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At least 307 records · Page 17Linked to original sources
PubMed1979

Birmingham Medical Research Expeditionary Society 1977 Expedition: the diuresis and related changes during a trek to high altitude.

Continuous 24-hr urine collections were made by 17 subjects during a trek to 5400 m. Fluid intake was recorded by diary. Weight and fat folds were measured daily. The results were compared with daily measurements of packed cell volume (PCV) and reticulocyte count. Early fluid retention was matched by a fall in PCV. There was a diuresis with negative fluid balance towards the end of the ascent and again early in descent. There was a slight trend for fluid retention to occur in those most affected by acute mountain sickness but the effect was not marked.

Adult↗
PubMed1979

Birmingham Medical Research Expeditionary Society 1977 Expedition: effect of a Himalayan trek on whole body composition, nitrogen and potassium.

The body composition of the 17 members of the BMRES was studied using body weight and fat fold calipers, with measurements of whole body potassium and nitrogen. The full assessment was made just before departure from Birmingham and immediately on return. Daily observations of body weight and fat folds were made during the trek to high altitude. During the ascent all subjects lost body fat but there was little change in lean body mass. After return it was found that there had been further loss of body fat and some loss of lean tissue also. One subject who took methandienone retained potassium but had no increase in body nitrogen. There was no correlation between changes in body composition and acute mountain sickness.

Adult↗
PubMed1979

Birmingham Medical Research Expeditionary Society 1977 Expedition: changes in renal function observed during a trek to high altitude.

Changes in renal function were observed in 17 subjects during the course of a trek to high altitude. Comparison was made between these changes and the clinical assessment of acute mountain sickness (AMS). Periods of natriuresis occurred during ascent and descent, that during ascent being related to a fall in plasma aldosterone. Alterations in serum and urinary potassium suggested that potassium retention occurred during the ascent to altitude. No significant correlation occurred between changes in renal function and the severity of AMS before the illness being clinically apparent. When this was so, the severity of AMS correlated with a decreasing urine output, increasing positive fluid balance and a decreasing excretion of sodium and potassium; these changes were produced in part by a decrease in glomerular filtration rate.

Adult↗
PubMed1979

Birmingham Medical Research Expeditionary Society 1977 Expedition: cardiopulmonary function before, during and after a twenty-one-day Himalayan trek.

The heart rate response to exercise was studied in 17 normal subjects before, during and after a 21-day Himalayan trek to 5490 m. The group were fitter before the trek when compared to normal subjects of a similar age (P less than 0.001) having a lower heart rate response to exercise for their lean body mass. The trek significantly increased the 'fitness' of the group as a whole (P less than 0.025) but this was not seen in the 5 members of the group who had severe acute mountain sickness. Similar changes were noted within the first 8 days of the trek before symptoms of mountain sickness occurred. The group had normal pulmonary function before the trek but peak expiratory flow rate and vital capacity decreased with altitude. The effect was more marked in the subjects with acute mountain sickness.

Adult↗