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Results for “CARDIAC GLYCOSIDES”

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At least 307 records · Page 17Linked to original sources
PubMed1987

Experimental investigation of the effect of cardiac glycosides on the ischemic coronary circulation.

The paper presents new evidence of the vasoactivity of cardiac glycosides in the myocardium. Experiments were performed on the in situ dog heart. The present study primarily focuses on the analysis of K-strophantoside induced topo-optical and thermographic alterations in acute myocardial ischemia. The strong binding of K-strophantoside to the coronary vessel wall and the endothelial cells was found to be accompanied by vasoconstriction in the regionally ischemic heart muscle. The potential clinical impact of these findings on therapy is briefly evaluated.

Animals↗
PubMed1959

The duration of action of some cardiac glycosides and aglycones in the guinea-pig.

A method is described for determining the duration of action of cardiac glycosides and aglycones in the guinea-pig. It is based on their property of potentiating the cardiac response to adenosine. The method is particularly suitable for those drugs with a short duration of action, whereas previous methods are more suitable for those drugs with longer durations of action. The duration of action of one-fifth of the lethal dose has been found for: digoxigenin, lanatoside C, ouabain, digitoxigenin-3-one, digitoxin, 3-acetyldigitoxigenin, digoxin, digitoxigenin, lanatoside A; these drugs are arranged in order of increasing duration of action. The possible relationship between the elimination of these drugs and their duration of action can provide an estimate of their rates of elimination.

Biological Transport↗