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At least 289 records · Page 16Linked to original sources
PubMed2006

St. Jude Children's Research Hospital, Memphis, Tennessee: gestational choriocarcinoma.

This paper describes a recent tumor board presentation conducted at our institution involving an adolescent with gestational choriocarcinoma. Despite its rarity in pediatrics, gestational choriocarcinoma offers unique diagnostic, treatment and off-therapy considerations in adolescent patients who have become pregnant. Key features and findings of the case as well as important management issues will be discussed.

Adolescent↗
PubMed1998

The University of Tennessee experience with the Indigo 830e laser device for the minimally invasive treatment of benign prostatic hyperplasia: interim analysis.

Benign prostatic hyperplasia (BPH) is the most common benign tumor in men and is responsible for urinary symptoms in the majority of men older than 50 years of age. Although transurethral resection of the prostate (TURP) is the gold standard, its complications have impacted upon its utility. As a consequence, new pharmacologic and minimally invasive approaches to the management of BPH have been developed. One minimally invasive approach that employs interstitial laser coagulation by the Indigo 830e LaserOptic system heats the prostate to the point of irreversible necrosis while preserving the urethral lining, potentially resulting in fewer complications. To test the efficacy of this device we evaluated the interim results obtained in 25 patients treated for BPH. Parameters evaluated included the AUA symptom score, uroflowometry, post-void residual, and prostate size. Following treatment, patients were discharged home and the catheter was removed within 3-7 days. Patients were assessed at 1 month and at subsequent 3-month intervals following the procedure using a questionnaire, AUA symptom score, and uroflowometry. The results of the paired t-tests demonstrated a significant increase in the maximal and average flow rates from baseline. The mean baseline maximal flow rate was 8.3 ml/s and increased to 10, 12.7, 14.1, and 12.0 ml/s at 1, 3, 6, and 9 months, respectively, and the mean baseline average flow rate was 4.4 ml/s and increased to 5.3, 6.0, 6.6, and 6.2 ml/s at 1, 3, 6, and 9 months, respectively. The AUA symptom scores decreased from 20.2 to 9.8 at 9 months. There was no intraoperative complication. Six patients developed transient retention. No patient developed bladder neck contractures, urinary incontinence, impotence, or urinary tract infections. One patient developed retrograde ejaculation and one patient required retreatment by TURP. Hence, improvements in symptom scores and voiding parameters suggest that the laser interstitial coagulation prostatectomy is safe and effective for the treatment of BPH.

Academic Medical Centers↗
PubMed1978

Drug prescribing during pregnancy. A controlled study of Tennessee Medicaid recipients.

The effect of pregnancy on prescribing was assessed in a population of pregnant Medicaid recipients and two matched groups of control women. Of the 2,528 gravidas, 62 per cent received systemic legend drugs (excluding dietary supplements) during their pregnancies. White women and women 30 years of age and older were most likely to receive these medications. Systemic anti-infectives were the most frequently prescribed category of drugs (excluding dietary supplements). One fourth of the women received a narcotic-containing drug and 13 percent of the women received psychotropic drugs, most frequently diazepam. Barbiturates and narcotic-containing drugs were often "hidden" a fixed combination medication. In general, prescribing did not decrease as a result of pregnancy. This study and other studies reviewed here emphasize the need for comprehensive drug-use guidelines for physicians who care for pregnant women.

Adult↗
PubMed1984

Cervical cancer occurrence in Memphis and Shelby County, Tennessee, during 25 years of its cervical cytology screening program.

This review of the cytologic history of 430 women with histologically proved invasive cancer of the uterine cervix indicates that several significant subgroups can be defined. One major subgroup consists of 142 patients or 33% of the total group in whom invasive cancer developed within 1 to 5 years, with an average of 2.6 years, after one or more negative cytologic findings. This appears to be a significant proportion of the occurrence of invasive cervical cancer and warrants consideration in the recommendation of screening intervals. The second major subgroup, consisting of 88 patients (20.5%), had a delay in diagnosis averaging 9.9 years after the first abnormal cytologic finding. In some of these patients either the cytologic examination results reverted to negative for a period or the biopsy material did not confirm the cytologic abnormalities. The disease progressed to invasion. These findings appear to bear out the importance of close follow-up of patients with any abnormal cytologic finding in the intraepithelial neoplasia category even though intermittent cytologic studies may appear negative.

Adult↗
PubMed1986

Reported sexual assault in Nashville-Davidson County, Tennessee, 1980 to 1982.

A review of the experience of 440 women reporting they had been raped was made from their initial contact with the police, through their medical-forensic examination at the county hospital emergency room, by any judicial proceedings, and by their longer term psychological counseling. The data were then compared with those from other municipalities. The assailant's use of a weapon seemed the strongest variable correlated with the victim's decision to press for prosecution. Being raped by a stranger or being physically injured did not correlate with this decision. Women most likely to have been victims of a previous rape were over 40 years old, were black, were assaulted by someone well known to them, or had some sort of mental health problem, and these variables were independent of each other. This implies these victims somehow suffer from an increased vulnerability to repeated rape. The data suggest that use of a county hospital emergency room for the medical management of rape victims discourages their reporting the event to the authorities and their seeking medical treatment.

Adolescent↗
PubMed1991

Child sexual abuse in Shelby County, Tennessee: a new epidemic?

Following the introduction of a comprehensive child sexual abuse program in 1985, there was a significant increase in the number of validated incidents of abuse involving minors. However, following the initial increase, the number of validated incidents of abuse remained relatively stable at about 30-35 per month. While the overall validation rate was 57%, it fluctuated widely from as low as 21% to as high 92%. The validation rate rose from 1984 through 1987, declining in the latter part of 1989. The validation rate appeared to reflect the number of validated cases and not be dependent upon the number of reported cases. The number of cases validated was not significantly correlated with time, but was moderately correlated with the number of cases reported (estimated Spearman correlation coefficient was .45 with p less than .05). However, after adjusting for time, the partial correlation between the number of validated and the number of reported cases was no longer significant. The percent of validated cases (the validation rate) was correlated with number of cases validated (estimated Spearmen correlation coefficient was .84 with p less than .0001), but not with the number of cases reported. Validation rates were higher for girls than for boys, 71.1% and 31.8% respectively. The majority of the perpetrators (78%) were known to the children and had access to the victims. In over half the incidents, family members were implicated as the perpetrators.

Adolescent↗
PubMed2005

Diurnal variation of dissolved gaseous mercury (DGM) levels in a southern reservoir lake (Tennessee, USA) in relation to solar radiation.

Variations of dissolved gaseous mercury (DGM) concentrations in a southern reservoir lake (Cane Creek Lake, Cookeville, TN, USA) in relation to solar radiation were investigated consecutively from June 2003 to May 2004. The daytime DGM levels in the lake exhibited a two-phase diurnal trend; the DGM concentrations rose in the morning, peaked around noontime and then fell in the afternoon through the evening; these trends followed the general pattern of diurnal solar radiation variations. The morning and afternoon phases appeared to be asymmetrical with the former relatively steep and the latter gradual. A variety of daytime DGM level variations other than the typical two-phase diurnal patterns were also observed. For the time spans studied, the daytime mean DGM concentrations of the lake ranged from 12 to 68 pg L(-1) (60-340 fM). The daytime mean DGM levels in the summertime (June, July, August) showed values above 30 pg L(-1) (150 fM) in most cases and a large number of peak DGM concentrations above 50 pg L(-1) (250 fM). The summer DGM levels in the lake appear to be comparable to those observed in the large northern lakes for the summertime. The daytime DGM levels in the lake were found to correlate with solar radiation to various degrees (cases of r values above 0.8: approximately 12% and approximately 18% of the total sampling days for correlation with global solar radiation and UVA radiation, respectively). Correlating trends are recognizable between the daytime mean DGM concentration and the corresponding mean global solar radiation (r = 0.66, p < 0.0005) and between the daytime mean DGM concentration and the corresponding mean UVA radiation (r = 0.62, p < 0.0005).

Environmental Monitoring↗