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Colposcopic evaluation of cervical neoplasia in pregnancy.

The need for histologic examination of the cervix during pregnancy is not uncommon. Classically, the cone biopsy has been the diagnostic procedure of choice, but this procedure is attended by a significant and excessive complication rate. The cumulative data strongly supports the conclusion that the combination of cytology and colposcopically directed biopsy can be relied upon to provide an accurate diagnosis in a high percentage of patients. Colposcopy should be a routine diagnostic procedure in the evaluation of patients with abnormal Pap smears or grossly abnormal cervices.

Biopsy↗

[Colposcopic picture of vessels in decidual ectopy (deciduosis) at the portio vaginalis uteri].

The types of bloodvessel visible on colposcopic examination in various forms of decidual ectopia are described. The two main tapes are linear-spiral vessels and "asymmetrical loops". The possible differentiation, on the basis of the vascular picture of decidual from malignant changes in the cervix uteri by colposcopy is pointed out stressed. The functional state of the bloodvessels, probably newly-formed during the proliferation of the decidually transformed epithelial stroma, is briefly discussed.

Cell Division↗

[Colposcopic monitoring of primary chemotherapy in patients with locally advanced cancer of the uterine cervix].

OBJECTIVE: To evaluate colposcopy in the monitoring of patients affected by locally advanced cervix cancer treated with primary chemotherapy. MATERIALS AND METHODS: Eight patients (42-54 years old) affected by squamous cervical cancer locally advanced (stage FIGO IIa "bulky"/IIb/III) were treated with primary chemotherapy (cisplatin 50 mg/m2 vincristin 1 mg/m2 bleomicin 30 UI in 24 hours continuous infusion q 7 days for 3 cycles). Colposcopy was performed before chemotherapy, after the second cycle and at the end of chemotherapy. RESULTS: Two pathological complete responses, 5 partial responses and one case of stable disease were observed. Patients with complete and partial response were treated with radical hysterectomy. In responding patients we observed a typical sequence of colposcopic findings. Regression of distinctive malignancy feature, reduction of atypical vessels, gradual disappearance of peripheral lesions and centripetal reepilization of the cervix were sequentially registered. At the end of treatment the cervix appeared with a colposcopy imaging as well as a centripetal squamous complete or incomplete metaplasia, open--for most part--glandular exit and weak acid-iodic positivity. CONCLUSION: In responding patients we observed a typical sequence of colposcopy finding, useful in order to evaluate the effects of chemotherapy and to programme the surgical approach.

Antineoplastic Agents↗

[Genital intraepithelial lesions in immunosuppressed female patients after renal transplant: cytologic, colposcopic, and histologic study].

Twenty seven female patients immunosuppressed after renal transplantation were studied. Cytological, colposcopic and histologic studies of biopsies were used to determine the incidence of neoplastic intraepithelial lesions and those due to infection by human papilloma virus. Intraepithelial neoplasia was found in 7.4% and papilloma virus infection in 60%. Cervix cytology was insensitive (33%) for diagnosis of intraepithelial lesions. Therefore, cytology and colposcopy are recommended for routine follow up of immunosuppressed women.

Adolescent↗

[Cytological and histological parallels in atypical colposcopic findings].

The aim of the present study was to analyse the cytological and histological equivalents in 112 patients with atypical colposcopical findings. The results showed the follow distribution of the findings: for cytological examination in 66 of the patients-I gr. PAP, in 32-II gr. PAP, in 6 III-A gr. PAP, in 1-III-B gr. PAP, in 4-IV gr. PAP and in 3-V gr. PAP. The histological study of the obtained target biopsies established: 7 cases with normal epithelium, 82 with different findings of abnormal epithelium with or without nonspecific and specific inflammatory changes; 18 cases with dysplasia from I to III degrees, 2 cases with CIS and 3 with invasive cancer. The degree of correlation of the different findings, as well as the possible causes for hypo and hyperdiagnostic assessments are discussed.

Adult↗