Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “urinary bladder”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 271 records · Page 15Linked to original sources
PubMed2002

Estimation of usefulness of monitoring tissue polypeptide antigen--TPA-M concentrations in the effectiveness surgical treatment of urinary bladder cancer.

BACKGROUND: Of all cancer tumours, urinary bladder cancer is the fourth must common in men and the seventh in women. The aim of this work was to answer the question whether tissue polypeptide antigen (TPA-M) determination in patients after electroresection of urinary bladder cancer can be used to establish the probability of tumour recurrence. MATERIAL AND METHODS: The research included 98 patients, all of whom had undertaken electroresection of urinary bladder tumour (TURT), which enabled its removal, and then estimation of malignancy and progression stage according to the international TNM scale. The mean age was 62.7 years. All patients had blood samples taken to determine TPA-M and then underwent routine cystoscopy examination. RESULTS: The patients with tumour recurrence (60, mean age 64 +/- 10) had TPA 30.2 +/- 4.3 U/l, the patients without recurrence (38, mean age 61.3 +/- 11) had TPA-M 26.2 +/- 3.18 U/l (p > 0.1). Taking the TPA-M threshold point 85 U/l as normal, true-positive results were 16.3%, true-negative were 31.6%, false-positive results were 7.1% and false-negative were 44.9%. The ROC curves with the calculated area under them are the measurement of the diagnostic estimation of TPA-M concentrations in specificity and sensitivity categories. CONCLUSIONS: For the examined group the calculated P was 0.45. If P value is under 0.5 it is considered that the test should not be used in diagnosing recurrence of urinary bladder cancer.

Journal Article↗
PubMed1980

The effect of normal rat urine on mucosal regeneration in heterotopic urinary bladder.

A heterotopically transplanted urinary bladder (HTB) of the rat with a communicating Ommaya reservoir was developed in our laboratory as a model to elevate potential bladder carcinogens and the role of urine on the carcinogenesis. Following transplantation the mucosa undergoes ischemic necrosis, but regeneration ensues rapidly within 2 weeks. The present investigation evaluated the effect of two variants on the natural history of the HTB mucosa immediately following its transplantation: (1) presence of normal rat urine, and (2) the effect of alteration of intraluminal osmolality. The results indicate that alteration of osmolality had no effect on the regenerative process, and the epithelium returned to normal in a few weeks. Weekly administration of pooled sterile rat urine into HTB, however, induced simple hyperplasia which persisted throughout the 20-week study period. The HTBs maintained with pooled rat urine did not attain the normal ultrastructural surface characteristics even at 20 weeks posttransplantation. It is concluded that urine exerts a stimulatory effect on the bladder epithelium when first administered to HTB during the active regenerating phase and as long as urinary contact continues.

Animals↗
PubMed2005

Bladder instillation of Escherichia coli lipopolysaccharide alters the muscle contractions in rat urinary bladder via a protein kinase C-related pathway.

Uropathogenic Escherichia coli is a common cause of urinary tract infection. We determined the effects of intravesical instillation of E. coli lipopolysaccharide (LPS, endotoxin) on muscle contractions, protein kinase C (PKC) translocation, and inducible nitric oxide synthase (iNOS) expression in rat urinary bladder. The contractions of the isolated rat detrusor muscle evoked by electrical field stimulations were measured short-term (1 h) or long-term (24 h) after intravesical instillation of LPS. One hour after LPS intravesical instillation, bladder PKC-alpha translocation from cytosolic fraction to membrane fraction and endothelial (e)NOS protein was elevated, and detrusor muscle contractions were significantly increased. PKC inhibitors chelerythrine and Ro32-0432 inhibited this LPS-enhanced contractile response. Application of PKC activator beta-phorbol-12,13-dibutyrate enhanced the muscle contractions. Three hours after intravesical instillation of LPS, iNOS mRNA was detected in the bladder. Immunoblotting study also demonstrated that the induction of iNOS proteins is detected in bladder in which LPS was instilled. 24 h after intravesical instillation of LPS, PKC-alpha translocation was impaired in the bladder; LPS did not affect PKC-delta translocation. Muscle contractions were also decreased 24 h after LPS intravesical instillation. Aminoguanidine, a selective iNOS inhibitor, blocked the decrease in PKC-alpha translocation and detrusor contractions induced by LPS. These results indicate that there are different mechanisms involved in the alteration of urinary bladder contractions after short-term and long-term treatment of LPS; an iNOS-regulated PKC signaling may participate in causing the inhibition of muscle contractions in urinary bladder induced by long-term LPS treatment.

Animals↗
PubMed1976

[Plastic repair of the urinary bladder].

Clinical observations of 76 patients in whom an artifical urinary bladder was constructed from the rectum are presented. 52 patients were operated upon for cancer of the urinary bladder, total papillomatosis, a metastasis of uterine cancer in the bladder, cancer of the sigmoid with the urinary bladder involvement, sarcoma and cancer of the prostate with the bladder involvement. 17 patients were operated upon for extrophy, 7 -- for cancer of the urethra. An isolation of the rectum is followed by ligation of the upper rectal and vein. Fifteen patients died postoperatively due to peritonitis (6), ascending infection of the urinary tract (4), postoperative shock (I), phlegmon of the minor pelvis (I). In late postoperative period an artificial urinary bladder provides for reservoir and excretory functions.

Aged↗
PubMed1987

Bladder vasodilatation and release of vasoactive intestinal polypeptide from the urinary bladder of the cat in response to pelvic nerve stimulation.

In the feline urinary bladder blood flow was determined by means of a direct blood flow measurement technique before and during pelvic nerve stimulation. Simultaneous sampling of venous blood from the bladder was performed, and the output of vasoactive intestinal polypeptide (VIP) was determined by means of radioimmunoassay. Maximal stimulation of the pelvic nerves led to a clearcut increase in intravesical pressure and a small but sustained increase of blood flow in the bladder wall. These changes were associated with a drastic increase in VIP output from the bladder, increasing from a control level of 0.2 fmol./min. to 15 fmol./min. during stimulation. The results suggest that VIP might be the neurotransmitter responsible for the vasodilatation in the feline urinary bladder in response to pelvic nerve stimulation. The discrepancy between the moderate blood flow increase and the pronounced increase in VIP-release might, however, indicate that VIP exerts its main effects elsewhere in the bladder than in the vascular bed, for instance the detrusor smooth muscle.

Animals↗
PubMed2005

Intraoperative pathology consultation for kidney and urinary bladder specimens.

CONTEXT: Intraoperative pathology consultation for kidney and urinary bladder specimens is relatively infrequent. Scant literature is devoted to this topic. OBJECTIVE: The clinical indications and diagnostic usefulness and pitfalls of intraoperative pathology consultation of kidney and urinary bladder specimens will be reviewed, based on literature and personally encountered cases. DATA SOURCES: The indications for intraoperative pathology consultation for renal lesions included (1) surgical margins in partial nephrectomy specimens, (2) solid renal mass in unusual clinical or radiologic settings, (3) synchronous renal and extrarenal masses, (4) cystic renal lesions, (5) ureteral surgical margin for transitional cell carcinoma, (6) multiple renal masses, (7) solid mass in a diffusely cystic kidney, and (8) evaluation of renal injury. The indications for urinary bladder included (1) status of the surgical margins, (2) diagnosis of bladder tumor biopsy, (3) diagnosis of extravesical tumors with vesical extension, (4) diagnosis of extravesical mass, including pelvic lymph nodes encountered during cystectomy, and (5) status of bladder neck margin during radical prostatectomy for cancer. The frequent problematic areas for the kidney included misdiagnosis or incorrect classification of cystic tumors or spindle cell tumors, and confusion of clear cell renal cell carcinoma with inflammatory lesions. The problematic areas for urinary bladder included the differential diagnoses of high-grade dysplasia/carcinoma in situ with reactive changes at the ureteral or urethral surgical margins. CONCLUSIONS: Distinctive indications and diagnostic pitfalls are recognized for intraoperative consultation of renal or urinary bladder lesions. Awareness of the pertinent problems should improve diagnostic accuracy and facilitate the proper management of these lesions.

Frozen Sections↗
PubMed2004

[The relevance of urinary bladder filling in suprapubic bladder catheterization].

Suprapubic punction of the urinary bladder (cystostomy) may cause typical, sometimes lethal injuries of pelvic organs especially in cases of an insufficient bladder filling. Some of these cases were described in the literature of legal medicine. To verify the importance of the cranial displacement of the vulnerable intestine by a filled bladder, the distances between the upper end of the symphysis and apex vesicae were measured in 76 forensic autopsies in situ and correlated with the filling volume of the urinary bladder. 69,2% of cases with a bladder filling volume up to 200 ml showed a suprapubic distance of only < or =4 cm. However, this distance collides with the preferred clinical intervention point, 2 fingers above the symphysis. In all cases with a bladder filling volume > or =300 ml, the distances were > or =5 cm. Based on our measurements, we recommend a preoperative bladder filling of > or =300 ml for an uncomplicated insertion of a suprapubic catheter.

Cadaver↗
PubMed1981

[Closed drainage of the urinary bladder. Method and results in the rehabilitation of the infected, contracted bladder in stroke patients].

Catheterism of the urinary bladder in the primary therapy after stroke is often the initial condition for the development of an infected contracted bladder. The patient is bearing his catheter for life because there is a disproportion of production of urine (greater than 1500 ml) and capacity of the urinary bladder (less than 100 ml). Infection and restriction of movement hinder his discharge from hospital. There are five conditions for a treatment of contracted bladder using a closed drainage of the bladder: 1. functional training of the capacity, 2. reduction of reinfection and antibiotic therapy, 3. training of sensibility, 4. use of day-and-night-rhythm, 5. gymnastics for pelvic floor. The therapeutic result--200 ml capacity of urinary bladder, control of infection and voluntary miction--can be reached after 4-6 weeks, if patient, nursing staff and physician are cooperative. The experiences of 8 cases demonstrate that a contracted bladder needs not be a final state, but can be rehabilitated.

Aged↗
PubMed2005

[Total laparoscopic excision of a leiomyoma of the urinary bladder -- a case report].

INTRODUCTION: Leiomyoma of the urinary bladder is a rare, benign tumor of mesenchymal origin. Treatment options are discussed. Besides open surgery and transurethral resection of small, submucosal tumors, laparoscopic excision is an effective therapeutical option with a low complication rate. CASE REPORT: We report the medical history of a 36-year-old woman suffering from a leiomyoma of the urinary bladder and the therapy through laparoscopic excision. CONCLUSIONS: Laparoscopic removal of urinary bladder leiomyomas is a suitable alternative to common therapeutical procedures.

Adult↗
PubMed1984

[A case of leiomyoma of the urinary bladder in a woman with the chief complaint of total urinary retention].

Benign nonepithelial tumor of the urinary bladder is very rare. We experienced a case of a 33-year-old woman who complained of total urinary retention. Vaginal examination revealed a hen's egg sized retrovesical tumor. IVP revealed a filling defect on the cystogram. Cystoscopy revealed protrusion of left side of the bladder neck and intact mucosa. Transvaginal needle biopsy of the tumor was done, and pathohistological diagnosis of the tumor was done, and pathohistological diagnosis of the specimen was leiomyoma. The tumor was intramural type and was resected. It was 5.5 X 5 X 5 cm in size, weighed 80 g, and pathohistological diagnosis was leiomyoma of the urinary bladder. 57 cases of leiomyoma of the urinary bladder including this case have been reported in Japan. No special method of diagnosing leiomyoma of the urinary bladder exists, but in some cases, needle biopsy is very effective.

Adult↗
PubMed1983

Membrane potential of rat urinary bladder epithelial cells.

Rat urinary bladder epithelial cells exhibited a membrane potential of about -22 (apical) and -24 (basal) mV in normal Krebs solution. Blockade of Na+ entry through the apical membrane by Na+ depletion of administration of amiloride, or inactivation of the Na pump in the basal membrane by ouabain resulted in marked hyperpolarization of the epithelial cells. N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), a specific carcinogen, and saccharin, a potent enhancer of carcinogenesis, inhibited development of the Na+ channel and/or Na pump on the bladder epithelium. This physiology may contribute to the abnormal intracellular environment leading to bladder carcinoma.

Animals↗
PubMed2006

Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts.

Deficiency of glutathione S-transferase (GST) or NAD(P)H:quinone oxidoreductase 1 (NQO1) in humans is associated with increased risk of urothelial bladder cancer. Broccoli sprouts are a rich source of several isothiocyanates (ITCs), particularly sulforaphane (SF) which has shown promising chemopreventive activities. We report herein that a broccoli sprout ITC extract significantly induced both GST and NQO1 in cultured bladder cells in vitro and in rat bladder tissues in vivo. The inducer activity of the extract was comparable to that of pure SF on the basis of total ITC concentrations. The bladder was one of the most responsive organs to induction of the enzymes by the extract. Induction of the enzymes by the extract was largely mediated by Nrf2, a transcriptional factor that plays a critical role in the induction of many detoxification enzymes. Moreover, induction of GST and NQO1 in the rat bladder in vivo by the extract was associated with high levels of urinary ITC metabolites, but no toxic effects on the bladder mucosa were detected. In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer.

Animals↗
PubMed1993

Primary angiosarcoma of the urinary bladder.

Angiosarcoma of the urinary bladder is an extremely rare neoplasm with only 5 cases having been reported in literature so far. The etiologic factors implicated in visceral angiosarcoma are exposure to thorium dioxide, arsenic, polyvinyl chloride, irradiation, chemotherapy and the presence of retained foreign body material. The histologic picture is characterised by irregular vascular channels showing anastomoses and lined by atypical endothelial cells. The prognosis of this neoplasm is uniformly poor. Herein we report a case of primary angiosarcoma of the bladder in a man who had no prior exposure to any of the etiologic factors and is disease free 8 months after treatment with partial cystectomy and adjuvant postoperative pelvic irradiation.

Hemangiosarcoma↗
PubMed1988

Neuronal and behavioural consequences of chemical inflammation of rat urinary bladder.

Exposure of the urinary bladder of rats to chemical irritants such as turpentine produces a long lasting inflammatory response. Chemosensitive primary afferent fibres supplying the bladder are excited by the irritants. Dorsal horn cells in L6, S1 are also excited, and show slowly developing and persistent increases in ongoing activity, responses to electrical stimulation of vesical afferents and distension of the bladder. These changes may provide an explanation for the sensory and reflex disturbances that occur in cystitis in man.

Animals↗
PubMed2002

An undiagnosed phaeochromocytoma of the urinary bladder.

Phaeochromocytoma of the urinary bladder is rare. We report a case of a patient with undiagnosed bladder phaeochromocytoma who developed haemodynamic disturbances during routine diagnostic cystoscopy. The diagnosis was only confirmed postoperatively.

Aged↗
PubMed2001

Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.

The significance of O6-methylguanine formation in urinary bladder carcinogenesis was examined using O6-methylguanine-DNA methyltransferase (MGMT) transgenic mice carrying the ada gene. The ada MGMT transgenic mice demonstrated no differences in development of carcinogens-induced urinary bladder carcinomas compared with non-transgenic mice. Furthermore, no variation in p53 mutation frequency was evident between the two groups. The results indicated that other repair systems may have an important role for urinary bladder carcinogenesis. p53 knockout mice showed high sensitivity to urinary bladder carcinogens and increased cell proliferation plays an important role in urinary bladder carcinogenicity of p53 knockout mice. In addition, p53 knockout mice have an organ-specific increased sensitivity to carcinogenicity.

Animals↗
PubMed1983

The role of CT in demonstrating perivesical tumor growth in the preoperative staging of carcinoma of the urinary bladder.

Carcinoma of the urinary bladder was staged both clinically and by CT in 32 patients before they underwent total cystectomy. Eleven of the patients had perivesical growth demonstrated at histopathological examination of the cystectomy specimen. This was diagnosed by CT in all 11 of these patients before cystectomy, but it was discovered by clinical staging in only four patients prior to cystectomy. Seven patients without histopathologically proved perivesical growth were considered to have perivesical spread as demonstrated by CT findings. Three of these patients had perivesical fibrosis that was misinterpreted as perivesical tumor growth, and in all seven patients the perivesical changes were adjacent to the area of present or previous changes in the bladder wall. CT is a valuable addition to clinical staging because it demonstrates perivesical tumor growth.

Carcinoma↗
PubMed2004

Long-term bladder, colorectal, and sexual functions after radical radiotherapy for urinary bladder cancer.

PURPOSE: To describe bladder, colorectal, and sexual dysfunctions among long time survivors after radical radiotherapy for urinary bladder cancer, and compare the results with a healthy control group. MATERIALS AND METHODS: We identified 261 patients who had received radical radiotherapy for bladder cancer in the period 1994-2001. Patients were treated with a CT-based three-field technique with 60 Gy in 2 Gy fractions, 5 fractions/week. Sixty-two patients were alive and candidates for the study. For comparison, 185 controls were selected from the Danish National Register. Information was collected in an interview based on the LENT SOMA tables and questions concerning changes in daily life following radiotherapy. RESULTS: Fifty-three patients (85%), median age 77 years (range 51-84) entered the study. Median follow-up time was 29 months (range 18-103 months). There were 63 controls (34%). Fourteen percent of the patients reported that radiotherapy had moderate to severe impact on their present bladder function. Compared with the control group, significantly more patients had dysuria, and urethral stenosis, and were using bladder catheter. Twenty-nine percent of the patients reported moderate to severe impact on their present bowel function. Significantly more patients had diarrhoea, fecal urgency and fecal incontinence, and were using antidiarrhoea medication and sanitary pads. Twenty-five percent of the patients reported moderate to severe impact on their present sexual function. Impotence and lack of sexual desire were significantly higher among the male patients. CONCLUSIONS: Following radical radiotherapy, most patients had a well functioning bladder, whereas 14% reported moderate to severe bladder dysfunctions. Due to the presence of bowel in the treatment field, radiotherapy is associated with considerable long-term intestinal side effects. Moreover, radiotherapy may result in sexual dysfunctions.

Aged↗