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Survival of pleomorphic sarcoma-37 transplanted virgin female DBA/2J mice: hyperthermia and hyperglycemia, alone and in combination with drugs.

Sarcoma-37 (S-37) transplanted DBA/2J mice were submitted to a controlled whole body hyperglycemic-hyperthermic ("double attack") treatment. A single exposure to the 3-hr 400-500-mg% blood glucose level coupled with 1 hr of whole body 40.0 degrees warming was safe and extended longevity by 40% over the nontreated controls. This increase suggests that additive or potentiated effects follow the two-parameter procedure. The treatment safety and resultant increased longevity were not enhanced by single-dose chemotherapy with doxorubicin and/or dacarbazine.

Animals↗