Poikilodermatous plaques on the torso of a young man. Granulomatous slack skin syndrome.
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Front-view line drawings of male and female physiques were rated for attractiveness. Both subject sexes rated female physiques with greater curvature as less attractive. Male subjects' ratings were unaffected by breast size while female subjects showed slight negative evaluation of large breasts. Both subjects sexes rated broad shoulders as attractive in male physiques. Greater chest muscularity resulted in slightly higher attractiveness ratings; waist slimness was also judged attractive, particularly in female subjects.
This article describes the author's experience in performing lipoplasty in patients over 50 years of age. Historically, emphasis was placed on selection of patients for this procedure who were under age 40 years. However, the author's experience with 20 patients over 50 indicates extremely high patient satisfaction. Subsequent skin excision was required in only 10% of the patients. The author concludes that many patients over 50 have good skin elasticity and represent satisfactory candidates for lipoplasty. Age alone should not exclude these patients.
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The contribution of afferent feedback to the regulation of locomotion in humans is not well understood. Animal experiments have suggested that loading of the leg during the stance phase may enhance the magnitude of extensor burst activity and delay the onset of swing phase. The aim of the present study was to determine whether transient loading of the leg at the end of stance would enhance extensor-muscle activity and delay the onset of swing in walking humans. To test this hypothesis, we applied loads to the hips of subjects so that the load was applied along the long axis of the leg at the end of stance (down-back unsupported, DBU). This resulted in an unexpectedly complex reaction characterised by rapid co-contraction of antagonist pairs of muscles around the ankle and knee and a prolongation of the stance phase. We speculated that the complexity of the reaction was, in part, due to a disturbance in equilibrium. To address this possibility, two additional perturbation paradigms were tested: (1) subjects held a rail during the loading paradigm (down-back supported, DBS), or (2) subjects received only a posteriorly directed perturbation of the hips, which added no additional load to the leg (backward unsupported, BU). As predicted, the DBS perturbation resulted in an enhancement of the ongoing soleus-muscle activity, and the unexpected tibialis anterior burst that was observed during the DBU paradigm was absent. Allowing the subjects to hold a rail substantially reduced the change in the timing of the step cycle observed in the DBU paradigm. The BU perturbation prolonged the stance phase duration and, as expected, resulted in a burst of activity in tibialis activity. This was usually accompanied by a reduction in the ongoing soleus activity. Two important conclusions are drawn from the present study. First, loading of the leg at the end of stance phase enhances the ongoing extensor-muscle activity. We suggest that afferent feedback responding to the increase load supported by the leg leads to rapid enhancement of the active extensor muscles to compensate for the increased load and prevent collapse of the leg. Interestingly, the duration of the stance phase was only marginally increased when loading was applied without a postural disturbance (DBS). Second, posterior perturbation of the centre of mass at the end of stance phase evokes an "automatic postural response" in tibialis anterior. Of particular interest, this evoked postural response can occur simultaneously with an enhanced activation of soleus. This indicates that the DBU perturbation employed in this study elicited two responses, one to prevent the collapse of the leg and the other to stabilise the centre of mass.
The capabilities and limitations of two-(2D) and three-dimensional (3D) fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting small tumors and lymph nodes were studied in a phantom modeling the human chest and axilla. Multiple dual-radionuclide phantom studies were performed. Five hollow spheres ranging in diameter from 3 mm to 15 mm were filled with carbon-11 and placed in the axillary and mediastinal regions of an anthropomorphic phantom containing hollow organs filled with 18F to simulate FDG uptake 1 h after injection. Dynamic imaging was performed to acquire PET images with varying target-to-background ratios. Imaging was performed in 2D and 3D acquisition modes, with and without attenuation correction, on a modern PET scanner. Lesion detectability was visually and quantitatively assessed. For objects larger than 9 mm in diameter, target-to-background ratios ranging from approximately 3:1 to approximately 10:1 were detectable. Objects < 9 mm in diameter required a target-to-background ratio of >/=18:1. Target-to-background ratios required for lesion detectability were equivalent for 2D and 3D PET images with and without attenuation correction. In conclusion, 2D and 3D PET with attenuation correction consistently detected "tumors" >/= 9 mm. Lesions < 9 mm could be detected if there was high enough tumor uptake. No statistically significant differences in lesion detection were found for 2D versus 3D PET, or for attenuation-corrected versus non-attenuation-corrected images.
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Models of the abdominal musculature, which used single slice MRI or CT scans to reconstruct the anatomy, were unable to explain magnitudes of abdominal flexion moment which exceed 100 Nm in living subjects. For example, the muscle areas and corresponding flexor moment arms measured from a transverse scan at L4-L5 predict maximum moments less than 50 Nm. The architecture of rectus abdominis, external and internal obliques, and transverse abdominis was examined from cadaveric specimens, from which the geometric details were incorporated into a revised model. Scaling of the muscles to obtain physiological cross-sectional areas were obtained using two methods: serial MRI slices; and from several locations of ultrasound measurement. The two major anatomically justified improvements that had dramatic effects on flexor moment production were: the increase in flexor moment arms of muscles (approximately 30%) measured in a standing posture when compared to the supine posture for MRI examination; reinterpretation of the line of action of the obliques which transmit their flexor forces through the linea semilunaris (increasing their effective flexor moment arm) to eventual skeletal attachment at the pelvis.
Major trauma provokes a stress response which is mediated, in part, via glucagon, catecholamines, and cortisol. These stress hormones modulate the choice of energy substrate for various tissues. While glucose and fatty acids are considered the preferred fuels, ketone bodies (26/ATP/mole) may be a viable alternative. In this study, we measured the concentrations of acetoacetate and beta-hydroxybutyrate (3-OHB) in the portal as well as systemic circulations of 10 critically injured patients (revised trauma score = 6.8 +/- 0.5, injury severity score = 27 +/- 3) during the first 5 postoperative days. At 6 hr postinjury, 3-OHB was elevated in the portal system (0.34 +/- 0.01 mM) while depressed systemically (0.09 +/- 0.02 mM), indicating that the gut was capable of ketogenesis. In contrast, at 24 hr, 3-OHB rose systemically (0.39 +/- 0.02 mM) while decreasing in portal blood (0.09 +/- 0.01 mM) implying gut ketone consumption. Moreover, the systemic ketone body ratio became elevated at 24 hr, suggesting an enhanced liver energy status. In summary, we believe ketogenesis is stimulated by major trauma. Initially, the gut supports ketone concentration in the systemic circulation, whereas, by 24 hr, the gut becomes a ketone consumer and the liver maintains circulating levels.
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Early development of the Drosophila embryo is under the control of some maternal genes responsible for the establishment of its general pattern. Three sets of genes determine the anteroposterior pattern; two distinct systems specify anterior and posterior development and a third one, the terminal system, is responsible for the development of the poles of the embryo. A different set of genes specifies dorsoventral polarity, which is established by the graded activity of the dorsal gene product. Here I analyze the effect of the terminal system on the expression of two zygotic genes involved in dorsoventral pattern, snail and decapentaplegic, and I show that this effect is mediated by a reduction on dorsal activity by the terminal system. Due to the interaction of these two systems, both of which use transmembrane signalling mechanisms, the poles adopt a more dorsalized fate than their counterparts in the middle of the embryo.
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