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Pig-bel--a zoonosis?

It is postulated that the combination of a very low protein diet, with low pancreatic tryptic activity, plus the continual consumption of sweet potato trypsin inhibitors leads to inadequate proteolysis when a meal containing meat contaminated with C. perfringens type C and its beta toxin is consumed. The necrotizing pathogenic process concluding as segmental gangrene is set in motion by toxin produced under altered dietary conditions first by motor paralysis via beta toxin, followed by villous attachment and colonisation by ingested or resident C. perfringens type C in the gut. Necrobiosis is maintained by further toxin production which may be blocked in immune individuals. The endemicity of the disease is governed by the amount of C. perfringens type C in both the general and gut environments, the latter determined by dietary influences and the protein nutrition of the host. A hypothesis put forward is that the organism is carried and dispersed by the domestic pig and man becomes an incidental host. Infectivity only occurs when critical ecological factors exist in the small gut of humans. Prevention in the short term is possible with a toxoided vaccine using three injections given at one month and twelve month intervals.

Animals↗

[A new zoonosis--investigation of Gardnerella vaginalis disease of fox. IV. Study of dot-ELISA for the detection of serum antibody of Gardnerella vaginalis disease of fox].

192 Gardnerella vaginalis antibody positive sera from artifically infected foxes, immunized foxes and foxes that the bacterial examination were positive were analysed by the established Dot-ELISA. The results showed that 187/192 were positive, the positive rate was 97.3%. Block and cross tests showed that the method was specific. The method was 28.1 times sensitive as PAT and 5.5 times sensitive as MAT respectively. The repeatability of the test was good and the positive coincidence rate among the three techniques was 100%.

Animals↗

[A new zoonosis--investigation of Gardnerella vaginalis disease of fox. I. Causative agent isolation and artificial infection].

It is the first time that this paper reports on using improved rabbit blood agar culture medium to isolate 145 strains Gardnerella vaginalis from the foxes and their abortion fortus organs of main fox farms. Among the strains, 26 strains were isolated from the abortion foetus organs, isolation rate was 92.86%; 118 strains were isolated from the vaginal exeretion of the abortion and empty foxes, isolation rate was 34.01%; 1 strain was isolated from inguinal lymph node of the pelted positive fox, isolation rate was 2%. None was isolated from blood. By causative agent isolation, we revealed the bacterium survival position in vivo, and the best isolation route isolation opportunity and isolation methods were selected. By artificial infection test, we have proved pathogenicity of the bacterium.

Abortion, Veterinary↗

[A new zoonosis--investigation of Gardnerella vaginalis disease of fox. II. Identification of pathogenic bacteria].

16 strains isolated from aborted foetus and vaginal exeretions of foxes were used for examination of cell morphology including fine structure of the cell wall and septa, test for homolysis, biochemical reactions and analysis of G+C content of the bacterial DNA. The cells are pleomorphic bacilli and coccobacilli, Gram stain reaction appear positive to variable, catalse and oxidase-negative, with a fermentative type of glucose metabolism, giving acetic and lactic acid as the major end products of fermentation. It's differentiated from the human strains of G. vaginalis by its less fastidious in growth requirements and being facultatively anaerobic to aerobic. We propose the name: a new subspecies--Gardnerella vaginalis subsp. fox, the type strain is U80.

Animals↗

[Babesiosis, a little-known zoonosis].

Babesiosis or piroplasmosis is a common zoonotic disease among wild and domestic animals. Man can be infected by this hemoprotozoan parasite transmitted by ixodid ticks. More than 400 cases have been observed in the United States, but only 21 cases have been reported in Europe. The American form, caused by B. microti, ranges in severity from asymptomatic to prolonged severe illness. It is characterized by irregular fever and moderate hemolytic anemia. The European form, caused by B. divergens, is a medical emergency with lethality close to 50%, most cases of which are seen in splenectomized patients. The diagnosis requires the identification of the parasite on blood smears (Giemsa). Its morphology is different from that of Plasmodium, but the parasites can be mis-identified, as was the case for the first patient with human babesiosis reported in Switzerland, probably imported from Wales. For clinicians early identification of this disease, which may require renal dialysis and exchange transfusion is essential. The treatment of choice is clindamycin and quinine.

Aged↗

[Monkey AIDS, a new zoonosis?].

Monkeys may carry dangerous infectious diseases. Several studies have demonstrated frequent lentivirus infections in different monkey species. This report describes virological and epizootiological aspects of and the diagnostic procedure for the evaluation of SIV infections in African green monkeys. Recommendations for the prevention of transmission of SIV to humans are discussed.

Animals↗

[Toxocariasis. A cosmopolitan parasitic zoonosis].

The infection by Toxocara canis transmitted by dogs (30% of them are infected in our countries) and less frequently by cats lead to larva migrans visceral syndrome with neurological manifestations, ophtalmological affection and various cutaneous manifestations observed in 24% of the extra-ocular infections: chronic urticaria often associated with asthmatic manifestations and chronic rhinitis, angio-oedema or local oedema reaching particularly the eyclid, chronic pruritus associated with lesions due to scratching or to nodular prurigo. An hypereosinophilia is an argument in favour of a progressive infection. High total IgE is an hallmark of visceral infections by parasites and total IgE level is well correlated with the presence of intra-tissular larva. The serological diagnosis is based on the determination of specific IgG by ELISA which appears also to be interesting for the patient's follow up. The western blot method seems to be more specific than the other methods and so is useful to confirm a diagnosis. The treatment given as early as possible is based on the use of diethylcarbamazine but also of thiabendazole, albendazole and mebendazole. Prophylaxis of toxocara infection includes the prohibition of dog access to children games areas but also a frequent turn over of the sand in public parks.

Animals↗

Zoonosis control.

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Campylobacter Infections↗

[Parasitic pruritus: bird mite zoonosis].

In three women with persistent pruritus, aged 49, 28 and 4 years, infestation with the bird or chicken mite (Dermanyssus gallinae) was demonstrated. These mites live in narrow openings and cracks close to the bird housing during the daytime. At night they attack the birds on whose blood they live. When their host disappears, they may attack men, notably when their breeding places are in or near houses. Mite bites result in urticarial and itchy papulovesicular skin eruptions. Treatment of bird mite infestation consists of removing the old nests. Treatment of the patients is symptomatic. Epizoonosis belongs in the differential diagnosis of pruritus; infestation with bird or chicken mites is one of the possibilities.

Adult↗

[Influenza, a special form of zoonosis].

Findings based on molecular genetics and phylogeny indicate that avian species represent an important reservoir for influenza viruses and that virus strains of man and different mammals originated from avian influenza virus ancestors. In contrast to infectious agents causing classical zoonoses, influenza viruses have to alter their genetic make up in order to change their host range. The special, segmented structure of the viral RNA allows an exchange of gene(s) between two different influenza viruses (reassortment) resulting in viruses with different combinations of genome segments and thereby creating new biological properties. Under the selective pressure of the new host the most adapted virus variants will succeed which arose from a genetically heterogeneous virus population with additional mutations. In particular mutations of the genes encoding the polymerase complex (mutator mutations) would be advantageous for rapid adaptation in a hostile environment. The generation of influenza viruses capable of overcoming the species barrier is a rare event since only virus variants will succeed which are genetically stable and transmissible and which replicate efficiently in the new host. It is considered likely that pigs act as intermediate hosts for adaptation of avian viruses to man.

Animals↗