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At least 289 records · Page 16Linked to original sources
PubMed1988

Effect of methylmercury body burden on kidney following unilateral nephrectomy.

The model of renal enlargement after unilateral nephrectomy is chosen to study the effect of methylmercury (MeHg) burden on organ growth. The results show that MeHg burden only impedes DNA synthesis, but not other macromolecular synthesis (RNA and protein). Despite the gradual increase of kidney weight and increase of total RNA and protein content in the remaining kidney, DNA remained unchanged. There is no difference between the control and the MeHg-treated group. 3H-thymidine incorporation study shows that unilateral nephrectomy elicited minimal DNA synthesis in the remaining kidney. Again there is no statistically significant difference of 3H-thymidine incorporation between the control and the MeHg-treated group. On a separate experiment, the folic-acid-induced renal DNA synthesis is also suppressed by MeHg burden. From these data it is concluded that chronic exposure to MeHg does not affect one of the cellular repair mechanisms: hypertrophy.

Animals↗
PubMed1990

[Observations on the course of borderline hypertension in workers in ore mining with variable occupational body burden].

The blood pressure response of 198 ore miners--working above ground as well as underground--suffering from borderline-hypertension was checked over a period of 5 years. After a period of 5 years 40.9% of the test persons developed a hypertension in 18.7% of the miners the blood pressure returned to normal and with 40.4% it remained within the limits. No statistically significant relationship could be established between the blood pressure response and the various work loads such as the complex work load on face workers, work above ground and underground, shift work, the total time away from home, physically heavy work as well as exposure of the body or part of it to vibrations. Since the individual risk of developing hypertension, particularly with regard to people affected by borderline-hypertension, cannot be predicted the factory doctor has to provide for the adequate health care the group in question.

Adult↗
PubMed1996

Metal body burdens and detoxifying enzymes in spiders from industrially polluted areas.

Detoxifying enzymes have been assayed and metal concentrations have been monitored in four species of spiders from differently contaminated localities in Southern Poland. A behavioural feeding activity and the life style decide on sensitivity and vulnerability of spiders. Wolf-spiders, more active than the web-spinners, cumulate higher amounts of metals, reflecting quantitatively and qualitatively the pollution level in their environment. Detoxifying systems in spiders appeared inducible and efficient to maintain normal physiological responses. Within web-spinning spiders the linyphiids seem to be the most effective regulators of metal burdens. Their detoxifying capabilities correlate well with increased industrial contaminants. The analysis of biochemical biomarkers of exposure confirmed earlier ecological findings that species of the family Linyphiidae are more favoured than the Araneidae. Differences in their feeding activity, behaviour of web-spinning and the size of animals would explain alterations in detoxifying abilities between Meta segmentata and Araneus diadematus.

Journal Article↗
PubMed1985

The human body burden of mirex in the southeastern United States.

Mirex is an organochlorine chemical with pesticidal and other industrial usages. Biologically, mirex was used as an insecticide for the control of imported fire ants in large areas of the southeastern United States. Evidence of mirex exposure in a national survey of chemicals in adipose tissue led to a more intensive survey of the general population in treated counties of the southeastern United States. Forty sites were selected randomly from 8 southeastern states where mirex was used widescale to combat fire ants; a total of 624 adipose tissue specimens were collected from these 40 sites. Tissue specimens were prepared by a modified Mills-Onley-Gather procedure and analyzed for mirex and selected other organochlorine compounds by electron-capture gas chromatography. Positive residue findings were confirmed by combined gas chromatography and mass spectrometry. Weighted statistical analysis of the data was conducted to estimate the level of mirex in the study area. It was estimated that 10.2% of the population of southern United States had quantifiable levels of mirex in adipose tissue. The estimated geometric mean of the quantifiable residue amounts was 0.286 ppm (lipid basis). Statistical tests of association and regression were used to investigate possible relationships between the presence and levels of mirex, and the Census Division or state of tissue-specimen collection, by age, race, and sex. These analyses indicated that region or location of tissue specimen collection (assumed to be area of residence) strongly related to both the presence of mirex residue and the amount of mirex residue detected. This may be correlated with the amount of mirex applied for fire ant control or with some other exposure patterns in different regions.

Adipose Tissue↗