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IMMUNOASSAY FOR HUMAN CHORIONIC "GROWTH HORMONE-PROLACTIN" IN SERUM AND URINE.

Chorionic "growth hormone-prolactin" in serum and urine from pregnant women, in serum from umbilical cord, and in amniotic fluid was assayed by a sensitive immunological method dependent on the combination of rabbit antiserum to the growth hormone-prolactin with the iodine-131-labeled hormone. The hormone is detectable in serum and urine early in gestation, and with advancing pregnancy its concentration in serum continues to increase to a maximum during the last trimester. It was not found in serum within 8 hours after delivery.

Amniotic Fluid↗

Management of hypernatremic dehydration due to insufficient lactation.

Critical malnutrition and hypernatremic dehydration resulting from inadequate breast-feeding have previously been reported; the finding of elevated sodium concentration in expressed samples of mother's milk from these infants is found concurrently. This is the first case report describing successful relactation following management of hypernatremic dehydration in a breast-fed infant. Mother's milk was of inadequate volume and had a high sodium content. Treatment of the primary cause of this disorder, insufficient lactation, was effective in allowing successful relactation; a nursing supplementer is described.

Adult↗

Lactate vulnerability after alprazolam versus placebo treatment of panic disorder.

Thirty-six patients with panic disorder underwent sodium lactate infusion before and after 8 weeks of treatment with alprazolam or placebo. With reinfusion, those patients panic-free with chronic alprazolam treatment displayed significantly decreased reactivity to lactate, as measured by subjective symptom ratings, duration of infusion before developing peak lactate-induced symptoms, and the proportion of patients experiencing lactate-induced anxiety or panic. Patients panic-free on placebo, as well as nonresponders to alprazolam treatment, displayed some, although less striking, decreases in reactivity to lactate with reinfusion. As a group, patients clinically unchanged with placebo treatment showed no systematic change in lactate response with reinfusion. Although the small numbers of patients in each treatment outcome group prohibit drawing definitive conclusions, these findings suggest that decreases in lactate-induced panic after successful alprazolam treatment of panic may result from a combination of changes in clinical state and direct effects of the medication.

Adult↗