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At least 289 records · Page 16Linked to original sources
PubMed1990

Severe intractable common warts associated with human papillomavirus 2, 3 and 20.

A 26-year-old male had had numerous common warts on the feet and hands since childhood. They had repeatedly undergone etretinate cryosurgery, always responding well to it. However, the warts reappeared. Human papillomavirus (HPV) 2, 3 and 20 were detected in the warts using Southern's blot hybridization technique with HPV DNA. Histologically, the warts showed swollen, clear keratinocytes with vacuolated degeneration not found in common warts. The findings are presented in this paper.

Adult↗
PubMed1976

Biochemical and physiological parameters on the healthy skin surface of patients with common warts.

Biochemical and physiological examinations were carried out on the healthy surface of the skin of 24 test persons who had had contracted common warts during the 2 years prior to examination and on a control group of 46 healthy persons of the same age and sex. The following significant results were obtained: (1) There was a significant reduction in the percentage amount of squalene in the lipids of the skin surface in the patients with common warts as compared with the healthy control persons. (2) The alkali neutralization time in the patients with common warts was significantly shortened as compared with the healthy control group. (3) The degree of moistening of the skin with water was significantly less in the patients with common warts than in the control persons. These results indicate important predisposing factors for common warts.

Adolescent↗
PubMed1993

Warts and lupus erythematosus.

The human papilloma virus is implicated in causing several diseases, ranging from the common wart to malignancy. We describe a high prevalence of cutaneous warts in lupus erythematosus. The presence of warts did not correlate with the taking of immunosuppressive drugs. This observation suggests that there is a primary immunological defect among patients with lupus erythematosus. We found this high rate among patients with discoid as well as systemic lupus erythematosus. We found no correlation between the prevalence of cutaneous warts and cervical dysplasia, or malignancy. Discoid lupus erythematosus is often considered to be a different disease from systemic lupus erythematosus, running a more benign course. The high prevalence of cutaneous warts in both conditions highlights yet another similarity between these two diseases.

Adolescent↗
PubMed2005

Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts.

BACKGROUND: Anogenital warts are the most easily recognized sign of genital Human Papilloma Virus infection. The objective was to develop a short, valid and reliable questionnaire to measure Health Related Quality of Life (HRQL) in patients with anogenital warts. METHODS: First a literature review was performed to identify relevant papers describing the impact of anogenital warts in HRQL; second the main domains were identified by some experts in a focus group, and third in-depth-semi-structured interviews were conducted in patients with anogenital warts to identify the initial set of items. A qualitative reduction of the initial set of items was performed based on the mean scoring of the experts for the three scales: clarity, frequency and importance. The initial questionnaire was pilot tested in 135 patients. Rasch analysis was performed with the results of the questionnaire in order to refine the instrument. Spearman's correlation was calculated between the initial questionnaire and the reduced version. Additionally the measurement properties (validity and reliability) of the resulting final questionnaire were tested and compared using standard procedures (Cronbach's Alpha and item-total correlation). RESULTS: the main domains identified as affected in patient's life were: sexual, colleagues and partner relationships. After a proper qualitative reduction the initial set of 134 items was reduced to 22. The questionnaire was pilot tested in 135 patients and two dimensions were identified after the multifactorial analysis: emotional dimension and sexual activity dimension. As a result of the Rasch analysis the questionnaire was reduced to 10 items. High correlation was found between the initial and the reduced version for the two dimensions. Cronbach's alpha values were acceptable (0.86). CONCLUSION: The initial 22 items questionnaire was reduced by Rasch analysis to a version of 10 items, with two dimensions: emotional and sexual. The results suggest the adequacy of the 10 items to evaluate HRQL of patients with anogenital warts in a valid and reliable way.

Adult↗
PubMed1995

Cimetidine therapy for plantar warts.

Although more than 50% of warts resolve spontaneously within 2 years, many, if untreated, have the propensity to spread and cause considerable discomfort. There are several treatments to date; however, most cause some type of tissue damage. Because spontaneous resolution of warts can occur, the role of cimetidine in the treatment of warts remains controversial. Anecdotal reports suggest cimetidine may have a role in the treatment of plantar warts with no side effects or tissue damage. A double blind trial in a large population should be conducted to further verify the effects of treating viral warts with cimetidine.

Adult↗
PubMedDate not supplied

Angiogenesis and vasodilation in skin warts. Association with HPV infection.

BACKGROUND: Angiogenesis is required for tumour growth. Since human papillomavirus (HPV) infection is associated with the development of neoplastic lesions, the aim of this study was to determine the possible association between HPV infection and angiogenesis in benign tumours. MATERIALS AND METHODS: Specimens of skin warts which were either negative for HPV types 1, 2, 3 and 4 (HPV-ve; n = 15), or positive for HPV2 (HPV+ve; n = 19) were compared with normal skin (NS, n = 10). Vascularity and inflammation were assessed in consecutive sections. vWF-positive blood vessels were classified as small or large using a cut-off value of 50 microns diameter. RESULTS: Vascularity values for small vessels increased significantly from NS to HPV-ve warts and from HPV-ve to HPV+ve warts. Large vessels were found only in warts and their abundance was not related to HPV status. No significant association was found between vascularity and inflammation or between vascularity values for small and large vessels. CONCLUSIONS: The development of skin warts is accompanied by angiogenesis and vasodilation and these two processes may be independently regulated. Further increased angiogenesis, but not vasodilation, is associated with the presence of HPV type 2 DNA.

Analysis of Variance↗
PubMed2002

Candida albicans intralesional injection immunotherapy of warts.

Often, the treatment of verrucae is frustrating for both the physician and patient. Treatment may be painful, scarring, ineffective, and costly. The object of this study was to compare the clinical outcomes and safety of Candida albicans intralesional injection immunotherapy (CI) versus conventional wart treatment. The results of a prospective, nonrandomized, open-label, comparison study are presented. CI is a novel, simple, and inexpensive modality for the treatment of verruca vulgaris (VV), including the plantar wart (PW) type. CI appears safe and well tolerated and is well suited for multiple warts on hands and fingers, PWs, and recalcitrant warts. Uninjected warts also may regress during CI. The new phenomenon of postimmunotherapy-revealed cicatrix (PIRC) is described. CI represents an off-label usage of Candida extract.

Adolescent↗
PubMed2002

[Cimetidine therapy for multiple warts in children].

Various treatment modalities are used to treat warts and this indicates that none is uniformly effective. Cimetidine, an H2-receptor antagonist, has been tried to treat warts because of its immunomodulatory effects. Sixty children with multiple and recalcitrant warts were included in a placebo-controlled, double-blind study. Patients were randomly allocated to treatment groups equally. The groups received cimetidine, 25 to 30 mg/kg daily, or placebo for 2 months. At the end of the therapy, only 10 cimetidine-treated and 9 placebo-treated were examined. Cure rates obtained were 60% in the cimetidie-treated group and 33% in the placebo-treated group. Among our data and the review of the literature, we believe that cimetidine is not appropriate as standard therapy for warts, but it may be an interested therapy for multiple and recalcitrant warts of children.

Adjuvants, Immunologic↗
PubMed2003

Efficacy of pulsed-dye laser for viral warts--an internal audit.

Pulsed-dye laser (PDL) surgery is a recognized treatment of viral warts. Initial studies in 1993 by Tan et al achieved a 72% cure rate for 39 patients after a mean of 1.68 treatments. Since then, conflicting response rates ranging from 47-95% have been reported. The records of 44 patients, who attended the Laser Unit at St. James's Hospital between January 1999 to June 2000, were reviewed. Follow-up was conducted by telephone interview or questionnaire. Twenty-eight (64%) patients identified for the study responded. The average number of treatments was 4 (range 1-12) and mean treatment intervals were 4.9 weeks (3-10). Our results showed 64% complete clearance of all the areas treated, and 46% complete clearance of the 13 areas identified as recalcitrant. Rates for complete clearance varied with anatomic site: 73% for the face, 68% for the hands, and 40% for feet. Seventy-eight percent (7/9) of periungal warts completely cleared, and 70% (7/10) mosaic warts cleared. Twenty-five percent of the patients complained of severe pain during treatment. Post-operative complications were few, and rarely affected the patients' lifestyle. The recurrence of warts, in weeks to months following the last treatment, was reported by 36% of the patients. Seventy-nine percent of patients were satisfied with the treatment they were given. PDL may be useful in treatment of refractory warts in selected patient populations. The study identified a need to address pain control in a significant number of patients.

Adolescent↗
PubMed1991

[Systemic treatment of common warts with beta-interferon].

A 21-year-old female suffering from recalcitrant subungual and periungual common warts was treated without success for 3 years by both conservative and surgical approaches. After intravenous therapy with human fibroblast beta interferon (IFN-beta; 3 cycles, 14 days each; daily dose 1-3 x 10(6) IU) complete remission of all warts was achieved. Even 1 year after the treatment with human IFN-beta, the patient was still free of warts. We conclude that in selected cases common warts can be treated with intravenous human fibroblast IFN-beta. However, because of the high cost of this well-tolerated therapy, it cannot be recommended for all patients with common warts.

Adult↗
PubMedDate not supplied

Treatment of recurrent common warts with one low dose of intralesional natural human leukocyte interferon alpha.

Nine patients with recurrent and long lasting common warts were treated with intralesional Hu-IFN-alpha. The schedule was a single dose per wart, ranged between 10(5) and 2 x 10(5) IU. Placebo was also administered in 3 of these patients. Complete remission was observed in 7 of the 9 patients. The pattern of warts involution and the possible interferon mechanism of action are discussed. A significant pain relief, produced by interferon injection was observed in the patients with plantar warts and in one patient with subungueal wart.

Adolescent↗
PubMed1989

Routine treatment of cutaneous warts: a questionnaire survey of general practitioners.

A postal questionnaire was sent to 185 general practitioners to assess their approach to cutaneous warts and their views on the future development of the routine wart treatment service; 159 (85.9%) replied. A wide range of treatments were offered and most patients were given some treatment. The main reasons respondents gave for referring patients to hospital were failure of wart paints (73.6%) and lack of availability of liquid nitrogen (70.4%). Most general practitioners (74.2%) believed that dermatologists should spend less than 5% of their time treating warts. Many general practitioners (61.6%) wanted a practice-based wart clinic offering cryotherapy and 30.8% would like to refer directly to a hospital clinic run by a nurse. A practice clinic was more popular with general practitioners who have a treatment room nurse (P less than 0.01). Most seemed to appreciate the need for training to use liquid nitrogen. We conclude that general practitioners are keen to use cryotherapy and we argue that hospital management should provide the necessary resources for running a community-based service.

Adult↗
PubMed1978

[Immunology of human warts (author's transl)].

Specific immune reactions in man subsequent to infection by wart virus have been the subject of various studies. Most concern humoral immunity and show an antibody distribution which rises with age comparable to the viral exanthems of childhood with a maximum at 20 years and show decline thereafter. The acquisition of antibody is prolonged and sometimes irregular and its role in wart healing is questionable. The most recent work on cellular immunity has demonstrated profound abnormalities in cases of profuse verrucosis and in epidermodysplasia verruciformis, increased incidence of warts in immunodeficient states and the existence of specific reactions to viral antigen both in vitro and in vivo. Such results indicate and predominant role for cellular immunity in the evolution of this viral infection and suggest the possibility of specific immunotherapy. Very recent studies of biochemical identification of purified virus particles of various clinical types of wart show viral heterogeneity. This fact implies the need to reexamine these immune reactions in the light of the existence of crossed serological reactivity and specific wart treatment.

Antigens, Viral↗
PubMed1984

Dinitrochlorbenzene (DNCB) treatment of viral warts. A 5-year follow-up study.

A series of 43 patients with therapy-resistant viral warts of long-duration were treated with dinitrochlorbenzene (DNCB). Of the 37 patients, who completed the treatment, 19 were cured, including five of seven patients with hyperkeratotic tumor-like warts. The majority of the patients showed a depressed cell-mediated immune response. 25 patients were reexamined 5 years later and 8 additional patients answered on inquiry. Six (18%) of these patients had warts. Eight of the 21 primarily tuberculin-negative patients had developed immunity to tuberculin, and none of them had warts. Five of the 6 patients with warts were still tuberculin-negative. The reaction to DNCB had reverted to negative in 17 (68%) out of 25 tested patients and in the majority of the remaining cases a weak reaction only was seen. The study does not tell if the cure is a consequence of the DNCB treatment or a function of time. However, it shows that cure is associated with normalization of the cell-mediated immune response. The DNCB hypersensitivity seemed to disappear with time and late complications were not documented.

Adolescent↗
PubMed1980

The common wart: intralesional treatment with bleomycin sulfate.

Thirty-six patients were treated for single or multiple warts by intralesional injection of bleomycin sulfate (Blenoxane) at the base of the wart. The dose varied according to the size of the lesion and ranged from 0.2 to 0.8 mg per injection, up to a maximum total dose of 2 mg. The cure rates were as follows: 67 percent in plantar warts; 82 percent in ungual warts; and 80 percent in warts located elsewhere. The cure rate for all patients was 75 percent. The drug was well tolerated and the procedure readily accepted by the patients.

Adolescent↗
PubMedDate not supplied

Genital warts.

Human papillomaviruses have not been propagated in tissue culture, so they cannot be studied by the procedures of classical virology. Recently, DNA hydridization techniques and restriction enzyme analysis have revealed that multiple strains of human papillomaviruses exist. It is now accepted that genital warts are a sexually transmitted disease; other routes of infection are possible, but unusual. An association between maternal warts during pregnancy and the development of vulval warts and laryngeal papillomatosis in infants and young children has been shown. The epidemiology of anal warts in homosexual men is not well understood. The flat condyloma, visible on colposcopy, is a human papillomavirus-containing lesion with a wart-like histology. It is a common condition which in the past may have been mistaken for dysplasia. Flat condylomas may regress spontaneously, or develop into condylomata acuminata. A link between these lesions and some cases of cervical carcinoma has been suggested.

Animals↗
PubMed1984

The prevalence of warts on the hands of workers in a New Zealand slaughterhouse.

Ninety-nine adult male meat workers and 55 similar textile workers were questioned about their current and past experience of hand warts, their contact with affected family members and non-workplace exposure to animals. Period prevalence rates for workers who slaughtered cattle (72%) and pigs (60%)--were significantly higher than those for other meat industry workers (27%) and textile workers (22%). Beef and pig slaughtermen employed for more than five years had a significantly higher period prevalence rate than other meat workers and textile workers. There were no differences between prevalence rates of warts in children and other family members of affected and unaffected meat workers. There was an inverse relationship between the prevalence of hand warts and non-workplace exposure to cats and dogs. Very few meat workers had time off work due to hand warts. The data support the hypothesis that the work environment of beef and pig slaughtermen enhances the prevalence of hand warts.

Abattoirs↗
PubMed1983

Human warts permanently removed by static electricity.

The CED was found to be a highly effective, safe, inexpensive, and simple device to use for complete wart removal with no regrowth or scarring. The warts are shed in the same manner as the surface epithelium exfoliates or sloughs off. Plantar warts cause a great deal of pain in walking and surgical procedures are warranted in some cases. Since these warts tend to become very large and to extend deeply into the dermis, when they are removed surgically the patient is incapacitated for a period of time. Opening the area to bacteria may cause additional infection, and the surgery may result in tender scar formation. According to our study group, the CED offers an effective alternate means of therapy for removing warts and alleviating the pain associated with them.

Electric Stimulation Therapy↗