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PubMed1990

[Climacteric keratoderma (Haxthausen's syndrome)].

This condition was described by Haxthausen in 1934 for the first time; it is one of the diseases explained by hyperkeratosis of the palms and soles. This disease is difficult to diagnose, and patients often complain of such conditions; therefore the authors consider it useful to regularly publish descriptions of clinical cases. Besides involvement of the palms and soles, manifesting by hyperkeratotic layers, painful fissures and itching, the patients with climacteric keratoderma develop metabolic endocrine, neurovegetative, and psychoemotional disorders. When choosing the treatment strategy, the physician should bear in mind specific features of the pathogenesis and clinical picture. Earlier therapy and its efficacy are of importance, as are the presence of allergies or drug intolerance and particulars of the climacteric period course in the first- and second-degree relatives.

Adult↗
PubMed1990

[Clinical and neurohumoral indicators in women-alcoholics of reproductive and climacteric age].

As many as 94 women of reproductive and climacteric age were subjected to clinical and laboratory studies. Women of reproductive age demonstrated abnormalities of menstrual function of the type of ovulatory and anovulatory hemorrhages. The group over 40 years manifested an early onset of menopause. Alcoholism standing was from 2 to 15 years. Study of the neurohumoral characteristics in women suffering from alcoholism during abstinence revealed a considerable lowering of serotonin content in the blood as compared with normals. The content of acetylcholine, the activity of genuine and false blood cholinesterase were increased in women suffering from alcoholism, pointing to excitation in the cholinergic system. During abstinence, women of reproductive and climacteric age suffering from alcoholism demonstrated discrepancy in the activity of the neuromediator systems.

Acetylcholine↗
PubMed1990

A clinical test for calcium absorption in climacteric women. A two tracer, single blood sample procedure with corrections for body size and skeletal turnover.

This paper reports a two tracers (45Ca for estimating calcium absorption and stable fluoride for assessing skeletal turnover), single blood sample procedure that estimates the absorption of calcium in climacteric women. The proposed technique determines the percentage (Ac) of the dose of 45Ca administered orally (in the fasting state, diluted with 150 ml of milk), present in the extracellular fluid (estimated as 15% of body wt) five hours after intake, corrected for skeletal turnover (assessed by the whole body retention of fluoride). In a series of 13 patients, Ac has been found to be operationally equivalent to the ratio: net Ca absorption/Ca intake, measured under balance conditions. The calcium balances of 60 climacteric women, estimated as: net Ca absorption (Ca intake factored by Ac) minus calciuria was found, as expected, to be correlated with skeletal turnover.

Body Weight↗
PubMed1989

[Interdisciplinary diagnosis and therapy concepts in climacteric osteoporosis].

50 patients with signs of osteoporosis have been selected from special outpatient clinics for climacteric or rheumatic complaints for a complex interdisciplinary programme concerning diagnostics and therapy. 46 patients could be treated successfully for one year with estrogens and progestogens, fluoride and calcium preparations as well as physiotherapeutic treatments including electrotherapy and dietetic advice. X-ray examinations done after this period did not show any progression of the osteoporosis. But only in 4 patients an increase of bone density could be demonstrated. In the other patients health conditions were stabilized. Good results could be obtained with regard to climacteric complaints and improvement of fitness and efficiency. In 2 patients a long-time disablement could be stopped.

Adult↗
PubMed1989

[Study on climacteric symptoms in relation to ovarian function ageing and psychologic factors].

The present investigation was undertaken to establish the relation between climacteric symptoms, ovarian function, ageing, and psychological factors. The subjects were as follows; 1,270 women who received a screening test for cervical cancer and 247 women following hysterectomy. The methods of investigation were Kupperman menopausal index (K-index), Cornell Medical Index (CMI) and YG character questionnaire (YG test). The following results were obtained: 1) the K-index increased until 39 years of age and was constant after 40 years. Five symptoms (chills, nervousness, melancholia, excitability and vertigo) were not influenced by ageing, and seven symptoms (panting, hypesthesia, insomnia, wakefulness, fatigue, palpitation and formication) increased with age. Hot flushes, perspiration, numbness, shoulder stiffness, lumbago, and headache, occurred at peak frequency in the climacteric period. 2) In hot flushes, perspiration, numbness, hypesthesia, shoulder stiffness, lumbago, and formication, a significant difference was found between the control and those patients who had received bilateral oophorectomy. 3) The K-index and CMI score were significantly correlated, and six symptoms (palpitation, panting, excitability, vertigo, wakefulness and formication) in particular were related to CMI. 4) The K-index was lowest in the patients indicated to be the D type by the YG test, and was highest in the patients of the B.E type. Six symptoms (excitability, palpitation, panting, melanchoria, hypesthesia and formication) were thought to be associated with the character of the patients. Results showed that four symptoms (hot flushes, perspiration, numbness, shoulder stiffness and lumbago) were closely related to ovarian function, and three symptoms (panting, excitability, and palpitation) depended largely on mental factors. The relationship between vasomortor symptoms and gonadotropin was investigated.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[The effect of oral contraceptives on bone density in climacteric females].

The aim of the study was to investigate the influence of long-term administration of oral contraceptives on bone density in climacteric women. Two hundred (n = 200) climacteric women were allocated to three study groups (I, II, III). The first (n = 30) one had been using oral contraceptives for more than 10 years, the second (n = 50) one for between 2 and 9 years, while the third (n = 120) one had never used oral contraceptives. Bone mineral content (BMC) of the left forearm was measured by single photon absorptiometry. The results demonstrate that osteoporosis occurs later and is less frequent during the peri-menopause (p less than 0.05) in women who have used oral contraceptives on a long-term basis (greater than 10 yr). Our findings confirm that there is an important correlation between longterm use of oral contraceptives and bone density.

Adult↗
PubMed1989

[Pathogenetic mechanisms of the development of "hot flushes" in patients with climacteric disorders of the sympathetic-adrenal type].

Examinations of 19 patients aged 49 to 55, suffering from climacteric disorders of sympathoadrenal nature, have revealed during 42 hot flushes an activation of the sympathoadrenal section of the autonomic nervous system (increased arterial pressure, heart and respiration rates, and skin galvanic reflex), as well as activation of peripheral vasodilatation, elevated skin temperature, and increased concentrations of LH, ACTH, thyrotropic hormone (TTH), cortisol, aldosterone, and testosterone. These data suggest that the trigger mechanism of a hot flush in the patients with the climacteric syndrome represents modified (due to changes in the external or internal conditions) activity of the LH releasing factor-secreting neuron structures and of the central temperature-sensitive neurons. Activation of the sympathoadrenal section of the autonomic nervous system and of the hypothalamo-hypophyseo-adrenocortical system is explained by their important role in the adaptive reactions of the body. Increase of the TTH level results from increased activity of the thyrotropin releasing factor, contributing to the central mechanisms of thermoregulation.

Adrenal Glands↗
PubMed1989

The climacteric and gynaecological cancers.

Epidemiologic data show how the climacteric is definitely an high risk period for the developing of genital and mammary neoplasias. This can be probably explained for the genital district by the hyperestrogenic situation that the climacteric woman experiences and by the promoting effect that estrogens have on the neoplastic growth. As far as the mammary cancer concerns the reproductive history would seem to be more important than the perimenopausal hormonal in determining the high risk woman. Estrogen replacement therapy would seem to be dangerous only for the endometrium while little or no effect can be demonstrated for the ovary and the breast. The combined estrogen-progesterone therapy all the beneficial effects and seems to be absolutely safe.

Climacteric↗
PubMedDate not supplied

[Social change. The climacteric and depression].

We study different socio-environmental factors in relationship with depression in the climacterium. Our sample are women who have been diagnostic of depression and are impatient in the Department of Psychiatry of University Hospital San Carlos. The isolation and the social and familiar changes are the most important events that happen to the women depressive climacteric. The Spanish women in climacteric age have lived in a cultural-educational environment focus toward a maternal role. Because of this her personality has development dependent and submission.

Adult↗
PubMed1989

[Effectiveness of diet therapy of obesity in women in the climacteric period].

Twenty-five women at the climacteric age (mean age 48.5 +/- 5.5 years) were treated for simple obesity (mean overweight 37.8%) giving them low-calorie, low-carbohydrate and low-sodium diet for 14 days. The diet was very well tolerated by the patients. The mean weight loss was 4.4 kg, with 72.7% of this loss in the first week on the diet. A considerable reduction of the activity of dopamine beta-hydroxylase were noted, indicating a decrease of the activity of the adrenergic system. At the same time the diet stimulated thyroid function, as shown by increased concentration of total thyroxine (without exceeding the normal upper range), and higher free thyroxine index. Besides that, the serum uric acid level was increased. No changes of electrolyte levels were noted. The diet was effective and well tolerated in this treatment of women in climacteric age for obesity.

Adult↗
PubMed1988

[The beta-endorphin level in climacteric women].

UNLABELLED: Hot flushes are not caused by a hypergonadotrophinemia. Peaks of gonadotrophin in the serum do not coincide with the cutaneously measured hot flushes. There is an occurrence of hot flushes in hypophysectomized women as well. GnRH and other neurotransmitters (beta-endorphin?) effect the thermoregulation. - HYPOTHESIS: During the climacteric period changes of neurotransmitters, a decrease of catecholestrogens, a decrease of alpha-2-adrenoceptor activity and the ceasing of the ovarian steroid production lead to changes of the endogenous opiate activity and thus to disturbances of the thermoregulation resulting in the occurrence of hot flushes. Low beta-endorphin levels in the peripheral plasma, which increase again after a treatment with estrogens, are found during the climacteric period. On the other hand women with severe hot flushes as an expression of a stress event show enormously increased beta-endorphin values, which normalize again after a hormone substitution therapy, effected by still unknown neuroendocrinological feedback mechanisms.

Climacteric↗
PubMed1986

[Psychosocial backgrounds of climacteric symptoms and complaints].

Postal questionnaires about psychosocial factors related to climacteric symptoms and complaints were sent to women subjects with such symptoms, and to volunteers without such symptoms. Controls were selected from among the volunteers. Each of 216 subjects was matched at random with one of 639 volunteers within one year of the subject's age. Thus, 216 matched-pairs were created, each consisting of a subject and a control. Significantly high relative risks of the following factors as estimated by McNemar's test were shown by a case-control study: social: few intimate friends, low educational level, husband engaged in unskilled labor, employed subject; psychic: feeling of poor health, low self-esteem, perception of lack of respect by people surrounding the subject, dissatisfaction with present life, anxiety about the future, feeling of being a burden to family and/or community. Moreover, correlations between various items listed above were examined by means of the chi-square test. Statistically significant correlations were found for the following pairs of items: low educational level, suggesting low socio-economic status, and either dissatisfaction with present life or feeling of poor health, and few intimate friends, suggesting a lack in potential social support, and either low self-esteem or anxiety about the future. The first mentioned pairs were predominantly associated with severe climacteric symptoms and complaints and the latter with mild symptoms and complaints.

Anxiety↗
PubMed1981

Psycho-endocrine differences and correlations in symptomatic and asymptomatic climacteric women - the possible role of prolactin.

The hormonal and psychological profiles of 23 women with the climacteric syndrome were compared with those of 10 asymptomatic postmenopausal women. Statistical analysis of the results of this prospective study revealed significant differences in luteinizing hormone, oestradiol and prolactin values. Interesting correlations linking the clinical, hormonal and psychological parameters are presented and discussed. A hypothesis is advanced to explain the elevated levels of serum prolactin in asymptomatic postmenopausal women. A psycho-endocrine profile of the symptomatic climacteric women is presented.

Adult↗
PubMed1984

[Blood levels of estradiol, FSH and LH in women with climacteric syndrome--conjugated estrogen therapy].

To study the types of patients with climacteric syndrome who respond to conjugated estrogen therapy, we investigated the results of 1- to 2-month therapy in 52 patients by comparing their pre- and post-drug level of blood estradiol (E2), FSH and LH as well as comparing information through a questionnaire on menopausal complaints listed according to Kupperman. Predrug E2 in the patients studied was lower than normal, but the lowering was not significantly specific to any particular climacteric symptom. Blood FSH was higher in the patients complaining of hot flushing, sweating, depression, feeling of something sticking in the throat, and decreased sexual desire, whereas blood LH was higher in the patients with hot flushing and sweating. Changes in various symptom were investigated in relation to hormonal changes found after conjugated estrogen therapy. In the patients whose E2 was increased and FSH and LH were decreased after the therapy, hot flushing, cold sensation, excitability and insomnia were ameliorated at a high rate. Numbness was favorably treated in the patients responding with increased E2, whereas shoulder stiffness, fatigability and headache was reduced in those responding with decreased LH.

Adult↗
PubMed1983

Minor gynaecology of the climacteric.

The climacteric is a transitional phase of one to five years during which the genital organs involute in response to the cessation of gonadal activity. During the climacteric women suffer a range of gynaecological disorders. The patient's worries discussed in this article are particularly pertinent to general practice.

Adult↗
PubMed1983

[Menopausal indices as criteria for the effectiveness of acupuncture treatment of the climacteric syndrome (preliminary report)].

Ten female patients with manifested climacteric syndrome (CS) were treated by acupuncture according to the traditional east methodology, the basic therapy making use of the points--Năi-Guan, Gun-Sun, Hă-Gu and Zsu-San-Li and for the determination of the severity of CS and the effect of its treatment --five of the most often applied menopause indices (MI) in the hormonal treatment of CS were used. Copperman, Blatt--modification of Neugarten and Kreins: Jones, Marshall and Nordin: Wenderlein and Striker. The favourable clinical results observed from the acupuncture treatment, determined by MI, are similar to the results, reported by the authors, making use of MI in the hormonal treatment of CS. That provided grounds to admit that they are suitable criteria also for the objectivization of the effect of the acupuncture treatment of climacteric syndrome.

Acupuncture Therapy↗
PubMed1984

[Climacteric mask of endogenous depressions].

Eighty-six women of the menopausal age with neurotic and neurosis-like disturbances in the presence of the disrupted menstrual cycle were followed up at the Kazan psychoneurological outpatient centre. Out of the total number, 32 cases of masked depression in the framework of cyclothymia imitating climacteric disorders were ascertained. The author specifies the clinical characteristics of endogenic masked depression and the diagnostic criteria allowing its differentiation from climacteric neurosis.

Adult↗
PubMed1982

[Plasma LH-RH levels in normal men and women with increasing age, in women with castration, climacteric syndrome, also in pregnancy, delivery and puerperium].

In order to further clarify hypothalamic function, plasma LH-RH was measured by a sensitive radioimmunoassay in normal men and women with increasing age, in women with castration, climacteric syndrome, also in pregnancy, deliver, and puerperium. The following results were obtained: 1) Plasma LH-RH levels were the same in the follicular and luteal phases of adult and premenopausal women, and a gradual increase was noted through the premenopausal period. It had the highest peak in the group within one year after menopause, followed thereafter by a gradual decline throughout the senile period but still remaining higher than that in the adult period. 2) There was no change in plasma LH-RH in men between ages 22 and 55, but a slight increase was found over age 56. 3) There was a high plasma LH-RH peak in the first day after bilateral oophorectomy both in pre- and post-menopausal women. A slight increase was found postoperatively in the premenopausal but not in the postmenopausal group. 4) There was a low plasma LH-RH level in both pre- and post-menopausal women with climacteric syndromes. 5) There was a low plasma LH-RH level through 9-39 weeks of gestation and during labor, it became a little higher at one month postpartum than in non-pregnant women.

Adult↗