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PubMed2005

The birth of the empirical turn in bioethics.

Since its origin, bioethics has attracted the collaboration of few social scientists, and social scientific methods of gathering empirical data have remained unfamiliar to ethicists. Recently, however, the clouded relations between the empirical and normative perspectives on bioethics appear to be changing. Three reasons explain why there was no easy and consistent input of empirical evidence in bioethics. Firstly, interdisciplinary dialogue runs the risk of communication problems and divergent objectives. Secondly, the social sciences were absent partners since the beginning of bioethics. Thirdly, the meta-ethical distinction between 'is' and 'ought' created a 'natural' border between the disciplines. Now, bioethics tends to accommodate more empirical research. Three hypotheses explain this emergence. Firstly, dissatisfaction with a foundationalist interpretation of applied ethics created a stimulus to incorporate empirical research in bioethics. Secondly, clinical ethicists became engaged in empirical research due to their strong integration in the medical setting. Thirdly, the rise of the evidence-based paradigm had an influence on the practice of bioethics. However, a problematic relationship cannot simply and easily evolve into a perfect interaction. A new and positive climate for empirical approaches has arisen, but the original difficulties have not disappeared.

Bioethics↗
PubMed2004

Théodule Ribot's ambiguous positivism: philosophical and epistemological strategies in the founding of French scientific psychology.

Théodule Ribot (1839-1916) is regarded by many historians of psychology as the "father" of the discipline in France. Ribot contributed to the development of a "new psychology" independent from philosophy, relying on the methods of the natural sciences. However, such an epistemological transition encountered fierce opposition from both the champions of the old-fashioned metaphysical psychology and the representatives of the "scientific spirit." This article focuses on the objections raised by the latter, and especially philosophers of science, against the possibility of a scientific psychology. For instance, according to Auguste Comte, psychology does not satisfy certain basic methodological requirements. To overcome these objections, Ribot, in his La Psychologie Anglaise Contemporaine (1870/1914), devised an epistemological strategy that amounted to invoking criticisms of Comte's views made by other representatives of the positivist school, such as John Stuart Mill and Herbert Spencer.

France↗
PubMed2006

Gene-environment interactions in psychiatry: joining forces with neuroscience.

Gene-environment interaction research in psychiatry is new, and is a natural ally of neuroscience. Mental disorders have known environmental causes, but there is heterogeneity in the response to each causal factor, which gene-environment findings attribute to genetic differences at the DNA sequence level. Such findings come from epidemiology, an ideal branch of science for showing that a gene-environment interactions exist in nature and affect a significant fraction of disease cases. The complementary discipline of epidemiology, experimental neuroscience, fuels gene-environment hypotheses and investigates underlying neural mechanisms. This article discusses opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene-environment interactions.

Animals↗
PubMed1986

In-vitro fertilization: the ethics.

This paper is addressed to practitioners. It seeks to acquaint them with 'ethical' arguments against their work which, because they are simple and plausible, persuade many people. These arguments are briefly rehearsed and as briefly examined. A more positive ethics of in-vitro fertilization is presented which seeks to respect (a) what is known in the relevant science and done in developing practice; (b) the inseparability of research from clinical application; (c) a moral tradition of long-standing which relates the protection of fetal life pari passu with its own morphological growth towards maturity; (d) the moral sense of properly informed persons whose judgements we trust in other areas of life. Practitioners themselves are to be defended as the proper moral agents (that is, to be entrusted with decisions) provided that they are careful (a) to keep public confidence by means of a corporate self-discipline; (b) to keep faith with patients and research subjects; (c) to maintain mutual trust between research scientists and clinical practitioners; (d) to safeguard the liberty of disciplined enquiry, of purposeful curiosity, as being inherent in the notion of a science, necessary to therapeutic advance, and proper to the nature of man. The author writes from within the theological tradition of the Church of England.

Abortion, Legal↗
PubMed1992

[A functional explanation of normative prescriptive-evaluative judgments and the concept of "evolutionary ethics"].

Neodarwinian ethology, today above all represented by sociobiology, is conceived of by responsible exponents as a descriptive and explanatory theory that cannot include any normative declarations. Still other, indeed notable, authors belonging to the discipline in question, either underhand or frankly employ prescriptive or evaluative judgments, or they claim (what is not an insight of natural science) that it is impossible to provide a rational foundation for prescriptive or evaluative judgments. (Michael Ruse and Edward O. Wilson even assert the latter without relinquishing the former.) Several functional explanations of normative validity claims advanced by Michael Ruse, Edward O. Wilson, Donald T. Campbell, Florian von Schilcher and Neil Tennant are designed to show that prescriptive or evaluative judgments cannot be justified. The reasonableness of this move is, however, dubious, because it implies strategies of raising oneself into a privileged status or of rendering the position of oneself immune from criticism by shifting it among the objects of the theory. Then Wilson's concept of 'evolutionary ethics' is thoroughly--and critically--analyzed. The suspicion that Wilson's fallacies in the transition from biological facts to moral norms are of exemplary nature is finally examined on the basis of tenets advanced by Herbert Spencer, Wolfgang Wickler, and Hans Mohr.

Bioethics↗
PubMed1996

[Does medical education fulfill the requirements of physicians?].

Contemporary medical education is determined by an increasing proliferation and disintegration of disciplines within medical schools. This development runs against an emerging scientific understanding of the integrated nature of living systems, initiated by the recent developments in physics. Undergraduate medical education aimed to meet the demands of our society will have to be based on modern systemic science and today's priority health problems and not on academically established disciplines.

Clinical Competence↗
PubMed2000

Psychology and the science of human-environment interactions.

Psychology has an indispensable role in understanding environmental problems and finding solutions. To fill this role, psychologists must work within an interdisciplinary effort to build a scientific understanding of human-environment interactions. This article enumerates 8 widely held beliefs about these interactions and assesses the strengths and limitations of each belief. It suggests that psychology can contribute more strongly by counteracting disciplinary biases, focusing research where a behavioral analysis identifies major opportunities, making appropriately modest claims, collaborating with other disciplines, and building on psychology's relative strengths among the human sciences.

Conservation of Natural Resources↗
PubMed2005

Personal reflections on receiving the Roger Adams Award in organic chemistry.

The author reflects on his early experiences as a chemist, and on the subsequent shift in emphasis that his research has undergone from mechanistic and synthetic organic chemistry to natural products chemistry. Finally, the extension of the field of natural products chemistry into the emerging discipline of chemical ecology is noted. This essay concludes with a consideration of the importance of including science in the curricula of all college and university students.

Animals↗
PubMed2003

Reaction mechanisms and chemical explanation.

The methodological and ontological issues arising in the organic chemists' explanation of transformations of matter by means of reaction mechanisms are presented based on the general view that chemistry is at the same time an autonomous discipline with its own paradigm and an integral part of the unitary body of science. Among the issues relevant to research is the nature and actual observability of activated complexes, which have by definition a vanishing lifetime. That issue illustrates the interplay of molecular chemistry and quantum physics at the submicroscopic level of sensible reality. A moral concerning the planning and strategy of research is briefly outlined.

Journal Article↗
PubMed2004

A new biology for a new century.

Biology today is at a crossroads. The molecular paradigm, which so successfully guided the discipline throughout most of the 20th century, is no longer a reliable guide. Its vision of biology now realized, the molecular paradigm has run its course. Biology, therefore, has a choice to make, between the comfortable path of continuing to follow molecular biology's lead or the more invigorating one of seeking a new and inspiring vision of the living world, one that addresses the major problems in biology that 20th century biology, molecular biology, could not handle and, so, avoided. The former course, though highly productive, is certain to turn biology into an engineering discipline. The latter holds the promise of making biology an even more fundamental science, one that, along with physics, probes and defines the nature of reality. This is a choice between a biology that solely does society's bidding and a biology that is society's teacher.

Biology↗
PubMed2001

Skeletal remains of Dr. Eugenio Antonio Berríos Sagredo.

It is often noted that even a well-designed osteological technique may not provide accurate results when applied to single forensic cases. Case studies are ideal to test if this concern is valid, and forensic anthropology is a testing ground for applying a population based standard to individual skeletal remains. Secondly, the increasing role anthropologists have played in forensic sciences has aided the medicolegal disciplines in a number of ways. For example, identification of skeletal remains is now more accurate than ever before. Many of these cases have brought perpetrators to court for justice. The purpose of this paper is to use osteological techniques to analyze skeletal remains and make a positive identification. The victim was found partially buried in the sand near El Pinar, Uruguay in 1995. The analysis indicated that the victim was a 45-year old, white, male who was about 170cm tall. Based on preliminary evidence that the victim might be Dr. Eugenio Antonio Berríos Sagredo, a digital superimposition was made using the victim's photograph and the unknown skull. This examination revealed that the skull corresponded consistently with the individual in the photograph. Results were supported by the fact that personal belongings, such as a medal and wrist watch, also pointed to the same individual. Dental records and radiographs when made available later also indicated the same identity. Dr. Berríos was accused of making nerve gas during the dictatorial regime of former Chilean President General Augusto Pinochet. It was also alleged that he made bombs that killed a Spanish diplomat in his laboratory and a Chilean diplomat in Washington, DC. Many complex techniques are often needed to make a positive identification and such was the case for this study. Because of the nature of anthropology as a holistic discipline, such complexity is an integral part of human biology and behavior and can be used successfully in the forensic sciences and medicolegal investigations.

Cause of Death↗
PubMed1995

The eighteenth-century scientific community: a prosopographical study.

The object of this note is to provide a prosopographical analysis of the eighteenth-century scientific community with a view to explaining the gradual breakdown over the course of that century of the traditional general categories of 'natural philosophy' and 'natural history', and their replacement by a wide range of separate scientific disciplines.

History, 18th Century↗
PubMed2000

Accelerator mass spectrometry analyses of environmental radionuclides: sensitivity, precision and standardisation

Accelerator Mass Spectrometry (AMS) is the analytical technique of choice for the detection of long-lived radionuclides which cannot be practically analysed with decay counting or conventional mass spectrometry. AMS allows an isotopic sensitivity as low as one part in 10(15) for 14C (5.73 ka), 10Be (1.6 Ma), 26Al (720 ka), 36Cl (301 ka), 41Ca (104 ka), 129I (16 Ma) and other long-lived radionuclides occurring in nature at ultra-trace levels. These radionuclides can be used as tracers and chronometers in many disciplines: geology, archaeology, astrophysics, biomedicine and materials science. Low-level decay counting techniques have been developed in the last 40-50 years to detect the concentration of cosmogenic, radiogenic and anthropogenic radionuclides in a variety of specimens. Radioactivity measurements for long-lived radionuclides are made difficult by low counting rates and in some cases the need for complicated radiochemistry procedures and efficient detectors of soft beta-particles and low energy x-rays. The sensitivity of AMS is unaffected by the half-life of the isotope being measured, since the atoms not the radiations that result from their decay, are counted directly. Hence, the efficiency of AMS in the detection of long-lived radionuclides is 10(6)-10(9) times higher than decay counting and the size of the sample required for analysis is reduced accordingly. For example, 14C is being analysed in samples containing as little as 20 microg carbon. There is also a world-wide effort to use AMS for the analysis of rare nuclides of heavy mass, such as actinides, with important applications in safeguards and nuclear waste disposal. Finally, AMS microprobes are being developed for the in-situ analysis of stable isotopes in geological samples, semiconductors and other materials. Unfortunately, the use of AMS is limited by the expensive accelerator technology required, but there are several attempts to develop compact AMS spectrometers at low (< or = 0.5 MV) terminal voltages. Recent advances in AMS will be reviewed with highlights from the scientific programs at Lucas Heights and other AMS centres.

Journal Article↗
PubMed1998

Caring and cancer nursing: framing the reality using selected social science theory.

Despite the recent interest in caring for both academic and clinical nursing, the theoretical basis of this concept may appear somewhat elusive as the research and debate vary widely in their focus. As a result, the available literature may fail to consider the specific contextual issues which characterize caring as it is understood across different health care settings. Consideration of theory from disciplines close to nursing, it is suggested, may be useful in understanding the nature of such 'real world' caring. In this discussion the concept of caring within cancer nursing is explored by drawing on a number of social science and nursing sources. It is known that cancer provokes unique caring demands for nurses practising in this area. By examining the context of cancer, it is argued that effective caring deserves to be recognized as an important clinical variable which can influence a diverse range of issues such as patient satisfaction or therapeutic outcome. It is suggested that other nursing specialisms should also explore the psychosocial dimensions of caring in relation to their own role.

Empathy↗
PubMed1985

The nature of explanation in qualitative evaluation.

In recent years evaluation has mushroomed dramatically as a discipline. A number of evaluation "models" or approaches have been conceived, and varieties of social science methods have been employed serving several evaluative purposes. Missing from the health profession's literature on evaluation is a discussion of the underlying explanatory purposes of evaluative inquiry. It can be argued that systematic accounts of a logical inquiry (evaluation) are inextricably bound to particular views or accounts of the logic of explanation. In this article those accounts of explanation that pertain to conventional and qualitative evaluation are reviewed and compared. The article describes what one has "bought off on" when applying the explanatory rationale underlying qualitative evaluation approaches. Problems and possibilities are described for the practice of qualitative evaluation in the health professions.

Evaluation Studies as Topic↗
PubMed1984

A reorientation of clinical psychology? Look before you leap.

A recent proposal by Fox (1982) has suggested that the field of clinical psychology needs to undergo a reorientation away from psychopathology to the totality of human problems. This is viewed as a natural extension of the evolution of clinical psychology and is justified by the position that "Psychology is the only discipline that has both a comprehensive science of human behavior and an established professional arm" (Fox, 1982, p. 1052). Evidence is cited that suggests that many of the roles which Fox sees as appropriate for doctoral-level clinical psychologists can and are being performed adequately by master's-level professional social workers. The proposed reorientation of clinical psychology would be neither cost effective of educational resources nor feasible in terms of training adequate numbers of psychological service providers. This proposal by Fox further reflects a lack of awareness of the empirically based service tradition of many professional social workers (Thyer, 1981).

Forecasting↗
PubMed1992

Challenges to understanding spatial patterns of disease: philosophical alternatives to logical positivism.

Most studies of disease distribution, in medical geography and other related disciplines, have been empirical in nature and rooted in the assumptions of logical positivism. However, some of the more newly articulated philosophies of the social sciences, and of social theory, have much to add in the understanding of the processes and mechanisms underlying disease distribution. This paper represents a plea for creative synthesis between logical positivism and realism or structuration, and uses specific examples to suggest how disease distribution, as a surface phenomenon, can be explained using deeper analysis.

Cross-Cultural Comparison↗