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Discrimination learning in preschool children as a function of the stimulus and relevant dimension.

The purpose of the present study was to determine discrimination learning rates as a function of the nature of the stimulus and the relevant dimension. Ss were 160 preschool boys and girls. The design consisted of two stimuli (faces and cups), two constant dimensions (size and form), and two relevant dimensions (form and color when the size dimension was held constant, and size and color when the form dimension was held constant). The errors to criterion scores revealed that for cup stimuli the color dimension was learned more rapidly than size and form, while for face stimuli the dimensions of size and form were learned more rapidly than color.

Child, Preschool↗

Intensive language learning and increases in rapid eye movement sleep: evidence of a performance factor.

Ten anglophone students taking a 6-week French immersion course were recorded in the sleep laboratory during 4 consecutive nights before the course, during the course and after the course. There was a positive and significant (P less than 0.05) correlation between language learning efficiency and increases in the percentage of rapid eye movement (REM) sleep from pre-course to course periods. This observation suggests that learning performance may be an important factor in the relationship between information processing and REM sleep.

Adolescent↗

Mouse strains differ under a simple schedule of operant learning.

Recent advances in understanding the composition of the human and mouse genomes have paved the way to a more detailed understanding of the influence of genes on behavior, particularly learning and memory. One problem with many learning paradigms is the great length of training time required to generate a stable baseline. Our goal for the current studies was to develop a method of rapidly assessing learning and to use it to compare various strains of mice. The acquisition of a simple nose-poke was determined in operant chambers with two nose-poke holes illuminated: a single nose poke in one hole resulted in the presentation of 0.01 ml evaporated milk; responses in the other hole did not result in dipper presentation. All mice of the B6JxImJ F1, C57BL/6J, 129X1/SvJ and C3H/HeJ mice emitted 50 or more correct operant responses, whereas fewer than 50% of 129X1/SvJ and 75-90% of mice of Balb/cByJ, DBA/2J and the outbred CD-1 mice emitted 50 or more correct operant responses. On average, C57BL/6J emitted 50 operative responses in less than 30 min, whereas DBA/2J mice required nearly 1 h to complete 50 operative responses. Other strains performed at intermediate levels. There was no apparent relationship between operant activity and locomotor activity that may have influenced response acquisition. These findings are consistent with those reported using other learning paradigms and provide a rapid method of learning assessment.

Animals↗

A gaming strategy for teaching the use of critical cardiovascular drugs.

This article reports the use of a successful strategy for teaching non-critical care nurses how to safely administer critical cardiovascular drugs. The use of a gaming technique to accomplish this, accompanied by a caricature case study, is described in detail. Participants' evaluations evidenced a high degree of satisfaction and enjoyment in learning the pharmacological content. Readers can adapt this game to other learning topics for rapid and effective learning of material specific to their institutions.

Audiovisual Aids↗

How the brain learns to see objects and faces in an impoverished context.

A degraded image of an object or face, which appears meaningless when seen for the first time, is easily recognizable after viewing an undegraded version of the same image. The neural mechanisms by which this form of rapid perceptual learning facilitates perception are not well understood. Psychological theory suggests the involvement of systems for processing stimulus attributes, spatial attention and feature binding, as well as those involved in visual imagery. Here we investigate where and how this rapid perceptual learning is expressed in the human brain by using functional neuroimaging to measure brain activity during exposure to degraded images before and after exposure to the corresponding undegraded versions. Perceptual learning of faces or objects enhanced the activity of inferior temporal regions known to be involved in face and object recognition respectively. In addition, both face and object learning led to increased activity in medial and lateral parietal regions that have been implicated in attention and visual imagery. We observed a strong coupling between the temporal face area and the medial parietal cortex when, and only when, faces were perceived. This suggests that perceptual learning involves direct interactions between areas involved in face recognition and those involved in spatial attention, feature binding and memory recall.

Brain↗

Rapid auditory processing and learning deficits in rats with P1 versus P7 neonatal hypoxic-ischemic injury.

Hypoxia-ischemia (HI) is associated with premature birth, and injury during term birth. Many infants experiencing HI later show disruptions of language, with research suggesting that rapid auditory processing (RAP) deficits (i.e., impairment in the ability to discriminate rapidly changing acoustic signals), play a causal role in language problems. We recently bridged these lines of research by showing RAP deficits in rats with unilateral-HI injury induced on postnatal days 1, 7, or 10 (P1, P7, or P10. While robust RAP deficits were found in HI animals, it was suggested that our within-age sample size did not provide sufficient power to detect age-at-injury differences within the pooled HI group. The current study sought to examine differences in neuropathology and behavior following unilateral-HI injury on P1 versus P7 in rats. Ages chosen for HI induction reflect differential stages of neurodevelopmental maturity, and subsequent regional differences in vulnerability to reduced blood flow/oxygen (modeling age-related differences in premature/term HI injury). Results showed that during the juvenile period, both P1 and P7 HI groups exhibited significant RAP deficits, but deficits in the P1 HI group resolved with repeated testing (compared to shams), while P7 HI animals showed lasting deficits in RAP and spatial learning/memory through adulthood. The current findings are in accord with evidence that HI injury during different stages of developmental maturity (age-at-injury) leads to differential neuropathologies, and provide the novel observation that in rats, P1 versus P7 induced pathologies are associated with different patterns of auditory processing and learning/memory deficits across the lifespan.

Acoustic Stimulation↗

Rapid and transient learning-associated increase in NMDA NR1 subunit in the rat hippocampus.

Several lines of evidence indicate that glutamate NMDA receptors are critically involved in long-term potentiation (LTP) and in certain forms of learning. It was previously demonstrated that memory formation of an inhibitory avoidance task in chick is specifically associated with an increase in the density of NMDA receptor in selected brain regions. Here we report on the effect of a one trial inhibitory avoidance training in rats, a hippocampal-dependent learning task, on the levels of different subunits of the glutamate NMDA receptor in synaptic plasma membranes (SPM) isolated from the hippocampus. Training rats on a one trial inhibitory avoidance task results in a rapid, transient and selective increase (+33%, p < 0.05) in NMDA NRI subunit expression in hippocampal SPM of rats sacrificed 30 min posttraining. No changes were observed at 0 or 120 min after training or in shocked animals in comparison to naive control rats. In addition, no training-associated increase in the levels of NMDA NR2A and NR2B or AMPA GluR 2/3 subunits was observed at any timepoint tested. In conclusion, the present findings support the hypothesis that alterations in expression of synaptic NMDA NR1 subunits in the hippocampus are specifically associated with memory formation of an inhibitory avoidance task and strongly suggest that hippocampal NMDA receptors are crucially involved in the neural mechanisms underlying certain forms of learning.

Animals↗

Reversal learning tasks may provide rapid determination of cognitive deficits in lead-exposed children.

An historical cohort study of twins, aged 6 to 15 years, found reduced cognitive performance related to subclinical exposure to lead (Pb) much earlier in life. Pairs of twins discordant for blood Pb (low-Pb twins ranged from 30-50 micrograms/dl and high-Pb twins ranged from 43-80 micrograms/dl) exhibited reduced learning of a computer-administered visual discrimination and reversal by the twin having the higher exposure. There was no evidence that sensory or motor impairment contributed to the cognitive deficit. Performance of a reference group indicated that test's validity for age-related cognitive development and the method's suitability for children of varying socio-economic or racial status. Because the reversal learning approach required only one 20-min test session and was powerful enough to document Pb-related deficits in a small sample (n = 8), it may indicate a practical method for obtaining early evidence of environmentally induced developmental delays. An advantage of the test is that it can be used with both humans and animals. Tests capable of direct comparison of behavioral data from humans and animals can guide the search for behavioral and biological mechanisms in experiments that can be done only with animals. They also can augment the clinical procedures currently used.

Adolescent↗

Rapid development of learning-induced receptive field plasticity in the auditory cortex.

Classical conditioning induces frequency-specific receptive field (RF) plasticity in the auditory cortex after relatively brief training (30 trials), characterized by increased response to the frequency of the conditioned stimulus (CS) and decreased responses to other frequencies, including the pretraining best frequency (BF). This experiment determined the development of this CS-specific RF plasticity. Guinea pigs underwent classical conditioning to a tonal frequency, and receptive fields of neurons in the auditory cortex were determined before and after 5, 15, and 30 CS-US (unconditioned stimulus) pairings, as well as 1 hr posttraining. Highly selective RF changes were observed as early as the first 5 training trials. They culminated after 15 trials, then stabilized after 30 trials and 1 hr posttraining. The rapid development of RF plasticity satisfies a criterion for its involvement in the neural bases of a specific associative memory.

Animals↗

[Spatial memory in bank voles (Clethrionomys glareolus Schreb) assessed in the cue-controlled open field with the place of refuge].

The capacity of bank voles (Clethrionomys glareolus Schreb) for rapid spatial learning was assessed in cue-controlled open field using their species-specific habits (high fear). Animals were tested in open field after 3 days of pretraining. During testing, novel stimuli (black-and-white geometric figures arranged in symmetric or asymmetric modes for different vole groups) were attached to a curtain surrounding the open field, and a shelter (a familiar box from the home cage) was introduced into the field. Testing consisted of four 10-min trials, the last (probe) trial was performed without the shelter. Time spent in different fielld areas was recorded. The voles remembered previous location of the shelter and preferred to visit this area. It was possible only in the condition with asymmetric arrangement of visual stimuli when animals could use them for navigation. The findings conclude that bank vole have a good capacity for rapid spatial learning.

Animals↗

Pavlovian conditioning of agonistic behavior in male threespine stickleback (Gasterosteus aculeatus).

The red coloration of male stickleback (Gasterosteus aculeatus) possesses signal value in male-male interactions. Therefore, it was predicted that males would learn to associate a red signal more readily than a green signal with a conspecific rival in a Pavlovian conditioning experiment. Males were presented red and green signal lights where one signal was always paired with presentation of a rival (excitatory conditioned stimulus, CS+) and one signal was never paired with presentation of a rival (nonreinforced stimulus, CS-). Males learned the task rapidly, showing conditioned approach and zigzag responses, but CS+ vs. CS- differentiation persisted, even after a prolonged extinction period. In addition, there were no differences in learning rates between fish trained to the red signal as the CS+ and fish trained to the green signal as the CS+. The results suggest that, although males may rapidly learn about rivals, they are not predisposed to associated red (over green) with the appearance of a rival under the conditions of this experiment. Because males must establish and maintain territories in order to nest and mate, learning about neighboring rivals may be an adaptive mechanism by which males more effectively defend their territories and thereby increase their reproductive fitness.

Agonistic Behavior↗

Rapid taste-aversion learning by an isolated molluscan central nervous system.

The isolated lips and nervous system of the terrestrial slug Limax maximus will produce some of the feeding behavior of the intact animal; i.e., they generate the rhythmic neural activity characteristic of ingestion in response to food extracts applied to the lips. This preparation will respond to a variety of food extracts that elicit feeding in the whole animal. This provides the opportunity for aversive conditioning experiments involving taste discrimination. Pairing lip chemostimulation by attractive food extracts with lip chemostimulation by using bitte plant secondary substances can cause the isolatd brain to selectively suppress its neural response to one food extract while remaining responsive to another. Such isolated brains can learn after one or two trials and retain the learning for more than 8 hr.

Action Potentials↗

Rapid processing and unsupervised learning in a model of the cortical macrocolumn.

We study a model of the cortical macrocolumn consisting of a collection of inhibitorily coupled minicolumns. The proposed system overcomes several severe deficits of systems based on single neurons as cerebral functional units, notably limited robustness to damage and unrealistically large computation time. Motivated by neuroanatomical and neurophysiological findings, the utilized dynamics is based on a simple model of a spiking neuron with refractory period, fixed random excitatory interconnection within minicolumns, and instantaneous inhibition within one macrocolumn. A stability analysis of the system's dynamical equations shows that minicolumns can act as monolithic functional units for purposes of critical, fast decisions and learning. Oscillating inhibition (in the gamma frequency range) leads to a phase-coupled population rate code and high sensitivity to small imbalances in minicolumn inputs. Minicolumns are shown to be able to organize their collective inputs without supervision by Hebbian plasticity into selective receptive field shapes, thereby becoming classifiers for input patterns. Using the bars test, we critically compare our system's performance with that of others and demonstrate its ability for distributed neural coding.

Afferent Pathways↗

Discrete-trial alternation in the rat.

The acquisition and maintenance by rats of single alternation, double alternation, and four other repeating patterns of reinforced and non-reinforced trials was studied in a discrete-trial lever-pressing situation. The rats learned all these patterns in a small number of experimental sessions. Single alternation was learned more rapidly than the more complex patterns. Rate of learning single and double alternation decreased moderately as inter-trial interval increased. Abrupt changes in the scheduling of trials, either by doubling the inter-trial interval or by shifting from fixed to variable trial spacing, temporarily disrupted the patterned performance. Two hypotheses concerned with the means by which the rats could have learned to conform to the pattern were examined: (1) "timing" of the interval between successive reinforcements; and (2) control of responding on a trial by the outcome of preceding trials, depending on the consistency with which these outcomes were associated with reinforced or non-reinforced trials in the pattern and on how many trials back these outcomes occurred. The second hypothesis accounted for the relative frequency of errors on trials at various locations in the sequences, and predicted most of the changes in error frequency observed in experiments in which "inter-trial stimuli" were added to the sequences.

Journal Article↗

Learning new words: phonotactic probability in language development.

Though the influences of syntactic and semantic regularity on novel word learning are well documented, considerably less is known about the influence of phonological regularities on lexical acquisition. The influence of phonotactic probability, a measure of the likelihood of occurrence of a sound sequence, on novel word learning is investigated in this study. Thirty-four typically developing children (from ages 3 years 2 months to 6 years 3 months) participated in a multitrial word-learning task involving nonwords of varying phonotactic probability (common vs. rare) paired with unfamiliar object referents. Form and referent learning were tested following increasing numbers of exposures (1 vs. 4 vs. 7) and following a 1-week delay. Correct responses were analyzed to determine whether phonotactic probability affected rate of word learning, and incorrect responses were analyzed to examine whether phonotactic probability affected the formation of semantic representations, lexical representations, or the association between semantic and lexical representations. Results indicated that common sound sequences were learned more rapidly than rare sound sequences across form and referent learning. In addition, phonotactic probability appeared to influence the formation of semantic representations and the association between semantic and lexical representations. These results are integrated with previous findings and theoretical models of language acquisition.

Child↗

The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta).

Four rhesus monkeys (Macaca mulatta) were trained to learn novel sets of visuomotor associations in 50 trials or less, within single test sessions. After bilateral ablation of the orbital and ventral prefrontal cortex, the monkeys lost the ability to learn these associations within a session, although they could learn them when given several daily sessions. Thus, relatively slow, across-session visuomotor learning depends on neither the ventral nor orbital prefrontal cortex, but rapid, within-session learning does. The ablations also eliminated at least 2 response strategies, repeat-stay and lose-shift, which might account, in part, for the deficit in rapid learning. The deficit is unlikely to result from a failure of visual discriminative ability or working memory: The monkeys could discriminate similar stimulus material within a session, and reducing the working memory load did not improve within-session learning.

Animals↗

The influence of associability changes in negative patterning and other discriminations.

Normal rats showed faster learning of a serial negative patterning (NP) discrimination (X+, A+, X-->A-) than of a comparable feature negative (FN) discrimination (A+, X-->A-). This advantage was absent in rats with lesions of the amygdala central nucleus. Earlier data indicated that this brain lesion interferes with surprise-induced increases in attention specified by the Pearce-Hall model (J. M. Pearce & G. Hall, 1980). In the NP task, but not the FN task, omission of the reinforcer after X on X-->A- trials was surprising. A variation of the NP task (NPX), in which X was reinforced on both X+ and X-->A- trials, was learned more rapidly than the NP task. Lesioned rats were unimpaired in learning the NPX task. Evaluation of the lesion effects and the results of posttraining transfer tests suggested that the NP advantage involved attentional processes, whereas the NPX advantage was based on the acquisition of inhibitory control by aspects of excitation conditioned to X.

Animals↗

Belief-desire reasoning as a process of selection.

Human learning may depend upon domain specialized mechanisms. A plausible example is rapid, early learning about the thoughts and feelings of other people. A major achievement in this domain, at about age four in the typically developing child, is the ability to solve problems in which the child attributes false beliefs to other people and predicts their actions. The main focus of theorizing has been why 3-year-olds fail, and only recently have there been any models of how success is achieved in false-belief tasks. Leslie and Polizzi (Inhibitory processing in the false-belief task: Two conjectures. Developmental Science, 1, 247-254, 1998) proposed two competing models of success, which are the focus of the current paper. The models assume that belief-desire reasoning is a process which selects a content for an agent's belief and an action for the agent's desire. In false belief tasks, the theory of mind mechanism (ToMM) provides plausible candidate belief contents, among which will be a 'true-belief.' A second process reviews these candidates and by default will select the true-belief content for attribution. To succeed in a false-belief task, the default content must be inhibited so that attention shifts to another candidate belief. In traditional false-belief tasks, the protagonist's desire is to approach an object. Here we make use of tasks in which the protagonist has a desire to avoid an object, about which she has a false-belief. Children find such tasks much more difficult than traditional tasks. Our models explain the additional difficulty by assuming that predicting action from an avoidance desire also requires an inhibition. The two processing models differ in the way that belief and desire inhibitory processes combine to achieve successful action prediction. In six experiments we obtain evidence favoring one model, in which parallel inhibitory processes cancel out, over the other model, in which serial inhibitions force attention to a previously inhibited location. These results are discussed in terms of a set of simple proposals for the modus operandi of a domain specific learning mechanism. The learning mechanism is in part modular--the ToMM--and in part penetrable--the Selection Processor (SP). We show how ToMM-SP can account both for competence and for successful and unsuccessful performance on a wide range of belief-desire tasks across the preschool period. Together, ToMM and SP attend to and learn about mental states.

Choice Behavior↗