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Results for “FIBROSITIS”

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PubMed1977

Does allergy play a role in fibrositis?

Twenty patients with active fibrositis and no underlying disease (and with normal electromyographic findings) were evaluated for the possible role of an active allergic process in their conditions. A definite atopic history was obtained in just fewer than 50% of the patients, and an allergic diathesis in slightly more than 50% of the patients' families. Serum immunoglobulin E levels and eosinophil counts for all 20 patients fell within the normal range. Thus the traditional allergic reaction (type I hypersensitivity) would seem unlikely as a mediator of fibrositis.

Adult↗
PubMed1985

Fibrositis: symptom frequency and criteria for diagnosis. An evaluation of 291 rheumatic disease patients and 58 normal individuals.

We administered a 17-item symptom questionnaire modified from Campbell to 155 patients with fibrositis diagnosed at 3 centers, each using different criteria sets. A high degree of agreement in symptom proportions was found among centers. "Fibrositic" symptoms were also common in 136 patients with a variety of rheumatic diseases but not in the 58 normal individuals studied. Symptoms distinguished fibrositis patients from normals easily, but had insufficient specificity to distinguish them from other rheumatic disease patients. The tender point count better separated fibrositic and nonfibrositic patients than historical criteria. No combination of questions and tender point count performed better than the tender point count alone.

Back Pain↗
PubMed1988

Imaging fibrosing alveolitis.

Whenever fibrosing alveolitis is suspected a computed tomographic (CT) scan should be carried out using a high definition narrow section technique. Pulmonary involvement in cryptogenic fibrosing alveolitis and scleroderma may be demonstrated by CT before it is apparent clinically or by standard radiography. CT may be the most accurate and practical imaging technique in the follow-up of these cases and for indicating the optimal site for biopsy.

Diagnosis, Differential↗
PubMed1987

Pain perception and personality measures as discriminators in the classification of fibrositis.

Twenty patients with fibrositis were compared to age and sex matched groups of patients with rheumatoid arthritis (RA) and normal controls regarding personality variables measured by the Basic Personality Inventory (BPI) and responsiveness to experimentally induced pain. The group with fibrositis scored significantly higher than the normal group on 4 of the BPI scales and had lower pain threshold and tolerance than the normal group. The group with RA was found to be significantly different from the normal group on hypochondriasis and pain tolerance. Using only pain and personality measures, a statistical discriminant function that was developed resulted in a 72% classification accuracy for the 3 groups studied and 85% accuracy when only the 2 clinical groups were considered.

Adult↗
PubMed1985

[Changes in pneumocytes in fibrosing alveolitis].

Some unusual changes of proliferating type II pneumocytes were shown by electron microscopy in idiopathic fibrosing alveolitis. New pneumocytes in cubic metaplasia were loosely connected by abundant microvillous processes. These were scarce on the apical surface but numerous on the basis where they are normally lacking. In the absence of basement membrane microvillous processes communicated directly with fibrosed interalveolar septum.

Humans↗
PubMed1985

Familial idiopathic fibrosing alveolitis.

Case reports of two sisters with idiopathic fibrosing alveolitis are presented. On the basis of reports in the literature it seems that developmental anomalies and immunopathological changes occur more frequently in familial fibrosing alveolitis than in the general population.

Female↗
PubMed1985

[Fibrosing mediastinitis].

The case report is presented of a 35 year-old patient with fibrosing mediastinitis. Clinically, only non-specific features were present. Radiography, computed tomography and cavography were of great importance in establishing the diagnosis and in following up the patient. Diagnosis was confirmed histologically following thoracotomy. Fibrosing mediastinitis, although a rare condition, should be considered in the differential diagnosis of mediastinal processes.

Adult↗
PubMed1982

[Mast cells in biopsies of fibrosing alveolitis].

The mechanism of fibroproduction of the lung tissue in fibrosing alveolitis is connected with the presence of mixed cell exudate, persevering interalveolar and peribronchial edema and proliferation of glycoproteins. As the multiplication of heparinocytes in the conditions of fibrosing alveolitis as against the material compared in conclusive, we may infer that the release of their mediators leads to dilatation of interalveolar capillaries, to an increase in their permeability and thus to the origin of interstitial edema. The release of biogenic amines from the granules of heparinocytes is a possible agent even in the chemotactic influence on neutrophilic and eosinophilic granulocytes and thrombocytes. The fact that heparinocytes proliferate even in the latter phases of inflammation indicates that they create conditions for the perseverance of inflammatory exudation and interstitial edema. And this may be regarded as a direct cause of fibroproduction.

Adult↗
PubMed1981

Fibrosing pancreatitis--an obscure causes of painless obstructive jaundice: a case report and review of the literature.

We report a 3-year-old asymptomatic patient who had obstructive jaundice. Percutaneous transhepatic cholangiogram showed total obstruction of the distal common bile duct. At laparotomy, fibrosing pancreatitis was found. Sphincteroplasty and choledochoduodenostomy relieved his symptoms. A review of the literature disclosed ten patients, nine of whom had abdominal pain. Fibrosing pancreatitis should be considered in the differential diagnosis of obstructive jaundice in children, even in the absence of abdominal pain.

Adolescent↗
PubMed1995

[Conventional roentgen examination of the lung in fibrosing alveolitis--correlation with histological, clinical and biochemical findings].

QUESTION: Is it possible to draw conclusions on aetiology, histology or clinical course, looking at the different radiomorphologic appearance and its changes in chest x-rays of patients with "fibrosing alveolitis"? MATERIAL AND METHOD: Retrospective correlation of chest x-rays with all relevant clinical and histological data of 33 patients. RESULTS: In all patients typical clinical signs with changes of lung function and typical histological changes were found. There was no strict correlation between single parameters and radiological findings. In the estimation of the clinical course, no correspondence between radiological findings and clinical data was found in only 18% of the parameters. CONCLUSION: The chest x-ray is an objective investigation which clearly shows the course of fibrosing alveolitis beside its undisputed function in diagnosing acute complications like infiltration, effusion or development of pneumothorax.

Follow-Up Studies↗
PubMed1994

Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a pattern distribution.

BACKGROUND: Recession of the frontal hairline is a common event in postmenopausal women. This has been shown not to be a marker of gross androgenization, and is usually a progressive nonscarring alopecia. Six postmenopausal women, who developed a progressive frontal scarring alopecia, were studied and their clinical and laboratory data, as well as the results of scalp biopsy specimens in all six patients, were analyzed and compared with recognized forms of scarring alopecia and recently described findings in androgenetic alopecia. OBSERVATIONS: The six postmenopausal women developed a progressive frontal hairline recession that was associated with perifollicular erythema within the marginal hairline, producing a frontal fibrosing alopecia extending to the temporal and parietal hair margins. Scalp biopsy specimens from the frontal hair margin showed perifollicular fibrosis and lymphocytic inflammation concentrated around the isthmus and infundibular areas of the follicles. Immunophenotyping of the lymphocytes showed a dominance of activated T-helper cells. Clinical review of all six cases showed a progressive marginal alopecia without the typical multifocal areas of involvement seen in lichen planopilaris or pseudopelade. None of the patients had mucous membrane or skin lesions typical of lichen planus. Hormonal studies, in five patients, showed no elevated androgen abnormalities. CONCLUSIONS: Progressive frontal recession in postmenopausal women may show clinical features of a fibrosing alopecia. The histologic findings are indistinguishable from those seen in lichen planopilaris. However, the absence of associated lesions of lichen planus in all six women raises the possibility that this mode of follicular destruction represents a reaction pattern triggered by the events underlying postmenopausal frontal hairline recession.

Aged↗
PubMed1993

Fibrositis syndrome and narcolepsy.

Fibrositis is often associated with sleep disturbances and with an alpha nREM abnormality on sleep electroencephalogram. We describe a case occurring during the course of a typical longstanding narcolepsy-cataplexy. Modafinil, that is an effective treatment of hypersomnia, did not alleviate the symptoms of fibrositis in the short term.

Aged↗
PubMed1993

The management of cryptogenic fibrosing alveolitis in three regions of the United Kingdom.

The case notes of 200 patients with cryptogenic fibrosing alveolitis, from three regions in the United Kingdom, were reviewed, in order to determine how physicians manage this uncommon condition. In the majority of cases (119), the diagnosis was based solely on clinical grounds, with no attempt at histological confirmation of the diagnosis. Transbronchial biopsy was attempted in 66 patients, but was unhelpful in confirming a diagnosis of pulmonary fibrosis in 30% of these patients. Thirty five patients underwent bronchoalveolar lavage, and 15 had an open lung biopsy. Of the 132 patients treated, 110 received prednisolone alone, and the rest a combination of other immunosuppressive agents. The doses and duration of therapy varied considerably. These results suggest that, in the late 1980s, there were wide variations of practice in the management of cryptogenic fibrosing alveolitis in the United Kingdom. This is likely to reflect a paucity of information on the optimum management of this uncommon condition.

Adult↗
PubMed1997

[Pentoxifylline inhibits experimental bleomycin-induced fibrosing alveolitis].

Therapy of idiopathic pulmonary fibrosis (IPF) is directed at 1) inhibition of alveolitis and tissue damage, and 2) inhibition of matrix deposition. We and others have identified pentoxifylline (POF) as a promising drug in achieving these aims. For further clarification, we established a model of bleomycin-induced fibrosing alveolitis. Fisher 344 rats (n = 7 per group) were given bleomycin intratracheally once (0.7 U/100 g bw) and treated with POF (1.5 or 3 mg/kg bw per day i.p.), prednisolone (15 mg/kg bw i.m. per day), or sodium chloride solution (NaCL). The extent of inflammatory reactions was determined after 8 days by differentiation of cells of broncho-alveolar lavage (BAL) and by quantification of proliferating cells in lung interstitium subsequent to staining of the Ki-67 antigen. POF inhibited neutrophil alveolitis in BAL and reduced the amount of proliferating cells in the lungs significantly while prednisolone and NaCL did not. Both POF and prednisolone exerted a positive influence on postoperative weight loss as well as on lung weight increase subsequent to bleomycin instillation. The postoperative body weight loss and the lung weight increase after bleomycin instillation are most likely due to an inflammatory reaction subsequent to operation and bleomycin deposition. Tumor necrosis factor alpha (TNF-alpha) has been shown to be a key cytokine in bleomycin-induced fibrosing alveolitis as well as in IPF; it also exerts catabolizing effects. Since both POF and prednisolone are known to effectively inhibit proinflammatory cytokines and, among those, TNF-alpha, nonspecific antiinflammatory effects probably explain the benefits. Additionally, however, this study proved POF to be more effective in inhibition of BAL neutrophils and number of proliferating cells in lung interstitium. Further, it has been shown that POF, but not prednisolone, inhibits activation of neutrophil granulocytes and formation of reactive oxygen species. Thus we believe that the mechanism of action of xanthines might contribute to therapy of IPF. For further clarification, a prospective clinical study of POF in IPF therapy has been initiated.

Animals↗
PubMed1998

Localized idiopathic fibrosing mediastinitis as a cause of superior vena cava syndrome: a case report.

An unusual case of superior vena cava syndrome, caused by localized fibrosing mediastinitis is presented. A 41-year-old woman had swelling of the face and upper extremities, associated with headache and fatigue. Radiologic investigations, which included venography, computed tomography and magnetic resonance imaging of the chest, documented the presence of superior vena caval (SVC) obstruction secondary to what appeared to be an intraluminal tumour. The patient underwent SVC resection and reconstruction with a spiral saphenous vein graft under cardiopulmonary bypass and deep hypothermic circulatory arrest. On histopathological examination localized idiopathic fibrosing mediastinitis causing SVC obstruction was diagnosed.

Adult↗
PubMed2003

[Nephrogenic fibrosing dermopathy].

Nephrogenic fibrosing dermopathy (NFD) is a scleromyxoedema-like disease favoring the extremities and trunk. Histologically there is a cellular fibrosis throughout the entire dermis. NFD is associated with renal insufficiency and dialysis, although the pathogenesis has not been elucidated. A 71-year-old woman developed classical symptoms of NFD on both legs within a few weeks after initiation of hemodialysis and concomitant antibiotic treatment followed by presumed drug eruption.

Aged↗
PubMed2006

British Thoracic Society Study on cryptogenic fibrosing alveolitis: Response to treatment and survival.

BACKGROUND AND OBJECTIVE: The initial results of a survey of 588 patients with a clinical presentation of cryptogenic fibrosing alveolitis (CFA) also known as idiopathic pulmonary fibrosis, have been published. This article reports further results pertaining to response to treatment and survival. METHODS: Data on the treatment given and lung function response were collected over 4-6 years. Survival data were collected over 10 years. RESULTS: Treatment was given to 445 (76%) patients, 55% were given prednisolone alone and the remainder another immunosuppressive agent, usually with prednisolone. Treated patients had worse lung function initially. At 3 months after study entry, treated patients were more likely to have improved forced vital capacity (FVC) than the untreated patients. Patients whose FVC improved were younger (p = 0.001 analysis of variance (ANOVA)) and had lower initial FVC (p<0.001, ANOVA). Patients who responded to treatment at 3 months or at 1 year survived longer than those who remained stable, who in turn survived longer than those who deteriorated (p = 0.002). These differences were largely accounted for by patients with better lung function surviving longer. Younger age at entry, female sex and higher percentage predicted FVC and carbon monoxide transfer factor [corrected] at study entry were associated with greater chances of survival at 4 years. Overall median survival from entry was 2.43 years (95% confidence interval (CI) 2.17 to 3.18). CONCLUSIONS: About a third of patients with CFA showed improved lung function after initiation of corticosteroid or immunosuppressive treatment, and those who improved survived longer. Poorer lung function, male sex and age are adverse prognostic features. Overall survival was poor.

Analysis of Variance↗
PubMed2003

Nephrogenic fibrosing dermopathy with systemic involvement.

BACKGROUND: There is a growing literature regarding sclerotic and panniculitic cutaneous conditions seen in patients with end-stage renal disease (eg, calciphylaxis and soft tissue calcification). Nephrogenic fibrosing dermopathy (NFD) is a recent designation to describe cutaneous findings in patients with end-stage renal disease who developed sclerotic plaques with scleromyxedema-like histologic features. Soft tissue calcification is rare in patients with NFD and systemic involvement has not been reported. OBSERVATIONS: We describe a patient with end-stage renal disease who developed diffuse indurated woody plaques consistent with NFD in association with soft tissue calcification with catastrophic sequelae. A deep excisional biopsy specimen from the patient revealed thickened collagen bundles in the reticular dermis, plump bipolar spindle cells, and increased mucin. Focally, there were zones of calcium deposition in dermal collagen without vessel calcification. Autopsy of the patient revealed extensive fibrosis and calcification of the diaphragm, psoas muscle, renal tubules, and rete testes. The patient died 11 months after developing NFD. CONCLUSION: A subset of patients with NFD may have significant systemic involvement.

Calcinosis↗