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A mystery of Vladimir P. Demikhov: the 50th anniversary of the first intrathoracic transplantation.

Vladimir P. Demikhov was the first to perform intrathoracic transplantation of the heart alone, lung alone, and the heart and lungs in a warm-blooded animal and the first to perform an experimental coronary artery bypass operation with success. He designed the first mechanical cardiac substitute and was one of the first to use the vascular stapling device in experiments. In 1960 Demikhov published the world's first monograph dealing with the subject of thoracic transplantation. This monograph, Experimental Transplantation of Vital Organs, became a "bible of intrathoracic transplantation" and deserves the recognition of everyone who is interested in organ transplantation. However, to say only that Demikhov was the first in the world who performed these operations is to say nothing. It is important to describe the circumstances under which these operations were done to appreciate the true scale of his innovations.

Animals↗

The myth of DSM's invention of new categories of disorder: Houts's diagnostic discontinuity thesis disconfirmed.

Houts (2001) argues that increases in DSM diagnostic categories are due to the invention of new disorders that are discontinuous with old conceptions of disorder and would not have been previously diagnosed. He maintains that DSM category increases are not comparable in nature to ICD category increases, which are mainly refinements of recognized disorders. I survey categories of disorder introduced after DSM-II and assess whether they are discontinuous with old concepts and categories of disorder. Candidate categories are identified from: Houts and Follette (1998), Mentalism, mechanisms, and medical analogues: Reply to Wakefield. Journal of Consulting and Clinical Psychology; Kutchins and Kirk (1997) Making us crazy: DSM: The psychiatric bible and the creation of mental disorders. New York: Free Press; and my own list. The result is that virtually none of the candidate categories are invented, discontinuous categories. In almost every case, the newly labeled conditions were considered disorders at the time of DSM-II and would have been diagnosed under DSM-II categories. I also reexamine DSM-IV sleep disorder categories, which Houts claims are discontinuous with past diagnostic conceptions. The result is that all DSM-IV sleep disorders were recognized as disorders at the time of DSM-II, and most were recognized as mental disorders. I conclude that DSM category increases are comparable in nature to ICD category increases, and that the invention-of-disorder account cannot explain the vast majority of such increases.

Diagnosis-Related Groups↗

Ethical and medicolegal considerations in the obstetric care of a Jehovah's Witness.

Jehovah's Witnesses comprise a unique obstetric population. Their refusal of blood stems from an interpretation of a literal translation of the Bible, and it is this belief that puts them at an increased risk of morbidity and mortality if hemorrhage occurs. Many Jehovah's Witnesses feel that accepting a blood transfusion will lead them to eternal damnation. A patient's self-determination, or autonomy, allows her to make decisions regarding her care. The decision to refuse blood or blood products has been upheld in court. This brings a new twist to the physician's obligation to "do no harm." When one undertakes the care of one of these patients, it is important to understand the ethical and medicolegal ramifications. The decision to be the primary caregivers can only be made once the physicians have decided they can let the patient die when all other options have been exhausted. This commentary discusses the ethical concerns and reviews the alternatives available to a Jehovah's Witness.

Ethics, Medical↗

Plague: the dreadful visitation occupying the human mind for centuries.

Plague is one of mankind's greatest scourges, which has swept away millions of people over the centuries. The first available record of the occurrence of this calamity, in humans, is from the Bible, in 1000 bc, in the city of Ashdod. The first definitely identified pandemic originated in Egypt in ad 542 (the Justinian Plague) and is estimated to have caused 100 million deaths. The second one, lasting for three centuries and claiming over 25 million lives appeared in 1334 in China spreading to many spots on the globe. The third pandemic occurred in Europe from the fifteenth to eighteenth century. The current pandemic began around 1860, in the Chinese province Yunnan; it reached Hong Kong in 1894 killing 100 000 individuals. Within 20 years the disease spread from southern Chinese ports throughout the world resulting in more than 10 million deaths. Since the discovery of the causative agent in 1894, there have been remarkable advancements in immunoprophylaxis and chemoprophylaxis. However, the disease is still active in Africa, in Asia and in Americas and has been classified as a currently re-emerging disease. A 'Plague-free World' will probably remain a dream for an indefinite period.

Bioterrorism↗

Galactorrhea in the adolescent.

Inappropriate lactation--that which occurs beyond the usual postpartum or breast-feeding period or in the male--has been of medical interest for centuries. There is a suggestion that the first recorded case occurred in the Bible in the Book of Esther wherein Mordecai may have breast-fed his niece Esther [1,2]. The Talmud describes a man who nursed his infant after his wife's death during childbirth [3]. Lactation in virgin women was noted by the early Greeks [4], and Aristotle observed lactation in men [5]. The phenomenon of "witch's milk," seen in the newborn, was described as early as 1684 by Bonetus [6]. The first alleged pediatric case of nonpuerperal lactation was of an 8-year-old girl who was able to suckle her baby brother as reported in the 18th Century by Baudelocque [7]. Subsequently, many other cases of abnormal lactation were described in the 19th and early 20th centuries [7-10]. In the past 15 years, there has been a vast proliferation of cases and studies concerning galactorrhea of both sexes [11]. The advent of the prolactin radioimmunoassay was the single most important factor behind the profusion of these investigations [11-14]. Most recently, attention has focused on the high incidence of pituitary tumors--specifically the prolactinoma--in women and to some degree in men [13,15]. The occurrence of such tumors in children and adolescents is also receiving more attention [16,17]. The purpose of this review is to update the reader on galactorrhea with a specific emphasis on: 1) outlining the various causes of galactorrhea that may be seen in adolescent patients; 2) describing the work-up and management of both the male and female adolescent patient with galactorrhea; and 3) describing what is known about the natural history of galactorrhea. A brief description of the physiology of the hypothalamic-pituitary-breast axis and lactation is also presented.

Adolescent↗

Diagnosing moral disorder: the discovery and evolution of fetal alcohol syndrome.

The diagnosis of fetal alcohol syndrome (FAS) was invented in 1973. This paper investigates the process by which a cluster of birth defects associated with exposure to alcohol in utero came to be a distinct medical diagnosis, focusing on the first ten years of the medical literature on FAS. Fetal alcohol syndrome was "discovered" by a group of American dysmorphologists who published the first case reports and coined the term FAS. However, the nature of the diagnosis and its salient symptoms were determined collectively over time by the medical profession as a whole. The paper traces the natural history of the diagnosis in the U.S. through five stages: introduction, confirmation and corroboration, dissent, expansion, and diffusion. FAS serves as an example of the social construction of clinical diagnosis; moral entrepreneurship plays a key role and the medical literature on FAS is infused with moral rhetoric, including passages from classical mythology, philosophy, and the Bible. FAS is a moral as well as a medical diagnosis, reflecting the broader cultural concerns of the era in which it was discovered, including a greater awareness of environmental threats to health, the development of fetal medicine, an emphasis on "the perfect child," and a growing paradigm of maternal-fetal conflict.

Cross-Cultural Comparison↗

Faith and health self-management of rural older adults.

This analysis uses in-depth interview data collected from 145 African American, European American and Native American men and women aged 70 and older who reside in two rural North Carolina counties to understand the role of religious faith and prayer in the health self-management of these older adults. The analysis addresses three specific questions: how do these older adults use religion to help them manage their health; are there ethnic and gender differences in the use of religion; and are differences in health status related to differences in the use of religion? The integral role of religion in the lives of these older rural adults is an overarching theme present in the interview texts. Six major themes link religion and health self-management: (1) prayer and faith in health self-management, (2) reading the Bible, (3) church services, (4) mental and spiritual health, (5) stories of physical healing, and (6) ambivalence. Faith and religious activities provide an anchor in the lives of these older adults. There is little variation in the use of religion for health self-management by gender, ethnicity or health status. These results suggest that the strength of religion in rural culture may limit the effectiveness of general religiosity scales to discern the relationship of religion to health and health behavior in rural populations.

Journal Article↗

Radiometric dating of the Siloam Tunnel, Jerusalem.

The historical credibility of texts from the Bible is often debated when compared with Iron Age archaeological finds (refs. 1, 2 and references therein). Modern scientific methods may, in principle, be used to independently date structures that seem to be mentioned in the biblical text, to evaluate its historical authenticity. In reality, however, this approach is extremely difficult because of poor archaeological preservation, uncertainty in identification, scarcity of datable materials, and restricted scientific access into well-identified worship sites. Because of these problems, no well-identified Biblical structure has been radiometrically dated until now. Here we report radiocarbon and U-Th dating of the Siloam Tunnel, proving its Iron Age II date; we conclude that the Biblical text presents an accurate historic record of the Siloam Tunnel's construction. Being one of the longest ancient water tunnels lacking intermediate shafts, dating the Siloam Tunnel is a key to determining where and when this technological breakthrough took place. Siloam Tunnel dating also refutes a claim that the tunnel was constructed in the second century bc.

Journal Article↗

Hope: future imagined reality. The meaning of hope as described by a group of healthy Pentecostalists.

A holistic health care approach involves body, mind and spirit. Religiosity, spirituality and hope, as a part of the spiritual dimension, are often linked to various health-related outcomes such as physical health, spiritual well-being and experienced meaning in life. A person's outlook on life and the experience of hope are essential issues in all health care. The purpose of this paper is to describe the meaning of hope as expressed by a group of healthy adult Pentecostalists (n = 15). Using narratives, the ultimate hope was described as life after death, the future imagined reality, promised by God. Hope was strengthened by reading the Bible and saying prayers, through experienced meetings with God and shared values. Hope was quite stable but sometimes God was experienced as being at a distance, which resulted in a sense of alienation. Hope unconnected to Christian belief was of no significant importance to the interviewees.

Adult↗

Near death experience: a concept analysis as applied to nursing.

BACKGROUND: A concept is a thought or complicated mental illustration of a phenomenon. Concepts are essential in research development as they are described as the building blocks of theory. The occurrence of near death experiences (NDEs) is not an innovative subject. Parallels have existed as early as the Bible and Plato's Republic. The NDE was given further consideration in 1975 by Dr Raymond Moody who initiated an interest from the general public and researchers alike, with his book Life after Life. METHOD: This paper will use the strategy of concept analysis to find a working definition for the concept of the NDE and the implications it has for nursing. CONCLUSION: This paper will attest that the number of people who have claimed to have a NDE is phenomenal and overwhelming. In addition, it claims that the numbers of those who have experienced this phenomenon may be underestimated because of the persons' feeling of insecurity in talking with others about their paranormal incident. Therefore, it is vital that nurses become aware of the NDE and how to support the client who has had the experience. The following paper will summarize the different stages of a NDE, the consequences that one experiences, both positive and negative, and nursing implications.

Adaptation, Psychological↗

[The evolution of hand surgery in America].

The beginnings of modern hand surgery strongly reflect those advances made in the United States during the early decades of the last century particularly concerning the treatment of infections of the hand and tendon injuries in the upper extremity. Although Sterling Bunnell fully deserves to be called the father of hand surgery and his monumental book, "Surgery of the Hand", published in 1944 equally deserves to be considered the Bible of hand surgery, we should and must remember other American pioneers of hand surgery, who, from 1900 to 1950 laid the foundation for our specialty.

General Surgery↗

Laying down one's life for oneself.

Roman Catholicism has long opposed suicide. Although Scripture neither condones nor condemns suicide explicitly, cases in the Bible that are purported to be suicides fall into several different categories, and the Roman Catholic tradition can show why some of these should be considered morally wrong and some should not. While Christian martyrdom is praised, it is not correct to argue that this Christian outlook invites suicide, or that it recommends physician-assisted suicide for altruistic motives. Church Tradition, from its earliest days, has clearly distinguished martyrdom from suicide. The principles of double effect and cooperation, mainstays in Roman Catholic moral theology, enable one to see the moral difference between martyrdom and suicide, and to appreciate why physician-assisted suicide is wrong for both patient and physician.

Altruism↗

The man from Big Sur.

Nine Ninety-Nine is a novel about the life and literary work of a paranoid schizophrenic writer, who was hospitalized between 1958 and 1984. He rarely looked people in the face, but, instead, stared at their shoes, ankles, and socks. Living in a closed ward, daily he studied the Bible and edited the Ward M Quarterly, a magazine devoted to the struggle against all authority figures. Over the decades, David Hoffnung, the narrator, received many treatments. In this chapter, he describes his experiences in long-term group psychotherapy.

Female↗

Associations between religious behavior and attitude to Christianity among Australian Catholic adolescents: scale validation.

In a sample of 1,166 Catholic high school students (age = 13-18 years), the author used confirmatory factor analysis to validate a 30-item instrument that assesses 6 dimensions of attitude to Christianity (viz., attitude to prayer, attitude to God, attitude to Jesus, attitude to the Bible, attitude to Christian practice, attitude to social justice). Goodness-of-fit indices for the proposed measurement model revealed that the model fitted the data very well, thus confirming the instrument's structure. A correlation analysis revealed associations between religious behavior and attitude to Christianity.

Adolescent↗

Sexual morality of Christianity.

After discussing the origin of religion, functions of religion, and the construction of meaning by religion, the author focuses on the connection between religion and anxiety. The permanent anxiety in religion is determined by guilt feelings that arise for example from the violation of norms in the area of sexuality. In a religion at enmity with sexuality, such as Christianity, the satisfaction of sexual desires is considered bad and sinful; the permanent production of anxiety and a guilty conscience are the result of it. Christian sexual suppression leads to the propagation of asceticism as the taming of corrupt sensuality that only religious virtuosi can maintain. One result of asceticism is celibacy, although passages from the Bible demand monogamy for bishops without prohibiting celibacy. In Catholicism, celibacy institutionalizes the enmity with sexuality and causes a permanent depreciation of real sexuality in favor of one projected onto the mother church and the Virgin Mary. A further consequence of asceticism is the reduction of sexuality to reproduction. In the section about the factual consequences of Christian sexual morality, the author connects sexual instinctual gratification with religious affiliation on the basis of an analysis of the sexual behavior of Germans. The weekly frequency rate of sexual intercourse amounts to 3.1 with male and female nondenominationals, 2.6 with Protestants, and 2.3 with Catholics; 39% of nondenominational men, 20% of Protestant men, and 12% of Catholic men in Germany use condoms. The connection of religion and aggression is empirically significant as well. The religiously most active men feel more inclined to use aggression to reach sexual goals than religiously indifferent ones.

Adult↗

Alcohol consumption, strength of religious beliefs, and risky sexual behavior in college students.

Relationships among alcohol use, strength of religious convictions, and unsafe sexual practices of 210 students at a large public university in the "bible belt" were examined. The women with strong religious beliefs consumed less alcohol and were less likely to engage in risky sexual behavior than were female participants with weaker religious convictions. Among the men, religious conviction was not significantly correlated with alcohol consumption or risky sexual behavior, but alcohol consumption and inconsistent use of condoms and multiple sexual partners were significantly correlated. Men had higher rates of alcohol consumption and unprotected sexual activity than women did, yet the two groups did not differ in overall frequency of sexual activity. Future research is needed to (a) provide greater understanding of gender differences in alcohol use, risky sexual behavior, and religious beliefs of college students in the region and (b) determine whether similar correlations exist in other areas of the country.

Adolescent↗

Separation of conjoined twins and the principle of double effect.

This article examines the relationship between the principle of double effect and justification for separation surgeries for conjoined twins. First, the principle of double effect is examined in light of its historical context. It is argued that it can only operate under an absolutist view of good and evil that is compatible with the Bible. Given this foundation for application, scenarios for separating conjoined twins are considered against the criteria for the principle of double effect. It is concluded that the principle of double effect cannot be applied to cases wherein one of the twins must be killed. However, it is noted that this does not leave decision makers without options.

Double Effect Principle↗

Perfecting people: selective breeding at the Oneida Community (1869-1879) and the eugenics movement.

The paper describes the selective breeding experiment which took place in the Bible Communist Oneida Community in New York State. The Community was founded in 1848 by John Humphrey Noyes and grew to some three hundred members. It disbanded in 1880 and became a joint stock company, Oneida Ltd., which today is a multinational cutlery manufacturer. Between 1869 and 1880 there was a selective breeding programme ("stirpiculture") with parents chosen for intellectual, physical and spiritual characteristics. Fifty-eight children were born. The programme was inspired by Noyes' theology of Perfectionism, Plato's Republic, agricultural selective breeding and concerns about human heredity. It was later justified by Noyes with the writings of Darwin and Galton. The children were followed up and deemed to be superior in physique, intellect, health and other characteristics. Though it attracted attention in its day, the experiment had little influence on the later eugenic movements in the USA and the UK. It is argued that this was because the Community's system of "complex marriage" and the arranged matings were an unacceptably radical challenge to the conventional notions of love and marriage which dominated these later eugenics movements. The first generation of descendants' attempts to bury aspects of the history of the Community also contributed a lack of knowledge of the experiment and its outcome.

Consanguinity↗