Breast cancer genetics. Implications of clinical practice.
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The tumor suppressor gene encoding the cyclin-dependent kinase inhibitor p16 has, remarkably, been found to encode a second protein, p19, with a distinct sequence translated from an alternative reading frame; like p16, p19 can block the cell cycle in G1 phase.
Proto-oncogenes and tumor suppressor genes are primarily involved in orchestrating normal growth and differentiation--except for p53, which seems to be dedicated to controlling abnormal growth.
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