Public policy: newborn infants--test to detect hypothyroidism; objections on religious grounds.
Explore the source record for details and available documents.
Humans↗
SEARCH · Search PubMed
Results for “object detection”
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Objective aneuploidy detection for fetal and neonatal screening using comparative genomic hybridization (CGH).
Comparative genomic hybridization (CGH) allows entire genomes to be scanned for whole and segmental aneuploidy and thus may be an appropriate tool for the detection of clinically important abnormalities during fetal and neonatal screening. Criteria to distinguish between significant aberrations and experimental artifacts are essential for these applications. This report describes the use of a t-statistic to detect changes in CGH profiles that differ significantly from variations that occur in CGH profiles of normal samples. Eleven cell lines derived from fetal or neonatal patients were analyzed in this study. Aneuploidies in these lines included trisomies for chromosomes 13, 16, 18, and 21 and monosomy for distal 5p and tetrasomy 18p. Aneuploidy was detected in all samples by using the t-statistic, although the extent of the aneuploid region was not correctly estimated in some cases. A detailed description of the t-statistic fused for making these CGH comparisons is described in a companion paper (Moore et al., Cytometry 28:183-190, 1997.
Aneuploidy↗
A field model for human detection and tracking.
The large shape variability and partial occlusions challenge most object detection and tracking methods for nonrigid targets such as pedestrians. This paper presents a new approach based on a two-layer statistical field model that characterizes the prior of the complex shape variations as a Boltzmann distribution and embeds this prior and the complex image likelihood into a Markov field. A probabilistic variational analysis of this model reveals a set of fixed-point equations characterizing the equilibrium of the field. It leads to computationally efficient methods for calculating the image likelihood and for training the model. Based on that, effective algorithms for detecting nonrigid objects are developed. This new approach has several advantages. First, it is intrinsically suitable for capturing local nonrigidity. In addition, due to the distributed likelihood, this approach is robust to partial occlusions. Moreover, the two-layer structure provides large flexibility of modeling the image observations, which makes the new method robust to clutters. Extensive experiments demonstrate its effectiveness.
Algorithms↗
A temporal same-object advantage in the tunnel effect: facilitated change detection for persisting objects.
Meaningful visual experience requires computations that identify objects as the same persisting individuals over time, motion, occlusion, and featural change. This article explores these computations in the tunnel effect: When an object moves behind an occluder, and then an object later emerges following a consistent trajectory, observers irresistibly perceive a persisting object, even when the pre- and postocclusion views contrast featurally. This article introduces a new change detection method for quantifying percepts of the tunnel effect. Observers had to detect color changes in displays where several objects oscillated behind occluders and occasionally changed color. Across comparisons with several types of spatiotemporal gaps, as well as manipulations of occlusion versus implosion, performance was better when objects' kinematics gave the impression of a persisting individual. The results reveal a temporal same-object advantage: better change detection across temporal scene fragments bound into the same persisting object representations. This suggests that persisting objects are the underlying units of visual memory.
Attention↗
Segregation of object and background motion in the retina.
An important task in vision is to detect objects moving within a stationary scene. During normal viewing this is complicated by the presence of eye movements that continually scan the image across the retina, even during fixation. To detect moving objects, the brain must distinguish local motion within the scene from the global retinal image drift due to fixational eye movements. We have found that this process begins in the retina: a subset of retinal ganglion cells responds to motion in the receptive field centre, but only if the wider surround moves with a different trajectory. This selectivity for differential motion is independent of direction, and can be explained by a model of retinal circuitry that invokes pooling over nonlinear interneurons. The suppression by global image motion is probably mediated by polyaxonal, wide-field amacrine cells with transient responses. We show how a population of ganglion cells selective for differential motion can rapidly flag moving objects, and even segregate multiple moving objects.
Action Potentials↗
Quantitative analysis and cartography in scanning electron microscopy: application to the study of bacterial adhesion to respiratory epithelium.
This paper describes the coupling between a scanning electron microscope (SEM) and an image analysis workstation. The system was designed in order to drive the SEM and to analyse any sample. It allows automatic (edge detection) or semiautomatic (pointing, marking, drawing) object detection. Two types of data can be obtained: (1) topographical information, such as the location of the object within a region of interest drawn at any magnification of the microscope, or (2) quantitative data, such as morphometric characteristics of objects. In addition, high resolution maps of the section, regions of interest, and objects can be obtained with a laser printer. This software was first applied to quantitate the adhesion of the bacteria Pseudomonas aeruginosa to human respiratory epithelial cells in culture. P. aeruginosa was shown associated with ciliated cells. The second application concerned the study of the distribution of specific carbohydrate residues at the surface of the respiratory cells. The gal residues were revealed using the lectin Ricinus communis agglutinin II, adsorbed to colloidal gold particles. A relationship between the presence of adherent bacteria and labelling was shown.
Bacterial Adhesion↗
Comparison of statistical indicators for the automatic detection of 80 Hz auditory steady state responses.
OBJECTIVE: To evaluate, using receiver operation characteristic (ROC) curves, the performance of several statistical indicators in the objective detection of 80 Hz steady state auditory evoked responses. DESIGN: Steady state auditory evoked responses elicited by amplitude modulated tones of 500 and 1000 Hz, were obtained in 16 normal adults. Recordings were made at intensities ranging from 80 to 30 dB SPL and without stimulation. Four statistics: coherence synchrony measure, circular T2, a new variant of Hotelling T2 (labeled HT2) and a test for hidden periodicity (F test) were calculated. The statistics were compared using ROC curves and bootstrapping techniques. Two outcome measures were considered: behavioral threshold prediction and averaging efficiency. RESULTS: All indicators were highly accurate to detect a response (8 to 9 dB above mean behavioral threshold for the 1000 Hz and 14 to 16 dB for the 500 Hz carrier). Responses could be reliable detected after averaging about five individual epochs of long duration. No statistically significant differences were evidenced though in their capability to predict behavioral threshold or their averaging efficiency. CONCLUSIONS: Despite the more adequate statistical properties of some of these indicators no significant differences were found in their performance. Thus all of these indicators could be recommended for automatic detection of 80 Hz auditory steady state responses.
Adolescent↗
Functional optical detection based on pH dependent fluorescence lifetime.
BACKGROUND AND OBJECTIVES: Detection of possible alterations of physiological parameters (e.g., pH and temperature), resulting from malignant transformation of initially healthy tissue, can be a powerful diagnostic tool for earlier cancer detection. Such variations can be observed by comparing these parameters with those of healthy tissue surrounding the abnormality. Time-resolved spectroscopy of specifically targeted fluorescent labeled antibodies can be sensitive to such variations and provide a high resolution functional image of the region of interest. The goal of this study was to establish a forward experimental setup for calibration of the lifetime dependencies of near-IR fluorescent dyes on physiological parameters, and to develop analytical solutions, taking into account the effects of light propagation in turbid media (e.g., tissue), that was able to extract an original lifetime fluorescence signal from time-of-flight intensity distributions, measured in vivo from a deeply embedded live organ for further analysis. STUDY DESIGN/MATERIALS AND METHODS: Tissue-like phantoms with embedded fluorescent dyes and background optical properties simulating those of live tissues were designed and created. Fluorescence decay curves were measured for different fluorophore positions, and pH values. Those measurements were made with a system based on a time-correlated single photon counting (TCSPC) instrument and a tunable femtosecond Ti-Sapphire system built by our group. RESULTS: Decay curves were recorded for fluorophore depths of up to 5 mm and source-detector separation of 7 mm. It was shown that a forward model, based on the random walk theory, adequately described the experimental data. Measured pH dependencies of the fluorescence lifetime were characterized for two different dyes. CONCLUSIONS: Good correlation between experimental data and predictions of the theoretical model allows the use of close-form analytical solutions to separate the effects of photon time delays due to multiple scattering in tissues from the original intensity fluorescence time decay curve, determined by the fluorophore itself and its immediate surroundings. It is the latter dependence that can be diagnostically important. Experimentally obtained scaling between lifetime and a parameter of interest can be used in vivo to obtain a map of physiological parameter changes which can serve as a base for an in vivo specific diagnostic system.
Animals↗
[Assessment of HPV detection assays for use in cervical cancer screening programs].
OBJECTIVE: Detection of high-risk human papillomavirus types (HPV) infection is an important tool in the screening of cervical cancer and triage of cytological abnormalities. The different techniques for detection of this cancer need to be contrasted and validated for use in population screening. MATERIAL AND METHODS: Cervical cell samples were collected from 166 women attending a dermatology clinic in Oviedo (Spain). We evaluated the performance of three different assays for VPH detection. The methods utilized were 1) In-house PCR-EIA using LI consensus primers MY09/ MY11, 2) A PCR-reverse line blot hybridization (PCR-LBH) that uses LI consensus PGMY primers. 3) Hybrid Capture 2. All assays were performed blinded. The kappa statistic was used to test for global agreement between assay pairs. RESULTS: HPV DNA was detected in 24,7%, 25,3% and 29,5% of the women, respective to the assay. The overall agreement between the in-house PCR, PCR-LBH and HC2 was (73.5%) with all kappa values between assay pairs exceeding 0.56 (p<0.001). CONCLUSION: The three HPV assays were equally accurate in estimating high-risk HPV prevalence and HPV-related lesions. The method for HPV detection must be decided depending on the goals of the search (screening, follow-up or molecular studies).
DNA Probes, HPV↗
Seeing what is coming: building collision-sensitive neurones.
The image of a rapidly approaching object has to elicit a quick response. An animal needs to know that the object is approaching on a collision course and how imminent a collision is. The relevant information can be computed from the way that the image of the object grows on the retina of one eye. Firm data about the types of neurones that react to such looming stimuli and trigger avoidance reactions come from recent studies on the pigeon and the locust. The neurones responsible are tightly tuned to detect objects that are approaching on a direct collision course. In the pigeon these neurones signal the time remaining before collision whereas in the locust they have a crucial role in the simple strategy this animal uses to detect an object approaching on a collision course.
Animals↗
Human efficiency for recognizing 3-D objects in luminance noise.
The purpose of this study was to establish how efficiently humans use visual information to recognize simple 3-D objects. The stimuli were computer-rendered images of four simple 3-D objects--wedge, cone, cylinder, and pyramid--each rendered from 8 randomly chosen viewing positions as shaded objects, line drawings, or silhouettes. The objects were presented in static, 2-D Gaussian luminance noise. The observer's task was to indicate which of the four objects had been presented. We obtained human contrast thresholds for recognition, and compared these to an ideal observer's thresholds to obtain efficiencies. In two auxiliary experiments, we measured efficiencies for object detection and letter recognition. Our results showed that human object-recognition efficiency is low (3-8%) when compared to efficiencies reported for some other visual-information processing tasks. The low efficiency means that human recognition performance is limited primarily by factors intrinsic to the observer rather than the information content of the stimuli. We found three factors that play a large role in accounting for low object-recognition efficiency: stimulus size, spatial uncertainty, and detection efficiency. Four other factors play a smaller role in limiting object-recognition efficiency: observers' internal noise, stimulus rendering condition, stimulus familiarity, and categorization across views.
Contrast Sensitivity↗
Incorporating covariates into standard line transect analyses.
An implicit assumption of standard line transect methodology is that detection probabilities depend solely on the perpendicular distance of detected objects to the transect line. Heterogeneity in detection probabilities is commonly minimized using stratification, but this may be precluded by small sample sizes. We develop a general methodology which allows the effects of multiple covariates to be directly incorporated into the estimation procedure using a conditional likelihood approach. Small sample size properties of estimators are examined via simulations. As an example the method is applied to eastern tropical Pacific dolphin sightings data.
Analysis of Variance↗
Detection of subgingival calculus and dentine caries by laser fluorescence.
OBJECTIVES: Detection of subgingival calculus and dentine caries in the bottom of deep periodontal pockets is often difficult without visual observation. We thus examined the possibility of its detection using autofluorescence induced by laser irritation. METHODS: Autofluorescence was measured at various excitation and emission wavelength settings in five specimens each of sound dentine and enamel, subgingival calculus, and root caries. Periodontopathic model teeth with bacterial cells and blood clots were also irritated by laser to obtain autofluorescent images. RESULTS: Subgingival calculus and dentine caries showed a characteristic 700 nm emission when excited at 635 nm or a 720 nm emission when excited at 655 nm; sound dentine or enamel, however, did not. The calculus differentiation power, however, was higher with excitation at 635 nm than at 655 nm. The autofluorescent images photographed at an excitation of 633 nm provided clear calculus identification in periodontopathic model teeth when a 700 nm band-pass filter or a 700 nm high-pass filter was used. However, fluorescence intensity was masked when the calculus surface was covered by bacterial cells or blood clots. For clinical use, it would be important to remove subgingival plaque and debris from root surfaces before attempting to detect subgingival calculus and root caries with this manner. CONCLUSION: The autofluorescence method employing excitation of 633-635 nm was found to be a powerful tool for detecting subgingival calculus and root caries.
Actinomyces viscosus↗
[Detection of Mycoplasma species in urinary tract infections in children].
OBJECTIVE: detection of urogenital mycoplasmas using a commercial kit, Mycofast Evolution2 (International Microbio) from children's urinary tract infections (UTI). METHODS: We included in our study 95 children presenting symptoms of UTI, with repeatedly negative urine cultures, between June 2002 - February 2004. The culture of mycoplasmas and the antibiotic susceptibility testing (doxycycline, roxithromycin, ofloxacin) was performed using the broth and various substrates provided by the kit in a gallery system. RESULTS: 22 strains of Ureaplasma urealyticum and 14 strains of Mycoplasma hominis were identified. In 10 cases the two species were associated. The susceptibility pattern of isolates was diverse. CONCLUSIONS: M. hominis and U. ureaplasma might be detected from children's UTI.
Adolescent↗
Binaural sonar electronic travel aid provides vibrotactile cues for landmark, reflector motion and surface texture classification.
Electronic travel aids (ETAs) for the blind commonly employ conventional time-of-flight sonars to provide range measurements, but their wide beams prevent accurate determination of object bearing. We describe a binaural sonar that detects objects over a wider bearing interval compared with a single transducer and also determines if the object lies to the left or right of the sonar axis in a robust manner. The sonar employs a pair of Polaroid 6500 ranging modules connected to Polaroid 7000 transducers operating simultaneously in a binaural array configuration. The sonar determines which transducer detects the echo first. An outward vergence angle between the transducers improves the first-echo detection reliability by increasing the delay between the two detected echoes, a consequence of threshold detection. We exploit this left/right detection capability in an ETA that provides vibrotactile feedback. Pager motors mount on both sides of the sonar, possibly worn on the user's wrists. The motor on the same side as the reflecting object vibrates with speed inversely related to range. As the sonar or object moves, vibration patterns provide landmark, motion and texture cues. Orienting the sonar at 45 degrees relative to the travel direction and passing a right-angle corner produces a characteristic vibrational pattern. When pointing the sonar at a moving object, such as a fluttering flag, the motors alternate in a manner to give the user a perception of the object motion. When the sonar translates or rotates to scan a foliage surface, the vibrational patterns are related to the surface scatterer distribution, allowing the user to identify the foliage.
Animals↗
Objective versus visual detection of the auditory brain stem response.
The use of objective (mathematical) procedures in auditory brain stem response (ABR) testing has been suggested in order to eliminate the subjectivity of visual judgments and to increase sensitivity of detection. This investigation compared with effectiveness of visual and objective detection of the ABR. Auditory brain stem responses were obtained in normal adults at several click levels. An equal number of waveforms obtained without stimulation were used to measure false-positive responses. Visual judgments of ABR presence were made by four experienced raters. Objective analysis was accomplished using three methods: correlation, variance ratio, and multiple pre-post z tests. The mean sensitivity score was highest for visual detection, followed in order by the correlation, variance ratio, and multiple z test methods. While visual scoring was statistically the most sensitive, the practical difference between measures was small. In addition, there was considerable disagreement between raters in their judgments. Therefore, the most sensitive of the objective measures--correlation, is considered to be a useful detection procedure to eliminate observer bias and to achieve consistency of scoring.
Adult↗
Feasibility of intracranial near-infrared optical scanning.
Light injected at a point on a surface of a scattering medium is emitted at the surface after traveling a quasisemicircular path deep into the medium. This phenomenon can be exploited to detect objects immersed in the medium from time-resolved measurements of light intensity at the surface. Our experiments on model systems demonstrate that absorbing objects, surrounded by bone and other scattering material, can be detected. The technique yields surface images of absorbing objects submerged in a scattering medium. Images of the same phantoms inside the cavity of a skull can be obtained by the same technique.
Brain↗
Hemispheric specialization in the detection of subjective objects.
Three experiments were conducted to examine hemispheric specialization for the detection of subjective objects. In the first two experiments, observers searched for the presence of a square defined by subjective contours. The first experiment demonstrated that the left hemisphere made more errors for detecting these objects. The second experiment showed that the increased errors were due to the left hemisphere responding to the individual features of the objects and not the objects as a whole. In the second experiment, the right hemisphere was also faster for detecting the absence of a subjective object. A third experiment was conducted to determine if performance for the right hemisphere was due to object level processing. It was shown that the right hemisphere only makes illusory conjunctions for features within perceptual groups while the left hemisphere makes illusory conjunctions both within and across perceptual groups, providing converging evidence for object level processing in the right hemisphere. The results suggest that the right hemisphere conjoins feature information for the perception of objects.
Adult↗