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At least 289 records · Page 16Linked to original sources
PubMed1982

Cardiac fibroma: long-term survival after excision.

Four patients have had operation at the Mayo Clinic for a cardiac fibroma and all survived. Three patients have an excellent clinical result and are free of tumor 1 year, 13 years, and 17 years postoperatively. The fourth shows radiographic evidence of residual tumor near the mitral anulus, but is clinically well 15 years postoperatively. A fifth unoperated patient died suddenly 8 years after presumptive diagnosis of fibroma at the age of 83 years. This experience suggests that patients who have undergone successful excision of cardiac fibroma have an excellent probability of remaining free of disease.

Child↗
PubMed1980

[Non-ossifying fibroma in children: a surgical condition?].

From 21 non osteogenic fibromas submited to surgery, authors bring their surgical experience of that tumor. This frequent benign tumor of the bone in childwood has generally a good pronostic; it evolves to spontaneous recovery in most of the cases. It is often latent, asymptomatic, and of an accidental diagnosis. The roentgenographic exam allows most often an accurate diagnosis. Sometimes it remains doubtful, and a biopsy is then necessary. The histologic exam will easily confirm the nature of the lesion. In half of the cases, non ossifying fibroma is revealed by a spontaneous fracture. It seems illusive to hope a complete filling of the tumor cavity with an orthopaedic treatment alone; it must be done a resection of the tumor together with a bone graft and an osteosynthesis. In the end, in some cases of a fortuitous diagnosis, the bone is made so weak that a resection with bone graft is necessary. And so, during the evolution of non osteogenic fibroma, there is a certain place for surgical treatment.

Adolescent↗
PubMed1995

Anatomo-clinical considerations on the ovarian fibroma.

The Authors analysed from an anatomo-clinical point of view, 17 cases of ovarian fibroma, observed during the period between 1968 and 1992. The incidence of ovarian fibroma in this study was 2.52% and it affected women in different age groups, though with greater frequency those above 50 years. Even the symptomatology was variable and was characterized by pain in the hypogastric quadrant (47.1%); alteration of the menstrual cycle (17.6%); metrorrhagic episodes (17.6%); sterility (5.9%). Due to the fact that the ovarian fibroma can appear at any age, this suggests different surgical approaches according to age, general conditions of the patient and fertility.

Adult↗
PubMed1995

[Fibroma of the bladder associated with a large diverticulum: a case report].

A 57-year-old woman was admitted with a chief complaint of difficult urination on June 7, 1993. A filling defect and a large diverticulum were revealed on the cystogram. Cystoscopy showed a tumor, obstructing the internal urethral orifice at the bladder neck and a diverticulum at the right posterior wall of the bladder. Under the preoperative diagnosis of a benign bladder tumor with a diverticulum, resection of the tumor and transvesical diverticulectomy were performed by a suprapubic approach. The resected tumor was smooth-surfaced, elastic soft and was measured 2.0 by 1.5 by 1.0 cm in size. Histologically, the tumor was diagnosed as a benign fibroma of the urinary bladder. The postoperative course was uneventful. Non-epithelial benign bladder tumors are rare. To our knowledge, this is the 18th case of bladder fibroma in the Japanese literature. The characteristics of bladder fibroma are briefly described.

Diverticulum↗
PubMed1993

[Ossifying fibroma of the maxilla (apropos of 2 cases)].

The ossifiant fibroma is an authentic scarce benign tumoral processus. According to a literature review and two recent cases taken in charge in our service, having stand diagnostical and therapeutical problems. They seem interesting to accost the subject of the ossifiant fibroma in maxillo-facial surgery and put the accent on the differential diagnosis in histological plane between ossifiant fibroma and fibrous dysplasia having given different therapeuticals indicents. The two reported cases interest the masculine young subjects in one case with mandibular localisation and in the other one maxillary.

Adolescent↗
PubMedDate not supplied

Managing a peripheral ossifying fibroma.

The Peripheral Ossifying Fibroma is an inflammatory lesion which most often appears in twenty-five to thirty-four-year-old females. It averages 1.0 cm at its greatest dimension. This case reports a seven-year-eight-month-old female who presented with a peripheral ossifying fibroma lesion which measured 2.7 cm by 1.5 cm by 1.0 cm. A review of peripheral ossifying fibroma, and the management and postsurgical sequelae of this child are discussed.

Child↗
PubMedDate not supplied

Leptomeningeal fibroma.

Few cases of benign fibrous tumors have been reported in the central nervous system. Of the 9 cases in the literature only 1 was adjacent to the leptomeninges. We report a case of a fibroma of the leptomeninges of very low cellularity with calcified areas that had typical findings of a fibroma by electron microscopy. Immunophenotyping revealed unexpected positivity for S-100 and glial fibrillary acidic proteins. The histogenesis of this lesion may be a pluripotential cell, or the expression of these antigens may be induced by local factors in the central nervous system. The incidence of this unusual lesion is unknown, and ours is more typical of extracranial fibromas than the previously reported cases.

Adult↗
PubMed1998

Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature.

BACKGROUND: Collagenous fibroma (desmoplastic fibroblastoma) is poorly recognized and may be mistaken for other benign or even malignant spindle-cell tumors of soft tissue because of the small number of reported cases. DESIGN: Collagenous fibromas resected from four adult women were studied histologically and immunohistochemically. RESULTS: The tumors were well-circumscribed firm masses, measuring from 1.0 to 13.8 cm (mean, 5.5 cm) across the greatest diameter, located in the subcutaneous or deep soft tissue of the shoulder, thigh, back, and neck. Each of the tumors was characterized by a paucicellular lesion with spindle- and stellate-shaped fibroblastic cells embedded in a hypovascular, densely fibrous stroma. Mitotic figures and necrosis were not identified. One tumor contained dystrophic calcification and metaplastic bone, and another included small foci of floretlike multinucleated giant cells. Although appearing well demarcated on gross examination, one tumor focally infiltrated the surrounding skeletal muscle and adipose tissue. On immunohistochemical examination, all of the tumors were diffusely positive for vimentin. One tumor showed focal staining for alpha-smooth muscle actin, and another was partially positive for desmin, a staining profile that is typical of myofibroblasts. No tumor recurred during the follow-up periods of 67 to 108 months (mean, 93 months). CONCLUSION: Collagenous fibroma may be a distinctive fibrous soft-tissue tumor with benign biological behavior.

Adult↗
PubMed1964

RESPONSE OF CULTURED RABBIT CELLS TO INFECTION WITH THE SHOPE FIBROMA VIRUS. I. PROLIFERATION AND MORPHOLOGICAL ALTERATION OF THE INFECTED CELLS.

Hinze, Harry C. (University of Wisconsin, Madison), and Duard L. Walker. Response of cultured rabbit cells to infection with the Shope fibroma virus. I. Proliferation and morphological alteration of the infected cells. J. Bacteriol. 88:1185-1194. 1964.-Primary and serially cultured rabbit kidney cells were grown under conditions promoting rapid cell multiplication. When such cultures were infected with 5 to 10 plaque-forming units of Shope fibroma virus, cell multiplication was inhibited for a period of 2 to 3 days. After this stationary period, cell multiplication in the infected cultures was resumed at a rate approximating that of the uninfected controls. With the resumption of cell multiplication in the infected cultures, concurrent changes were observed in cell morphology and growth pattern. Cells showing such alterations also possessed the ability to form tumors when inoculated into the hamster cheek pouch.

Animals↗
PubMed1977

Cementomas. II. Aggressive cemento-ossifying fibroma of the ethmoid region.

Aggressive cemento-ossifying fibroma is the most aggressive tumor of all cementum-containing neoplasms. An extensive, destructive cemento-ossifying fibroma of the ethmoid region was found in a patient. To our knowledge, this is the first case of a cemento-ossifying fibroma in this location. A radical maxillectomy was ultimately required to control the tumor, preserving orbital contents. The unique site of origin is thought to be the result of an ectopic periodontal membrane or of a primitive mesenchymal cell rest.

Adult↗
PubMed1988

Fine-needle aspiration cytology of chondromyxoid fibroma: a case report.

The cytologic presentation of a case of chondromyxoid fibroma studied by fine-needle aspiration in a 17-yr-old black male is described. The cytologic features of chondromyxoid fibroma are presented, and the differential diagnosis of intraosseous cartilaginous neoplasms is reviewed, emphasizing the cytomorphologic differentiation of chondromyxoid fibroma from chondrosarcoma, enchondroma, and chondroblastoma.

Adolescent↗
PubMedDate not supplied

Chondromyxoid fibroma of the jaws.

A new case of chondromyxoid fibroma of the jaws is reported, and the current world literature on chondromyxoid fibroma is reviewed. Chondromyxoid fibroma is a rare tumor arising from cartilage-forming mesenchymal tissue. In the long bones, it has frequently been confused with chondrosarcoma or benign chondroblastoma. When it occurs in the jaws, apparent confusion with myxomas of myxofibromas may result. In the jaws the neoplasm typically occurs in the mandible. Initial symptoms are pain or a slowly growing expansile mass. After evaluation of the natural history of these lesions, a conservative approach to surgical therapy is advocated.

Adult↗
PubMed2005

Chondromyxoid fibroma resembles in vitro chondrogenesis, but differs in expression of signalling molecules.

Chondromyxoid fibroma is a rare benign cartilaginous bone tumour characterized by morphological features that resemble different steps of chondrogenesis in terms of both cellular morphology, ranging from spindled to rounded cells, and the extracellular matrix formed, which ranges from fibrous to cartilaginous. The presence in chondromyxoid fibroma of signalling molecules that regulate the spatial expression of proteins involved in normal cartilage proliferation and differentiation was investigated in samples from 20 patients and compared with articular chondrocytes from 11 normal donors cultivated in 3D pellet culture. Sections were stained with safranin-O and H&E, and immunohistochemistry was performed for p16, cyclin D1, FGFR3, BCL2, p21, PTHLH, PTHR1 and N-cadherin. Expression patterns were analysed using hierarchical clustering. In chondromyxoid fibroma, specific morphological features correlated with a distinct pattern of expression. Comparison with normal chondrocytes in pellet culture showed a striking morphological resemblance, but with an unmistakably different pattern of expression. N-cadherin, PTHLH, and PTHR1 were expressed to a significantly higher level (p < 0.01) in articular chondrocyte pellets but, conversely, there was significantly lower expression of cyclin D1, p16 and BCL2 (p < 0.05) in these cells. Morphological similarities reflect common steps in cartilage differentiation, albeit driven by different molecular mechanisms. The proteins we have found to be differentially expressed seem crucial for neoplastic chondrogenesis.

Bone Neoplasms↗
PubMed1975

The central odontogenic fibroma. Clinical and morphologic studies.

The clinical, pathologic, and ultrastructural features and pertinent case history of an 11-year-old boy with a rare benign odontogenic neoplasm, the central odontogenic fibroma, are presented. A review of the literature reveals seven other lesions with clinical and pathologic findings similar to those of this case. This study supports the concept that the central odontogenic fibroma is a distinct odontogenic neoplasm of bone which occurs most commonly in the mandible as a multilocular, radiolucent, and slowly growing expansile lesion with no tendency to recur after surgical enucleation. The ultrastructural findings indicate that the central odontogenic fibroma and the odontogenic myxoma share many common morphologic features and have an apparently similar histogenesis.

Cell Membrane↗
PubMed1993

Unusual presentation of a chondromyxoid fibroma of the mandible. Report of a case and review of the literature.

Chondromyxoid fibromas are uncommon central bone tumors that are most often found at the proximal metaphyses of long bones. Chrondromyxoid fibromas of the jaws are very rare with only 18 reported cases in the literature. This article reports on a recurrent chondromyxoid fibromas of the mandible in a 10-year-old boy. In addition, a literature review of the clinical and histologic features, as well as the diagnostic pitfalls and recommended modalities of treatment are presented.

Child↗
PubMed1989

Central odontogenic fibroma. A report of two controversial cases illustrating diagnostic dilemmas.

Two unusual cases of central odontogenic fibroma are described and used to illustrate differential diagnostic problems in this controversial group of lesions. The first case had a cystic lesion noted on routine radiography in the left ramus of the mandible. This particular case was unusual histologically as it showed in addition to typical areas of odontogenic fibroma a small inflamed cyst lined by epithelium containing many hyaline bodies. The second case presented with anaesthesia of the right lower lip and an enlarged chin prominence. The lesion was diagnosed as an odontogenic fibroma but with a somewhat unusual histological appearance in that there were abundant areas of osseous metaplasia throughout the lesion.

Adult↗
PubMed1991

A central odontogenic fibroma exhibiting pleomorphic fibroblasts and numerous calcifications.

A case of an odontogenic fibroma with unusual histopathological features is described. The tumour exhibited numerous, plump, stellate fibroblasts, similar to those found in the so-called giant cell fibroma. This finding has not been described previously in odontogenic fibromas. This case also exhibited an unusually large number of calcifications. Neither of these features should affect the biological behavior of this lesion.

Calcinosis↗
PubMed1996

A new method for the treatment of fibromas: interstitial laser hyperthermia using the Nd:YAG laser. Preliminary study.

Operative laparoscopy can replace hysterectomy in the treatment of submucous and subserosal uterine fibromyomas. Interstitial myomas are still treated using traditional methods. Using an Nd:YAG laser with a quartz fibre which diffuses the ray, we induced delayed necrosis of myoma secondary to the hyperthermia produced by this method-interstitial laser hyperthermia. We present an experimental study of fibromas from excised tissue. Optimal efficiency is achieved with continuous delivery at 5 W of power for 10 min. The temperature reaches 50 degrees C within a radius of 20 mm around the fibre. A clinical study was undertaken with the approval of the Ethics Committee. Seven patients suffering from symptomatic fibromas were treated by laparoscopy. Preliminary results at 12 months show that their symptoms have disappeared and the size of the fibromas has been reduced. A larger study is in progress.

Adult↗