprehensive diagnostic measures were taken to exclude other possible causes of a hyperplasia of the gingiva. Despite a rapid recurrence after gingivectomy, a "wait and see" attitude is assumed and the next therapeutical procedure is planned only after completion of puberty.

Child↗
PubMed1976

[Special technics for the enlargement of the vestibulum].

From a technical viewpoint, vestibuloplasty is the easiest method to deepen the vestibulum and is mostly preceded by gingivectomy or a flap operation. Grafting of free mucosa is the method of choice in cases of small regions of operation, prominent alveolar ridges, where open vestibuloplasty has already been performed and serious coronal shifting the scar has occurred, and where a coronal sliding of flap was planned as a second operation to cover a gingival recession. In cases of gingival recessions and areas with narrow, less than 3 mm broad gingiva propria having no obvious pathologically altered gingival sulcus, the method according to Edlan and Mejchar is offering the best results.

Humans↗
PubMed1999

The apically repositioned flap in tooth exposure.

Methods of exposing impacted teeth in order to bring them into the line of the arch include gingivectomy, the apically repositioned flap and closed eruption techniques. These procedures aim to facilitate the eruption of the impacted tooth with a minimum of disruption or damage to the tooth itself or adjacent structures. The aim of this paper is to discuss the various surgical methods of exposing impacted teeth and to help to identify where the use of the apically repositioned flap is indicated. Clinical examples are presented and a surgical method for carrying out this procedure recommended.

Journal Article↗