[Cancerogenic alkylating substances. 3. Alkyl-halogenides, -sulfates, -sulfonates and strained heterocyclic compounds].
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The simplest organic fragment, C(sp(3))-C(sp(3)), is unfortunately the most difficult to prepare by metal-catalyzed cross-coupling reactions (shown schematically) in the presence of functional groups. Recent advances show, however, that alkane moieties can be built within functionalized molecules by a careful choice of catalysts and conditions.
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