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PubMedDate not supplied

Famine, fiber, fatty acids, and failed colonic absorption: does fiber fermentation ameliorate diarrhea?

The salvage function of the colon for absorption of unabsorbed sodium and water from the jejunum and ileum depends upon the metabolic integrity of colonic epithelial cells maintained by luminal short-chain fatty acids. With the depletion of luminal short-chain fatty acids under conditions of starvation, metabolic compensation from vascular substrates is incomplete. Loss of luminal short-chain fatty acids diminishes cell membrane integrity and causes secretion by colonic epithelial cells, leading to starvation diarrhea. Because sodium absorption is dependent upon CO2 production from n-butyrate, no compensatory absorption occurs during starvation. Under conditions in which luminal short-chain fatty acids are depleted, dietary fiber is useful as a low osmolality food constituent and for renewal of short-chain fatty acid levels by bacterial fermentation. The "antisecretory" effect of dietary fiber depends on the degree of the preexisting depletion of short-chain fatty acids and the methodology used to assess absorptive function. Dietary fiber has not been found harmful in refeeding starvation victims for whom it is an essential food constituent.

Animals↗
PubMed2006

The malarial host-targeting signal is conserved in the Irish potato famine pathogen.

Animal and plant eukaryotic pathogens, such as the human malaria parasite Plasmodium falciparum and the potato late blight agent Phytophthora infestans, are widely divergent eukaryotic microbes. Yet they both produce secretory virulence and pathogenic proteins that alter host cell functions. In P. falciparum, export of parasite proteins to the host erythrocyte is mediated by leader sequences shown to contain a host-targeting (HT) motif centered on an RxLx (E, D, or Q) core: this motif appears to signify a major pathogenic export pathway with hundreds of putative effectors. Here we show that a secretory protein of P. infestans, which is perceived by plant disease resistance proteins and induces hypersensitive plant cell death, contains a leader sequence that is equivalent to the Plasmodium HT-leader in its ability to export fusion of green fluorescent protein (GFP) from the P. falciparum parasite to the host erythrocyte. This export is dependent on an RxLR sequence conserved in P. infestans leaders, as well as in leaders of all ten secretory oomycete proteins shown to function inside plant cells. The RxLR motif is also detected in hundreds of secretory proteins of P. infestans, Phytophthora sojae, and Phytophthora ramorum and has high value in predicting host-targeted leaders. A consensus motif further reveals E/D residues enriched within approximately 25 amino acids downstream of the RxLR, which are also needed for export. Together the data suggest that in these plant pathogenic oomycetes, a consensus HT motif may reside in an extended sequence of approximately 25-30 amino acids, rather than in a short linear sequence. Evidence is presented that although the consensus is much shorter in P. falciparum, information sufficient for vacuolar export is contained in a region of approximately 30 amino acids, which includes sequences flanking the HT core. Finally, positional conservation between Phytophthora RxLR and P. falciparum RxLx (E, D, Q) is consistent with the idea that the context of their presentation is constrained. These studies provide the first evidence to our knowledge that eukaryotic microbes share equivalent pathogenic HT signals and thus conserved mechanisms to access host cells across plant and animal kingdoms that may present unique targets for prophylaxis across divergent pathogens.

Amino Acid Motifs↗
PubMed1981

Famine relief and imperial policy in early modern Morocco: the political functions of public health.

There has been no systematic ethnology nor comparative history of public health. In fact, there has been a broad consensus that prior to the arrival of missionaries and colonial health authorities there was no indigenous public health. These assumptions apply to only some settings and do not reflect the general history of public health. The present study concerns public health in the first century of Alawi rule in Morocco, ca. 1670-1790. The early Alawi sultans undertook public health programs, most of which concerned the prevention and relief of mass starvation. Goals of the programs were consistent with other features of their public policies. Effectiveness of the programs was limited partly by technical and scientific factors, but more by political constraints, especially the sultans' higher priorities for political stability than public welfare and public health. These data provide important insights not only into Moroccan social and political history, but also into the more general problem of the political nature of public health.

Disasters↗