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PubMed1981

Chemodectomas of the head and neck.

The authors' experience in dealing with 10 cases of chemodectomas occurring in head and neck is outlined. The symptomatology of these tumors is discussed with their investigation and management. Analysis of this series suggests that polytomography is the most valuable tool in diagnosing lesions within the confines of the temporal bone, whereas angiography is the most rewarding method of investigating cervical lesions. Surgical resection is the preferred method of treatment, and the most definitive. However, in those cases where the patient's general medical condition or the size and location of the tumor create unacceptable risk factors, radiotherapy may be employed as a palliative measure.

Adult↗
PubMed1978

[Our way in the treatment of middle ear carcinoma (author's transl)].

The treatment of middle ear carcinoma is in first place surgical, completed electrocoagulation and post-operative irradiation. The first intervention should be as radical as possible. But we do not consider that a total resection of the temporal bone should be routinely performed in each case. The range of the operation should be adapted to the size and localisation of the tumours process. It is impossible and unnecessary to preserve the labyrinth with a radical operation. The facial nerve can be preserved only in singled out cases. The retroauricular incision should be left open whenever possible because it helps to discover a relapse in due time and to apply radium, i.e., radioactive isotopes. A radical neck-resection should be performed only in case of a clinically obvious metastasis.

Ear Neoplasms↗
PubMedDate not supplied

[Early diagnosis of benign tumors of the ear and their recurrences].

Early and initial symptoms of benign tumors of the ear are detailed. Clinical presentation of auricular new growths and those of external acoustic meatus, difficulties and errors in diagnosing ceruminoma, neurinoma, hemangioma and chemodectoma are outlined. The above errors can be minimized and prevented if the order of the above symptoms onset is taken into consideration. Early diagnosis is important for good outcome of such surgery.

Cerumen↗
PubMed1993

Photodynamic therapy for nasal and aural squamous cell carcinoma in cats.

Eighteen random-bred cats with a total of 19 nasal or aural squamous cell carcinomas were treated with photodynamic therapy, using aluminum phthalocyanine tetrasulfonate as the photosensitizer. Cats were irradiated at power densities of 100 mW/cm2 and energy densities of 100 J/cm2. Successful outcome was obtained in 10 tumors after 1 treatment, and 2 more tumors had complete responses after 1 or 2 additional treatments. Treatments were more effective in tumors of stage T2 or earlier. Five tumors had partial responses, and the response of 2 tumors could not be evaluated. The treatment was safe and well tolerated by most cats, although we found that cats should be kept out of sunlight for 2 weeks after treatment.

Animals↗
PubMed1997

["Hyaline-cell chondroid syringoma." Morphological, immunohistochemical and ultrastructural study of a case and review of the literature].

Chondroid syringoma represents the cutaneous counterpart of mixed tumor ("pleomorphic adenoma") of salivary glands, therefore it is also termed mixed tumor of the skin. The presence of hyaline cells in mixed tumors of salivary gland is a very well known event. Tumors mainly or exclusively composed of hyaline cells are termed myoepitheliomas of hyaline type, accordingly to their alleged myoepithelial origin. Scanty components of hyaline cells in chondroid syringomas of the skin have also been observed since more than a decade. However chondroid syringomas mainly or exclusively composed of hyaline cells have been reported only very recently. If the hyaline cells of chondroid syringomas are myoepithelial or epithelial in origin is still a matter of debate, we prefer to retain the descriptive label "hyaline cell-rich chondroid syringoma" as originally conceived by JA Ferrero and AG Nascimento the patronimic authors of the entity. A case of hyaline cell-rich chondroid syringoma is reported on in a white male patient aged 64, which occurred on the external ear of 1-year duration. This case was studied immunohistochemically and ultrastructurally. Both immunoprofile which included reactivity for vimentin, low molecular weight cytokeratins, S-100 protein, GFAP (focally), alfa-smooth actin and muscle-specific actin, and ultrastructural features including evidence of intermediate filaments (non-bundling filaments, tonofilaments), desmosomes, and thin filaments of actin type sustain a myoepithelial differentiation for hyaline cells of this tumor and site. The authors also remark the importance of being aware of this new entity during the diagnostic practice for avoiding misinterpretation. A list of condition to be taken into account in differential diagnosis is also given.

Adenoma, Pleomorphic↗
PubMed1998

[Merkel cell carcinoma of the auricle].

A case of a 80-year-old woman suffering from Merkel cell carcinoma of the auricle with regional cervical lymph nodes metastases has been described. Surgical treatment (tumour and regional lymph nodes dissection) was applied at first. Metastasis to one lymph node was established in postoperative histological examination. Chemotherapy (farmorubicin, cyclophosphamide, vincristine) in 3 cycles was applied within 2 months. In spite of the above, 4 months after tumour excision, metastatic lymph node manifested in the neck. Combined treatment, radical neck dissection and radiotherapy was applied then.

Aged↗
PubMed1988

Pleomorphic adenoma of the middle ear and mastoid with posterior fossa extension.

We describe the case of a pleomorphic adenoma of the middle ear and mastoid, with extension into the posterior cranial fossa. The lesion was characterized by extensive bony destruction and close proximity to the facial nerve. Ectopic or choristomatous salivary gland tissue within the middle ear cleft is the most probable origin of this tumor.

Adenoma, Pleomorphic↗
PubMed1983

Squamous cell carcinoma of the pinna.

A number of cases of squamous carcinoma of the pinna were examined. The rate and pattern of metastases were established and a review of the histology carried out. No histological parameters could be identified at the initial resection that were useful in predicting the likelihood of metastases. The importance of adequate initial surgery is emphasised.

Aged↗
PubMed1993

Malignant fibrous histiocytoma developing in burn scar of the ear.

Malignant fibrous histiocytoma is the most common soft tissue sarcoma. The tumours usually present as a painless enlarging mass deep to the subcutaneous tissue most often in the thigh. Wide excision is the recommended treatment, as the incidence of recurrence is high in patients with marginal excision. Metastases can occur in 50 per cent of patients. This patient represents a rare and previously unreported presentation of malignant fibrous histiocytoma in a burn scar of the ear.

Aged↗
PubMed2006

Merkel cell tumour of the external ear. Report of a case.

Merkel cells carcinoma (MCC) is an uncommon skin lesion, considered a malignancy of the neuroendocrine system, which is found mainly in elderly people. Its incidence is highly correlated with sun exposure or immunodeficiency syndromes. MCC is often an aggressive tumour with high tendency for local recurrence, lymph node involvement and distant metastasis. To our best knowledge 20 cases originated from the auricle have been described, 2 of them arising from external ear canal. The authors report a case of the ear canal characterized by two others synchronous tumours and the occurrence of a malignant high grade lymphoma, in which contribute of the pathologist was essential for a critical review. MCC diagnosis is not always easy for its pathological and clinical features and it should always be considered in presence of lymphoma. A multidisciplinary approach is basic.

Aged↗
PubMed2006

Primary radical radiotherapy for squamous cell carcinoma of the middle ear and external auditory cana--an historical series.

AIMS: To evaluate patients treated with radical radiotherapy alone for squamous cell carcinoma of the middle ear (MEC) and external auditory canal (EAC) in terms of freedom from local recurrence, cancer-specific survival and morbidity. MATERIALS AND METHODS: Between 1965 and 1988, 123 patients were treated, 70 with MEC and 53 with EAC. The median age was 64 years (range 21-86) and 78% presented as late stage. The median dose was 55 Gy (range 39-55) in 16 once daily fractions (range 13-21). RESULTS: At 5 and 10 years, respectively, freedom from local recurrence was 56 and 56%, disease-free survival was 45 and 43%, cancer-specific survival was 53 and 51%, and overall survival was 40 and 21%. Cancer-specific survival was significantly worse with late stage as opposed to early stage (P = 0.0026), as was local recurrence (P = 0.0088). No differences in survival and local control were seen according to site. Radionecrosis developed in 6% of patients. CONCLUSIONS: Combined treatment using radiotherapy and radical surgery is often favoured. This large series shows that radical radiotherapy achieves comparable results in terms of local control and cancer-specific survival. Our radiotherapy regimen is now 55 Gy in 20 daily fractions to reduce late morbidity. Radiotherapy alone remains a viable option, especially as morbidity can be minimised and target volume delineation optimised using computer planning in the future.

Adult↗
PubMed2004

[Malignant tumours of the external auditory canal and of the middle ear].

OBJECTIVES: To review our experience and results in the treatment of a low incidence pathology such as the malignant ear tumors. METHODS: The study reviewed 36 patients with malignant tumors of the EAC and middle ear treated between 1977 and 2000 in our hospital, excluding cancer of the pinna, metastatic tumours and sarcomas. It was used the staging system proposed by the M.D. Anderson. RESULTS: The most common histological type in our series is the squamous cell carcinoma, and the otorrhea and pain are the primary symptoms in 100% of patients. Surgery combined with radiotherapy obtained a 41% 5-year survival rate. CONCLUSIONS: The staging system is an important prognostic factor and it is important an early diagnosis to achieve a better therapeutical result.

Adult↗