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Cross-validation of the discriminative effectiveness of the Luria-Nebraska Neuropsychological Battery for learning disabled adolescents.

This study was a cross-validation of the discriminative effectiveness and diagnostic accuracy of the Luria-Nebraska Neuropsychological Battery (LNNB). Subjects were a group of 31 LD adolescents and a matched group of 31 non-learning disabled students whose achievement fell within the low average to average range. Multivariate analysis of variance (MANOVA) confirmed that the LNNB was sensitive to group differences in analyses with either the basic or localization scales. Discriminant function analyses with 12 basic scales yielded overall rates of diagnostic accuracy ranging from 87.1% to 98.4%. A classification rule, based on the number of basic scale elevations, yielded 95% overall accuracy. Rates of overall accuracy for the eight localization scales ranged from 82.26% to 85.48% in discriminant function analyses. A classification rule, basedon the number of localization scale elevations, yielded 81% overall accuracy. The significance and accuracy of various indicators of dysfunction were investigated. Implications for the diagnosis of learning disability are discussed

Journal Article↗

Performance of normal adults on the Luria-Nebraska Neuropsychological Battery, form I.

To examine three problems in the interpretation of the Luria-Nebraska Neuropsychological Battery (LNNB), the normal participants from four different studies were pooled to form a sample of 241 LNNB profiles. The first problem addressed was the LNNB's false positive rate. All five yes/no decision rules were applied simultaneously. Each individual rule had a 0% to 8% false positive rate: combining the rules in four different ways increased the false positive rate by 0% to 6%. When divided into over and under 65 years old groups, each rule applied to the younger group had a 0% to 5% false positive rate: combining them increased the rate to 6-8%. When applying the rules to the older group, each rule had a 0 to 27% false positive rate: combining all rules but the one with the highest error rate produced a false positive rate of 27%. The false positive rate for the entire sample was 12%. To solve the second problem of interpretation, making qualitative item analyses easier, the difficulty level (i.e., percentage of normals missing the item) for each item was calculated. The third problem was the LNNB's malingering formula's accuracy. The formula was applied to the sample: as expected, the normal profiles had an inaccuracy rate of 26%. The few mildly impaired profiles had a 6% inaccuracy rate. When applied to the entire sample of normals and using the appropriate interpretive guidelines, the formula had a false positive rate of 1%.

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Revised norms and decision rules for the Luria-Nebraska Neuropsychological Battery, Form II.

All control subjects from a previous Luria-Nebraska Neuropsychological Battery, Form II (LNNB2) normative study were combined with a considerably larger normative sample to produce a composite normative sample of 392 subjects with a mean high school educational level. Revised norms for the LNNB2 were developed based on this sample and were scaled with uniform T-scores to make scale elevations comparable across LNNB2 measures. Differences between the scalewise LNNB2 normative values and published alternatives were highly significant. A critical level and actuarial decision rules for differentiation of normal from neurologically impaired performance level were developed for the LNNB2 using the current empirical norms (86% accuracy with current sample empirical critical level; 89% accuracy with LNNB1 critical level). The normative prediction values of Golden, Purisch, and Hammeke for the LNNB2 were not satisfactory (69% overall, with 45% accuracy among brain damaged sample). There was no significant effect of sex of subject on LNNB2 performance level among the control subjects.

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Concurrent validity of the Luria-Nebraska Memory Scale.

Investigated the concurrent validity of the Luria-Nebraska Neuropsychological Battery (LNNB) Memory Scale using the Wechsler Memory Scale (WMS) as the criterion. For 32 psychiatric patients, the LNNB Memory Scale yielded a significant correlation with the WMS MQ, r (30) = -.65, p less than .001. Moreover, there was a 72% agreement between the two scales with respect to the identification of memory impairment. Memory-impaired Ss earned a significantly higher (p less than .01) mean T-score on the LNNB Memory Scale than did Ss without memory problems. It was concluded that the LNNB Memory Scale is an adequate measure of short-term memory.

Adult↗

Complement fixation test of Nebraska calf diarrhea virus with calf serum.

A complement fixation (CF) test for neonatal calf diarrhea has been developed with Nebraska calf diarrhea virus (NCDV) as antigen. The CF antigenicity of NCDV appeared in BK cell cultures for the first time 3 days after inoculation. Usually, the unconcentrated BK cell culture fluid infected with NCDV possessed poor CF antigenicity. The fluid concentrated by ultracentrifugation and ultrafiltration and with polyethylene glycol 6000 revealed a high-titered CF antigenicity to antiserum against NCDV. The antigen was not sensitive to lipid solvents, but was relatively resistant to heating. It was recognized that the concentrated fluid of cell culture infected with NCDV was available as antigen in the CF test for the serological demonstration of infection with a calf reovirus-like agent. The wide prevalence of diarrhea among Japanese calves with the calf reovirus-like agent was revealed from the results of CF and neutralization tests of NCDV.

Animals↗