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Further evidence for an inhibitory role of central 5-HT in male rat sexual behavior.

The 5-hydroxytryptamine (5-HT) reuptake inhibitors zimelidine (10 mg/kg IP 1.5h pretest) or alaproclate (20 mg/kg IP 1.5h pretest) produced a prolongation of the ejaculation latency and of the post-ejaculatory interval in male rats treated with a subthreshold dose of 5-hydroxytryptophan (5-htp) (12.5 mg/kg IP 1h pretest). The 5-HTP-induced (50 mg/kg IP 1h pretest) prolongation of ejaculatory latency was effectively counteracted by administration of the 5-HT receptor blocking agent metergoline (1 mg/kg IP 1.5h pretest). All animals were treated with an inhibitor of peripheral aromatic amino acid decarboxylase, indicating that the effects are of central origin. The results support the contention that central 5-HT plays an inhibitory role in male rat sexual behavior.

5-Hydroxytryptophan↗

Effects of an AIDS education program on the knowledge, attitudes and practices of low income black and Latina women.

The purpose of this study was to test the effects of an AIDS education program on the knowledge, attitudes and practices of low income black and Latina women. A pretest-posttest nonequivalent control group design was used with a 2-3 month retest of the experimental group. The sample consisted of 506 experimental and 206 control group women who were clients of the Public Health Foundation's Nutrition Program for Women, Infants and Children in Los Angeles County. The program included a slide-tape presentation, and educational and resource brochures in English and Spanish. Knowledge, attitudes, and sexual and drug use practices were measured using a structured questionnaire that was developed in English and Spanish. Content validity and reliability of the questionnaire were established. A 2-way repeated measures ANOVA examined differences in pretest-posttest knowledge, attitudes, and practices for experimental and control groups and for both racial/ethnic groups. The experimental group made significant gains over the control group on pretest-posttest measures of knowledge and attitudes. Both experimental and control groups made significant changes in practice. Changes in knowledge were retained on retest; changes in practices came close to significance on retest. Blacks and Latinas differed on pretest knowledge and attitudes but not practices. Blacks had more knowledge and positive attitudes on pretest. However, posttest improvements for both knowledge and attitudes were greater in Latinas than in blacks. A multiple regression analysis revealed that the best predictors of knowledge, attitudes and practices were racial/ethnic group, education, and religion. It is concluded that a didactic audio visual program can positively affect the knowledge and possibly the practices of participants and that these are retained over time but that changes in attitudes will take further efforts.

Acquired Immunodeficiency Syndrome↗

The effect of changing disease risk on clinical reasoning.

OBJECTIVE: To assess the ability of health care professionals to evaluate the effect of clinical test results in different settings. DESIGN: Subjects were presented with a series of generic clinical scenarios in which information about the test performance and the pretest probability of disease was varied. The subject estimates of posttest probability were compared with those calculated on the basis of Bayes' theorem. PARTICIPANTS: Fifty health care professionals, including 31 physicians and 19 nonphysicians, associated with a university teaching hospital. MEASUREMENTS AND MAIN RESULTS: Under a variety of testing conditions, both the physicians and the nonphysicians inaccurately estimated the posttest probability of disease. Based on a logarithmic transformation, the error in probability estimation was divided into a portion related to the pretest probability of disease and a portion related to the test performance. Most of the error in posttest probability estimation was associated with the incorrect use of pretest probabilities. The subjects consistently overestimated the posttest probability of disease expected under Bayes' theorem, with increasing error associated with decreasing pretest probability. Physician estimates of posttest probability increased with increasing likelihood ratios for each scenario. Nonphysician estimates of posttest probabilities increased with increasing likelihood ratios for a positive test, but the estimates associated with a negative test result were inconsistent. CONCLUSIONS: Physicians and nonphysicians overestimate posttest probabilities with increasing error associated with decreasing disease risk. Some nonphysicians may not fully understand the effect of test performance on risk estimation, particularly in the setting of a negative test. Health care professionals should receive training in the proper evaluation of test information, with particular emphasis on the influence of pretest disease risk on the posttest probability of disease.

Bayes Theorem↗

Value of a simple measure of estrogen status for improving the diagnosis of coronary artery disease in women.

PURPOSE: To determine the potential impact of estrogen status on the pretest and postexercise test diagnostic accuracy of exercise testing. PATIENTS AND METHODS: The study comprised a total of 234 women and 326 men who underwent exercise testing followed by coronary angiography. We performed incremental logistic regression analysis of pretest (age, symptoms, smoking, diabetes, cholesterol level) with and without estrogen status (defined according to menopausal and oral estrogen status) and exercise test (two ST-segment and three non-ST-segment) variables separately for men and women. Outcomes were assessed by receiver operating characteristic (ROC) curve area analysis. RESULTS: Estrogen status was an independent pretest predictor of angiographic coronary disease. Pretest ROC curve areas: women without estrogen status = 0.79, women with estrogen status = 0.85, men = 0.78 (women with estrogen status versus other groups, p < 0.001). Postexercise test ROC curve areas: women without estrogen status = 0.83, women with estrogen status = 0.87, men = 0.88 (women without estrogen status versus other groups, p < 0.001). CONCLUSION: Consideration of estrogen status allowed for a significant improvement in the pretest clinical diagnosis of coronary disease in women. When these improvements were added to the results of exercise testing, the diagnostic accuracy of the combined clinical and exercise test data was similar for men and women. Estrogen status may be an important diagnostic clinical variable in women with suspected coronary disease.

Adult↗

Diagnostic accuracy of predicting coronary artery disease related to patients' characteristics.

Patients' demographic and clinical characteristics may affect diagnostic accuracy of cardiologists. We asked a group of experienced cardiologists from three institutions to estimate the pretest probability of coronary artery disease in 257 patients referred for diagnostic coronary angiography and with no history of previous myocardial infarction nor valvular heart disease. Physicians pretest estimates were compared with the diagnostic findings of coronary angiography. We tested the influence of five variables on the accuracy of the pretest estimates: age, sex, chest pain characteristics, rest electrocardiogram and electrocardiographic exercise test result. Cardiologists tended to overestimate the presence of coronary artery disease and this tendency was particularly remarkable in the group of patients showing a negative exercise test. Pretest diagnostic accuracy was 0.72 when the test result was negative and 0.85 when the test result was positive (95% confidence interval of the difference 0.03 to 0.23; p < 0.001). The diagnosis of coronary artery disease was also more accurate for male than for female patients (0.81 vs 0.70; 95% confidence interval of the difference 0.02 to 0.21; p < 0.02). Characteristics of chest pain, age and rest electrocardiogram did not affect the level of pretest diagnostic accuracy. Cardiologists should be cognizant of correctly interpreting a negative exercise test and the clinical data of female patients; in both cases, they should move circumspect of the diagnosis of coronary artery disease.

Age Factors↗

Analysis of covariance (ANCOVA) with difference scores.

When comparing pretest to posttest changes in non-randomized groups, most researchers are correctly avoiding ANCOVA with posttest as the dependent variable and pretest as the covariate. However, there is a widespread use of ANCOVA in which the difference score (posttest minus pretest) is used as the dependent variable, and pretest as the covariate. A computer simulation study is presented which shows that measurement error causes identical, biased conclusions when comparing changes using either the posttest score or the posttest minus pretest difference score as the dependent variable. The reasons for this bias are explained and illustrated.

Analysis of Variance↗

Nutrition intervention group program based on preaction-stage-oriented change processes of the Transtheoretical Model promotes long-term reduction in dietary fat intake.

OBJECTIVE: To develop and evaluate the long-term effectiveness of an intervention program, based on preaction-stage-oriented change processes of the Transtheoretical Model of Behavior Change, that could be delivered in a group setting to help participants lower dietary fat intake. DESIGN: An enhanced version of the nonequivalent control group experimental design was used. Entire sections of an undergraduate introductory nutrition science course were assigned to an experimental, pretest/posttest control, or posttest-only control group. Daily fat intake and stage of change of the experimental and pretest/posttest control groups were determined at the pretest and posttest and 1-year later at a follow-up test. Every 1 to 2 weeks during the study, stage of change of the experimental group was assessed. Daily fat intake of the experimental group was assessed at study midpoint. Daily fat intake and stage of change of the posttest-only control group was determined at the posttest. Pretest results were used to place participants of the experimental and pretest/posttest control groups in either the preaction stage (i.e., precontemplation, contemplation, or preparation) or the action/maintenance stage. SUBJECTS/SETTING: The sample consisted of 38, 30, and 42 undergraduate students who were assigned to the experimental, pretest/posttest control, and posttest-only control groups, respectively. INTERVENTION: The experimental group participated in a group-based, dietary fat intake intervention that included a series of 11 lessons taught over a 14-week period. Each lesson was based on 1 or 2 of the preaction-stage-oriented change processes of the Transtheoretical Model. MAIN OUTCOME MEASURES: Data were evaluated to determine the effects of the intervention program on long-term dietary fat reduction and stage of change progression. STATISTICAL ANALYSIS PERFORMED: Analysis of variance, repeated-measures analysis of variance, and paired t tests. RESULTS: For pretest and posttest dietary fat intake scores, stage and time were significant, and there was a significant time-by-stage interaction. Time was significant for pretest and posttest stage scores. Subjects in the preaction-stage experimental group significantly increased their mean stage of change and reduced their fat intake between the pretest and posttest; these changes persisted for 1 year. Pretest/posttest control group participants who began in a preaction stage also significantly increased their mean stage and reduced fat intake by the posttest, but these changes did not endure until the follow-up test. APPLICATIONS/CONCLUSIONS: This intervention program produced an enduring, significant reduction in mean dietary fat consumption and a significant progression in mean stage of change of subjects in the experimental group who were in the preaction stage. It may be appropriate to design group interventions to use preaction stage processes rather than the more traditionally used action and maintenance stages change processes.

Adolescent↗

The experience of loss and anticipation of distress in colorectal cancer patients undergoing genetic testing.

OBJECTIVE: The purpose of this paper is to describe pretest psychological functioning in a sample of colorectal cancer (CRC) patients undergoing genetic testing. We also explored the relationship among demographic, medical, family history and loss variables and current pretest distress, and those related to anticipated posttest distress. METHODS: This paper reports pretest findings from a prospective, longitudinal psychosocial survey. Data are presented on 220 CRC patients at pretest. RESULTS: We found a subgroup of CRC patients that are currently distressed and anticipate becoming depressed if they receive a positive genetic test result. There were significant associations among pretest distress, family history of CRC and loss related to CRC and anticipation of becoming depressed at posttest. CONCLUSIONS: The findings suggest that a subgroup of CRC patient's experience or anticipate distress that may warrant attention. Family history of CRC and losses related to CRC may be important indicators of posttest adjustment.

Adaptation, Psychological↗

Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat.

In a recent study, we reported the presence of neurones expressing 5-HT2B receptor protein in the medial amygdaloid nucleus of the adult rat brain. In the present study, bilateral micro-injection of the 5-HT2B receptor agonist 1-[5-(2-thienylmethoxy)-1H-3-indolyl]propan-2-amine hydrochloride (BW 723C86, 0.09 and 0.93 nmol, 5 min pretest) into the medial amygdaloid nuclei increased the total interaction time of a pair of male rats in the social interaction test, to a comparable extent to chlordiazepoxide (5 mg/kg p.o., 1 hr pretest) without altering locomotor activity; indicative of anxiolytic activity. The increase in social interaction was prevented by pretreatment with the 5-HT2C/2B receptor antagonist N-(1-methyl-5-indoyl)-N'-(3-pyridyl) urea hydrochloride (SB 200646A, at 2 but not 1 mg/kg p.o., 1 hr pretest), which did not alter behaviour when given alone. Intra-amygdala BW 723C86 (0.09, 0.31 and 0.93 nmol, 5 min pretest) did not significantly alter the number of punished responses made when the same rats were examined seven days later in a Vogel punished drinking test, although chlordiazepoxide (5 mg/kg p.o., 1 hr pretest) produced the expected anxiolytic profile. The results are consistent with the proposal that activation of 5-HT2B receptors in the medial amygdala induces anxiolysis in the social interaction model but has little effect on behaviour in a punished conflict model of anxiety. These data suggest that serotonergic neurotransmission in this nucleus may selectively affect specific kinds of anxiety generated by different animal models.

Amygdala↗

Pelvic anatomy for obstetrics and gynecology residents: an experimental study using clay models.

OBJECTIVE: To determine whether clay modeling with lecture is more effective than lecture alone in teaching female pelvic anatomy. METHODS: A pretest preceded a lecture on female pelvic anatomy in the following five groups of obstetrics and gynecology residents: postgraduate year 1 (PGY-1) residents at Women and Infants Hospital of Rhode Island (RI), PGY-1 residents at University of Connecticut (CT), and PGY-2, -3, and -4 residents at RI. The study group (PGY-1 RI) also participated in a clay modeling session. Both groups of PGY-1 residents were tested immediately (posttest 1) and then 8 weeks later (posttest 2). The PGY-2, -3, and -4 residents had only posttest 2. Data were analyzed with parametric, nonparametric, and repeated measures analyses. RESULTS: There was no significant difference between the mean pretest scores of the five groups. The study group showed significant improvement in mean scores at posttest 1 (29.7 +/- 0.9, P <.001) and at posttest 2 (24.1 +/- 4.6, P =.03) compared with the mean pretest score (17.4 +/- 3.7). The CT residents demonstrated significant improvement in mean scores at posttest 1 (25.2 +/- 4.4, P =.02) but not at posttest 2 (19 +/- 3.7, P =.2) compared with their mean pretest score (15.2 +/- 2.9). There was no significant improvement in the mean scores at posttest 2 for PGY-2, -3, and -4 resident groups compared with their pretest scores. CONCLUSION: Clay modeling with lecture was more effective than lecture alone for teaching pelvic anatomy.

Aluminum Silicates↗

Skills-building methods to prevent smoking by adolescents.

This study evaluated cigarette smoking prevention methods with a sample of adolescent females and males. Arranged by school, 331 informed and consenting sixth graders were randomly divided into four groups: 1) pretest, skills-building methods, posttest; 2) pretest, discussion methods, posttest; 3) pretest and posttest; and 4) posttest only. All subjects were followed for 6 and 15 months after the posttest. Outcome results on measures of non-smoking intentions, attitudes, predictions, problem-solving abilities, and peer interactions favored subjects in the skills-building group when compared with subjects in the discussion and pretest-posttest control groups. Smoking rates at posttest and at both follow-ups were lower in the skills-building group than in the other three groups. Results from posttest-only subjects did not support pretest reactivity. The study's strengths and limits are discussed along with directions for future smoking prevention research.

Adolescent↗

Comparison scan training and the matching and scanning performance of severely and profoundly mentally retarded students.

This study investigated the effects of comparison scan training on the matching and visual scanning performance of severely and profoundly mentally retarded students. A match-to-sample-problem pretest was administered to 32 students, whose eye movements were recorded on videotape, and the 12 subjects who demonstrated at least minimal competence on the pretest task were matched on pretest performance and assigned to training (n = 6) or comparison (n = 6) groups. Training-group students were provided with visual comparison scan training, while the comparison group performed the same task but received no training. A posttest identical to the pretest followed. The training group was superior to the comparison group during training and showed a significant increase in correct responding from pretest to posttest, whereas the comparison group did not. Neither measures of scanning behavior nor the latencies of the choice response were related to matching performance or affected by the training procedure. Possible relationships among visual scanning, comparison scan training, and matching-task performance were discussed.

Discrimination Learning↗

Impact of receiving blood cholesterol test results on dietary change.

INTRODUCTION: The study objective was to determine the impact of receiving results of a blood cholesterol test on changes in dietary behaviors among individuals participating in a Health Risk Appraisal Program. METHODS: This randomized trial of maintenance employees at six hospitals included two groups: Group 1 received their blood cholesterol test results at the pretest; Group 2 received results only at the posttest (16-20 weeks later). The pretest interview included (1) a 24-hour dietary recall; (2) an evaluation of dietary behaviors and suggestions on how to change; (3) height, weight, and blood cholesterol measurement. Five hundred employees participated, and 429 eligible employees completed both pretest and posttest interviews. RESULTS: Blood cholesterol levels decreased by 4.8% (P < .001) and saturated fat intake decreased by 7.4% (P < .05). Regression analyses indicated that individuals more likely to have lowered saturated fat intake had higher pretest saturated fat intakes, had a family history of high blood cholesterol, and were light-maintenance employees (P < .05); no other variables were associated (receiving blood cholesterol test results, previous blood cholesterol test, pretest blood cholesterol levels, personal history of heart disease, BMI, age, gender, tobacco/alcohol use). Among subjects with normal cholesterol levels, those not receiving blood test results reduced saturated fat intake more than those receiving test results; both groups had similar saturated fat intakes (> 12%) greater than recommended intake (< 10%). CONCLUSIONS: Screening programs should include an assessment of saturated fat intake as screening for blood cholesterol may provide normocholesterolemic subjects with a false sense of security.

Adult↗

Evaluation of a peaceful conflict resolution and violence prevention curriculum for sixth-grade students.

PURPOSE: To evaluate a Social Cognitive Theory-based violence prevention curriculum among sixth-grade students. METHODS: The evaluation was conducted using a quasi-experimental pretest-posttest control group design. Students were pretested 2 weeks before the intervention started and were posttested 2 weeks after it ended. The study was conducted in four middle schools serving children and adolescents living in or around public housing in a southeastern city. The participants included all sixth-grade students who were predominantly African-American (88.7%), 41% lived in public housing, and 80% lived in homes with an employed head of household. The intervention schools had 292 students, and the control schools 412 students. The Peaceful Conflict Resolution and Violence Prevention Curriculum is a 13-module skills-building curriculum based on Social Cognitive Theory. It taught identification of situations that could result in violence; avoidance, confrontation, problem-solving, and communication skills; conflict resolution skills; the conflict cycle; the dynamics of a fight; and how to express anger without fighting. MAIN MEASURES: The primary outcome variable was a five-item scale assessing the frequency of fighting and weapon carrying behaviors (alpha =.72) and a scale measuring intentions to use violence in 11 hypothetical situations (alpha = .81). Levels of exposure to violence and victimization (alpha = .82) and depression (alpha = .86) were also assessed. The data were analyzed with general linear modeling with repeated measures. RESULTS: At pretest, the intervention and control groups did not differ in gender, age, depression, exposure to violence, or any other demographic variable. A group x time interaction effect (p = .029) was found in the use of violence scale. From pretest to posttest there was a decrease in the use of violence by students in the intervention group and an increase in the use of violence in the control group. Most of the changes were accounted for by changes in the frequencies of carrying concealed guns and fighting resulting in injuries requiring medical treatment. A group x time interaction effect (p = .002) was also found for the intention to use violence scale. Students in the intervention group did not change their mean scores from pretest to posttest, whereas students in the control group increased in their mean intention to use violence scale scores. Neither interaction effect was influenced by gender, exposure to violence, or level of depression. CONCLUSION: The Peaceful Conflict Resolution and Violence Prevention curriculum appears to have positive short-term effects on self-reported use of violence and intentions to use violence by these middle-school students.

Adolescent↗

Dynamic assessment of school-age children's narrative ability: an experimental investigation of classification accuracy.

UNLABELLED: Two experiments examined reliability and classification accuracy of a narration-based dynamic assessment task. PURPOSE: The first experiment evaluated whether parallel results were obtained from stories created in response to 2 different wordless picture books. If so, the tasks and measures would be appropriate for assessing pretest and posttest change within a dynamic assessment format. The second experiment evaluated the extent to which children with language impairments performed differently than typically developing controls on dynamic assessment of narrative language. METHOD: In the first experiment, 58 1st- and 2nd-grade children told 2 stories about wordless picture books. Stories were rated on macrostructural and microstructural aspects of language form and content, and the ratings were subjected to reliability analyses. In the second experiment, 71 children participated in dynamic assessment. There were 3 phases: a pretest phase, in which children created a story that corresponded to 1 of the wordless picture books from Experiment 1; a teaching phase, in which children attended 2 short mediation sessions that focused on storytelling ability; and a posttest phase, in which children created a story that corresponded to a second wordless picture book from Experiment 1. Analyses compared the pretest and posttest stories that were told by 2 groups of children who received mediated learning (typical and language impaired groups) and a no-treatment control group of typically developing children from Experiment 1. RESULTS: The results of the first experiment indicated that the narrative measures applied to stories about 2 different wordless picture books had good internal consistency. In Experiment 2, typically developing children who received mediated learning demonstrated a greater amount of pretest to posttest change than children in the language impaired and control groups. Classification analysis indicated better specificity and sensitivity values for measures of response to intervention (modifiability) and posttest storytelling than for measures of pretest storytelling. Observation of modifiability was the single best indicator of language impairment. Posttest measures and modifiability together yielded no misclassifications. CONCLUSION: The first experiment supported the use of 2 wordless picture books as stimulus materials for collecting narratives before and after mediation within a dynamic assessment paradigm. The second experiment supported the use of dynamic assessment for accurately identifying language impairments in school-age children.

Abstracting and Indexing↗

Effect of exercise-induced dehydration on lactate parameters during incremental exercise.

Cyclists often use heart rate limits or power output zones, obtained from lactate parameters during incremental exercise testing, to control training intensity. However, the relationship between heart rate or power output, and blood lactate can be changed by several factors including dehydration. Therefore, in the current study we investigated the impact of exercise-induced dehydration on lactate parameters during graded exercise. Nine triathletes completed two test sessions in random order, with a 1-week interval. Each session consisted of 2 graded cycling tests to exhaustion (pretest, posttest), interspersed by a 2-h endurance exercise bout. In one session the cyclists received adequate fluid replacement (EH, 1350 ml . h (-1)) whilst in the other session dehydration was not prevented (DH, 225 ml . h (-1)). Subjects received equal amounts of carbohydrates (150 g) during either condition. The 4-mmol lactate threshold (OBLA) and the d (max) lactate threshold (TH-Dm) were calculated from the power : lactate curves. Weight loss was 0.5 +/- 0.3 kg in EH versus 2.5 +/- 0.2 kg in DH (p < 0.05). Heart rate (HR) at TH-Dm remained unchanged in all test occasions. Conversely, HR at OBLA increased by approximately 10 beats . min (-1) from the pretest to the posttest (p < 0.05), in both EH and DH. Compared to the pretest, in the posttest power output at TH-Dm was reduced (minus approximately 12 %, p < 0.05) in DH, but not in EH. Gross mechanical efficiency at TH-Dm was 20.7 +/- 1 % in the pretest in EH and was not different from the pretest value in DH (21.4 +/- 0.7 %, n.s.). Gross efficiency decreased in the posttest in DH (18.4 +/- 0.6 %, p < 0.05), but not in EH (20.2 +/- 0.8 %, n.s.). It is concluded that heart rate rather than power output should be used to monitor training load in cyclists exercising in environmental conditions predisposing to dehydration. Furthermore, in the latter condition, adequate rehydration is essential to preserve optimal mechanical efficiency.

Adult↗

Carbohydrate supplementation improves stroke performance in tennis.

The effect of carbohydrate supplementation on stroke quality during prolonged simulated tennis match-play was investigated. Well-trained tennis palyers reported to the test center three times. At each occasion they performed a pretest, consisting of the leuven Tennis Performance Test (LTPT) and a shuttle run (SHR), which they repeated (posttest) after a 2-h strenuous training session. Throughout the test session, they received in a double blind random order either a placebo drink (P), a carbohydrate solution (0.7 gxkg(-1) BWxh(-1); CHO), or CHO plus a dose of caffeine (5 mg per kg BW). Stroke quality was evaluated during the LTPT by means of measurements of error rate, ball velocity, precision of ball placement, and a velocity-precision (VP) and a velocity-precision-error (VPE) index. Pretest scores were similar during P and CHO. During P, compared with the pretest, stroke quality during the posttest deteriorated (P < 0.05) both for the first service and strokes during defensive rallies and for SHR performance. However, compared with P, the increase in error rate and number of nonreached balls indefensive rallies was smaller (P < 0.05) during CHO. Similarily, CHO attenuated (P < 0.05) the increase in error rate and the decrease in both the VP (P < 0.1) and VPE (P < 0.05) indices for the first service upon fatigue. Furthermore, CHO improved posttest SHR performance. Stroke quality and SHR time were similar during CHO alone and during combined CHO plus caffeine administration, both for the pretest and for the pretest and for the posttest. It is concluded that CHO supplementation improves stroke quality during the final stages of prolonged tennis play. The data prove that CHO intake may facilitate the maintenance of physical quality during long-lasting intermittent exercise to fatigue.

Adult↗

Does the pediatric advanced life support course improve knowledge of pediatric resuscitation?

OBJECTIVE: To determine whether the pediatric advanced life support (PALS) course contributes to the knowledge required by health care providers for pediatric resuscitation and whether differences in achievement exist between professional groups. METHODS: Physicians, nurses, and paramedics from across Israel who registered for PALS were administered a standardized test both before and on completion of the course. Pretest and posttest results were compared by statistical analysis. A score of 80 or higher was considered a passing grade. RESULTS: Paired pretest and posttest results were available for 370 participants (72.5%): 128 physicians, 158 nurses, and 84 paramedics. The percentage of participants who passed the course was 83.5% for the entire cohort, 85.9% for physicians, 78.5% for nurses, and 89.3% for paramedics. Physicians and paramedics had higher pretest and posttest scores than nurses. There was a significant improvement in mean posttest scores compared with pretest scores for the entire group (86.6 +/- 9.8 vs 78.0 +/- 12.7, P < 0.001) and when results were stratified by profession. A significantly greater proportion of participants passed the posttest than the pretest both for the entire cohort (83.5% vs 61.9%, P < 0.0001) and by profession. CONCLUSIONS: The pediatric advanced life support course significantly increases immediate short-term knowledge of pediatric resuscitation for all professional groups. This finding supports the use of PALS as an educational tool. Further studies are required to determine the effect of PALS on actual performance and outcome of resuscitation.

Allied Health Personnel↗