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At least 289 records · Page 16Linked to original sources
PubMed1996

International medical graduates in rural America: the 1987 distribution of physicians who entered the U.S. medical system between 1969 and 1982.

This study examines the differential location on Dec. 31, 1987, in nonmetropolitan U.S. counties of a cohort of international medical graduates (IMGs) (n = 246,754) certified by the Educational Commission for Foreign Medical Graduates between 1969 and 1982, and a matched group of U.S. medical graduates (USMGs). Analysis of counties grouped into categories of population size revealed disparities across certain U.S. census divisions. IMGs were distributed disproportionately in the West North Central and East South Central census divisions. The implications of the IMG presence in numerous rural counties is discussed from the perspective of recent policy proposals to reduce the number of IMGs in the United States.

Chi-Square Distribution↗
PubMed2006

Tryptophan metabolism in the central nervous system: medical implications.

The metabolism of the amino acid L-tryptophan is a highly regulated physiological process leading to the generation of several neuroactive compounds within the central nervous system. These include the aminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT), products of the kynurenine pathway of tryptophan metabolism (including 3-hydroxykynurenine, 3-hydroxyanthranilic acid, quinolinic acid and kynurenic acid), the neurohormone melatonin, several neuroactive kynuramine metabolites of melatonin, and the trace amine tryptamine. The integral role of central serotonergic systems in the modulation of physiology and behaviour has been well documented since the first description of serotonergic neurons in the brain some 40 years ago. However, while the significance of the peripheral kynurenine pathway of tryptophan metabolism has also been recognised for several decades, it has only recently been appreciated that the synthesis of kynurenines within the central nervous system has important consequences for physiology and behaviour. Altered kynurenine metabolism has been implicated in the pathophysiology of conditions such as acquired immunodeficiency syndrome (AIDS)-related dementia, Huntington's disease and Alzheimer's disease. In this review we discuss the molecular mechanisms involved in regulating the metabolism of tryptophan and consider the medical implications associated with dysregulation of both serotonergic and kynurenine pathways of tryptophan metabolism.

Animals↗
PubMed1990

[Helicopter emergency medical system in the Basel region].

Between 1986 and 1988, 999 patients were treated on the emergency scene, then transported with the rescue-helicopter in the Basle area. 687 were victims of a trauma (70.5%) and 287 patients were suffering from an acute internal medicine disease. We performed in-field therapy on the accident scene itself in 53.9% of all the cases. According to our scoring system the presence of a physician was absolutely necessary in 56% of all the cases. Air rescue by helicopter allows fast transportation of patients and immediate high quality intensive care. The low mortality rate during treatment before transport (2.6%) and during the transport itself (0.3%) shows that early beginning of medical treatment on the accident scene is connected to better survival chances.

Accidents, Traffic↗