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Final surgical results with a suction trephine.

The suction trephine was studied in 31 aphakic and pseudophakic penetrating keratoplasty patients (31 eyes). The postoperative corneal astigmatism averaged 3.9 +/- 2.8 diopters overall. The 15 pseudophakic cases in nonscarred corneas showed a marked reduction in postoperative corneal astigmatism (3.59 diopters) when compared to previous reports. Our results have encouraged us to continue use of the suction trephine in all aphakic or combined keratoplasty procedures.

Aphakia↗

Skin tumors and trephines.

Outmoded glaucoma and corneal trephines may be used to obtain incisional and excisional biopsies from eyelid lesions. The wounds created in doing the incisional biopsy are ignored and those created by doing excisions are closed by grafts using the same trephine.

Biopsy↗

A new microsurgical corneal trephine.

A new corneal trephine has been described which allows the surgeon to see the circumference of the cutting edge, as well as most of the cornea, lens and iris, while looking through the operating microscope. The trephine has a 3-mm cutting ring supported by an open "branding iron" structure.

Cataract Extraction↗

The effect of corneal trephination on neovascularization.

In order to investigate a neural influence on corneal neovascularization, we attempted to induce new vessel growth within a denervated zone produced by trephination. The stimulus for vascularization was cauterization central to the trephined margin. We demonstrated that in corneas denervated and stimulated in this manner neovascularization did not occur. This finding supports our hypothesis of a neural influence on neovascularization.

Angiogenesis Inducing Agents↗

Diagnostic value of trephine biopsy in bone disease.

A clinical diagnosis of myeloma was made in a 44-year-old woman with anaemia, a markedly raised erythrocyte sedimentation rate, osteolytic lesions in the pelvis, and a pathological fracture of the femur. Confirmatory trephine biopsy showed, instead of plasma cell infiltration, destruction of the normal micro-anatomy of the marrow with bridging fibrosis, gross osteoclastic proliferation, and areas of new bone formation. These are the features of hyperparathyroidism. Subsequently, a solitary adenoma of the parathyroid glands was demonstrated and resected. This case illustrates the value of examination of the trabeculae in trephine biopsy specimens in the diagnosis of bone disease.

Adult↗

The single point cam guided trephine: an interim report.

The development of the single point cam guided cornea trephine frees the cornea surgeon from always cutting a round recipient window perpendicular to the visual axis of the eye. This new trephine allows for any angle of cut relative to the visual axis of the eye and any shaped window, be that window round, ellipse, oval or "other than round." Full development of the technique lies in the future with the development of more complete topographical measuring techniques and the integration of the measurement into a computer program wherein the computer controls the indexing of the blade cutting the recipient window and the angle of the blade while the blade is making the incision.

Cornea↗

[Trephine biopsy of the bone marrow in hematologic tumors].

A group of 1000 random trephine biopsies were evaluated according to their usefulness for typing and staging of haematological tumours. Trephine biopsy contributed someway to clinical data in half the cases. Primary medullary processes showed an excellent correspondence of clinical and bioptical data. Biopsy contributed substantially to specification of myeloproliferations and myodysplasias. There were only 24% of negative results (descriptive inconclusive). Malignant lymphomas presented situation analogical to leucaemias. Peripherical malignant lymphomas in medulla mostly did not follow diversity of lymph node phenomena and did not contribute to more detailed typing but enabled satisfactory staging. Malignant lymphomas were located, unlike leucaemia, intertrabeculary or peritrabeculary and often induced reactive myeloproliferation or scarring. Biopsy was usually good for separation of medullary carcinosis. Remarks to technology of getting and processing of bioptical sample were discussed.

Biopsy↗

Clinical outcomes following penetrating keratoplasty using the Barron-Hessburg and Hanna corneal trephination systems.

Two corneal suction trephination systems currently in use are the Barron-Hessburg and the Hanna trephine. This study assessed the outcome of patients who received penetrating keratoplasty using these two systems. One hundred twenty-four eyes (62 with the Hanna system, 62 with the Barron-Hessburg system) from 98 patients undergoing penetrating keratoplasty were evaluated retrospectively. Best corrected spectacle acuity and corneal astigmatism were assessed 6 and 12 months after surgery. No significant difference was noted between the groups 6 months after surgery. At 12 months, a significant improvement in spectacle acuity was present with 55% of the Hanna group having visual acuity of 20/40 or better compared with 33% of the Barron-Hessburg group (p < 0.005). This difference was greater if eyes having the best visual prognoses were separately evaluated: 74% of the Hanna group had 20/40 vision or better compared with 41% of the Barron-Hessburg group (p < 0.005). In eyes having a good visual prognosis, a significant improvement in visual acuity was present, with 33% of the Hanna group improving nine or more lines compared with 9% of the Barron-Hessburg group (p < 0.05). Postoperative keratometric and refractive astigmatism were not different at 6 or 12 months. We found that visual recovery at 1 year is better using the Hanna system, especially in eyes with good visual prognoses.

Adult↗

The trephine stoma: formation of a stoma without laparotomy.

A trephine stoma may be an attractive alternative for those patients who require a stoma but not a laparotomy. Twenty-seven consecutive patients were candidates for formation of a trephine stoma. A loop ileostomy was successfully constructed in seven patients and an end sigmoid colostomy in 15, while conversion to a formal laparotomy was necessary in five patients mainly because the sigmoid colon was immobile or there were extensive adhesions. The absence of a major abdominal wound made the postoperative course simple with little pain, a quick recovery, and early discharge from hospital.

Adult↗

Ketamine for bone marrow aspiration and trephine biopsy in children.

To make bone marrow aspiration and trephine biopsy less painful and more acceptable in children a short acting anaesthetic ketamine was used in a dose of 1-2 mg/kg body weight intravenously or 4-5 mg/kg intramuscularly. One hundred cases aged 2 to 13 years were studied. The actual procedure time ranged between 20 seconds and 3 minutes, adequate samples were obtained in 80% of children on first attempt. Vomiting was the only side effect noted in two children. Ketamine is safe and recommended in all children undergoing bone marrow aspiration and trephine biopsies.

Adolescent↗

Engineered cellular response to scaffold architecture in a rabbit trephine defect.

Tight control of pore architecture in porous scaffolds for bone repair is critical for a fully elucidated tissue response. Solid freeform fabrication (SFF) enables construction of scaffolds with tightly controlled pore architecture. Four types of porous scaffolds were constructed using SFF and evaluated in an 8-mm rabbit trephine defect at 8 and 16 weeks (n = 6): a lactide/glycolide (50:50) copolymer scaffold with 20% w/w tri-calcium phosphate and random porous architecture (Group 1); another identical design made from poly(desaminotyrosyl-tyrosine ethyl ester carbonate) [poly(DTE carbonate)], a tyrosine-derived pseudo-polyamino acid (Group 2); and two poly(DTE carbonate) scaffolds containing 500 microm pores separated by 500-microm thick walls, one type with solid walls (Group 3), and one type with microporous walls (Group 4). A commercially available coralline scaffold (Interpore) with a 486-microm average pore size and empty defects were used as controls. There was no significant difference in the overall amount of bone ingrowth in any of the devices, as found by radiographic analysis, but patterns of bone formation matched the morphology of the scaffold. These results suggest that controlled scaffold architecture can be superimposed on biomaterial composition to design and construct scaffolds with improved fill time.

Animals↗

Modified bifrontal interhemispheric approach to aneurysms of the anterior communicating artery with the use of a trephine craniotomy. A review of personal experience with 25 cases.

A modified microsurgical bifrontal interhemispheric approach (small trephine craniotomy) for clipping of aneurysms of the anterior communicating artery (ACoA) is described. This approach has been used in a series of 23 patients with ACoA and 2 patients with distal anterior cerebral artery aneurysms. Feasibility, indications and problems related to this approach to ACoA aneurysms are assessed. Twenty-one patients (84%) made an excellent or good recovery. The result was poor in an 80-year-old patient who was in grade 3 pre-operatively. Three patients of this series died: one of them was pre-operatively in grade 4 and died from pneumonia; the other two died as consequence of unrelated ailments. Incidence and extent of vasospasm was within the normal range, corresponding to the amount and distribution of subarachnoid blood clots. From our experience it can be concluded that this approach is safe and feasible for patients with ACoA aneurysms graded 1-2 (Hunt-Kosnik's grading system) and evaluated as group 1-2 of Fisher's CT classification. But it is not recommended for patients with larger amounts of subarachnoid blood clots. Advantages of this microapproach to ACoA aneurysms are: a) minimal brain damage, b) adequate visualization and anatomical orientation, c) preservation of the olfactory nerves and the gyrus rectus, d) reduced operative time, e) easy clip application to aneurysms pointing in any direction.

Adult↗

Effect of cranioplasty on cerebrospinal fluid hydrodynamics in patients with the syndrome of the trephined.

Forty patients with cranial bone defects after craniectomy underwent extensive cerebrospinal fluid (CSF) hydrodynamic investigations by means of a CSF infusion test before and after cranioplasty. The results of these investigations were related to the clinical signs of the patients before and after cranioplasty and to the size and location of the skull bone defect. Twenty-two patients were considered to have "the syndrome of the trephined" (ST). The remaining patients were either free of symptoms or had symptoms not related to ST. CSF hydrodynamic variables that were changed before and normalized after cranioplasty include the following: Resting pressure, sagittal sinus pressure, buffer volume, elastance at resting pressure and pulse variations at resting pressure. The changes were statistically significant mainly in ST patients who were also relieved of their symptoms after cranioplasty.

Adult↗

Eyebrow incision with supraorbital trephination for endoscopic corpus callosotomy: a feasibility study.

OBJECTIVE: We describe a novel technique for the partial bisection of the corpus callosum in order to increase the minimally invasiveness of this procedure. METHODS: Brow incisions with midline trephinations were performed in six adult cadavers. An endoscope was next introduced and used to transect approximately the anterior two-thirds of the corpus callosum. RESULTS: No complications such as injury to the superior sagittal sinus or anterior cerebral artery were encountered in any of our cadaveric specimens. The corpus callosum was easily transected in each specimen. CONCLUSION: As a feasibility study, we believe this technique could provide a less invasive mechanism for patients who require corpus callosotomy and will minimize much of the morbidity associated with the traditional methods of sectioning the corpus callosum.

Aged↗

A new corneal trephine.

A new corneal trephine, using suction and disposable razor blades, comprised two cones, one revolving inside the other. A slide mechanism was attached to the inner cone that inclined a disposable razor blade either vertically or at 20 degrees, assuring clear view of either side of the incision and more accurate centering. The effective diameter of the cut was varied continuously from 8.5 to 2.0 mm.

Corneal Transplantation↗

The trephining of bone from the iliac crest: an anterior approach.

A quick and simple method of trephining moderate amounts of cancellous bone (up to 6 cc) from the iliac crest via an anterior approach is presented. The advantages of this technique are that no muscle or ligamentous attachments are disturbed and postsurgical morbidity is low.

Adult↗