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Rupture of the gravid uterus.

A detailed analysis of 129 cases of rupture of the gravid uterus between 1980 and 1983 is presented and compared with two previous reports from King Edward VIII Hospital, Durban, over the last 2 decades. Statistically significant decrease in the occurrence of this condition (from 2,7 to 1,06/1000 deliveries (P less than 0,001; chi 2 = 20,38)) and in the maternal mortality rate (from 12% to 3%) have taken place since the initial study. The most probable reasons for this improvement are the provision of a community-based obstetric service, the early detection of cephalopelvic disproportion, awareness of the condition, immediate and adequate resuscitation once the diagnosis is established, and the performance of a total abdominal hysterectomy as definitive treatment in most cases.

Adult↗

Sequential analysis of spontaneous abortion. II. Collaborative study data show that gravidity determines a very substantial rise in risk.

Evidence from more than 14,000 reproductive histories in the Collaborative Perinatal Project of the National Institute of Neurological and Communicative Disorders and Stroke indicates that the risk of spontaneous abortion increases considerably with gravidity. Maternal age, memory errors, and sampling bias related to recurrence risk do not account for the trend. Clustering, or tendency for abortions to follow one another, occurs in histories which include live births.

Abortion, Spontaneous↗

Current concepts of management of rupture of the gravid uterus.

Fifteen cases are reported of spontaneous rupture of the gravid uterus occurring at the Naval Regional Medical Center (NRMC), Portsmouth, Virginia, over a 21-year period. Forty-seven percent of the patients had previously undergone a cesarean section. Thirteen percent of the patients had received oxytocin prior to the rupture. Fetal mortality associated with these ruptures was 13%. No maternal deaths occurred. Forty percent of the patients had repair of the defect, with 60% undergoing some type of hysterectomy. Preventive measures, early diagnosis, and prompt treatment are emphasized.

Adult↗

Studies on the integument of cestodes. II. The nature of protein component in the integument of gravid proglottides of Taenia hydatigena.

The main cuticle of the gravid proglottides shows differences in their chemical make up, in that there is a transformation of SH groups into -S-S bonding resulting in the refractivity of the cuticle. Another feature is the coexistence of dityrosine linkages with -S-S bondings. The mode of dityrosine formation from tyrosine residues is found to be possible by the presence of a peroxidase enzyme system in the cuticle. The evolutionary and physiological significance of the occurrence of -S-S bonding and dityrosine links have been discussed.

Animals↗

Glucocorticoid therapy for the induction of pulmonary maturity in severely hypertensive gravid women.

Twenty hypertensive gravid women who had their pregnancies terminated for maternal indications because of the severity of pre-eclampsia or chronic hypertension were studied. They were treated at 27 to 33 weeks of gestation with 48 hours of betamethasone therapy prior to delivery. There was one antepartum fetal death, and it is believed that this death was preventable. There was an incidence of respiratory distress syndrome (RDS) of 23% with two neonatal deaths secondary to RDS, for a treated neonatal survival of 85.7%. All losses were from mothers with pre-eclampsia. Pregnancy-related hypertension is not thought to be an absolute contraindication to glucocorticoid therapy for the induction of pulmonary maturity.

Betamethasone↗

Tetrameres columbicola (Nematoda: Spiruridae) infection of pigeons: ultrastructure of the gravid female in glands of the proventriculus.

The light and electron microscopies of Tetrameres columbicola gravid females in sections of the parasitized proventriculus of pigeons were studied. By light microscopy, the most conspicuous structures in the sectioned parasite were the intestine, ovary, and especially the uterus that contained numerous eggs. By electron microscopy, there was a thick mat of pigment-coated microvilli on the surfaces of the intestinal epithelial cells. The germinal zone of the ovary contained nonmembrane-bound oocytes, but oocytes were confined by a membrane in the growth zone of the ovary. The core of the spermatheca contained oocytes and the periphery harbored sperm. In this location, the unfertilized oocyte had pseudopods; sperm had invaginations of the plasma membrane. After fertilization, there was proliferation of ribosomes within the oocyte. Embryonating eggs in the uterus had thick shells and were partially enveloped by elongations of the uterine epithelial cells. Surfaces of the epithelial cells were pleated and they had electron opaque areas at the points of the pleats. Larvae in eggs had a well developed annulated cuticle and muscular layer. Somatic muscle cells had tailed appendages that protruded into the pseudocoelom. The single layer of cells beneath the hypodermis had lateral processes at the base of the cells that interdigitated with similarly elongated processes of adjacent muscle cells. Striated fibers were present in the central portion of the cells.

Animals↗

[Contraction of non-gravid human uterus in various menstrual phases (author's transl)].

Using microtransducer, the author has studied the uterine contraction in various menstrual phases and during dysmenorrhea, and also the effect of the administration of PG synthetase inhibitors. The results obtained can be summarized as follows: 1) In normal non-gravid uterus, the contraction was 25.6mmHg in amplitude and 19.9/10min. in frequency in the proliferative phase, 12.4 and 28.4 in the early half of secretory phase, 28.3 and 11.5 in the latter half, and 42.3 and 12.9 during menstruation. In other words, while the contractions were the most pronounced during menstruation, no difference was found between proliferative and the latter half of secretory phase, and they were the weakest during the early half of secretory phase with the ripple like small waves. 2) During the proliferative phase, relatively regular contractions were found in various kinds of patients, - that is - , patients with normal menstrual cycles, with organic disorders but without dysmenorrhea, with functional dysmenorrhea, or with organic dysmenorrhea. 3) Compared to other menstrual phases, the contractions were weak in the early half of secretory phase. However, the patients with organic dysmenorrhea had stronger contractions than other patients. 4) In the latter half of secretory phase, the patients with organic disorders or organic dysmenorrhea showed stronger contractions than in those without the organic changes, and the contractions were approximately 55mmHg in amplitude in patients with organic change, -almost twice higher than in patients without organic change. 5) During menstruation, patients with dysmenorrhea, functional or organic, showed contractions with the average amplitude of 87mmHg, -more than twice the height found in the patients without dysmenorrhea. 6) When the amplitude was higher then 140mmHg, all the patients complained of pain. 7) In patients with dysmenorrhea, the administration of PG synthetase inhibitors, such as Indomethacin, Naproxen, etc., caused the reduction of contraction amplitude, resulting in the relief of pain.

Female↗

[Single administration of a progesterone preparation during early gravidity of gilts following synchronized ovulation and induction of puberty to lower the age of first insemination].

The action of one single injection of 62.5 mg of hydroxy-progesterone-capronate on the 14th day after first insemination was tested for the purpose of defining the fertility performance of 180 gilts with synchronised ovulation and induced puberty. Synchronised ovulation caused significant rise in litter size and enhancement in gravidity rates. By comparison with a control group, the number of piglets born additional to each first insemination was 2.3. Induction of puberty to lower first-insemination age was of significant positive effect only on the pregnancy result, and somewhat fewer piglets were actually born. Nevertheless, the surplus birth figure to each first insemination was 2.1, as compared to untreated sows. The positive effect on puberty-induced animals was inversely proportional to daily weight rise.

17 alpha-Hydroxyprogesterone Caproate↗

[Acute post-gravidic Budd-Chiari syndrome. One case (author's transl)].

The sixth case of post-gravidic Budd-Chiari syndrome is reported. In the acute stage of the disease heparin seems to have given immediate favourable results, and the value of long-term heparin treatment is discussed. Post-mortem findings seven years after the acute episode confirmed the evolution towards a certain type of cirrhosis characterized by macroscopically and histologically heterogenous lesions and by persistent liver congestion. Portal hypertension was associated with arterialization of the portal vein and considerable dilatation of the right diaphragmatic veins. The venous drainage of the liver had undergone complex alterations: the supra-hepatic veins were affected with fairly recent incomplete ostial thrombosis, many intra-hepatic veins were reduced to a vestigial reticulum and others were the seat of recent or old re-canalized thrombosis. Cancerous transformation was found to be present in the larger hepatic nodules.

Acute Disease↗

Benzoyl-L-arginine methyl ester (BAME)-esterase activity in human plasma during the gravidic-puerperal cycle.

Benzoyl-L-arginine methyl ester (BAME)-esterase activity of plasma was measured in women going through the gravidic-puerperal cycle and compared with plasma of non-pregnant women. Plasma from women in the 36th to 40th week of pregnancy hydrolyzes BAME two times more rapidly than that from non-pregnant women. During pregnancy, BAME-esterase activity in plasma increases progressively up to the 40th week, decreases during labor, and after delivery reaches the same level as in non-pregnant women. The BAME-esterase activity of plasma was affected by the storage temperature, with differences demonstrable between -20 and -4 C and between pregnant and non-pregnant women.

Arginine↗

Acute urinary retention and the incarcerated, retroverted, gravid uterus. A case report.

A case of urinary retention was associated with an incarcerated, retroverted, gravid uterus. In a literature review of the English language we encountered 26 similar cases. Although no series of cases has allowed evaluation of a specific protocol for evaluation and management or analysis of outcomes, a review of the literature does outline certain diagnostic tests and treatment modalities that may be useful when one is faced with this uncommon condition.

Female↗

Acanthocephala of marine fishes off Fiji Islands, with descriptions of Filisoma longcementglandatus n. sp., Neorhadinorhynchus macrospinosus n. sp. (Cavisomidae), and gravid females of Rhadinorhynchus johnstoni (Rhadinorhynchidae); and keys to species of the genera Filisoma and Neorhadinorhynchus.

A parasitological collection from marine fishes off the Fiji Islands yielded 5 species of acanthocephalans from 4 species of fish as follows: Filisoma longcementglandatus n. sp. from scat Scatophagus argus; Neorhadinorhynchus macrospinosus n. sp. from vermiculated rabbit fish Siganus vermicularis; Neorhadinorhynchus nudum (Harada, 1938) Yamaguti, 1939 (Cavisomidae) from mackerel tuna Euthynnus affinis; Rhadinorhynchus johnstoni Golvan, 1969 (Rhadinorhynchidae) from E. affinis; and Neoechinorhynchus agilis (Rudolphi, 1819) Van Cleave, 1916 (Neoechinorhynchidae) from striped mullet Mugil cephalus. All are new locality records and, except for N. agilis, new host records. Filisoma longcementglandatus is distinguished from all other species of the genus by its very long cement glands and size and armature of its proboscis. Neorhadinorhynchus macrospinosus has distinctly larger proboscis hooks than all other members of the genus. Keys to species of the genera Filisoma and Neorhadinorhynchus are included. Gravid females of the inadequately described R. johnstoni are described for the first time. Taxonomic notes on the other acanthocephalan species are also included.

Acanthocephala↗

Ultrastructure of the gravid uterus of Hymenolepis diminuta (Platyhelminthes: Cestoda).

The fine structure of the uterus in gravid proglottids of Hymenolepis diminuta was examined by standard techniques for scanning and transmission electron microscopy. The uterus consisted of a syncytial uterine epithelium attached to the medullary parenchyma through a thin extracellular basal matrix. The epithelium contained prominent nuclei in the juxtalumenal cytoplasm. The cytoplasm was dominated by extensive granular endoplasmic reticulum, with dilated cisternae containing an electron-lucent material and widely scattered electron-dense spherical bodies. No Golgi body or other agranular endomembrane component was observed, but the epithelium contained numerous free ribosomes and a few mitochondria. The apical plasma membrane was folded into long microlamellae. Epithelial and epitheliomesenchymal folds and villi resulted in a compartmentalized uterine lumen, with each chamber containing 1 to several eggs. These data suggest a high level of synthetic activity within the uterine epithelium, but the chemical products and functional significance of this activity are not yet known.

Animals↗

Effect of thyroxine, prolactin and adrenalin on the gravid ovaries of the frog Rana cyanophlyctis (Schn.).

The effects of thyroxine, prolactin and adrenalin on the gravid ovaries of R. cyanophlyctis were studied during late prebreeding period when vitellogenic growth of oocytes is complete or near completion. Specified doses of hormones were injected (ip) six days a week for one month. They were fed guppies ad libitum daily 6 days a week. Administration of 2 or 5 micrograms eltroxine (synthetic thyroxine) had no effect on ovaries or oviducts. Whereas, higher doses 8, 12 and 16 micrograms thyroxine caused significant (P < 0.05) decrease in the per cent weight of ovaries and oviducts. The mean diameter of the largest oocyte was also reduced significantly compared to the controls. There was an increase in the atresia of vitellogenic oocytes. Treatment with 100 micrograms prolactin also caused reduction in the per cent weight of ovaries and oviducts. However, mean diameter of the largest oocyte did not change significantly. Follicular atresia increased only moderately. Injection of 180 micrograms adrenalin bitartrate caused drastic decrease (P < 0.05) in the per cent weight of ovaries and oviducts and mean diameter of the largest oocyte. Many yolky follicles became atretic. The findings suggest that increase in the levels of thyroxine (beyond a certain limit), prolactin and adrenalin around the breeding period decrease the fecundity of the frog by inducing atresia of yolky oocytes. We conclude that the above hormones in excess quantities act as negative modifiers of ovarian activity in R. cyanophlyctis.

Animals↗

Response of gravid Phlebotmus papatasi females to an oviposition attractant/stimulant associated with conspecific eggs.

Oviposition response of gravid P. papatasi females to conspecific eggs was studied in laboratory colonized sandflies. It was observed that significantly higher number of eggs were laid in the vicinity of conspecific eggs. However, a certain minimum number of eggs were required to be placed on the substratum to influence the rate of oviposition. The fecundity of females (mean = 56.5 +/- 4.9 eggs) exposed to conspecific eggs was significantly higher (P < 0.05) than that of blank control group. Perhaps, the chemical substances/pheromone of egg origin stimulated the oviposition rate. In an attempt to isolate the active ingredient, solvent washing of the conspecific eggs were tested. No increase in the rate of oviposition was noticed when the test site was treated with distilled water extract, whereas, significantly larger number of eggs were laid at the site treated with di-ethyl ether extract. This indicated that the oviposition attractant associated with the eggs dissolved in the organic solvent, but not in water. The possible application of this attractant for wild sandflies in nature and for regulating the site of oviposition on the substratum in the laboratory colonized sandflies needs to be explored.

Animals↗

Pressure necrosis of a caesarean section scar with exteriorization of the gravid uterus. A case report.

A case of pressure necrosis of a caesarean section scar with protrusion of the gravid uterus through the wound is described. We can find no mention of a similar case in the literature. The management during the pregnancy presented some alarming problems, all of which were overcome, and the pregnancy was terminated by caesarean hysterectomy at 38 weeks. A healthy baby was delivered and the mother recovered.

Adult↗

Gravidic macromastia. A problem for the patient and for the doctor.

Gravidic macromastia is a condition characterized by an excessive and generalized enlargement of the breasts which occurs during pregnancy or shortly after pregnancy. It is a rare condition whose etiology is unknown. Most Authors describe it as a pathology which is influenced by a disturbed play of hormones of hypersensitivity of mammary tissue to normal hormone stimulation. A therapeutic approach is discussed with reference to the literature.

Adult↗