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Results for “CAT SCRATCH DISEASE”

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At least 289 records · Page 16Linked to original sources
PubMed2001

Cat-scratch disease neuroretinitis diagnosed by a polymerase chain reaction approach.

PURPOSE: To assess the value of polymerase chain reaction in the diagnosis of cat-scratch disease neuroretinitis without conclusive serology. METHODS: Interventional case report. A 13-year-old girl developed a right neuroretinitis 2 months after a cat scratch. Despite the lack of accompanying features, an infection by Bartonella henselae was suspected and a systemic check-up was performed. RESULTS: Serologic results excluded other proposed origins but were insufficient in making the diagnosis because of low B. henselae specific IgG level in serum. A polymerase chain reaction analysis for B. henselae DNA in a small axillary lymphadenopathy aspirate enabled us to achieve a definitive diagnosis of cat-scratch disease. CONCLUSION: Polymerase chain reaction is a valuable method of diagnosing cat-scratch disease when serology is considered negative or borderline.

Adolescent↗
PubMed1995

Serology to Bartonella (Rochalimaea) henselae may replace traditional diagnostic criteria for cat-scratch disease.

Bartonella (Rochalimaea) henselae has been identified as causative agent of cat-scratch disease (CSD). Employing an indirect fluorescence antibody test we found that 20 (100%) out of 20 children with suspected CSD had serum titres to B. henselae of > or = 512. By contrast, in all but one of the controls (n = 332) including subjects exposed to the same cats, patients with diseases other than CSD, and blood donors the antibody titres were < or = 256 (P < 0.001). However, significant regional differences in seroprevalence were noted. CONCLUSION. Serology to B. henselae may supplant traditional criteria for the diagnosis of CSD and prevent patients from unnecessary surgery.

Adolescent↗
PubMed1997

Detection of antibodies to Bartonella henselae in clinically diagnosed cat scratch disease.

OBJECTIVE: To determine the usefulness of an indirect immunoflourescence antibody test for antibodies to Bartonella henselae in diagnosing cat scratch disease (CSD). DESIGN AND SETTING: Retrospective case survey of 354 patients whose sera were tested for antibodies to B. henselae at Royal Perth Hospital, Perth, and the Institute of Clinical Pathology and Medical Research, Sydney. In 1994; and measurement of the background prevalence of antibodies to B. henselae. MAIN OUTCOME MEASURES: Prevalence of antibodies to B. henselae, odds of a positive titre (> or = 64) in patients with and without specific risk factors for CSD and clinical features of the disease; prevalence of antibodies to B. henselae in randomly selected blood donors. RESULTS: Demographic, clinical and cat contact data were available for 303 patients. Sixty-four (21.1%) had a positive titre, as did 53 of 98 (54%) patients with a history of cat contact and lymphadenopathy. This proportion increased to 62% (38 of 61 patients) in patients with a history of cat scratch or bite and to 90.3% (28 of 31) in those with cat contact, lymphadenopathy and histological evidence of granulomatous lymphadenitis. Patients who developed lymphadenopathy after cat contact were significantly more likely to have a positive titre than those without this history (odds ratio [OR], 20.8; 95% confidence interval [95% Cl], 9.6-46; P < 0.0001). Inclusion of a history of a cat scratch or bite significantly raised the odds of being seropositive (OR, 13.7; 95% Cl, 6.8-28.1; P < 0.0001), and the presence of granulomas on lymph node biopsy further increased the odds (OR, 124.4; 95% Cl, 19.4-1073; P < 0.0001). The prevalence of antibodies to B. henselae in random blood donors in New South Wales was about 5% (five of 102 sera samples). CONCLUSIONS: The immunofluorescence antibody test for B. henselae can be expected to be positive in just over half the patients with clinically suspected CSD, and it has a positive predictive value of 83%. In a significant number of cases the diagnosis cannot be made on the basis of the results of immunofluorescence antibody testing alone and further investigations, including lymph node biopsy, may be required.

Adolescent↗
PubMed1990

Cellular fatty acid compositions of an unidentified organism and a bacterium associated with cat scratch disease.

The cellular fatty acid composition of a gram-negative bacterium associated with cat scratch disease was determined by capillary gas chromatography-mass spectrometry (GC-MS). The fatty acid profile of this organism was distinct from those of other bacteria we have tested and was characterized by an unknown acid which was identified as 11-methyloctadec-12-enoic acid. The position of the branched methyl group in this acid was established by GC-MS of the reduced acid, and the location of the double bond was confirmed by GC-MS analysis of dimethyl disulfide derivatives. Another clinical isolate with no known relationship to cat scratch disease but with similar morphological and biochemical features had a similar fatty acid profile, including 11-methyloctadec-12-enoic acid.

Cat-Scratch Disease↗
PubMed1992

Intracellular growth of Afipia felis, a putative etiologic agent of cat scratch disease.

The organism Afipia felis, which is though to be an etiologic agent of cat scratch disease, is a gram-negative rod that is clearly seen in infected tissue but is very difficult to isolate from clinical specimens; there has been only one report to date of the successful isolation and maintenance of the bacterium on artificial medium. We have found that A. felis will attach, invade via phagocytosis, and multiply intracellularly within the phagosomes of primary human monocytes and HeLa cells. Once in the cell, the bacterium appears to change morphologically, becoming longer and more pleomorphic, and loses its ability to grow on an artificial medium. Unique proteins have been identified in both the intra- and extracellular variants of A. felis. Convalescent-phase sera from patients with cat scratch disease react poorly with intracellular and extracellular bacteria, suggesting a poor humoral response. The tissue culture protocol presented has been used to isolate 14 new strains of A. felis and has for the first time permitted study of the pathogenesis of this unique organism.

Blotting, Western↗