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Occult infection in the facial area presenting as fever of unknown origin.

Dental infections, otitis media or sinusitis may present as fever of unknown origin (FUO), lacking local symptoms and signs. Physicians are often unaware of this possibility, since current textbooks and major articles do not mention occult facial infections among the causes of FUO. Patients with FUO typically undergo a laborious series of uncomfortable, time-consuming, expensive and often unnecessary investigations in the search for the cause of pyrexia. We report five such patients from a community hospital, representing 14% of cases in a series of patients with FUO. In most of these patients local signs were absent, laboratory investigations were noncontributory, and antibiotic treatment was ineffective. Surgical drainage of pus collections was followed a few days later by defervescence. We suggest that occult infections in the facial area should be considered among the common causes of FUO, and careful dental examination, otoscopy and X-rays of the teeth and sinuses should be included early in the investigation of these patients.

Adult↗

The dental defects of vitamin D-resistant rickets.

Clinical, roentgenographic and morphologic features of teeth from patients with vitamin D-resistant rickets are described based on a study of 28 teeth from 5 patients. Clinically normal teeth become symptomatic and develop roentgenographic evidence of periapical infection. The exposed dentin is vulnerable to microbial invasion because of a defective globular-type calcification as seen in both ground and decalcified sections. The changes are distinctive and pathognomonic, but the effects of therapy (vitamin D) have not yet been ascertained.

Adolescent↗