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At least 271 records · Page 15Linked to original sources
PubMed2000

Extensor tendon rupture after internal fixation of a distal radius fracture using a dorsally placed AO/ASIF titanium pi plate. Arbeitsgemeinschaft für Osteosynthesefragen/Association for the Study of Internal Fixation.

Extensor tenosynovitis has been reported as a complication of the Arbeitsgemeinschaft für Osteosynthesefragen/Association for the Study of Internal Fixation (AO/ASIF) pi plate. The authors present a case of extensor tendon rupture after internal fixation with a pi plate after one of the screws in the distal limb loosened. This mechanism of extensor tendon rupture has not been reported previously. With appropriate prevention, monitoring, and intervention this complication could have been avoided. Schnur DP, Chang B. Extensor tendon rupture after internal fixation of a distal radius fracture using a dorsally placed AO/ASIF titanium pi plate.

Bone Plates↗
PubMed1998

Intercomparison of radon and decay product measurements in an underground mine and EPA Radon Laboratory: a study organized by the IAEA International Radon Metrology Programme. International Atomic Energy Agency.

The International Atomic Energy Agency (IAEA) in Vienna and the European Union (EU) in Bruxelles formed the "International Radon Metrology Programme" (IRMP, scientific secretary: F. Steinhäusler, University of Salzburg, Austria). The IRMP is designed to assess and foster the improvement of radon and decay product measurements that are made around the world. Within the framework of the IRMP, the U.S. Environmental Protection Agency Radiation and Indoor Environments National Laboratory (EPA) in Las Vegas, Nevada, organized jointly with the U.S. Bureau of Mines an international intercomparison exercise at a former uranium mine (Twilight Mine, Colorado) and the EPA Radon Laboratory. The main objective of this exercise was to compare radon and radon decay product instruments under both well-controlled as well as widely fluctuating exposure conditions. The laboratory exposures occurred under relatively steady radon and decay product conditions, with a moderate equilibrium ratio, while the conditions in the mine fluctuated greatly and the equilibrium ratio was low. An additional purpose of the exercise was to provide a forum for manufacturers and measurement organizations worldwide to exchange information and plan improvements in their operations and calibration programs. Altogether 19 organizations from seven countries intercomparing 32 different radon and radon decay product instruments participated in this exercise. This paper summarizes the results from the analysis of the experimental data obtained in the Bureau of Mines Twilight Mine in July of 1994, as well as the results from the EPA Radon laboratory in August of 1994.

Calibration↗
PubMed1999

Biomechanical evaluation of a newly developed monocortical expansion screw for use in anterior internal fixation of the cervical spine. In vitro comparison with two established internal fixation systems.

STUDY DESIGN: The primary biomechanical stability of anterior internal fixation of the cervical spine obtained with a new monocortical expansion screw in vitro was evaluated. OBJECTIVES: To determine whether the anterior internal fixation of the spine obtained with the new monocortical expansion screw provides biomechanical stability comparable with that obtained with bicortical fixation. SUMMARY OF BACKGROUND DATA: The anterior plate instrumentation used with bicortical screw fixation in the cervical spine provides a primary stability superior to that associated with monocortical screw fixation. However, bicortical screws have the potential to perforate the posterior cortex. Therefore, monocortical instrumentation systems were developed, but without the biomechanical stability associated with bicortical systems. A new expansion screw for monocortical fixation was developed to improve biomechanical stability of monocortical systems. METHODS: Three different internal fixation systems were compared in this study: 1) H-plate with AO 3.5-mm bicortical screws, 2) cervical spine locking plate with monocortical screws, and 3) H-plate with the new monocortical expansion screws. Eight fresh human cadaver spine segments from C4 to C7 were tested in flexion-extension, axial rotation, and lateral bending using pure moments of +/- 2.5 Nm without axial preload. Five conditions were investigated consecutively: 1) intact spine; 2) uninstrumented spine with the segment C5-C6 destabilized; 3-5) instrumentation of the segment C5-C6 with the three implants mentioned above after removal of the disc and insertion of an interbody spacer. RESULTS: Between bicortical and monocortical expansion screw H-plate fixation, no significant differences were observed in all load cases concerning range of motion and neutral zone. The neutral zone and range of motion were significantly larger for the cervical spine locking plate than for bicortical and monocortical expansion screw fixation in all load cases, except neutral zone for axial rotation versus bicortical screw fixation. The instrumented cases only had a significantly lower range of motion and neutral zone than the intact cases in extension-flexion, whereas for lateral bending and axial rotation no significant differences could be observed. Because the experimental design precluded any cyclic testing, the data represent only the primary stability of the implants. CONCLUSIONS: In anterior instrumentation of the cervical spine using a H-plate, the new monocortical expansion screw provides the same biomechanical stability as the bicortical 3.5-mm AO screw and a significantly better biomechanical stability than the cervical spine locking plate. Therefore, the expansion screw may be an alternative to the bicortical fixation and does not involve the risk of penetration of the posterior vertebral body cortex.

Aged↗
PubMed1978

An International Collaborative Study of the assay of human placental lactogen: Establishment of WHO International Reference Preparation of human placental lactogen.

A reference preparation of human placental lactogen (HPL) for use in immunoassays is described. In an international collaborative study is was found to be stable and suitable for use as a standard for HPL in plasma. Estimates of HPL in plasma made in different laboratories agreed more closely when expressed in terms of this reference preparation than in terms of individual laboratory standards. The reference preparation is available in ampoules (coded 73/545) which each contain an identical amount of HPL, found in the study to be approximately 850 microgram. The preparation has been established as the International Reference Preparation for HPL for immunoassay and, based on the results of the study, the content of each ampoule is defined as 850 micro International Units.

Female↗
PubMed1983

The first international reference preparation of human parathyroid hormone for immunoassay: characterization and calibration by international collaborative study.

An international collaborative study of an ampouled preparation of highly purified human PTH (hPTH) was carried out on behalf of WHO by 29 laboratories in 12 countries. The results reported here show that the preparation of human PTH, freeze-dried and sealed in ampoules coded 79/500, has appropriate biological activities in in vitro bioassay systems, is free from cleaved products, as shown by high performance liquid chromatography, and is stable under conditions of accelerated thermal degradation. The ampouled hPTH was calibrated by immunoassays against the Research Standard of hPTH for immunoassay (ampoule code 75/549) distributed internationally from the National Institute for Biological Standards and Control since 1977. On the basis of this study and the agreement of the participants, the preparation coded 79/500 was established in 1981 by WHO as the First International Reference Preparation of PTH, Human, for Immunoassay; the unitage was defined as 0.1 IU (100 mIU)/ampoule. An ampouled preparation of unpurified extracted hPTH had characteristics similar to those of the purified ampouled preparation and was calibrated simultaneously to serve as a research reagent for immunoassay. Two ampouled lyophilized materials derived from tissue culture medium and secondary hyperparathyroid plasma, representative of biological fluids widely used as working standards for clinical immunoassays, were included in the collaborative study for comparative purposes. Results from immunoassay, bioassay, and high performance liquid chromatography systems suggest that these preparations contained little intact hPTH and consisted of mixtures of metabolites having predominantly carboxyl region immunoreactivity.

Biological Assay↗
PubMedDate not supplied

Plasma membrane steroidogenic cholesterol: the relative importance of membrane internalization rate and cholesterol extraction rate of internalized membrane.

Most cholesterol destined to become steroid hormone passes through the plasma membrane. Using MA-10 Leydig tumor cells as a model system, we determined that plasma membrane cholesterol disappeared 2.5-fold faster in cAMP-stimulated cells. Stimulation of MA-10 cells increased internalization so that 1.4-fold more membrane cycled through the cell per unit time. Increased internalization accounted for 26% of the cholesterol actually lost from cycling membrane. The remaining 74% was accounted for by increasing the extraction of cholesterol from internalized membrane.

Animals↗
PubMed2003

Distribution of interstitial cells of Cajal in the internal anal sphincter of patients with internal anal sphincter achalasia and Hirschsprung disease.

CONTEXT: Interstitial cells of Cajal (ICCs) are pacemaker cells in the smooth muscles of the gut. The internal anal sphincter (IAS) is the most caudal part of gastrointestinal tract. It has the important function of maintaining fecal continence. It has been proposed that ICCs in the IAS mediate the inhibitory innervation of the recto-anal reflexes. OBJECTIVE: To investigate the distribution of ICCs in the normal IAS and in the IAS of children diagnosed with internal anal sphincter achalasia (IASA) and Hirschsprung disease (HD). METHODS: At the time of IAS myectomy, specimens of the IAS were taken from 8 patients with IASA, 4 patients with HD, and 4 normal controls. All specimens were examined using anti-c-Kit and antiperipherin antibodies; immunolocalization was detected with light microscopy. Density of the ICCs was graded by computerized image analysis. RESULTS: There was strong peripherin immunoreactivity in the ganglia cells and nerve fibers in the normal IAS. The number of peripherin-positive nerve fibers was markedly reduced in the IAS in patients with IASA. In HD patients, there was lack of peripherin immunoreactivity in the IAS, but hypertrophic nerve trunks stained strongly. Many c-Kit-positive ICCs were present among the muscle fibers and between the muscle bundles in the normal IAS. In HD and IASA patients, ICCs were absent or markedly reduced. CONCLUSION: Altered distribution of ICCs in the internal sphincter in IASA and HD may contribute to motility dysfunction in these patients.

Adolescent↗
PubMed1998

International comparative analysis of injury mortality. Findings from the ICE on injury statistics. International Collaborative Effort on Injury Statistics.

OBJECTIVE: This report investigates international differences in injury mortality rates among 11 of the countries participating in the International Collaborative Effort on Injury Statistics. METHODS: The cause, intent, and age-specific injury mortality rates are calculated and presented from Australia, Canada, Denmark, England & Wales, France, Israel, New Zealand, The Netherlands, Norway, Scotland, and the United States. Data are presented by cause (or mechanism) and intent (or manner of death) according to the matrix framework for presenting injury mortality statistics published in August 1997. The benefits of this matrix approach to investigating injury mortality are explained with numerous examples. RESULTS: Injury death rates are higher in France and Denmark and lower in England & Wales, Israel, and The Netherlands than elsewhere. New Zealand, the United States, and Norway had similar average annual injury death rates of 56-57 per 100,000 population. As an example of the benefit of presenting data in the matrix framework, the total poisoning death rate in Denmark for all categories of intent (13 per 100,000) is about twice the rate in the United States. Unintentional poisoning death rates, however, are similar in the United States and Denmark (about 4 per 100,000) and are higher than elsewhere. However, the suicide poisoning death rate in Denmark is 3 times the rate in the United States. CONCLUSION: Using these results, the ICE on Injury will be investigating death registration practices in each of the countries to better understand international variation in injury mortality due to reporting or registration procedures.

Accidents↗
PubMed2002

[Redo coronary artery bypass grafting using the patent left internal thoracic artery graft as an in flow with composite internal thoracic artery Y grafting; report of a case].

In redo coronary artery bypass grafting (CABG), graft selection and revascularization methods are major problems. We experienced a redo-CABG with occluded previous vein grafts. These grafts were to the circumflex artery and right coronary artery. We conducted operation using cardiopulmonary bypass. We at this operation, chose right internal thoracic artery (RITA) as a conduit and anastomosed it to the side of functioning left internal thoracic artery (LITA) graft, and then diogonal branch, posterolateral branch, and atrioventricular branch were revascularized with the RITA. Post operative course was uneventful. Internal thoracic artery (ITA) is superior to vein graft and other arterial graft as to long term patency. We believe composite Y graft with the use of bilateral ITA can be one of the revascularization strategy in redo CABG.

Coronary Artery Bypass↗
PubMed1979

[Acute hypoxia and internal intensive care. IV. Results of respirator therapy in an internal intensive care unit].

In the fourth information on the topic acute hypoxia and internal intensive medicine the results of an internal intensive unit in the respiration of internal emergencies during one year are described. Issuing from this, questions of the respiration in insufficiency of the left heart, acute and chronic obstruction of the respiratory tract, restrictive disturbances of the lung, of neurological pictures of the disease, intoxications and shock lung are in the centre of the treatise.

Adult↗
PubMed1985

[Studies on the internal pressure of bone tumors and tumorous conditions. I. Pain and internal hypertension of bone lesions].

Internal pressure of bone tumors and tumorous conditions were measured in twenty patients. High pressure were frequently found in the patients with painful bone lesions while low pressures were common in the patients with no pain. High internal pressure may be a causative factor of aching bone pain at rest. It is suggested that venous obstruction without high internal pressure is not a causative factor of bone pain in simple bone cyst.

Adolescent↗
PubMed1984

Development of a nutrient data system for international use: INFOODS (International Network of Food Data Systems).

The current interest in the area of nutrition, diet, and cancer has called attention to some major deficiencies in the data base available to support a variety of research activities in the field. These deficiencies have been especially evident in epidemiologic studies where attempts are being made to characterize the dietary differences existing among various populations who have markedly different incidences of chronic diseases, including cancers, thought to be associated with diet. Such studies have been able to characterize international differences in diet by broad, nutrient-food categorizations, but they suffer from a dearth of detailed information on the nutrient content of the enormous variety of foodstuffs consumed by different populations and by the subgroup populations within each of the countries or geographic areas. At the present time, there is no internationally agreed upon food composition data system that provides a continuum of information on food composition. Current diet and disease studies require data on the human requirements or allowances for essential nutrients and quantified data on the ability of the food supply to provide these factors. In addition, information on other chemical components of foods that represent protection for or risk to good health is needed. Such a comprehensive data base would be helpful in providing criteria for formulation of public policy on diet-related public health issues. The Diet and Cancer Branch of the Division of Cancer Prevention and Control, National Cancer Institute, together with other groups support the development of an International Food Composition Data System (INFOODS) as a response to the need for more complete, reliable, and comprehensive information on the nutrient and nonnutrient composition of foods and beverages and their ingredients.

Food Analysis↗
PubMed1993

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

Ligand-induced internalization of epidermal growth factor (EGF) receptors via a high affinity saturable pathway requires sequences located in the carboxyl terminus distal to the tyrosine kinase domain. Three regions were found to contain endocytic motifs as defined by their ability to restore internalization function to EGF receptors truncated at the distal border of the kinase domain at residue 958. Deletional analysis identified the sequence 996QQGFF as essential for function of the region encompassing residues 993-1022. QQGFF and the deduced sequence of the region encompassing residues 973-991 (973FYRAL) could effectively replace the endogenous endocytic code of the transferrin receptor (YTRF). FYRAL and YTRF were less active than QQGFF when substituted into region 993-1022 of the EGF receptor, but a synthetic sequence (NNAYF), predicted to have structural features of a tight turn, effectively replaced QQGFF for EGF receptor internalization. Whereas EGF receptor sequences functioned effectively in the transferrin receptor, function of these sequences in the EGF receptor was strictly dependent on intrinsic tyrosine kinase activity as demonstrated kinetically and by immunofluorescence using semithin cryosections. Ligand-dependent endocytosis and down-regulation of the EGF receptor thus require multiple sequence motifs that are exchangeable between ligand-dependent and -independent receptors, but that require intrinsic tyrosine kinase activity for function in the context of the EGF receptor.

Amino Acid Sequence↗
PubMed1993

International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B. III. Comparability of apolipoprotein A-I values by use of international reference material.

In the third phase of the International Federation of Clinical Chemistry (IFCC) study for the standardization of apolipoprotein (apo) measurements, the preparation SP1-01, selected as the candidate international reference material for apo A-I, was investigated for its ability to transfer an accuracy-based value to the immunoassay calibrators and to produce comparability of the values for patients' samples. An apo A-I value of 1.50 g/L (SD 0.08 g/L) was assigned to SP1-01 by a highly standardized RIA calibrated with purified apo A-I for which the mass value had been determined by amino acid analysis. According to a common detailed protocol, the participants transferred the mass value from SP1-01 to the calibrator of each method. To confirm that uniformity of calibration ensures comparability of the values over a wide range of apo A-I values, each laboratory analyzed 50 fresh-frozen samples from individual donors, using an approach similar to that adopted by the Cholesterol Reference Laboratory Network. The consensus mean value for each sample was in excellent agreement with the value assigned by the Northwest Lipid Research Laboratories, with the average absolute bias between assigned and consensus value being 0.01 g/L. The among-laboratory CV on each of the 50 samples ranged from 2.1% to 5.6% (mean 3.6%), demonstrating that comparable apo A-I results can be obtained by a variety of immunochemical methods through the use of certified reference material. Based on the results obtained in these studies, SP1-01 has been approved as Apolipoprotein A-I International Reference Material by the World Health Organization.

Apolipoprotein A-I↗
PubMed1996

Relation between fever and outcome in injured victims of an internal armed conflict: the experience in a war surgery hospital of the International Committee of the Red Cross.

The records of 1,941 consecutive patients-victims of an internal armed conflict-admitted and treated over a period of 12 months at the surgical hospital of the International Committee of the Red Cross are analyzed retrospectively. They are divided in two groups: those with "fever" and those with "no fever." Patients are classified as having fever when the orally measured temperature is 39.0 degrees C or more for 2 or more subsequent days. The study indicates that fever is associated with the outcome in terms of an increase in the number of operations, the use of blood, the number of days in the hospital, and mortality, Surgeons working in internal armed conflicts without microbiological testing facilities have to consider fever as an important indicator for the clinical condition of their patients.

Afghanistan↗
PubMed1994

The movement of people in Asia: internal, intra-regional and international migration.

"The comprehensive overview of Asian-Pacific migration summarizes early population movements during the colonial period and describes the major types of contemporary Asian population movements: (1) environmental refugees, (2) political refugees, (3) internal population movements, (4) contract labor migration, (5) migration of permanent settlers, (6) business related movements and tourism. Projections of net international migration are given. Population growth, employment absorption and emigration pressures are likely to contribute to a large mobility potential for Asia, with significant implications for Australia."

Asia↗
PubMed1994

Removal of internal fixation--the effect on patients' complaints: a study of 66 cases of removal of internal fixation after malleolar fractures.

To estimate the effect of removal of internal fixation after treatment of malleolar fractures on postoperatively presented complaints, we retrospectively evaluated 66 patients by their records and by personal questionnaires. Of all the patients, 89.4% had one or more complaints. These were typically soreness over implant and cicatrix, reduced movement of the ankle joint, and strain-related pain. About 75% of these patients reported improvement after removal. The AO mode of fixation, i.e., typically by lateral semitubular plating and transsyndesmotic screw and a medial screw or pins, and the Wiberg-Cedell mode, i.e., typically consisting of lateral single or double cerclage and staple and medial pinning, constituted the principal groupings of the patients. The two groups were comparable. In this series, we found significantly more complaints associated with the AO mode in the postoperative period. We conclude that removal of internal fixation after malleolar fractures is indicated when common types of complaints are presented.

Adolescent↗
PubMed2000

Prediction of long-term response to recombinant human growth hormone in Turner syndrome: development and validation of mathematical models. KIGS International Board. Kabi International Growth Study.

It has become common practice to apply GH treatment in short Turner syndrome patients with the objective of promoting growth. The variability in response and the high costs of this treatment demand the individualization and optimization of therapy. Based on 686 prepubertal Turner patients from the Kabi International Growth Study (KIGS; Pharmacia & Upjohn, Inc. International Growth Database), we undertook a multiple regression analysis of height velocity (centimeters per yr) by using various parameters of potential relevance. Derived prediction models for the first 4 yr of GH treatment were validated with 76 additional KIGS patients and 81 patients from Tuebingen, Germany. Among the 6 predictors identified, the most influential variable for first year growth response was the natural log (ln) of the weekly GH dose. The first year growth response was also correlated with age and distance between height and target height (SD score; both negative) and body weight SD, number of GH injections per week, and oxandrolone treatment given additionally (positive). The first year model explains 46% of the variability, with 1 SD of 1.26 cm. For the second to fourth years, 5 predictors were identified: height velocity during previous years, weekly GH dose (ln), weight SD, oxandrolone therapy (all positive), and age (negative). These models explained 32%, 29%, and 30% of the variability, respectively, with SD scores of 1.1, 1.0, and 1.0 cm, respectively. When the models were applied to the other cohorts, no significant difference was noted between observed and predicted responses. Although the parameters used in our models do not entirely explain the variability in the growth response in Turner syndrome, the parameters themselves were clinically relevant to our present understanding and proved to be of high precision. Some of the tested markers, such as karyotype, do not contribute to the growth response. These variables make the models practical and suitable for planning beneficial and cost-effective therapy.

Anabolic Agents↗