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At least 307 records · Page 17Linked to original sources
PubMed1995

Central odontogenic fibroma mimicking a lesion of endodontic origin.

The central odontogenic fibroma is a rarely reported lesion that can be associated with vital teeth. Although it is uncommon and unlikely to recur after enucleation, the central odontogenic fibroma should be considered in a differential diagnosis of radiolucencies associated with vital teeth. This case report presents the radiographic and clinical signs of a central odontogenic fibroma occurring in the maxillary anterior region.

Adult↗
PubMed1986

Epithelium-connective tissue junction in follicular ameloblastoma and ameloblastic fibroma: an ultrastructural analysis.

The ameloblastoma and ameloblastic fibroma are tumors of odontogenic origin. During odontogenesis, there is a sequence of inductive stimulations, or interactions, between the epithelium of the enamel organ and the connective tissue of the dental papilla. We review 7 cases of follicular ameloblastoma and 1 case of ameloblastic fibroma under the electron microscope to investigate possible induction-stimulated changes at the epithelium-connective tissue junction. Thickening of the basal lamina by a granulo-filamentous material was a universal finding. Horizontal proliferation and convolutions of this thickened material were found in 2 ameloblastomas. The ameloblastic fibroma evidenced fine aperiodic fibers perpendicular to the basal lamina. These changes are consistent with attempted inductive stimuli directed toward tooth formation.

Adolescent↗
PubMed1998

Pseudoanaplastic chondromyxoid fibroma.

A 19-year-old man presented with a chondromyxoid fibroma of the distal phalanx of the great toe that was originally diagnosed as osteosarcoma rather than "dedifferentiated" chondrosarcoma. Radiographs showed a large, expansive, and calcified tumor of the distal phalanx. Although the tumor had the architectural and matrix patterns of a chondromyxoid fibroma, high-power examination demonstrated that the lesion had such severe nuclear pleomorphism that it was mistaken for high-grade sarcoma. The purpose of this report is to present the criteria used to differentiate a benign pseudoanaplastic chondromyxoid fibroma from chondrogenic high-grade sarcomas.

Adult↗
PubMed1987

Cystic cemento-ossifying fibroma of the ethmoidal cells (a case report).

A case report of an aggressive cystic cemento-ossifying fibroma of the ethmoidal cells is presented. Fibro-osseous lesions containing cementum are considered to be of periodontal membrane origin and are most common in the mandible and maxilla. Following the WHO classification, fibro-osseous lesions containing cementum are grouped together under the heading of cementoma and are divided into four subgroups. Cemento-ossifying fibroma is considered to be a variant of cementifying fibroma which is a sub-group of cementoma. The unique site of origin seen in this case is thought to have been the result of an ectopic periodontal membrane or of a primitive mesenchymal cell rest or incomplete migration of the medial part of the nasal anlage and differentiation into the periodontal membrane.

Adolescent↗
PubMed1996

Chondromyxoid fibroma-like osteosarcoma: a distinct variant of low-grade osteosarcoma.

Chondromyxoid fibroma-like osteosarcoma is a recently described, extremely rare subtype of low-grade osteosarcoma. Two such cases were encountered among 102 cases of osteosarcoma seen in the Prince of Wales Hospital, Hong Kong, between 1984 and 1994. The first patient, a 39-year-old woman, presented with a mass in her right maxilla which was resected and mistaken as a myxoma. The tumour recurred locally four years later and she now has extensive local recurrent disease six years after initial presentation and is amenable to support treatment only. The second patient, a 28-year-old man, had a pelvic tumour which recurred in the form of a polypoid left atrial tumour and pulmonary nodules six years after operation. The left atrial tumour recurred one year after operation, and led to sudden death of the patient seven years after initial presentation. Radiologically, the tumours in both cases appeared as expansile osteolytic lesions with erosion of adjacent bone and infiltration into soft tissue. Histologically, they consisted of lobules of spindle, stellate or polygonal tumour cells showing mitotic activity and with moderate nuclear pleomorphism and hyperchromatism, set in a highly myxoid stroma superficially mimicking chondromyxoid fibroma. The histological hallmark was the direct production of osteoid by tumour cells. Chondromyxoid fibroma-like osteosarcoma merits recognition as a distinct variant of low-grade osteosarcoma for which early appropriate surgery is indicated.

Adult↗
PubMed1999

Ossifying fibroma of the lateral orbital wall in an adult.

Orbital ossifying fibroma is an extremely rare condition, especially in adults. This rare tumor mostly develops at the medial wall of the orbit. We report a histopathologically confirmed ossifying fibroma involving the lateral orbital wall in an adult. This case suggests that orbital ossifying fibroma should be considered in the differential diagnosis of orbital bony lesions in adults and that unusual presentations may occur.

Journal Article↗
PubMed2005

Chondromyxoid fibroma of the skull base: differential diagnosis and radiotherapy: two case reports and a review of the literature.

Chondromyxoid fibromas are uncommon tumours mostly arising in long bones of young males. Involvement of the skull base is extremely rare. We describe two new cases of base of the skull chondromyxoid fibromas. The tumours were incompletely excised and irradiated with protons because of the high risk of complications of another surgical procedure. The rationale for proton therapy was based on the intimate relations between the tumour and the organs at risk. Skull base chondromyxoid fibroma is a very rare, slowly growing benign tumour that can cause severe disabilities due to tumour compression of critical structures. Only surgical resection has been shown to be relatively effective. We report two cases of incompletely excised lesions treated by postoperative high-dose radiation including proton therapy with no active disease and complication. Our review of the literature allows us to conclude that histological diagnosis of lesions in this site is a trap for pathologists and that radiotherapy is not contraindicated.

Adolescent↗
PubMed2004

Cemento-ossifying fibroma of the ethmoidal sinus in a child presenting with isolated pain in the nasal region.

The authors present a case of a previously healthy 8-year-old girl who presented with pain on the right side of the nose (bony part) radiating to the frontal and temporal regions. Physical examination was normal, whereas magnetic resonance imaging (MRI) of the facial region revealed a tumor limited to the right ethmoidal sinus with a small extension to the medial wall and the upper part of the nasal septum. The tumor was removed by using a 5-degree nasoscope and sent for pathologic examination, which revealed a cemento-ossifying fibroma of the ethmoidal sinus. This is a rare condition, and MRI is a valuable tool in its detection because results of physical examination may be normal in patients reporting nasal pain. According to the World Health Organization classification, this tumor is a variant of cementifying fibromas, which represent a subgroup of cementomas, fibro-osseous lesions containing cementum. Cementifying fibromas are rare tumors. They are usually small, asymptomatic lesions, but although benign, they can develop into aggressive, expansible masses.

Cementoma↗
PubMed2005

Chondromyxoid fibroma of the parietal bone.

We report the case of an 11-year old girl who presented with an intracranial chondromyxoid fibroma arising from parietal bone. Chondromyxoid fibroma is a benign cartilaginous neoplasm, which can be easily mistaken for chondrosarcoma, especially in small biopsies. It is more common in long bones and is least common in cranial bones. Published work describes about 33 cases occurring in cranial bones with almost equal incidence in the bones of the base of the skull and cranial vault. To our knowledge, this is the second case of chondromyxoid fibroma reported to occur in parietal bone and is the first case reported in an English-language journal. We present this case for its rare anatomical, clinical, radiological and histological presentations.

Child↗
PubMed1984

Ultrastructure of cartilaginous tumors and S-100 protein in the tumors. With reference to the histogenesis of chondroblastoma, chondromyxoid fibroma and mesenchymal chondrosarcoma.

Twelve cartilaginous tumors were studied by electron microscopy and the presence of S-100 protein was studied immunohistochemically in order to clarify the cell origin of chondroblastoma, chondromyxoid fibroma, and mesenchymal chondrosarcoma. Three chondroblastomas were characterized by round or ovoid tumor cells with some cytoplasmic processes, well-developed organelles and thick fibrous laminae in the nuclear membrane, occasional multinucleated giant cells and scanty chondroid matrix. S-100 protein was demonstrated in the tumor cells and some multinucleated giant cells Two chondromyxoid fibromas revealed tumor cells of varied shapes with characteristic cartilaginous differentiation and abundant chondroid matrix. Spindle tumor cells showed the ultrastructural features of cartilage cells rather than of fibroblasts and S-100 protein was also demonstrated in their cytoplasm. Chondroblastoma and chondromyxoid fibroma were considered to arise from chondrocytes. Mesenchymal chondrosarcoma ultrastructurally exhibited round tumor cells with cartilaginous nature in cartilage islands. Poorly-differentiated portions were composed of primitive round or elongated cells with occasionally admixed round cells with ultrastructural features of cartilaginous differentiation. S-100 protein was demonstrated in the cells in cartilage islands and in single cells admixed in poorly-differentiated portions. These results support the hypothesis of primitive mesenchymal origin with a tendency to differentiate toward cartilage cells.

Cartilage↗
PubMed1994

A simple cryo-technique for the treatment of cutaneous soft fibromas.

OBJECTIVE: We propose a simple cryo-technique for the treatment of cutaneous soft fibromas. METHODS: This method, useful for fibromas larger than 4-5 mm in diameter, allows the freezing of the only soft fibroma without affecting the surrounding skin. RESULTS: The technique shows the following advantages: it is simple to perform, it avoids local anesthesia, and it can be used in pacemaker holders. CONCLUSION: The cosmetic results are very good.

Cryosurgery↗
PubMed1998

Assessment of growth potential by MIB-1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma.

Specimens from two ameloblastic fibromas (including one recurrent case), two ameloblastic fibro-odontomas, and one ameloblastic fibrosarcoma were subjected to investigation by MIB-1 immunohistochemistry in order to elucidate the growth potential of these tumors. MIB-1 labeling indices in the epithelial component of these tumors ranged from 2.9 to 7.5%, whereas those in the mesenchymal component ranged from 1.5 to 13.5%. Of these, labeling indices in the mesenchymal component of the recurrent ameloblastic fibroma and ameloblastic fibrosarcoma were quite high. These findings suggest that evaluation of growth potential in ameloblastic fibroma and related lesions could be of help in understanding tumor aggressiveness and in selecting appropriate surgical procedures.

Adolescent↗
PubMed1981

Recurrent cementifying fibroma of the jaws.

The cementifying fibroma is a benign fibro-osseous tumor of the jaws, and is generally believed to originate from the periodontal ligament. The tumor commonly presents as an asymptomatic mass lesion, and is usually well-circumscribed clinically so that conservative excisions have been the treatment of choice. From 1970-1980, 94 cases of cementifying fibromas involving either the maxilla or the mandible were accessioned by the Tumor Registry of the Armed Forces Institute of Pathology. Recurrences were found in 11 of these cases, of which 6 involved the mandible. Experiences with these cases are described, as well as experiences with two patients who were managed at the National Naval Medical Center and National Institutes of Health. Conclusions indicate that preferred management for most recurrent cementifying fibromas involves conservative removals which attempt to preserve form and function of the affected site. Residual disease when unavoidable often remains quiescent for extended periods of time without compromise to the patient involved.

Adolescent↗
PubMed2000

Ameloblastic fibroma in the midline of mandible: a case report.

The ameloblastic fibroma (AF) is a rare benign mixed odontogenic tumor. It is composed of both epithelial and mesenchymal elements, but lacks of any calcified dental structures. Most of these tumors occur in the mandible and appears preferentially in the posterior portion of the dental arch with molar area predominates over premolar area. It is important to differentiate the lesion from ameloblastoma, since unlike the latter, it does not exhibit a locally invasive growth pattern. It is a well-circumscribed lesion and does not require the radical excision that may be necessary to effect cure with ameloblastoma. The present case report describes a 15-year-old patient with an ameloblastic fibroma in the symphysis of the mandible, a rare reported site. In the beginning of the article an extensive review of the previously published literature on ameloblastic fibroma has been made. In the later part, the diagnosis, differential diagnosis, histology and therapeutic procedures and postoperative follow up of the present case have been described.

Adolescent↗
PubMed2005

Ameloblastic fibroma at the University of Nairobi Dental Hospital.

OBJECTIVE: To document the occurrence of cases of ameloblastic fibroma. DESIGN: A retrospective study. SETTING: The Division of Oral Pathology and Oral Medicine histopathology laboratory at the Faculty of Dental Sciences, University of Nairobi, January 1991 to December 2000. RESULTS: Seven complete records of histopathologically confirmed cases of ameloblastic fibroma were identified. There were four male and three female cases with an age range of 10 to 22 years (mean=14 years). Remarkably, six of the cases had lesions in the molar regions of the mandible with a single case with a maxillary molar area lesion. One of the cases had the neoplasm associated with an unerupted tooth. From the clinical notes all the patients were managed by meticulous enucleation and curettage of the lesions. After follow up periods ranging from several months to eight years no recurrences had been recorded. CONCLUSION: Evidently ameloblastic fibroma is an uncommon neoplasm as noted in the earlier literature. Although the lesions can be quite extensive at the time of diagnosis, the recurrence rate appears to be relatively low if the neoplasms are meticulously extirpated.

Adolescent↗
PubMed1968

Shope fibroma virus growth curve in suspended tissue culture.

As a tumour-producing agent, Shope's rabbit fibroma virus (a member of the myxoma-fibroma subgroup of the poxviruses) is endowed with potentialities which differ from those of vaccinia virus. This work attemps to find, by the technique of the one-step growth curve in suspended cells, if the virus replication scheme is similar to other poxviruses. Fibroma virus seems to multiply rather slowly and to a limited level, but the pattern is characteristic of the poxviruses: eclipse phase, exponential multiplication, reduced release of virus in the medium are the main features.

Animals↗
PubMedDate not supplied

[Polycythaemia and uterine fibroma. A case with in vitro demonstration of an erythropoietic activity in the tumor (author's transl)].

A new case of polycythaemia associated with an uterine fibroma is presented. The presence of erythropoietin in the tumor has been demonstrated by an in vitro technique of titration using a microculture of foetal mouse liver cells. The study of 46 previously reported cases show that the usual pattern is that of an isolated polycythaemia occurring in a woman in her fifty and of a large fibroma. The surgical cure of the tumor relieves rapidly and definitively the polycythaemia. The hypothesis of an inappropriate secretion of erythropoietin seems admitted, three factors playing probably a role in the occurrence of the polycythaemia: size of the fibroma, state of the iron stores and presence of an inhibitory factor against erythropoiesis.

Erythropoiesis↗
PubMed1984

[Ultrastructural and pathological studies of chondromyxoid fibroma of bone].

Histological and electron microscopic studies were carried out on a chondromyxoid fibroma in the right femur of a 8 years old boy. Although chondromyxoid fibroma contained chondroid, fibrovascular and myxoid components, the chondroid zone was transformed into myxoid zone through degeneration of chondroblastic tumor cells. Fibroblastic tumor cells gave no findings specific for fibroblast and fibrocyte on electron microscopy. Most primitive tumor cells were found in the fibromatoid zone. These cells have probably differenciated to fibroblastic and chondroblastic tumor cells. Histiocytes were gathered around the blood vessel. Despite the native of chondromyxoid fibroma as one of the bone tumor of cartilagenous deviation, it showed the characteristics of histiocytic tumors in part.

Cell Transformation, Neoplastic↗