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Mutagenic effects of combinations of chemical carcinogens and environmental pollutants in mice as shown by the micronucleus test.

The effects of combinations of the chemical carcinogens, dimethylnitrosoamine (DMN) or N-methyl-N'-nitro-N'-nitrosoguanidine (MNNG), with the environmental pollutants, cadmium (Cd) or polychlorinated biphenyls (PCB) were examined by Schmidt's micronucleus method with ddY strain mice. DMN had a positive mutagenic effect by oral administration, with a dose response between 25 and 100 mg/kg body weight. MNNG gave a slight positive, though not consistent result, and seemed to be more sensitive at an earlier stage after administration of the drug. Cd was given for up to 7 days in drinking water as a solution of CdCl2 at concentrations of 3, 30 or 300 ppm as Cd. PCB was administered orally at 100 mg/kg daily for 6 days as a solution in corn oil, or subcutaneously injected in ethanol. Neither Cd nor PCB gave positive results in the micronucleus test. However, a synergistic positive effect of Cd with DMN was seen, but PCB with either of these nitrosamines was not positive.

Animals↗

[Occurrence of pleural mesothelioma. Chronic fibrosing pleurisy and calcified pleural plaques in Turkey in relation with environmental pollution by mineral fibers (author's transl)].

The incidence of pleural mesothelioma (PM), chronic fibrosing pleurisy (CFP) and calcified pleural plaques (CPP) has been studied in Anatolia (Turkey) in relation with environmental pollution by mineral fibers: 1) In central Anatolia, where asbestos deposits have been described, the frequency of CFP and CPP was in the range 2-25%; several cases of PM have been encountered. 2) One area (Cappadoce) is free of asbestos, but contains another kind of mineral fiber: zeolite. In this area, an outbreak of PM has been described in some villages. Among the 600 inhabitants of Karain, 28 cases of PM occurred for the period January 1975-June 1979.

Air Pollutants↗

[Bio-indicating function of soil protozoa to environmental pollution].

Due to the abundant species and huge biomass, soil protozoa play an important role in soil ecosystem. As a bio-indicator, soil protozoa have many advantages over other soil animals. Studies on the community structures, quantities, and dynamic variations of biodiversity of soil protozoa could provide powerful means to evaluate natural environmental changes and to monitor the environmental pollution brought by anthropic activities. Based on the current study at home and abroad, this paper gave a review on the function of soil protozoa in ecosystems, their advantages as bio-indicator, and their responses to environmental factors, soil contaminants and the change of atmospheric CO2. The application prospect of soil protozoa in eco-toxicity diagnosis was also discussed.

Animals↗

[Environmental pollution studies of fluorine coming from industry].

Fluorine in optimal concentration prevents dental caries, while an excess or deficiency in it may lead to pathologic alterations which make fluorine be one of the environmental pollutants the concentration of which is limited by health standards. This investigation, carried out in the area of an aluminium plant, showed the presence in excess of fluorine and fluorine-containing dusts in the atmospheric air, determining an increased fluorine content in the ground and vegetal cultures of the respective area. Negative effects of these noxae upon vegetation and animals were noticed.

Air Pollutants↗

[Use of dust and air as indicators of environmental pollution in areas adjacent to a source of stationary lead emission].

This study measured lead concentrations in both the outdoor air and household dust from houses located around a lead-acid battery repair shop. Such installations are one of the largest sources of lead exposure, since outdated technology is still used, coupled with the lack of strict air-quality control programs. Measurements of the air lead concentration around the repair shop were carried out at 6 points, approximately 25 and 500 m from the shop. Over 50% of the air samples exceeded the limit of 1.5 microg Pb.m-3 (range 0.03 - 183.3 microg Pb.m-3). House dust samples were collected from 6 places in houses located at approximately 25, 50, and 500 m from the repair shop, and the concentration of 1,500 microg Pb.m-2 for lead in house dust was exceeded in 44% of the samples, with results varying from 2.2 to 54,338.9 microg Pb.m-2.

Air Pollutants↗