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Hypercalcaemia and soft tissue mineralisation associated with lymphosarcoma in two horses.
Two horses with deposits of lymphosarcoma, one in the spleen, the other in the mediastinum, several lymph nodes and kidneys, lost weight rapidly and became depressed and weak. They were hypercalcaemic and post mortem examination revealed extensive calcification of the heart and major vessels. There was no evidence of bone marrow metastases in the one horse whose marrow was examined, and the thyroid and parathyroid glands of both horses were grossly normal.
Tumorigenesis and carcinogenesis studies of a number of insulation oils and fluids on hairless and SENCAR mice with special reference to skin tumours and malignant lymphomas.
Petroleum and synthetic hydrocarbons are used for the impregnation of paper-insulated power cables. To study the possible risk of skin cancer from such fluids a large series of hairless and a smaller series of SENCAR mice were exposed to long-term skin paintings with these fluids. The assayed fluids were two mineral oils, one C12-C20 polyisobutylene, two C14-20 alkylbenzenes, and one phenylxylylethane. The experiments were carried out according to three protocols: 1) A two-stage protocol using an initial single application of either 51.2 or 25.6 micrograms DMBA (7,12-dimethylbenz(alpha)anthracene) followed by long-term painting twice a week with 100 microliters of different concentrations of the fluids, with acetone as solvent; 2) a complete tumorigenesis protocol with long-term applications twice a week of the fluids alone or in various concentrations in acetone solution; and 3) a co-carcinogenesis protocol with long-term paintings with alternate applications twice a week of very small doses of DMBA and the fluid being studied. The animals were painted and/or observed for 18 months. Signs of skin toxicity, the occurrence of skin papillomas and carcinomas, swollen lymph nodes, and tumours and lesions in other organs found by autopsy were recorded. The results are documented in tables and in figures, and have been analysed by appropriate statistical methods. The oils were toxic to mouse skin, and had a certain general toxic effect indicated by a significantly increased death rate after long-term treatment with polyisobutylene, alkylbenzene A and PXE on hr/hr mice (see Appendix, p. 51), and there was also a tendency to increased amyloidosis. The fluids tested generally displayed a very low, non-significant tendency to induce skin tumours, mostly papillomas, and they are not significantly carcinogenic for skin. Generally, they do not enhance DMBA-induced tumorigenesis, with two exceptions (mixture of heavy mineral oils B/C after pretreatment with 25.6 micrograms, but not after 51.2 micrograms DMBA; and alkylbenzene A which very significantly enhanced DMBA-induced carcinogenesis, without enhancing tumorigenesis). Thus, in the concentrations used, the tested oils and fluids generally do not act as "promoters". On the contrary, most of them are so toxic that the number of tumours occurring after a single application of 51.2 micrograms DMBA is reduced by long-term applications of the oils and fluids, especially by higher concentrations, so in this respect they act in an antitumorigenic way. The fluids, except phenylxylylethane, were significant or suggestive inducers of malignant lymphomas in mice, either alone or in connection with initial treatment with DMBA.(ABSTRACT TRUNCATED AT 400 WORDS)
Endometrial adenocarcinoma in a mare.
An endometrial adenocarcinoma with metastases to the lung, liver, spleen, mesentery and serosal peritoneal surfaces was found in an 11-year-old Arabian mare. Clinical signs included generalized weight loss, depression, anorexia, ventral edema and abdominal distension. Ascites was due to thrombosis of the caudal vena cava. The diagnosis of endometrial adenocarcinoma was based on the histological appearance of uterine glandular epithelium and the presence of similar tissue in the metastatic tumors.
[Spontaneous rupture of the spleen, site of metastatic carcinoma: presentation of a clinical case].
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[Radiologic aspects of metastasis to the colon. Description of 4 cases].
The paper describes four cases of metastatic colon emphasizing its radiological aspect, represented by irregular and eccentric stenoses with stiffness and angling of the colon segments involved. In three cases, peritoneal carcinomatosis was also present and its radiological aspects (ascites, mesentery and omentum thickening, small intestine infiltration) were investigated by CT.
[Clinical usefulness of thin-needle aspiration biopsy in the diagnosis of abdominal masses].
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[A case of granulocytic sarcoma of the ovary with minimal involvement of the bone marrow, liver and spleen (author's transl)].
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[A case of ectopic insulinoma].
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CT scanning in patients with Zollinger-Ellison syndrome and carcinoid syndrome.
Computed tomography of the upper abdomen was performed in 11 patients with Z--E syndrome and 6 patients with carcinoid syndrome. The liver, pancreas, spleen and upper part of the retroperitoneal space were examined to localize a primary tumour and/or metastases. The CT findings were correlated to the final diagnoses obtained by operation or by other diagnostic procedures. The correlation between CT and the clinical findings was acceptable, and we are of the opinion that with further experience this new noninvasive radiological technique might be a helpful tool in the preoperative evaluation in these diseases. Furthermore, CT is an easy method in the control of a tumour or metastases during treatment.
[Malignant thecoma with extensive metastasis (a case report)].
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[Intraperitoneal paraganglioma simulating a retroperitoneal neoplasm].
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[Spontaneous splenic rupture with hemothorax without hemoperitoneum. Description of a case of angiosarcoma of the spleen].
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Cavernous hemangiomas of the liver and spleen.
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Spontaneous rupture of a splenic vascular malformation. A report of three cases and review of the literature.
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[Spinal lymphosarcoma in a foal].
The present report describes the clinical and pathological findings of a one year old foal presented with paralysis of the hind legs. Macroscopically and histologically, a lymphosarcoma in the vertebral body and the adjacent epidural space of T 16, in the spleen and the mesenterial lymph nodes was observed. The adjacent spinal cord showed focal degenerative changes characterized by dilatation of myelin sheaths, swollen axons and few macrophages.
[Modern imaging procedures in splenic diseases].
Imaging procedures have lately become important in pathologic conditions of the spleen, because they are simple to use and do not cause much stress to the patient. Ultrasonography is the method of choice for determination of the position, shape, size and volume of the spleen, and also for the diagnosis of changes within the spleen. Circumscribed lesions cannot be detected by ultrasonography until they have reached a size of 0.5-1.0 cm; the same limit of detection applies for CT, which has approximately the same diagnostic reliability. In the presence of generalized splenic disease (e.g. splenomegaly in myeloid leukaemia) imaging procedures are being used increasingly for staging and for monitoring of the results of treatment. Perhaps in future histochemical determinations made with the aid of core-spin spectroscopy will present a further means of diagnosis without the necessity for biopsy. Angiography was the leading diagnostic technique for spleen conditions for many years, and continues to occupy this place for primary disease of the spleen (aneurysm, arterioportal fistula, haemangioma); it is currently gaining in importance with the advent of therapeutic embolization as an option. For diffuse spleen disease and also for circumscribed lesions, however, it has now been superseded by the non-invasive methods of diagnosis.