On the effect of anorectic drugs on striatum homovanillic acid in rats.
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A female drug abuser inadvertently injected an intravenous injection of an oral anorexiant, phentaramine (Preludin), into her own brachial artery. Severe hand pain, vasospasm, and ischemia occurred. Treatment with regional axillary block, intravenous dextran, intra-arterial priscoline, and salicylate anticoagulation may have influenced a favorable outcome. Intimal damage, vasospasm, and various additive effects after intra-arterial injection contribute to the potential for serious sequelae. Prompt diagnosis, vasodilatation, elevation and compression, pain relief and, in some cases, surgery appear to improve salvage of what is frequently a major extremity injury.
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A single dose of alpha-methyl-p-tyrosine induced catalepsy in rats, commencing 6 h after administration. This catalepsy was strongly enhanced by (+)-amphetamine and (-)-ephedrine, but was antagonized by other amphetamine-like drugs. The implication of these findings is briefly discussed.
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