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PubMedDate not supplied

Social background and age at menarche in Portuguese university students: a note on the secular changes in Portugal.

Menarcheal age of a sample of Portuguese university students (n = 3366), born between 1972 and 1983, age 18-23 years, was analyzed. The influence of parents' educational level and occupation, family size, birth order, and degree of urbanization of girl's locality of residence during childhood and adolescence were analyzed as well as secular trend in the Portuguese population. Mean age at menarche for girls born in 1983 was 12.32 years. Parents' educational level and occupation did not show any significant influence on mean age at menarche. Place of residence during childhood years and adolescence showed a significant effect on mean age at menarche, with girls from rural places with a later age at menarche than those who spent their childhood or adolescence in urban areas (P <or= 0.01 and P <or= 0.05 for childhood and adolescence, respectively). Family size and birth order showed the highest effect. Girls born in small families, with one child, matured earlier (12.32 years) than those born in large families with four or more children (12.67 years), (P <or= 0.01). Also, girls that were first-born had an earlier menarche (12.41 years) than those who were third or later (12.58 years, P <or= 0.01). Regression analysis selected family size and place of residence in childhood as the most important determinants of mean age at menarche in our university students. In this sample, from 1972 to 1983, mean age at menarche remained stable. When we considered published data from all the Portuguese population we found a decrease in mean age at menarche from 15 years for girls born in 1880 to 12.44 for those born in the 1980s. This decrease was the result of great improvements in the social and economic living conditions that occurred in Portugal especially after the 1970s concerning nutrition and health care, among many other environmental factors.

Adolescent↗
PubMed1989

Chest X-rays in hypersensitivity pneumonitis: a metaanalysis of secular trend.

A metaanalysis of published reports of outbreaks of hypersensitivity pneumonitis was undertaken. A statistically significant substantial decline was seen in the sensitivity of chest X-rays (percent of positive in cases of disease) for the diagnosis of hypersensitivity pneumonitis over the years 1950-1980. Chest X-rays were also less likely to be abnormal where a population-based approach to the diagnosis of disease had been undertaken. Such declines in the diagnostic "sensitivity" of a test may be related to secular trends in knowledge and recognition of disease or to changes in the disease itself. Standardization of chest X-ray interpretation alone, even if successful, may not resolve the issue of accurate diagnosis of interstitial lung disease.

Alveolitis, Extrinsic Allergic↗
PubMed1977

Aging and secular change in adult stature in rural Colombia.

Age-associated changes in adult stature of a cross-sectional sample of 634 adults from rural Colombia were estimated by multiple regression of stature and age controlling for subischial length, and from equations predicting maximum attained stature from subischial length. From these analyses the estimated rate of loss in stature due to aging per se for men was 0.12 cm/yr, while for women it was 0.03 cm/yr. When corrected for aging, several secular trends in adult stature were evident, although none were statistically significant.

Adult↗
PubMed1987

Some secular changes in body height and proportion of Japanese medical students.

Anthropometric dimensions of 738 medical students at Kyushu University in Japan were analyzed to determine secular changes of height and body proportions during a 20-year period. Since 1961, means of standing height, leg length, and ratio of leg length to standing height have increased, although the rate of increase from 1971 to 1981 has been rather slow. On the contrary, the mean sitting height X 100/standing height has declined during this same period. Compared with data on the Japanese general population, the medical students were considerably taller, but the difference has decreased.

Adult↗
PubMed1988

Secular changes in the angle of divergence of the first two metatarsals in the Japanese.

This investigation concerns secular changes of the intermetatarsal M1-M2 angle in the foot of Japanese, from the prehistoric Jomon period to early modern times. The divergence of the first metatarsal from the second in both sexes in the reconstructed tarsometatarsal bones gradually decreased during this period. In addition, the difference between sexes or sides in each period is small and statistically insignificant. With time, the first metatarsocuneiform angles, in both sexes, also decreased in parallel with the reduction of the intermetatarsal M1-M2 angle, while the second metatarsocuneiform angles in both sexes increased. Both may play a role in decrease of the intermetatarsal M1-M2 angle. A conspicuous angular divergence of the first metatarsal from the second one occurred in comparatively recent times. This change would be accelerated by modification in life-style, together with the effects of footwear.

Anthropology, Physical↗
PubMed1988

Lack of secular change in male adult stature in rural Mali (West Africa).

A study has been carried out on a sample of 2,158 male subjects between 20 and 50 years old representative of the rural Malian population (West Africa), and the results are compared with historic data obtained since 1885. This comparison suggests that there has been no modification in stature during this century. The analysis of each ethnic group does not show any disparity. Our results are in agreement with the theory that certain factors lead to the secular increase of stature in developed countries. These etiologic factors are not found in our West African population.

Adult↗
PubMed1995

Possible secular trend in the incidence of an anatomical variant: median artery of the forearm.

Occurrence of a secular trend in the presence of a common anatomical variant-median artery of the forearm is studied. Data from the literature indicated the incidence of the median artery to be between 4.4 and 8.3% in adult cadavers studied before 1960 while our recent study found a frequency of 27.2%. In 224 adult and 60 infant cadavers of people born between 1900 and 1991 studied using a uniform method the incidence of the median artery in the birth cohort 1900-1910 was 15.0% of individuals, it rose to 29.7% in 1921-1930 and further to 38.1% in 1951-1960 to become 52.8% in 1980-1991. This trend is statistically significant. Since the median artery is deemed to dwindle away in most individuals around the 7th week of the intrauterine life, the increasing proportion of individuals who retain it into postnatal life may indicate a recent trend in human intrauterine development.

Adult↗
PubMed1991

Secular changes in published clinical trials of second-line agents in rheumatoid arthritis.

The present investigation was undertaken to explore changes over time in the design and reporting of trials of second-line drugs in rheumatoid arthritis, in the characteristics of patients included in the trials, and in the sources of funding. We studied 105 trials of second-line agents for the treatment of rheumatoid arthritis, including placebo-controlled and comparative trials involving 8 different agents. Three time periods, 1945-1969, 1970-1979, and 1980-1989, were compared. We found little change in the standards for reporting on the design of trials or for reporting information on patient dropout and drug side effects, some increase in the complexity of the statistical methods used, but no increase in the use of power analysis (reported in only 13% of trials). The average age of patients in clinical trials has increased. In recent years, there has been a substantial shift from placebo-controlled to comparative trials, and it is increasingly common for trials to be financially supported by pharmaceutical companies. The possible effects of secular trends should be considered when combining or comparing results of trials conducted in different years.

Age Factors↗
PubMed2004

Secular decreasing trend of the frequency of hypospadias among newborn male infants in Spain.

BACKGROUND: The frequency of hypospadias is not uniform worldwide. Several countries have reported an increase in its frequency at birth. Although a better ascertainment of the minor forms has been considered as an explanation, the potential effect of environmental endocrine disrupters has also been proposed. We studied the secular trend of hypospadias in Spain over the past 22 years, separating the minor and major forms. METHODS: We used data from the Spanish Collaborative Study of Congenital Malformations (ECEMC) registry, analyzing the frequency in two different periods: from 1978 to 1995, and from 1996 to 2002. To evaluate the "step" of the frequency between the two periods, we applied a parametric Student's t-test, and the nonparametric Mann-Whitney rank test. RESULTS: The birth frequency of isolated and total hypospadias was quite stable between 1978 and 1995. In 1996, it decreased dramatically in a step, essentially due to isolated cases with minor forms of hypospadias. Study of the geographical distribution by the 17 Spanish regions showed that the frequency step occurred in nearly all of them. CONCLUSIONS: It is difficult to consider that the observed decrease of the frequency of minor forms of hypospadias could be due to less accurate reporting of these minor forms in all 87 hospitals in the same year without any previous physician agreement. This decrease rather suggests a change in some product or exposure affecting the whole country. We think that the observed change in the frequency cannot be attributable to a lower exposure to endocrine disrupters or the voluntary interruption of gestation.

Geography↗
PubMed1982

Absence of secular changes in the prognosis of patients with an initial myocardial infarction.

A community-based study was conducted in metropolitan Baltimore in which secular trends in the in-hospital and long-term prognosis of 935 male and female patients hospitalized with an initial myocardial infarction were examined for the two periods of 1966-1967 and 1971. The in-hospital case fatality rate among males in both periods remained unchanged (19.0% vs 19.0%), whereas there was a decrease over time among women hospitalized in 1966-1967 as compared to those in 1971 (37.2% vs 26.6%) (p less than 0.10). For patients discharged alive from the hospital and followed up for as long as 10 years, no significant differences in overall survival were observed between male patients discharged in 1966-1967 and 1971 or between female patients discharged in these two periods. These findings may reflect the lack of major therapeutic advances in the care of the acute coronary patient between the two study periods and, therefore, support continuing efforts directed at the primary and secondary prevention of the atherosclerotic process.

Age Factors↗
PubMed2006

Secular trends and geographic variations of hepatitis B virus and hepatitis C virus-associated hepatocellular carcinoma in Taiwan.

Etiological variations in hepatocellular carcinoma (HCC) exist across different geographic areas. To gain better control of HCC, we retrospectively studied the secular trends and geographic variations in hepatitis B virus (HBV)-related and hepatitis C virus (HCV)-related HCCs in Taiwan. A total of 18,423 HCC cases enrolled in 8 medical centers from 1981 to 2001 were reviewed. Overall, 67% of male HCC in Taiwan was related to HBV infection whereas 55.2% of female HCC in Taiwan was related to HCV infection. The mean age of patients with HBV-related HCC was 53.2 +/- 13.6 years, while the mean age of patients with HCV-related HCC was 65.1 +/- 9.1 years (p < 0.001). The male/female ratio was 6.4 for HBV-related HCC, while it was 1.7 for the HCV-related HCC (p < 0.001). The percentage of HBV-related HCC progressively decreased from 81.5 to 66.2% in males, and from 66.7 to 41.4% in females over the study period. Our study demonstrates that the percentage of HBV-related HCC has progressively decreased over the last 20 years. The relative decrease in HBV-related HCC was not due to a decrease in HBV-related HCC death. Instead, it was caused by an increase in HCV-related HCC. Prevention of new HCV infection and the treatment of chronic hepatitis C should be the primary goals, which will result in better control of HCC in the future, even in an HBV-endemic area like Taiwan.

Age Distribution↗
PubMed2006

Non-linearity influences on the axial secular-motion spectrum of ions confined in a Fourier transform ion trap mass spectrometer. Experimental studies.

A Fourier transform operating mode is applied to an ion trap. The trap is truncated at 2r(0) and presents unwanted defects that induce confinement electric-field non-linearities. Ion axial secular-motion spectrum is examined by experiments near the resonance line beta(z) = 0.5. Ion-loss processes and ion axial-motion peak splitting are observed. In the non-linear ion trap, the ion-motion frequency depends on its initial conditions in position and velocity. This brings an enlargement of the motion-frequency peak and limits the resolution. With a 2r(0) truncated ion trap, the Fourier transform ion trap mass spectrometer (FTIT-MS) leads experimentally to a mass resolution of about 4000 at 130 u.

Journal Article↗
PubMed1993

Secular trend and geographical variation in hepatitis A infection and hepatitis B carrier rate among adolescents in Taiwan: an island-wide survey.

During the last two decades an economic boom has occurred in Taiwan, a region where the prevalence of both hepatitis A and B virus infection was formerly very high. To examine the impact of socioeconomic developments on the secular trend and geographical variation in hepatitis A and B virus infection, 875 adolescents selected randomly from 20 junior high schools were studied. Serum samples collected from the subjects were tested for hepatitis A antibody (anti-HAV) and hepatitis B surface antigen (HBsAg) by enzyme immunoassay using commercial reagents. The anti-HAV prevalence increased from northern through central to southern Taiwan; the prevalence was highest in aboriginal townships and lowest in metropolitan precincts. This striking variation in anti-HAV prevalence in different geographical locations and at different urbanization levels remained significant in multiple logistic regression analysis. The HBsAg prevalence was significantly higher in aboriginal townships than in rural and urban townships and metropolitan precincts. In addition, HBsAg prevalence was related inversely to the number of physicians per 1,000 population. The prevalence of both anti-HAV and HBsAg declined significantly during the last decade in Taipei City and County. The decrease in anti-HAV prevalence may be due to improvements in environmental hygiene, water supply, and food sanitation, while the decline in the HBsAg carrier rate may result from the use of disposable needles and syringes as well as screening for HBsAg in blood banks.

Adolescent↗
PubMed1992

Secular trends in the incidence of postmenopausal vertebral fractures.

Several studies suggest secular increases in hip fracture incidence through this century, but little is known about such trends for vertebral fracture. We have examined changes in the incidence of clinically ascertained vertebral fractures among Rochester, Minnesota residents aged 35-69 years, that were first diagnosed between 1950 and 1989. Our results indicate no overall increase in incidence over the 40-year period. Categorization of fractures according to the level of preceding trauma, however, revealed a significant increase in the incidence of fractures following moderate trauma among women aged 60-69 years. This increase occurred between 1950 and 1964, and leveled off thereafter. Rates for severe trauma fractures among postmenopausal women, and for vertebral fractures from any cause among younger men and women, remained stable. The rise in moderate trauma fractures in postmenopausal women paralleled that for hip fractures in Rochester and began to plateau at around the same time. It might have resulted from increased diagnosis of vertebral fractures, but the increase in hip fracture incidence is inconsistent with this explanation. An increase in the prevalence of osteoporosis, however, might account for the trend in both types of fractures.

Adult↗
PubMed1985

The secular trend of height and menarche in Belgium: are there any signs of a future stop?

Changes such as an increase in stature, in weight and an earlier physical and sexual maturation have been observed since the 19th century in Belgium as in most industrialized countries. In this paper, we consider the secular trend in height, weight and puberty (especially menarche) over the last 20 years in Brussels. During the period 1980-1982, 4177 subjects, from the Belgian population of Brussels, aged 3-26 years, have been measured and compared with Belgian subjects living in Brussels in 1960. In our sample, we observe a statistically significant increase in height (and weight), but this trend is less rapid than the increases noticed before in Belgium. Status quo data on menarche from 1048 girls from this sample were analysed by centiles and the probit method. For the first time in Belgium, it seems that the median age is stabilized at 13.0 years. However, the number of late menarches is still evolving.

Adolescent↗
PubMed1987

Secular trends in the incidence of hip fractures.

To explore possible changes in proximal femur (hip) fracture incidence over time, an earlier study among Rochester, Minnesota residents for 1928-1977 was updated through 1982. Reanalysis of data demonstrated rising age-adjusted rates for men over this time. Crude rates rose for women as well, but age adjusted rates leveled off in the mid-1950s, as did overall rates, since the majority of hip fractures were in women. Secular trends were primarily due to changes in the incidence of initial hip fractures associated with moderate trauma, the sort usually attributed to osteoporosis. No differences were noted in trends for cervical vs. intertrochanteric femur fractures; and, excluding the low values for 1928-1942, no significant trends were noted for women within various age groups. Our results for women conflict with estimates from a number of other studies, but these differences may provide a basis for hypothesis development.

Age Factors↗
PubMed2006

Secular trends in the prevalence of diabetes and impaired glucose tolerance in urban South India--the Chennai Urban Rural Epidemiology Study (CURES-17).

AIMS/HYPOTHESIS: The aim of this study was to determine the secular trends in prevalence of diabetes and IGT in urban India. MATERIALS AND METHODS: The Chennai Urban Rural Epidemiology Study (CURES) screened 26,001 individuals aged > or =20 years using the American Diabetes Association fasting capillary glucose criteria. The study population, which was representative of Chennai, was recruited by systematic random sampling. Every tenth subject from Phase 1 of CURES was invited to participate in Phase 3 for screening by World Health Organization (WHO) plasma glucose criteria. The response rate was 90.4% (2,350 responders from 2,600 potential subjects). The prevalences of diabetes and IGT in CURES were compared with three earlier studies: two conducted on a representative population of Chennai in 1989 and 1995, and the other the National Urban Diabetes Survey (NUDS) completed in 2000. RESULTS: The overall crude prevalence of diabetes using WHO criteria in CURES was 15.5% (age-standardised 14.3%), while that of IGT was 10.6% (age-standardised 10.2%). Prevalence of diabetes increased by 39.8% (8.3-11.6%) from 1989 to 1995; by 16.3% (11.6-13.5%) between 1995 and 2000; and by 6.0% (13.5-14.3%) between 2000 and 2004. Thus within a span of 14 years, the prevalence of diabetes increased by 72.3% (chi (2) trend 22.23, p < 0.0001). The prevalence of IGT increased by 9.6% from 1989 to 1995 and by 84.6% between 1995 and 2000 (chi 2 trend 52.9, p < 0.0001). However, it decreased by 39.3% between 2000 and 2004 (p < 0.0001). There was a shift in the age at diagnosis of diabetes to a younger age in CURES compared with NUDS. CONCLUSIONS/INTERPRETATION: Compared with earlier studies, the prevalence of diabetes in Chennai, representing urban India, has increased while that of IGT has decreased.

Blood Glucose↗