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PubMedDate not supplied

The Beaver Dam Health Outcomes Study: initial catalog of health-state quality factors.

The Beaver Dam Health Outcomes Study (BDHOS) is an ongoing longitudinal cohort study of health status and health-related quality of life for a random sample of adults (age range at interview was 45 to 89 years; mean = 64.1, SD = 10.8) in a community population. In a face-to-face interview lasting approximately an hour, each participant responds to several batteries of questions. Included are a history of chronic medical conditions, current medications, and past surgeries; the SF-36 (a general health-status questionnaire); the Quality of Well-being index; self-rated health status on a five-point scale from "excellent" to "poor"; and evaluation of current health using the method of time tradeoffs. The authors present results from 1,356 interviews on these four principal measures, reporting mean scores by sex, by age, and for persons reporting being affected by various medical conditions. They believe data from the BDHOS will provide researchers and policy makers a reference collection of vital statistics for health-related quality of life. Additionally, the data provide a way to compare results from studies that utilize different indices from among the four principal measures of the BDHOS.

Adult↗
PubMed2001

Large-scale cDNA analysis of the maternal genetic information in the egg of Halocynthia roretzi for a gene expression catalog of ascidian development.

The ascidian egg is a well-known mosaic egg. In order to investigate the molecular nature of the maternal genetic information stored in the egg, we have prepared cDNAs from the mRNAs in the fertilized eggs of the ascidian, Halocynthia roretzi. The cDNAs of the ascidian embryo were sequenced, and the localization of individual mRNA was examined in staged embryos by whole-mount in situ hybridization. The data obtained were stored in the database MAGEST (http://www.genome.ad.jp/magest) and further analyzed. A total of 4240 cDNA clones were found to represent 2221 gene transcripts, including at least 934 different protein-coding sequences. The mRNA population of the egg consisted of a low prevalence, high complexity sequence set. The majority of the clones were of the rare sequence class, and of these, 42% of the clones showed significant matches with known peptides, mainly consisting of proteins with housekeeping functions such as metabolism and cell division. In addition, we found cDNAs encoding components involved in different signal transduction pathways and cDNAs encoding nucleotide-binding proteins. Large-scale analyses of the distribution of the RNA corresponding to each cDNA in the eight-cell, 110-cell and early tailbud embryos were simultaneously carried out. These analyses revealed that a small fraction of the maternal RNAs were localized in the eight-cell embryo, and that 7.9% of the clones were exclusively maternal, while 40.6% of the maternal clones showed expression in the later stages. This study provides global insights about the genes expressed during early development.

Animals↗
PubMed2002

[Psychosomatic and psychotherapeutic medicine goes DRG -Procedure-catalog OPS-301 2.1 as a first step].

To demonstrate the repercussions for Psychosomatic and Psychotherapeutic Medicine of the politically motivated decision to introduce case mix funding for inpatient treatment in Germany. Description of the development of an appropriate code list of procedures for Psychosomatic and Psychotherapeutic Medicine within the DRG-System. The code list OPS-301 which was valid in 2001 had no appropriate procedures for Psychosomatic and Psychotherapeutic Medicine. The scientific societies therefore had to develop possibilities for coding psychosomatic-psychotherapeutic procedures in the new OPS-301 2.1 which is valid since January 2002. This was achieved through the formulation of so-called complex codes, which are presented together with first coding tips. There are further tasks with risks and potential benefits which have to be accomplished after establishing these complex codes.

Cost-Benefit Analysis↗
PubMed2006

Cataloging the relationships between proteins: a review of interaction databases.

By organizing and making widely accessible the increasing amounts of data from high-throughput analyses, protein interaction databases have become an integral resource for the biological community in relating sequence data with higher-order function. To provide a sense of the use and applicability of these databases, we describe each of the major comprehensive interaction databases as well as some of the more specialized ones. Content description, search/browse functionalities, and data presentation are discussed. A succinct explanation of database contents helps the user quickly identify whether the database contains applicable information to their research interest. Broad levels of search/browse functions as well as descriptions/examples allow users to quickly find and access pertinent data. At this point, clear presentation of search results as well as the primary content is necessary. Many databases display information graphically or divided into smaller digestible parts over a number of tabbed/linked pages. In addition, cross-linking between the databases promotes interconnectivity of the data and is an added layer of relational data for the user. Overall, although these protein interaction databases are under continual improvement, their current state shows that much time and effort has gone into organizing and presenting these large sets of data-describing protein interactions.

Database Management Systems↗
PubMed1988

Cataloging blood alcohol level and alcohol consumption data in field settings: feasibility and findings.

A team of two female interviewers, two male interview assistants, and one or two additional male observers were stationed in front of targeted drinking establishments to survey individuals about their drinking practices and to collect blood alcohol levels (BALs) using portable breath testers. Of the 176 individuals asked to participate, 156 (88%) consented to be interviewed and 141 (90%) provided breath samples. Of those tested, 40 (29%) were legally intoxicated (BAL greater than or equal to 100 mg/dl) while 68 (49%) registered a BAL of 50 mg/dl or greater. The mean BAL was 72 mg/dl. Individuals reporting that they were going to drive had significantly lower BALs than those planning not to drive. Subjects who thought they were legally intoxicated, on average, had BALs greater than the legal level of intoxication, and BALs significantly greater than those who felt they were not intoxicated. These data suggest that the collection of BAL, in combination with self-reported alcohol data, is an important component of methodologically sound alcohol field research.

Adult↗
PubMed2004

Sequence tag catalogs of dust mite-expressed genomes: utility in allergen and acarologic studies.

Dust mites are a major source of indoor allergens. They contain a large number of components that react with immunoglobulin (Ig) E in individuals with allergies and are capable of inducing sensitization, and allergic respiratory and cutaneous diseases. With a significant proportion of the population affected in some way by mite allergies, it is essential that we improve our understanding of these organisms so that control strategies could be defined and its allergens better understood. Thus, we have initiated a project using the expressed sequence tagging (EST) strategy to study the major species of dust mites associated with allergic diseases, in particular, the American house dust mite, Dermatophagoides farinae, as well as Blomia tropicalis, the most prevalent mite in domestic tropical dwellings. The work has recently been expanded to include 'storage' mites such as Tyrophagus putrescentiae, Acarus siro, Lepidoglyphus destructor, Glycyphagus domesticus, Suidasia medanensis, and Aleuroglyphus ovatus. More than 50% of the initial 3000 ESTs from the D. farinae and B. tropicalis dust mites showed significant matches to known genes and were categorized into eight functional groups (such as proteins involved in metabolism, gene expression, protein synthesis, cell signaling, etc.). Of specific interest, however, were the homologs to known mite allergens, in addition to a number of sequences bearing significant homology to allergens from non-mite sources previously not known to exist in mites. The availability of these allergen sequences has facilitated their expression and subsequent characterization in our laboratory in terms of their IgE-binding reactivity. The wealth of sequence information, generated via the EST project, has also facilitated the identification of polymorphic forms of allergens, the investigation of differential gene expression under various environmental conditions via DNA microarrays, as well as the analysis of protein level expression profiling via the proteomics approach. Additionally, ESTs have also ameliorated the understanding of the phylogenetic relationships between mites, and enabled the isolation of gene products crucial for life processes so that mite control strategies can be more effectively devised. Taken together, the utilization of the EST strategy has opened up numerous new avenues by which the allergist can engage more effectively in the study of dust mites with the ultimate aim of developing appropriate treatment regimens for mite-induced allergy.

Animals↗
PubMed1996

[Cataloging the diversity of the human body: 19th-century French nosology concerning unlawful behavior (1800-1855)].

This work aims to contribute to the study of the factors which influenced the process of the classification of the diversity of human behaviour. As a result this study will look at the changes in operation at the beginning of the nineteenth century regarding the classification of one type of deviant behaviour: homicide. The creation by French psychiatrists of the diagnostic category "monomanie homicide instintive" meant that certain types of homicide were no longer considered a crime and began to be regarded as forms of madness. The emergence and gradual disappearance of this morbid species of psychiatric classifications in the first half of the XIXth century illustrates how the assignation of aberrant behaviour to one kind or other of deviance depends on the way in which various factors are related: changes in scientific theories, permutations in the professional objectives of those who make the classifications, and the degree of social consensus which is achieved for the new meaning that the deviatory behaviour acquires on changing its position among the various forms of deviation.

France↗
PubMed2005

The Internet for pathologists: a simple schema for evaluating pathology-related Web sites and a catalog of sites useful for practicing pathologists.

CONTEXT: With the increasing popularity of the Internet as a primary medical information source, it is critical for pathologists to be able to use and evaluate both general medical- and pathology-related Web sites. Several published models for evaluating Web sites prove cumbersome to use and often involve computer- or statistic-based algorithms. OBJECTIVES: To develop a simple group of scoring criteria to objectively evaluate medical Web sites and provide a list of the highest-scoring pathology-related sites that will be useful to the practicing pathologist. DESIGN: Using 11 commonly used Internet search engines, the top 50 "hits" retrieved from the search term websites for pathologists were scored using 5 criteria, including accuracy, ease of navigation, relevance, updates, and completeness. A possible 6 to 12 points per area were awarded, and the total score was summated. RESULTS: Scores obtained ranged from 12 to 21. Thirty-five Web sites, all scoring 15 or higher based on these criteria, were listed as most useful. CONCLUSION: A simple, easy-to-use, 5-category scoring system can prove useful in evaluating pathology- and medical-related Web sites.

Evaluation Studies as Topic↗
PubMed2001

A catalog of prostate cancer nomograms.

PURPOSE: Prediction is central to the management of prostate cancer. Nomograms are devices that make predictions. We organized many nomograms for prostate cancer. MATERIALS AND METHODS: Using MEDLINE a literature search was performed on prostate cancer nomograms from January 1966 to February 2000. We recorded input variables, prediction form, the number of patients used to develop the nomogram and the outcome being predicted. We also recorded the accuracy measures reported by the original authors and whether the nomograms have withstood validation. In addition, we noted whether the nomograms were proprietary or in the public domain. Each nomogram was classified into patient clinical disease state and the outcome being predicted. RESULTS: The literature search generated 42 published nomograms that may be applied to patients in various clinical stages of disease. Of the 42 nomograms only 18 had undergone validation, of which 2 partially failed. Few nomograms have been compared for predictive superiority and none appears to have been compared with clinical judgment alone. CONCLUSIONS: Patients with prostate cancer need accurate predictions. Prognostic nomograms are available for many clinical states and outcomes, and may provide the most accurate predictions currently available. Selection among them and progress in this field are hampered by the lack of comparisons for predictive accuracy.

Biopsy↗