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At least 289 records · Page 16Linked to original sources
PubMed2001

Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: a case for recommending hysterectomy at surgical prophylaxis.

OBJECTIVE: BRCA-1 and BRCA-2 germline mutations increase the risk of ovarian and breast cancer. Primary cancer of the fallopian tube is rare; however, recent evidence suggests that patients harboring a germline mutation conferring an increased risk of ovarian cancer may be at risk for fallopian tube cancer as well. We discuss the finding of occult fallopian tube cancer diagnosed at surgical prophylaxis in women harboring BRCA-1 mutations. METHODS/RESULTS: Two patients undergoing surgical prophylaxis to address an increase in ovarian cancer risk were discovered to harbor occult primary fallopian tube carcinoma on final pathology review. Mutational analysis confirmed the presence of a deleterious mutation in BRCA-1 in both patients. CONCLUSION: Currently, consensus opinions regarding ovarian cancer surgical prophylaxis in gene mutation carriers do not include hysterectomy as part of the preventative procedure. This report as well as a growing number of cases of fallopian tube cancer reported in known BRCA-1 and BRCA-2 mutation carriers has important implications for recommendations regarding surgical prophylaxis in these women.

BRCA2 Protein↗
PubMed1989

Posthysterectomy carcinoma of the fallopian tube presenting as vaginal adenocarcinoma: a case report.

The clinical and pathological features of a case of adenocarcinoma of the fallopian tube with a unique presentation are described. The 68-year-old patient presented with vaginal bleeding 25 years after a vaginal hysterectomy. Pelvic examination revealed a 0.5-cm nodule of tumor involving the mucosa of the vaginal apex. At laparoscopy, the left fallopian tube was dilated and adherent to the vaginal vault. Pathological examination of the upper vaginectomy and bilateral salpingo-oophorectomy specimen revealed a primary papillary adenocarcinoma of the left fallopian tube that had invaded directly into the mucosa of the vaginal apex. Vaginal involvement, either at the time of presentation or subsequently in the course of the disease, is very rare in patients with carcinoma of the fallopian tube.

Adenocarcinoma, Papillary↗
PubMed1989

Cystadenofibroma of fallopian tube.

We present two cases of cystadenofibroma of the fallopian tube in 2 patients of 49 and 32 years, respectively. The first tumor was a chance finding in a hysterosalpingo-oophorectomy because of multiple leiomyomas. The second tumor appeared in a pregnant woman; the tumor was considered in an echographic study as an ectopic pregnancy. This tumor was a borderline cystadenofibroma. The second case is the first report of cystadenofibroma of the fallopian tube associated with pregnancy.

Adenofibroma↗
PubMedDate not supplied

Recurrent adenocarcinoma of the fallopian tube presenting as leptomeningeal carcinomatosis.

Primary adenocarcinoma of the fallopian tube is a rare malignant neoplasm of the female reproductive system. Unusual patterns of metastasis may be observed. Report is made of a patient with recurrent adenocarcinoma of the fallopian tube, which presented as leptomeningeal carcinomatosis, as a first site of distant metastasis three years after initial diagnosis. The diagnosis was made by cytologic examination of the cerebrospinal fluid. No other sites of distant metastasis were present.

Adenocarcinoma↗
PubMed1994

[Clinical study of the treatment of fallopian tube obstruction with catheter recanalization and blood stasis removing drugs].

50 patients with fallopian tube obstruction were initially treated by catheter recanalization, and then randomly divided into two groups. Chinese medicine group (CMG) treated with Tongjingbao and Angelicae Complex Injection and Western medicine (Gentamycin, Dexamethasone, Chymotrypsin) group (WMG) as a control. The course of treatment was three months. Before and after treatment, the hemorheology change was analysed. After treatment, all patients except subsequent pregnancy were repeatedly performing hysterosalpingography. The results showed effective rate of recanalization was 94%; corrected pregnancy rate was 100% in CMG and 50% in WMG; the reocclusion rate of fallopian tube was 9% in CMG and 25% in WMG (P < 0.05). The difference of hemorheology change between two groups was significant (P < 0.01) and it was also different before and after treatment in CMG (P < 0.01). This study showed that catheter recanalization was effective in recanalizing the mechanical occluded fallopian tube. The Chinese medicine would inhibit the reocclusion and re-adhesion of tube.

Adult↗
PubMed2001

Fallopian tube necrosis after postpartum sterilization.

Because it usually presents with nonspecific symptoms and occurs rarely, the diagnosis of fallopian tube torsion and necrosis is usually done at laparotomy. A 32 year-old woman returned to the hospital with right lower quadrant pain three days after a postpartum tubal sterilization procedure. Clinical, laboratory and imaging findings did not assist with the diagnosis. At laparotomy, after dissection of adhesions, a necrotic right fallopian tube was found. A salpingectomy was performed and the patient had an uneventful postoperative course. Fallopian tube torsion should be included in the differential diagnosis of pelvic pain in women. This patient has a good prognosis.

Adult↗
PubMed1975

[Comparison of temperature measurements during laparoscopic sterilization and the histologic findings of the cauterized segments of the fallopian tube (author's transl)].

During laparotomies the temperature generated by tubal sterilization with the laparoscopic equipment was measured continually in 32 fallopian tubes. The thermal damage to the fallopian tube caused by different energies and coagulation durations was examined microscopically. During the coagulation of the fallopian tube, with an energy of 20-30 watt temperatures of around 100 degrees C are produced at the point of coagulation. The effective coagulation time is dependant upon the energy created and the duration of the coagulation. The best histologic results were obtained with a duration of the coagulation of 60 seconds at an energy of 30 watts. This corresponds to an effective coagulation time of 50 seconds. The temperature of the coagulation instrument becomes normal within 1 to 2 minutes after the coagulation. If the electric energy is increased to 50 or 100 watt, sparking is observed almost consistently. With these energies, temperatures up to 600 degrees C are observed. The temperature of the metal parts of the coagulation forceps then become normal after 3-4 minutes. In order to avoid burns during laparoscopic tubal sterilizations and in order to obtain a good histologic result the procedure should be done with an electrical energy of 30 watt and a duration of the coagulation of 60 seconds.

Body Temperature↗
PubMed1996

[Carcinoma of fallopian tubes. Presentation of 2 cases].

The carcinoma of the Fallopian tube is at the present time, one of the most rare gynecologic tumors, representing approximately less than 1% in world literature, being in our experience of 0.15%. We presented two cases of adenocarcinoma of the Fallopian tube, seen in a lapse of 25 years, not diagnosed preoperatorily with the clinical trial of abnormal bleeding, negative biopsy of endometrium and adnexal mass. As it is written in the literature, the diagnosis is rarely established previous to the operation and it usually corresponded to an adenocarcinoma. The classification of the FIGO for the stage is used. In relation to the survival follow-up: the stages I and II present 60% approximately of survival to the five years and it is suggested radiotherapy additional to the surgery; however, according to some authors this doesn't improve the survival.

Adenocarcinoma↗
PubMed1975

Morphology of metastatic cancer of the fallopian tube in uterine cervix carcinoma.

Morphological examination of 452 Fallopian tubes removed together with the uterus for uterine cervix cancer revealed in 221 patients at the time of operation and in 5 dead on autopsy, metastatic cancer in 8 females (3.5%) in 12 tubes (right-side involvement 2 cases, left-side 2 cases, ambi-lateral 4 instances). In 37 patients there were metastases in inner organs; of these diseased 21.6% were affected by metastatic cancer of the Fallopian tube. Macroscopically, metastatic tumors were of different form in 4 cases; in the remaining instances they were only discovered on microscopical examination. In two cases the tubes were affected in their whole length, in the other case the tumor was located in the ampullary portion. The cyto- and histological structures of the metastatic cancer were the same as those of the primary uterine cervix tumor. The predominating route of tumor dissemination has proved to be lymphogenic propagation (5 cases). In two cases lymphohematogenic dissemination, in one case propagation by implantation were observed.

Adult↗
PubMed1994

Transitional cell carcinoma of the fallopian tube: a light and electron microscopic study.

Carcinomas other than adenocarcinomas are extremely rare in the fallopian tube. We report a case of a malignant neoplasm of the fallopian tube with histological features of transitional cell carcinoma that presumably arose from an extraluminal region of the tube. A 57-year-old postmenopausal woman with vaginal bleeding was found to have a left adnexal tumor. Exploratory laparotomy revealed a left tubal tumor with a metastatic nodule on the rectal surface. Histologically, the tumor surrounded the lumen of the left fallopian tube and was composed of cells with "coffee-bean"-like nuclei arranged in solid nests without keratinization. No abnormalities were found in the right tube, ovaries, or uterus. Electron microscopy revealed the tumor cells to have nuclei with deep nuclear indentations, cytoplasmic tonofilaments, and intercellular spaces with prominent interdigitations of the cell membrane. In addition, several tumor cells with protruding microvilli formed abortive lumina. These histological and ultrastructural features were consistent with the diagnosis of transitional cell carcinoma.

Carcinoma, Transitional Cell↗
PubMed2003

Laparoscopic approach to an uncommon adnexal neoplasm associated with infertility: serous cystadenofibroma of the fallopian tube.

A rare case of serous cystadenofibroma of the fallopian tube was discovered during evaluation for in vitro fertilization-embryo transfer. Bilateral tubal occlusion was noted on hysterosalpingogram, and a right adnexal cyst, initially thought to be of ovarian origin, was identified by office transvaginal sonography. Laparoscopy revealed a 5.5-cm, fluid-filled mass involving the distal aspect of the right fallopian tube. Both ovaries and uterine exterior appeared grossly normal. The cyst was decompressed and removed intact without incident through a 5-mm laparoscopic cannula. The mass showed histologic features consistent with benign serous cystadenofibroma. The patient had an uncomplicated postoperative convalescence and continued to do well 3 months after surgery.

Adnexa Uteri↗
PubMed1993

Immunohistochemical staining for CA-125 in fallopian tube carcinomas.

From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.

Adenocarcinoma↗
PubMed1994

Treatment of primary fallopian tube carcinoma with cisplatin-containing chemotherapy.

Because of the rarity of the primary fallopian tube carcinoma, optimal primary therapy is still not well defined, and there is little information available regarding the efficacy of combination chemotherapy in advanced disease. The experience obtained by treating 14 patients with fallopian tube carcinoma--most of them with advanced disease--using a combination of cisplatin, adriamycin, and cyclophosphamide (CAP) (10 patients) or carboplatin plus cyclophosphamide (4 patients) is reported. One patient had Stage Ic disease, 2 had Stage II, 9 had Stage III, and 2 had Stage IV. Eleven patients had clinically measurable disease (> 2 cm) at the start of chemotherapy. Eight of these patients had a complete clinical response (CR), 2 had partial response (PR), and 1 had progressive disease (PD). Of the 8 CR patients, 5 underwent second-look operation (SLO). Pathological complete response (pCR) confirmed in 4 out of 5 patients at SLO. The 3 patients without measurable disease (< 2 cm) after primary surgery had an indeterminate response to chemotherapy. Two of them (Stages Ic and II, respectively) had a negative SLO, while the third patient with Stage IV disease, who refused the SLO, remains disease-free 41+ months. This high response rate shows that this carcinoma is very responsive to cisplatin- or cisplatin analogue-containing regimens. One pCR and two clinical CR patients relapsed after 20, 14, and 16 months, respectively, from the completion of chemotherapy and died despite the second-line treatment. The toxicity of the regimens was moderate. The median survival was 40 months, and the actuarial 5-year survival rate was 48%. Carcinoma of the fallopian tube appears to respond favorably to cisplatin- or carboplatin-containing chemotherapy.

Adenocarcinoma↗
PubMed1990

The management of primary fallopian tube carcinoma.

The outcome of 30 patients with primary fallopian tube carcinoma is described. Treatment varied over the 22 year period of accrual and included combinations of surgery, radiotherapy and chemotherapy. There was an apparent increase in stage at treatment with time which was probably related to more precise staging at laparotomy and the greater use of computerized tomography. The median survival for all patients was 28 months and the 5-year survival was 18%. Ten patients received postoperative chemotherapy for residual disease with an overall response rate of 80% and median progression-free and overall survival times of 14 and 21 months respectively. The pattern of relapse was similar to that seen in ovarian carcinoma, with all but one patient having the pelvis or abdomen as the main site of recurrence. Primary fallopian tube carcinoma has a response to treatment and a tumour biology similar to that of ovarian carcinoma. It is recommended that the management of this uncommon malignancy should continue to be along the lines of ovarian carcinoma, with initial treatment by cytoreductive surgery followed by chemotherapy or radiotherapy for residual disease.

Adult↗
PubMed1976

Carcinoma in situ of the Fallopian tube associated with cervical carcinoma. Case report.

A case of carcinoma in situ of the fallopian tube in a 55-year-old woman, associated to cervical carcinoma is described. The necessary criteria for the diagnosis of pre-invasive carcinoma of the fallopian tube, among which the number of mitoses seems to be of great importance, are discussed. This previously unreported association of carcinoma in situ of the fallopian tube, with carcinoma of the uterine cervix, emphasizes the notion of the multicentric neoplastic possibilities of the müllerian tract derivatives.

Carcinoma in Situ↗
PubMed1987

Salpingoscopy. A method for direct examination of the fallopian tube.

Using flexible endoscopes 0.6-2.3 mm in diameter, direct tubal endoscopy was performed on human uteri and fallopian tubes ex vivo. Fourteen studies were performed both transcervically using the operating channel of a hysteroscope and transtubally via the fimbriae of the Fallopian tube. Different anatomic segments of the fallopian tube were readily identified, as was a possible tubal "sphincter" not previously described. This technique holds great promise for the evaluation and potential treatment of intratubal pathology in the gynecologist's office.

Adult↗
PubMed2000

Preoperative diagnosis of the primary fallopian tube carcinoma by three-dimensional static and power Doppler sonography.

OBJECTIVE: To investigate whether three-dimensional static and power Doppler ultrasound improves the diagnosis of primary Fallopian tube carcinoma. METHODS: During a 2-year period five cases of primary Fallopian tube carcinoma were selected from a cohort of 520 patients with a previous scan suggestive of an adnexal tumor. RESULTS: Tubal malignancy occurred in patients between 49 and 64 years, with presenting symptoms such as pain, vaginal bleeding and leukorrhea. CA 125 was elevated in three cases of tubal carcinoma with stages II and III, while in two patients with stage I, CA 125 was within the normal limits. Two-dimensional ultrasound demonstrated sausage shaped cystic masses with papillary projections in two patients and a complex adnexal mass in one patient. Three-dimensional ultrasound revealed sausage shaped cystic and/or complex masses with papillary projections in all five cases of tubal malignancy. In one patient preoperative 3-D ultrasound correctly predicted bilateral tumors, while 2-D transvaginal sonography found only unilateral changes. Additional 3-D power Doppler examination depicted vascular geometry typical for malignant tumor vessels such as arteriovenous shunts, microaneurysms, tumoral lakes, blind ends and dichotomous branching in each of the cases with Fallopian tube carcinoma. CONCLUSIONS: Three-dimensional ultrasound allows precise depiction of tubal wall irregularities such as papillary protrusions and pseudosepta. Improved understanding of anatomical relationships may aid in distinguishing ovarian from tubal pathology. Multiple sections of the tubal sausage like structures enable determination of local tumor spread and capsule infiltration. Study of the vascular architecture in cases of Fallopian tube malignancy is further enhanced using 3-D power Doppler imaging.

Aged↗
PubMed1989

Epithelial hyperplasia of the fallopian tube. Its association with serous borderline tumors of the ovary.

We examined sections of fallopian tube from 99 patients with serous borderline tumors of the ovary (SBT) to determine the prevalence of epithelial hyperplasia. Fifty-eight patients with carcinoma of the cervix (CC) and 30 with grade 2 or 3 ovarian carcinoma (OC) served as controls. Patient ages were similar in each group. Epithelial hyperplasia was identified in 68 of 99 patients with SBT (68.7%), compared with 15 of 58 with CC (25.9%) and 4 of 30 with OC (13.3%). Epithelial thickness and nuclear crowding were greater in hyperplastic than in normal fallopian tubes. There was no correlation between hyperplasia and menstrual cycle. In patients with SBT, the presence of epithelial hyperplasia correlated with tumor stage. Hyperplasia was present in 38 of 60 (63%) patients with Stage I tumors. In Stage II and III tumors, hyperplasia was present in 18 of 25 (72%) patients with noninvasive peritoneal implants and 12 of 14 (86%) with invasive implants. Fallopian tube epithelial hyperplasia may represent an example of a field effect in müllerian carcinogenesis.

Adult↗