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At least 289 records · Page 16Linked to original sources
PubMed2000

The ups and downs of protein topology; rapid comparison of protein structure.

Protein topology can be described at different levels. At the most fundamental level, it is a sequence of secondary structure elements (a "primary topology string"). Searching predicted primary topology strings against a library of strings from known protein structures is the basis of some protein fold recognition methods. Here a method known as TOPSCAN is presented for rapid comparison of protein structures. Rather than a simple two-letter alphabet (encoding strand and helix), more complex alphabets are used encoding direction, proximity, accessibility and length of secondary elements and loops in addition to secondary structure. Comparisons are made between the structural information content of primary topology strings and encodings which contain additional information ("secondary topology strings"). The algorithm is extremely fast, with a scan of a large domain against a library of more than 2000 secondary structure strings completing in approximately 30 s. Analysis of protein fold similarity using TOPSCAN at primary and secondary topology levels is presented.

Amino Acid Sequence↗
PubMed1987

Postpartum sit-ups.

Explore the source record for details and available documents.

Abdominal Muscles↗
PubMed2004

Flare-ups in endodontics: II. Therapeutic measures. 1985.

Various treatment regimens for the relief of pain during endodontic therapy, including relief of occlusion, pre-medication, establishment of drainage, and intracanal and systemic medications are presented. In addition, the rationale for the use of placebos is discussed.

Dental Pulp Diseases↗
PubMed1993

Long-term outcome of treated schizophrenia in a Nigerian cohort. Retrospective analysis of 7-year follow-ups.

Consecutive case records of 142 patients (55 males and 87 females) who fulfilled stringent criteria for schizophrenia, and attended the psychiatric facilities at the Ibadan teaching hospital for at least 7 consecutive years were studied in detail in order to determine outcome in a period of follow-up that ranged from 7 to 26 years (mean +/- SD, 13.3 +/- 4.6 years). A unique history of stability of staff and research record keeping, as well as the fact that relatives frequently accompany patients to hospital, enhanced the reliability and validity of documents. Using outcome criteria that included the presence of positive and negative symptoms of schizophrenia and social adjustment in the past 12 months, it was found that 72 (50.7%) patients were in the good outcome group, while 34 (23.9%) and 36 (25.4%) had moderate and poor outcome, respectively. The social and clinical characteristics of the patients were similar to those of participants in World Health Organization prospective studies in this country. Whereas there was a nonsignificant trend for more females to be without psychotic symptoms, the males performed significantly better in social adjustment outcome measures. In contrast with reports from the Western world, patients with acute onset and episodic course were a common feature of the cohort. The results support previous reports indicating fairly good outcome of schizophrenia in developing countries.

Acute Disease↗
PubMed2003

Respiratory syncytial virus epidemics: the ups and downs of a seasonal virus.

Respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract infections in infants worldwide. Lower respiratory tract infections caused by RSV occur epidemically, and the appearance of epidemics seems to vary with latitude, altitude and climate. This study uses a review of the literature on RSV seasonality to investigate whether a global pattern in RSV epidemics can be found. A comparison of morbidity and mortality caused by RSV in developed vs. developing countries is also presented. The seasons in which RSV epidemics occur typically depend on geographic location and altitude. During these seasons the epidemics tend to appear in clusters. Although the appearance pattern of these epidemics varies from one continent to another, they usually begin in coastal areas. RSV is the cause of one-fifth of lower respiratory infections worldwide. Generally RSV mortality is low, with a median value of zero. However, RSV mortality in developing countries is significantly higher than RSV mortality in developed countries.

Child↗
PubMed2001

Buoyant balaenids: the ups and downs of buoyancy in right whales.

A variety of marine mammal species have been shown to conserve energy by using negative buoyancy to power prolonged descent glides during dives. A new non-invasive tag attached to North Atlantic right whales recorded swim stroke from changes in pitch angle derived from a three-axis accelerometer. These results show that right whales are positively buoyant near the surface, a finding that has significant implications for both energetics and management. Some of the most powerful fluke strokes observed in tagged right whales occur as they counteract this buoyancy as they start a dive. By contrast, right whales use positive buoyancy to power glides during ascent. Right whales appear to use their positive buoyancy for more efficient swimming and diving. However, this buoyancy may pose added risks of vessel collision. Such collisions are the primary source of anthropogenic mortality for North Atlantic right whales, whose population is critically endangered and declining. Buoyancy may impede diving responses to oncoming vessels and right whales may have a reduced ability to manoeuvre during free ascents. These risk factors can inform efforts to avoid collisions.

Animals↗