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Results for “17-Hydroxycorticosteroids”

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At least 307 records · Page 17Linked to original sources
PubMed1978

Feminizing adrenocortical carcinoma with Cushing's syndrome and pseudohyperparathyroidism.

A patient with adrenocortical carcinoma had three major endocrine abnormalities attributable directly to the tumor: hypercortisolism (Cushing's syndrome), hyperestrogenism (feminization), and hypercalcemia (pseudohyperparathyroidism). There were higher levels of immunoreactive parathyroid hormone in venous effluent from the tumor or its abdominal metastases compared to that found in the veins draining the parathyroid glands. This, together with the presence of normal parathyroid glands on autopsy, established the diagnosis of pseudohyperparathyroidism as the cause of hypercalcemia in this patient.

17-Hydroxycorticosteroids↗
PubMed1978

[A radioimmunoassay for plasma 11-desoxycortisol and its use in the rapid metopirone test].

A radioimmunoassay for the measurement of 11-deoxycortisol in plasma is described. Antiserum against 11-deoxycortisol was produced by immunizing rabbits with the 21-hemisuccinate of 11-deoxycortisol coupled to bovine serum albumin. The method does not require chromatography but instead makes use of a simple extraction procedure which, in combination with the antibody characteristics, is relatively specific for the 11-deoxycortisol determination. The smallest amount measurable is 5 pg. The intra-assay coefficient of variation was 6.3% before metopirone and 7.2% after metopirone. The inter-assay coefficient of variation was 12.5% before metopirone and 10.3% after metopirone. Pituitary-adrenal reserve was evaluated in control and hypopituitary subjects by a simple midnight metopirone test.

17-Hydroxycorticosteroids↗
PubMed1978

[Infantile cushing's disease with paradoxical response to dexamethasona due to a probable periodic hormogenesis (author's transl)].

A case of Cushing's disease in a ten year old girl with bilateral diffuse hyperplasia of the adrenal cortex and postoperative enlargment of the sella turcica is presented. The administration of dexamethasone elicited a paradoxical response with a clear elevation of the already high excretion of 17-hydroxycorticoids. The possible mechanisms for this previously described, but infrequent, response to dexamethasone are discussed. It is concluded that: 1) Interpretation of the classical dexamethasone suppression test can occasionally be misleading; and 2) Periodic hormonogenesis may account for this type of paradoxical response.

17-Hydroxycorticosteroids↗
PubMed1978

[Treatment of ischemic heart disease of old age at a cardiologic sanatorium near Moscow].

On the basis of scientific and practical experience at a sanatorium located near Moscow, the authors claim that in the management of elderly patients with ischemic heart disease due consideration must be given to concomitant diseases and complications. The low adaptability of the organism of such patients and the increased meteorolability make it difficult to choose the dosage of the therapeutic natural and performed physical factors and call for careful control over the tolerance to the procedures and the course of the treatment, particularly in the rehabilitation departments. A properly chosen complex of sanatorium treatment promotes improvement of hemodynamics, hemostasis, and lipid metabolism and increase in the adaptability of the organism and in the patients' physical activity.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Cortisol metabolism in diabetes mellitus].

A number of cortizol metabolic indices were examined in 162 patients with moderately severe and severe diabetes mellitus of different duration. The following disturbances of the hormone metabolism which depended on decompensation of the disease were revealed: changes in the rate of cortizol elimination from the circulation, the prevalence of compounds with the oxygroup in the 11th carbon atom, an increase of the urinary excretion of nonconjugated 17-OCS with a relative reduction of excretion of glucoronide fraction and some increase of the sulfate fraction content. Possible causes of the detected disturbances and the informative character of the method of 17-OCS determination in the urine after Silber and Porter in patients with diabetes mellitus are discussed.

17-Hydroxycorticosteroids↗
PubMed1978

[Clinical value of the dexamethasone-HCG test in females with hirsutism with special reference to 17-beta-hydroxyandrogens].

The dexamethasone-hcg-test was administered to 34 hospitalized patients, aged 17 to 45, who were suffering from hirsutism in order to reveal the source of their androgen levels, which in most cases were elevated. In addition to the usual estimation of urinary 17-ketosteroids and urinary 17-OH-corticosteroids plasma 17-beta-hidroxiandrogens and androstendione were measured by RIA. The results of the tests varied to a high degree and could not be related to the clinical findings. The authors conclude that administration of dexamethasone-hcg-test is of small value in detecting the source of hirsutism.

17-Hydroxycorticosteroids↗
PubMed1978

On the appearance, levels and regulation of pancreatic enzyme serum concentrations.

The evaluation of serum pancreatic enzyme activity on whole and diluted serum permits the estimation of serum enzyme inhibitor activity via a ADS/AWS ratio. This has diagnostic value in chronic pancreatic disease. The serum pancreatic ferment activity appears to be regulated in part by serum steroid levels. It is responsive to high protein diet. A physiologic rationale is presented for the use of steroids and high protein diet in the treatment of acute and chronic pancreatic inflammation.

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