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At least 289 records · Page 16Linked to original sources
PubMed1979

[The optic nerve in the cat. I. Quantitative aspects in the adult cat].

A quantitative study was carried out on the adult cat optic nerve near the eyeball by systematically measuring the perimeters of all the axons seen through the optic microscope. The main purpose of this study was to define the topographical distribution of these axons in function of their size. Statistical studies show the existence of an area of maximal concentration of large axons in crescent form situated in the temporal zone of the nerve. The neurophysiological implications are discussed.

Age Factors↗
PubMed1979

[The optic nerve in the cat. II. Qualitative aspects of maturation in the adult cat].

54 healthy cats were studied. In almost all cases, two types of degenerative signs could be seen: in the primary optic pathways, but also in the posterior funiculi and the spinal-cerebellar tracts, lesions of wide-diameter axons seen by their initial demyelination, accompanied by intense neuroglial reactions, and, on the other hand, a Wallerian degeneration of smaller axons situated in the axial part of the nerve. The percentage of these abnormalities must still be evaluated. Their eventual consequences and nature are discussed.

Age Factors↗
PubMed1994

[Analysis of electrically evoked response in relation to the central pathway of the cat (3). Current source density analysis in area 17 of cats].

We analyzed current source density and multiple unit activity of area 17 of cats in response to transcorneal electrical stimuli to clarify the localization of the transmembrane current flows contributing to the generation of the electrically evoked response. The results of the current source density analysis were as follows. 1. Current sinks within 20 ms were observed in layers 4 and 6. 2. Current sinks corresponding to N3 (latency 35 ms) were detected in layers 4 and lower 3 and current sources were in the supragranular layers. 3. Current sinks with a latency of more than 40 ms were observed in the supragranular layers. Simultaneous multiple unit activity was present in cases 1 and 2. With increased stimulus frequency or double electrical stimuli, the current sinks corresponding to N3 were decreased. These findings indicate that N1 (latency 9 ms) and N2 (latency 20 ms) reflect near-field potentials generated by geniculocortical afferents in layers 4 and 6, and that N3 is a post-and polysynaptic component. In addition, it appears that dipoles consisting of cell bodies and apical dendrites of pyramidal cells in layer 3 generated by satellite cell in layer 4, play a major role in generating N3.

Animals↗
PubMed2005

FISH approach to determine cat eye syndrome chromosome breakpoints of a patient with cat eye syndrome type II.

We report a 19-year-old man with craniofacial dysmorphic features, anorectal malformations, eye colobomas, orthopaedic anomalies, and mild neurodevelopmental delay. Cat eye syndrome (CES) was suspected, and confirmed by cytogenetic analysis which showed the presence of a supernumerary bisatellited chromosome, identified by fluorescence in situ hybridization (FISH) as invdup(22). The marker was further analyzed with six BAC clones located at the 22q11.1 and 22q11.2 regions; this analysis allowed correct assignment at low copy repeat 4 on chromosome 22 (LCR22-4) of the two breakpoints, confirming the presence of a CES chromosome type II. The patient's phenotype is considered in the light of the cytogenetic, and FISH investigations results and other patients reported in literature. Molecular definition of the breakpoints at the LCR22-4 copy confirms the role of different chromosome 22-specific LCRs in CES chromosomes generation, as well as in other chromosome 22 germ line rearrangements. Our report confirms that, unlike other conditions, i.e. the invdup(15) bisatellited dicentric marker, the CES phenotype does not appear to correlate with the size of the marker chromosome. Additional cases are necessary to be able to draw more specific genotype-phenotype correlations and to determine the outcome of patients with CES, especially when this rare condition is diagnosed in prenatal age.

Abnormalities, Multiple↗
PubMed1991

Introduction of the glucocorticoid binding sequences into the expression vector p delta SVE-CAT and its effect on the CAT gene expression in mammalian cells.

We have demonstrated that synthetic oligonucleotide representing glucocorticoid responsive element (GRE I) of MMTV inserted into the enhancerless early promoter of SV40 in p delta SVE-CAT expression vector, enhances transient expression of chloramphenicol acetyltransferase gene in HeLa and hepatoma cells cultivated in the presence of dexamethasone. The following changes in the structure of the core sequences (GTTACAAACTGTTCT) of the synthesized GRE eliminated its enhancing ability: i, changes in the left end of the core sequences from GTTACAAAATGTTCT to TCTTCAAACTGTTCT or to TACTCAAACTGTTCT; ii, the increase of gap between TGTTCT and the inverted repeat of this sequence. The above changes did not eliminate specific binding of glucocorticoid receptor to the synthetic oligonucleotides studied.

Animals↗