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PubMed2002

Perineal muscles and motoneurons are sexually monomorphic in the naked mole-rat (Heterocephalus glaber).

Naked mole-rats are eusocial mammals that live in colonies with a single breeding female and one to three breeding males. All other members of the colony, known as subordinates, are nonreproductive and exhibit few sex differences in behavior or genital anatomy. This raises questions about the degree of sexual differentiation in subordinate naked mole-rats. The striated perineal muscles associated with the phallus [the bulbocavernosus (BC), ischiocavernosus (IC), and levator ani (LA) muscles], and their innervating motoneurons, are sexually dimorphic in all rodents examined to date. We therefore asked whether perineal muscles and motoneurons were also sexually dimorphic in subordinate naked mole-rats. Muscles similar to the LA and IC of other rodents were found in naked mole-rats of both sexes. No clear BC muscle was identified, although a large striated muscle associated with the urethra in male and female naked mole-rats may be homologous to the BC of other rodents. There were no sex differences in the volumes of the LA, IC, or the urethral muscles. Motoneurons innervating the perineal muscles were identified by retrograde labeling with cholera-toxin-conjugated horseradish peroxidase. All perineal motoneurons were found in a single cluster in the ventrolateral lateral horn, in a position similar to that of Onuf's nucleus of carnivores and primates. There was no sex difference in the size or number of motoneurons in Onuf's nucleus of naked mole-rats. Thus, unlike findings in any other mammal, neither the perineal muscles nor the perineal motoneurons appear to be sexually differentiated in subordinate naked mole-rats.

Animals↗
PubMedDate not supplied

Psychosocial factors, sex differences, and atherosclerosis: lessons from animal models.

OBJECTIVE: Premenopausal women, compared with men, are relatively spared from coronary heart disease and the underlying atherosclerosis. Our purpose has been to elucidate the reason for this difference and to explore the role of behavioral factors in this phenomenon. METHODS: Studies employed socially housed cynomolgus macaques (Macaca fascicularis) fed an atherogenic diet and subjected to behavioral observations. Ovariectomy, with or without hormone replacement, was used to test specific hypotheses about estrogen's role in the protection of females from atherosclerosis and coronary heart disease. RESULTS: Female macaques, like women, are resistant to atherosclerosis. However, this resistance is modified by social status-dominant monkeys develop little atherosclerosis, whereas subordinates resemble males in the amount of lesion that occurs. Subordinate females also are characterized by hypercortisolemia, behavioral dysfunction, and impaired ovarian function; the resulting low concentrations of circulating estrogen perhaps explain their accelerated atherosclerosis. Notably, atherosclerosis is exacerbated in ovariectomized monkeys but is suppressed in association with pregnancy, a hyperestrogenic state. Moreover, exogenous estrogen (an oral contraceptive) inhibits atherosclerosis in premenopausal social subordinates. CONCLUSIONS: To the extent that our results apply to women, they highlight the potential importance of behavioral stressors and their effects on estrogen activity in the premenopausal development of atherosclerosis. The triad of hypercortisolism, ovarian impairment, and psychiatric morbidity found in monkeys also occurs in women and may represent a high-risk state for disorders of the cardiovascular system and perhaps, other estrogen-sensitive tissues.

Adrenocortical Hyperfunction↗
PubMed1995

Visible burrow system as a model of chronic social stress: behavioral and neuroendocrine correlates.

In mixed-sex rat groups maintained in visible burrow systems (VBS), consistent asymmetries in offensive and defensive behaviors of male dyads are associated with the development of dominance hierarchies. Subordinate males are characterized by particular wound patterns, severe weight loss, and a variety of behavioral changes, many of them isomorphic to target symptoms of clinical depression. In two VBS studies, subordinate males showed increased basal levels of plasma corticosterone (CORT), and increased adjusted adrenal and spleen weights compared to controls, and often, to dominants as well. Thymus weights and testosterone levels of subordinates were not reliably different in one study using highly aggressive males, but were reduced, along with testes weights, in a second study using unselected males. Glucocorticoid receptor binding levels in hippocampus, hypothalamus, and pituitary were not different, nor were aldosterone levels. When tested in a restraint stress procedure, subordinates had higher basal CORT levels, but about 40% of these animals showed a reduced, or absent, CORT response to restraint. These findings indicate that subordination may be reflected in high magnitude changes consistent with physiological indices of prolonged stress. Dominant rats of such groups may also show physiological changes suggesting stress, particularly when the groups are comprised of highly aggressive males only. The VBS colony model thus appears to enable rat groups to produce natural, stress-engendering, social interactions that constitute a particularly relevant model for investigating the behavioral, neural, and endocrine correlates of chronic stress.

Adrenal Glands↗
PubMed1991

Synergistic effects of kinship, sex and rank in the behavioural interactions of captive stump-tailed macaques.

In almost all non-human primate species kinship, sex and rank bias the patterning of interactions among subjects, seemingly in a way that favours the individual's fitness. A number of studies have been done in order to study separately the effects of these variables, concluding that an adequate model of interactions cannot be developed assuming preponderance of a single variable. The 'willingness' of one animal to interact with another can be explained as the result of assessing the possible outcomes (proximate and/or ultimate) of the interaction. The interrelationship of variables such as kinship, sex and rank, among others, provides the actors with a basis for deciding their rates of social interactions. The following study was done to assess whether kinship, rank and sex exerted independent, additive effects in the within-group distributions of eight social behaviour categories of captive groups of stump-tailed macaques. We found that the three variables synergistically affected the patterning of all behavioural categories. This suggests that the pay-offs of social interactions do not vary linearly, being intrinsically correlated with the actors' attributes so that uncertainty in the choice of a potential partner is minimized.

Aggression↗
PubMed2007

Antecedents and outcomes of abusive supervision: test of a trickle-down model.

The authors examined antecedents of abusive supervision and the relative importance of interactional and procedural justice as mediators of the relationship between abusive supervision and the work outcomes of affective organizational commitment and individual- and organization-directed citizenship behaviors. Data were obtained from subordinate-supervisor dyads from a telecommunication company located in southeastern China. Results of moderated regression analysis revealed that authoritarian leadership style moderated the relationship between supervisors' perceptions of interactional justice and abusive supervision such that the relationship was stronger for supervisors high rather than low in authoritarian leadership style. In addition, results of structural equation modeling analysis revealed that subordinates' perceptions of interactional but not procedural justice fully mediated the relationship between abusive supervision and the work outcomes. Implications for future investigations of abusive supervision are discussed.

Authoritarianism↗
PubMed2002

Transformational leadership and moral reasoning.

Terms such as moral and ethical leadership are used widely in theory, yet little systematic research has related a sociomoral dimension to leadership in organizations. This study investigated whether managers' moral reasoning (n = 132) was associated with the transformational and transactional leadership behaviors they exhibited as perceived by their subordinates (n = 407). Managers completed the Defining Issues Test (J. R. Rest, 1990), whereas their subordinates completed the Multifactor Leadership Questionnaire (B. M. Bass & B. J. Avolio, 1995). Analysis of covariance indicated that managers scoring in the highest group of the moral-reasoning distribution exhibited more transformational leadership behaviors than leaders scoring in the lowest group. As expected, there was no relationship between moral-reasoning group and transactional leadership behaviors. Implications for leadership development are discussed.

Adult↗
PubMed2004

Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits.

The question of how ostensibly aversive social stress experiences in an aggressive confrontation can persistently increase intense drug taking such as cocaine 'bingeing' needs to be resolved. The biology of social conflict highlights distinctive behavioral, cardiovascular and endocrine profiles of dominant and subordinate animals, as seen also in rodents and primates under laboratory conditions. In contrast to continuous subordination stress that produces chronic pathophysiological consequences and often is fatal, animals adapt to brief episodes of social defeat stress, but show enduring functional activation in mesocorticolimbic microcircuits. Uncontrollable episodes of social defeat stress produce long-lasting tolerance to opiate analgesia and, concurrently, behavioral sensitization to challenges with either amphetamine or cocaine. One week after a single social defeat stress, cross-sensitization to cocaine is evident in terms of enhanced motor activity as well as in terms of increased Fos labeling in the periaqueductal grey area, the locus coeruleus, and the dorsal raphe nuclei. When challenged with a low amphetamine dose, the behavioral and neural effects of repeated brief episodes of social defeat stress persist for months. Previous exposure to social defeat stress can (1). significantly shorten the latency to acquire cocaine self-administration, (2). maintain this behavior at low cocaine unit doses, (3). significantly increase the levels of cocaine taking during a 24 h binge of continuous drug availability, (4). dysregulate the timing of consecutive infusions, and (5). abolish the circadian pattern of self-administration. Amygdaloid modulation, especially originating from central and basolateral nuclei, of dopaminergic pathways via peptidergic and glutamatergic neurons appears to be a key mechanism by which social defeat stress affects cocaine self-administration. Social stress alters the feedback from prefrontal cortex and thereby may contribute to the dysregulation of dopaminergic activity that is necessary for cocaine self-administration.

Aggression↗
PubMed2006

The effect of chronic exposure to highly aggressive mice on hippocampal gene expression of non-aggressive subordinates.

Exposure to a chronic psychosocial stressor changes the behavioral and neuroendocrine response pattern and causes structural changes in the rodent hippocampus. However, the underlying molecular mechanism of these changes induced by chronic stress is largely unknown. Recently, it was shown that exposure to a dominant highly aggressive mouse in the sensory contact model induced long-lasting stress symptoms in subordinate mice genetically selected for long attack latency (LAL mice). The aim of the present study was to study the effect of chronic stress on hippocampal gene expression in these subordinate LAL mice. GeneChips (Affymetrix) were used to compare gene expression profiles of LAL mice exposed to a sensory contact stressor for 25 days and their controls (one array per mouse, n=5 per line). After this stress paradigm, 131 genes were found differentially expressed (P<0.01). Strikingly, all of these genes showed a subtle downregulation in response to a chronic stressor. Interestingly, a significant overrepresentation of genes encoding structural components of ribosomes were found, suggesting diminished protein biosynthesis in the hippocampus of chronically stressed LAL mice. In addition, several genes of the NFkappaB signaling cascade, a pathway crucially involved in neuronal viability and neurite growth, were found to be downregulated. Together, we hypothesize that reduced NFkappaB signaling and diminished protein biosynthesis form part of the molecular mechanisms by which a chronic psychosocial stressor induces structural alterations in hippocampus of LAL mice.

Aggression↗
PubMed2006

Glucocorticoid receptors in lateral septum are involved in the modulation of the emotional sequelae induced by social defeat.

The current research studied the behavior adopted in the elevated plus maze (EPM) of rats previously subjected to a social defeat using the resident-intruder paradigm. One day after defeat, intruder animals exhibited an anxiogenic-like behavior in the EPM. In addition, we also evaluated the role of the corticosteroid receptor system (minerlocorticoid - MR - and glucocorticoid - GR - receptors) from the lateral septum (LS) on the anxiety generated by social defeat. The LS is an area of the aversive circuitry that is preferentially activated in passive defensive postures, and participates - together with other brain areas - in the modulation of aversive states. Intruder animals were infused into the LS with the MR or GR antagonist (ZK 91587 and RU 38486, respectively) and then submitted to social stress. All rats were tested in the EPM 1 day later. Only the administration of the GR antagonist, but not the MR antagonist, into the LS normalized the anxiogenic response induced by defeat. Furthermore, we examined whether a single injection of corticosterone (CS) could induce the same influence on the behavior in the EPM as that observed after social defeat. Moreover, we explored the effect of local infusions of MR or GR antagonists into the LS on the behavior exhibited by CS-treated rats in a subsequent EPM exposure. CS administration also exerted an increased anxiogenic-like behavior, which was normalized only by the local infusion of the GR antagonist. Based on these findings, we suggest that CS secreted by emotionally relevant stimuli acting via GR in LS plays an important role in the modulation of the emotional sequelae induced by social defeat.

Analysis of Variance↗
PubMed2006

[The personality change in epilepsy patients].

UNLABELLED: Personality disorders in epilepsy patients are frequent, and cause behaviour that is quite often troublesome for social environment of patients. The peculiarity of the clinical picture and mechanism of disorder formation has caused great interest. The term 'characteropathy in epilepsia patient', with characteristic viscosity as its important basic symptom, was eliminated from present medical terminology. Current worldwide international disease classification systems (DSM-IV and ICD-10) do not distinguish the separate form of personality disorders related to epilepsy. THE AIM: of the work is to analyse personality change in epilepsy patients on the basis of information from the patients and their relatives by means of the Adjective Check List (ACL) by Gough and Heilbrun, with taking into consideration the incidence of depression and the phenomenon of 'out-of-body experience'. MATERIAL AND METHODS: 40 patients with idiopathic generalized epilepsy with tonic - clonic seizures in age 19-55 years (mean 28 years) and 30 persons of age - matched control groups were examined. Each examined person and relative filled in ACL form two times in order to answer a question about the features of actual and premorbid patient's personality. The change of personality was evaluated according to ACL criteria and the psychoterapeutic criteria. In analysis were also taken into account the incidence of depression and the phenomenon of 'out-of-body experience'. RESULTS: The personality change in epilepsy patients was more frequent than in the control group and more frequent concerned need scales of ACL (endurance, deference, self- and others understanding, and aggression scale). In the grave epilepsy group considerable behavioral and interpersonal relationships change (more subordination tendency), features of dementia, and often phenomenon 'out-of-body experience' were observed. The range of personality change in the mild epilepsy group, like in control group, included the adaptation of family functioning principles to the patients' needs, the change of patients' emotional reaction and the meaning of life. In this group depression was often, but the phenomenon 'out-of-body experience' hardly ever appeared. CONCLUSIONS: The personality change in epilepsy patients was found in more than 80% of patients and concerned need scales of ACL (endurance, deference, self- and others understanding and aggression scale), and thematic scales (self ideal, self-control, and self-confidence scale). In the grave epilepsy group considerable behavioral changes, features of dementia, and often the phenomenon 'out-of-body experience' were observed. In the mild epilepsy group the changes were limited to alter of conviction and emotional response, often depression appeared, but hardly ever the phenomenon 'out-of-body experience' was observed.

Adult↗
PubMed2006

The self salience model of other-to-self effects: integrating principles of self-enhancement, complementarity, and imitation.

In a series of studies the Self Salience Model of other-to-self effects is tested. This model posits that self-construal salience is an important determinant of whether other-to-self effects follow the principles of self-enhancement, imitation, or complementarity. Participants imagined interactions (Studies 1 and 2) or were confronted (Studies 3 to 5) with dominant, submissive, agreeable, or quarrelsome person targets. Findings support the prediction that subsequent self-evaluations (Studies 1 to 3) and behaviors (Studies 4 and 5) follow the principles of self-enhancement when the personal self is activated (contrast away from undesirable targets, assimilation toward desirable targets); the principles of complementarity when the relational self is activated (contrast on the dominant-submissive dimension, assimilation on the agreeable-quarrelsome dimension); and the principles of imitation when the collective self is activated (assimilation regardless of desirability or dimension).

Affect↗
PubMed1993

Vaginal secretions increase the likelihood of intermale aggression in Syrian hamsters.

Although sexually receptive female hamsters prefer dominant males as mating partners, it is not clear what role the female might play facilitating aggressive interactions among males that would lead to the establishment of a status relationship. The ability of vaginal odors to stimulate male aggression was examined by paring randomly chosen males in a neutral arena with vaginal odors either present or absent. Males exhibited significantly more aggression when tested in the scented arena. Vaginal odors are efficient broadcast signals serving to space females, attract males, and to stimulate aggressive interactions among the males while inhibiting aggression towards the female.

Aggression↗
PubMed2003

Repeated social stress and the development of agonistic behavior: individual differences in coping responses in male golden hamsters.

In male golden hamsters, repeated social subjugation during puberty accelerates the development of adult aggressive behavior and enhances its intensity in the presence of smaller individuals. The current study is focused on the characterization of the hormonal and behavioral responses to social subjugation during puberty. Subjugation consisted of daily exposure to an aggressive adult for 20-min periods from postnatal day 28 (P-28) to P-42, while controls were placed into an empty clean cage. Plasma cortisol levels were measured prior to or immediately after treatment on P-28 and P-42. On P-28, exposure to an aggressive adult or a clean and empty cage caused an increase in plasma cortisol levels. However, only social subjugation resulted in elevated cortisol levels on P-42, showing that juvenile hamsters habituate to an unfamiliar environment but not to social subjugation. In addition, we found a relationship between the frequency of submissive responses during social subjugation and the development of aggressive behavior. The transition from play fighting to adult aggression was most accelerated in the least submissive animals. These data show that behavioral response to social subjugation determines the development of aggressive behavior in golden hamsters. Our data also suggest that submissive behavior is a form of coping that attenuates the behavioral consequences of social subjugation in male golden hamsters.

Adaptation, Psychological↗
PubMed2003

Circadian clock resetting by arousal in Syrian hamsters: the role of stress and activity.

Circadian rhythms in the Syrian hamster can be markedly phase shifted by 3 h of wheel running or arousal stimulation during their usual daily rest period ("subjective day"). Continuous wheel running is predictive but not necessary for phase shifts of this "nonphotic" type; hamsters aroused by gentle handling without running can also show maximal shifts. By contrast, physical restraint, a standard stress procedure and thus presumably arousing, is ineffective. To resolve this apparent paradox, phase-shifting effects of 3-h sessions of restraint or other stress procedures were assessed. In a preliminary study, phase shifts to arousal by gentle handling were significantly potentiated by the cortisol synthesis inhibitor metyrapone, suggesting that stress-related cortisol release may inhibit phase shifts to arousal. Next, it was confirmed that restraint in the subjective day does not induce phase shifts, but behavioral observations revealed that it also does not sustain arousal. Restraint combined with noxious compressed air blasts did sustain arousal and induced a significant cortisol response compared with arousal by gentle handling but did not induce shifts. Restraint combined with continuous horizontal rotation was also ineffective, as was EEG-validated arousal via confinement to a pedestal over water. However, 3 h of resident-intruder interactions (an intense psychosocial stress) or exposure to an open field (a mild stress) did induce large shifts that were positively correlated with indexes of forward locomotion. The results indicate that large phase shifts associated with arousal in the usual sleep period are neither induced nor prevented by stress per se, but are dependent on the expression of at least low levels of locomotor activity. Sustained arousal alone is not sufficient.

Animals↗