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At least 289 records · Page 16Linked to original sources
PubMed1989

[Experimental study on the cleft lip and palate. VIII. Induction of cleft palate in Wistar rats by vitamin A].

We tried to induce cleft palate in Wistar rats by injecting Vitamin A. We injected Vitamin A into the stomach of females when they were pregnant on the eighth, ninth, tenth and eleventh day. We them sacrificed them to observe the fetuses while they were still pregnant on the eighteenth-twentieth day. The results showed that a high rate of cleft palate could be induced by injecting 5-10 x 10(4) I.U/kg of Vitamin A during pregnancy on the tenth day.

Animals↗
PubMed1988

Roentgenocephalometric study of complete unilateral cleft lip and palate patients treated with delayed closure of the hard palate--a preliminary report.

Cephalometric radiographs of a sample of complete unilateral cleft lip and palate patients (15 males, 15 females, aged 6.5 to 7.5 years) were analysed. In most cases, an adhesion cheiloplasty was done at 3 months of age, followed by definitive cheiloplasty at 6 to 12 months, then by posterior palatoplasty at 1.5 years. The hard palate was not repaired till the age of 5-7 years. This preliminary study indicated that: (1) The growth of maxilla and mandible shows no sex difference, except the anteroposterior maxillary length, which is longer in the cleft males. (2) The maxilla of our group is more retruded than that of normal noncleft children. (3) The mandibular growth is essentially normal except the higher mandibular plane in the cleft females. (4) The intermaxillary relation and skeletal profile of the cleft males are more favourable than in the early closure group.

Cephalometry↗
PubMed1993

Application of hydroxyapatite-coated implants as support for palatal lift prostheses in edentulous patients with cleft palate: a clinical report.

A palatal lift prosthesis (PLP) is a prosthetic speech aid used to compensate for palatopharyngeal incompetence. However, it requires dental abutments to facilitate its function. In two edentulous patients with cleft palate, hydroxyapatite-coated dental implants were used to increase PLP retention. In both cases, palatopharyngeal closure was obtained and PLP function was deemed effective, as determined by speech evaluation and nasal air flow measurements, for more than 3 years. This treatment is useful for enhancing the retention of a PLP in patients who have few or no remaining natural tooth abutments.

Adult↗
PubMedDate not supplied

Facial growth and development in unilateral complete cleft lip and palate from palate surgery up to adulthood.

Mixed longitudinal and cross-sectional roentgen-cephalometric data were used for studies of the growth and development of the face in unilateral complete cleft lip and palate from the time of primary palatoplasty up to adulthood. The results were compared with the data obtained in controls at the age of 5 years and in adults. The vertical growth of the upper and lower face exceeded its sagittal growth. The lower face showed a higher growth rate in both directions than did the upper face. The depth of the maxilla showed the lowest growth rate. The height of the upper lip increased very little as well. The most important deviation in facial development consisted of the deficient growth of maxillary depth and the prolongation of the lower face. Both these deviations develop predominantly after palate surgery and the former resulted in a gradual retrusion of the maxilla, a flattening of the face, and impairment of sagittal jaw relations. The reduction of upper face height, the posterior position of the maxilla, and the shortening of the mandible (both of the body and ramus) represented, on the contrary, early changes. The a persisting posterior rotation of the mandible, changes in the shape of the mandible, and vertical disproportion of the face increased with age, the steep slope of the mandibular body remaining at the level ascertained in early childhood. An improvement in the occlusion of incisors was obtained prior to the age of 12 years, but it regressed during the period of puberty. The prominence of the upper lip gradually decreased and the lip was short.

Adolescent↗
PubMed1995

The relation of isolated cleft of the hard palate to submucous cleft palate.

The authors report a case of a spontaneous development of a fistula in a nonoperated submucous cleft palate in a male aged 40 years. This observation and the search of the underlying causes are based on their report from 1971 dealing with an analysis of 5 cases of an inborn defect in the hard palate.

Adult↗
PubMed1998

The healing process of palatal tissues after palatal surgery with and without implantation of membranes: an experimental study in dogs.

The aim of this study was to evaluate the wound-healing process clinically and histologically in growing beagle dogs after palatal repair according to von Langenbeck, with and without implantation of membranes of a copolymer of polyhydroxybutyrate 80%-hydroxyvalerate 20% (=PHB-co-HV 80/20). Von Langenbeck's repair was performed in 12 dogs (age 12 wk), while von Langenbeck's repair followed by implantation of PHV-co-HV membranes was carried out in 11 dogs (age 12 wk). Four dogs (age 12 wk) served as unoperated controls. Standardized intra-oral slides of the palate were taken and measurements of the wound surface areas were carried out. Histological sections were prepared at three different ages. The animals were studied until the age of 25 wk. It was found that wound closure after the von Langenbeck's procedure took about 3 wk, while the use of PHB-co-HV membranes after von Langenbeck's repair resulted in complete wound closure after approximately 7 wk after the membranes had sequestered. At the age of 25 wk, the histologic results after the von Langenbeck procedure showed that the entire scar tissue covering the former denuded bony areas was attached to the bone by means of Sharpey's fibres, while after implantation of the membranes only local scar tissue attachment by means of Sharpey's fibres was found. Further research is necessary to develop a membrane which allows wound closure without sequestration of it.

Journal Article↗
PubMed1997

Retrospective survey of resin-retained cast-metal palatal veneers for the treatment of anterior palatal tooth wear.

Anterior palatal tooth wear is easily recognized, but its precise pathogenesis remains unknown. Treatment of this condition with cast-alloy palatal veneers used in combination with an adhesive cement is described. Forty-eight patients, aged 11 to 71, were treated with a total of 210 cast metal veneers over a period of 56 months. Twenty-three of the restorations failed, resulting in an overall success rate of 89%. All failures were confined to 13 patients. A glass polyalkenoate cement was less effective than a chemically active resin composite luting agent. Nickel-chromium veneers cemented with activated resin composite recorded a survival probability of 0.74 at 56 months. Adhesive cast-alloy veneers provided a useful method of restoring maxillary anterior teeth affected by acid erosion.

Acrylic Resins↗
PubMed1999

Palatal tremor, progressive multiple cranial nerve palsies, and cerebellar ataxia: a case report and review of literature of palatal tremors in neurodegenerative disease.

We describe a patient with an unusual clinical presentation of progressive multiple cranial nerve palsies, cerebellar ataxia, and palatal tremor (PT) resulting from an unknown etiology. Magnetic resonance imaging showed evidence of hypertrophy of the inferior olivary nuclei, brain stem atrophy, and marked cerebellar atrophy. This combination of progressive multiple cranial nerve palsies, cerebellar ataxia, and PT has never been reported in the literature. We have also reviewed the literature of PT secondary to neurodegenerative causes. In a total of 23 patients, the common causes are sporadic olivopontocerebellar atrophy (OPCA; 22%), Alexander's disease (22%), unknown etiology (43.4%), and occasionally progressive supranuclear palsy (4.3%) and spinocerebellar degeneration (4.3%). Most patients present with progressive cerebellar ataxia and approximately two thirds of them have rhythmic tremors elsewhere. Ear clicks are observed in 13% and evidence of hypertrophy of the inferior olivary nucleus in 25% of the patients. The common neurodegenerative causes of PT are OPCA/multiple system atrophy, Alexander's disease, and, in most of them, the result of an unknown cause.

Adult↗
PubMedDate not supplied

A new method for strengthening palatal closure defects of the hard palate.

Closure of minor defects in the hard palate can be done with local flaps. There is often a risk of perforation of the reconstructed area. In the case reported this complication was obvious due to a large, thin, flap-covered area. In strengthening the reconstruction fascia lata and Surgicel was used. The postoperative result was excellent and the rehabilitation of the patient was without complications.

Carcinoma, Squamous Cell↗
PubMed1975

Development of the palatal arch in relation to unilateral cleft lip and palate surgery: a comparison of the effects of different surgical approaches.

Our cases are too small in number to conclude which kind of surgical method retards the maxilla development. But we can say that a maldevelopment of the maxilla may be expected to occur in the case of any surgery performed. In the cleft lip only patients, Millard's method and our method show a better effect than the other methods from the point of view of the retardation of the mid-third of the face. In the group of unilateral cleft lip and palate patients our method may be the best on this point. At the end, we would like to present our typical cases with figures (Figures 4 and 5).

Child↗
PubMed1984

[Postnatal development of the width and height of the palate and the palate foramina].

During the postnatal development the anterior width of the palatum durum increases between the 2nd and 5th year more than the posterior palatal width. Also increases the height of the palatum durum and large during the 2nd dentition as to the distance of the foramen palatinum majus from the dens caninus . The size of the foramina palatina enlarges inconstantly during postnatal growth. In children there are 2.37, in adult 2.42 (mean) foramina palatina minora on the right side. Side differences are not significant.

Adolescent↗
PubMed1980

Palate morphogenesis. I. Immunological and ultrastructural analyses of mouse palate.

Midpalate was analyzed for the presence of nonmuscle contractile systems. The results indicate that increased amounts of actin and myosin are present in cells of regions 2 and 3. A localization of the contractile proteins in cellular projections (filopodia) and in the peripheral cytoplasm of the cell body was confirmed by indirect immunofluorescence studies, using antibodies directed against smooth muscle myosin and against skeletal muscle actin. Specificity of the immunofluorescence reactions was ascertained by immunoabsorption studies using purified myosin and actin. Electron microscopic observations of the mesenchymal cells in region 2 revealed 70A microfilaments along the cell periphery and packed in fliopodia-like projections which course between the cells. These cells, which surround a small ossification center, show no orientation, but extend up to the cranial base perichondrium and down into the shelf between the tongue side epithelium and the ossification center. The cells and projections are attached to each other by adherens and tight-like junctions, forming a putative cohesive contractile network. Putative contractile cells in region 3 are strikingly aligned perpendicular to the oral epithelium and extend one-third of the distance into the shelf. Projections from region 3 cells are contiguous with basement membrane material of the oral epithelium. Axonal bundles and single axons were commonly observed coursing through regions 2 and 3, often seen in close association with the mesenchymal cells. Both clear and dense-core vesicles were found in the axons and cells of these regions. The possible role of these putative nonmuscle contractile cells in palate morphogenesis is discussed.

Actins↗
PubMed2003

Transversal palatal expansion using a palatal distractor.

METHOD AND RESULTS: The method and first results of transversal expansion with a palatal distractor in adolescents and adults with transverse maxillary deficiencies are presented. In ten patients with a mean age of 25.8 years, a newly developed distractor was applied for bone-borne expansion of the two halves of the maxilla following osteotomy of the lateral walls of the maxillary sinuses and the midpalatal suture. After a 3-week distraction period, mean changes of 8.8 mm in intercanine distance (ICD), 8.6 mm in anterior dental arch width (ADA), and 8.3 mm in posterior dental arch width (PDA) were registered. 6 months after the subsequent multibracket appliance therapy, these values were found to be largely constant. CONCLUSION: Because of the short treatment period, the absence of relapses, and the handling simplicity for the patient, this method is recommended for clinical application.

Adolescent↗
PubMed2005

Chlorhexidine in cleft lip and palate patients with multibracket appliances. Results of a prospective study on the effectiveness of two different chlorhexidine preparations in cleft lip and palate patients with multibracket appliances.

AIM: The aim of this study is to reduce the caries risk in cleft lip and palate (CLP) patients with multibracket appliances via a compliance-independent method. PATIENTS, MATERIALS AND METHODS: Sixty-eight CLP patients with multibracket appliances were submitted to professional tooth cleaning at 4-week intervals. After randomization, patients in group A wore a splint filled with chlorhexidine (CHX) gel (Chlorhexamed) for 15 minutes (3 x 5 min) every 12 weeks. Patients in group B were treated with CHX varnish (EC40) every 12 weeks. Fluoride varnish (Fluoridin) was applied to all teeth 4 and 8 weeks after the respective CHX treatments. Regular salivary bacteria counts (CRT) were carried out to determine therapeutic effectiveness. Initial DMFS values were compared to the final ones. RESULTS: Initial findings of the salivary test and DMFS index confirmed the high caries risk. The DMFS value increased dramatically in both groups despite this systematic prophylaxis program. The bactericidal effect of both CHX preparations turned out to be markedly weaker than that described in the literature. CONCLUSIONS: Though the CHX and fluoride application had a limited effect (at least in this test population), one should keep in mind that it is precisely this population that requires very intensive prophylaxis, and that no antibacterial adjuvant is more effective than CHX. However, the application interval should be individually adapted to the bacteria count.

Adolescent↗
PubMed1992

Facial balance in cleft lip and palate. II. Cleft lip and palate and secondary deformities.

The cleft abnormality is the cause of underdevelopment and subsequent loss of function. Primary cleft surgery and surgery to correct the secondary deformities of previous non-functional repair should aim to restore normal anatomy and physiology, with an emphasis on muscle reconstruction of the lip and soft palate if normal facial development is to be encouraged.

Cleft Lip↗