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Results for “Vinyl Compounds”

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At least 271 records · Page 15Linked to original sources
PubMed1999

Enzymic acylation of 506U78 (2-amino-9-beta-D-arabinofuranosyl-6- methoxy-9H-purine), a powerful new anti-leukaemic agent.

A practical enzymic approach for acylation of 506U78 (2-amino-9-beta-D-arabinofuranosyl-6-methoxy -9H-purine), a powerful anti-leukaemic agent, is described. Novozyme-435, an immobilized preparation of Candida antarctica lipase, was used to acylate 506U78 regioselectively at the 5'-position. This rendered the compound more soluble and bioavailable. Vinyl acetate was used as the acyl donor and reactions were carried out in anhydrous 1,4-dioxane with up to 100 g/l of substrate input. Bioconversions were optimised to achieve impurity (3'-mono- and di-acetates) levels of less than 0.5%.

Acylation↗
PubMed2003

Qualitative and quantitative solid-phase microextraction gas chromatographic-mass spectrometric determination of the low-molecular-mass compounds released from poly(vinyl chloride)/polycaprolactone-polycarbonate during ageing.

A solid-phase microextraction (SPME) method was developed to quantitatively determine the amount of 6-hydroxyhexanoic acid in aqueous solutions. The SPME method in combination with GC-MS was then applied to identify and quantify the low-molecular-mass compounds migrating from a new poly(vinyl chloride) (PVC) material, PVC/polycaprolactone-polycarbonate (PCL-PC) during ageing in water. It was shown that only a small amount of 6-hydroxyhexanoic acid, the final hydrolysis product of PCL-PC, migrated from the blend during ageing at 37 and 70 degrees C. If, however, the temperature was raised to 100 degrees C rapid hydrolysis of PCL-PC resulted. In addition to 6-hydroxyhexanoic acid, 6-hydroxyhexanoic acid dimer, caprolactone, different carboxylic acids, acetophenone and phenol were identified. SPME-GC-MS was also applied to monitor the low-molecular-mass compounds migrating from the PVC/PCL-PC blend during thermo-oxidation.

Calibration↗
PubMed1994

Aerobic mineralization of trichloroethylene, vinyl chloride, and aromatic compounds by rhodococcus species.

Two Rhodococcus strains which were isolated from a trichloroethylene (TCE)-degrading bacterial mixture and Rhodococcus rhodochrous ATCC 21197 mineralized vinyl chloride (VC) and TCE. Greater than 99.9% of a 1-mg/liter concentration of VC was degraded by cell suspensions. [1,2-C]VC was degraded by cell suspensions, with the production of greater than 66% CO(2) and 20% C-aqueous phase products and incorporation of 10% of the C into the biomass. Cultures that utilized propane as a substrate were able to mineralize greater than 28% of [1,2-C]TCE to CO(2), with approximately 40% appearing in C-aqueous phase products and another 10% of C incorporated into the biomass. VC degradation was oxygen dependent and occurred at a pH range of 5 to 10 and temperatures of 4 to 35 degrees C. Cell suspensions degraded up to 5 mg of TCE per liter and up to 40 mg of VC per liter. Propane competitively inhibited TCE degradation. Resting cell suspensions also degraded other chlorinated aliphatic hydrocarbons, such as chloroform, 1,1-dichloroethylene, and 1,1,1-trichloroethane. The isolates degraded a mixture of aromatic and chlorinated aliphatic solvents and utilized benzene, toluene, sodium benzoate, naphthalene, biphenyl, and n-alkanes ranging in size from propane to hexadecane as carbon and energy sources. The environmental isolates appeared more catabolically versatile than R. rhodochrous ATCC 21197. The data report that environmental isolates of Rhodococcus species and R. rhodochrous ATCC 21197 have the potential to degrade TCE and VC in addition to a variety of aromatic and chlorinated aliphatic compounds either individually or in mixtures.

Journal Article↗