Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Sebaceous Glands”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 271 records · Page 15Linked to original sources
PubMed1975

Congenital stalked fibromatous polyp of the superior pole of the tonsil containing hairless sebaceous glands.

A polyp of the size of a small bean was discovered incidentally on the superior pole of the right tonsil of a 29-year-old man. Morphologically it bore a considerable resemblance to the immature infantile variant of the sebaceous-gland nevus, the Naevus epitheliomatosus sebaceus Wolters, but its top was mature. The polyp is viewed as a congenital dysontogenic tumor which, owing to its fibromatous basis, lack of hair, and its immature and mature sebaceous glands, may be informally classified as a "missing link" between the haired pharyngeal polyp and the pure pharyngeal fibroma.

Adult↗
PubMed1987

Sebaceous gland hyperplasia and senile comedones: a prevalence study in elderly hospitalized patients.

Two hundred and eighty-six patients over the age of 65 (age range 65-102, mean age 82 years), who were hospitalized in geriatric wards, were examined clinically for the presence of sebaceous gland hyperplasia and senile comedones. The degree of solar elastotic change present was scored on a visual analogue scale. The prevalence rate of sebaceous gland hyperplasia and of senile comedones was found to be 26% in each case. Approximately one third of patients had both lesions. Neither of these lesions was related to either the degree of solar elastotic change or the skin type with regard to tanning ability. It was concluded that chronic solar exposure was not a likely cause of these common conditions.

Acne Vulgaris↗
PubMed1994

Sebaceous gland adenoma of the palpebral conjunctiva in a patient with Muir-Torre-syndrome: a case report.

BACKGROUND: Muir-Torre syndrome (MTS) is a hereditary genodermatosis associated with internal malignancies. METHODS: We report the histological case of an atypical sebaceous gland adenoma of the palpebral conjunctiva in a 42-year-old female patient. RESULTS: The combination of this adenoma with atypical adenomatous hyperplasia of the endometrium and a strong family history of gastrointestinal and urogenital cancers led to the diagnosis of MTS. CONCLUSION: We present a case where the diagnosis of an atypical solitary sebaceous gland adenoma of the palpebral conjunctiva combined with a conspicuous personal and family history led to the diagnosis of MTS.

Adenoma↗
PubMed1986

The isolation of human sebaceous glands and apocrine sweat glands by shearing.

A new method of isolating human sebaceous and apocrine sweat glands by the repeated dissection of skin biopsies with scissors is described. The success of the technique is attributed to a line of weakness between the investing capsule and the surrounding connective tissue which parts under shear forces. The glands are judged to be viable by: (i) light and electron microscopy; (ii) ATP, ADP and AMP contents of 148.8 +/- 30.3, 30.6 +/- 4.7 and 14.9 +/- 4.7 pmol (mean +/- s.e.m.) for sebaceous glands and 310.2 +/- 34.1, 90.35 +/- 16.3 and 40.1 +/- 11.8 pmol (mean +/- s.e.m.) for apocrine sweat glands, which gave energy charges of 0.84 and 0.81, respectively; and (iii) a rate of sebaceous gland lipogenesis of 39.7 +/- 3.7 pmol glucose incorporated into lipid/gland/h (mean +/- s.e.m.).

Adenine Nucleotides↗
PubMed1980

Role of the gonads in the regulation of sebaceous glands in rats: comparison of the effects of castration at and after birth.

Sprague-Dawley rats were castrated either within 24 h of birth or at 4 weeks of age. Control animals were sham operated. Intact female rats were also included for comparison. Sebum production was assessed at 80 days of age by measuring the amount of skin-surface lipids that could be extracted with acetone and which had been produced during 2 days. The removal of the testes at birth reduced the activity of the sebaceous glands to level more nearly approaching that seen in the female rats whereas castration at 4 weeks of age only partially decreased the rate of sebum secretion so that it was intermediate between the male and female rats. The weights of the pituitary gland, thyroid and adrenal glands increased after castration but there were no differences between rats castrated at birth and those castrated at 4 weeks of age except in the weight of the thyroid gland. It would appear that the role of the testes in the control of the activity of the sebaceous glands is a sequential event which has already started at birth.

Animals↗
PubMed1984

Sebaceous gland tumors and systemic disease: a clinicopathologic analysis.

The association of sebaceous gland neoplasms with visceral carcinomas, first described by Muir and Torre, has become widely recognized. The purpose of our study was to determine the prevalence of malignancy, other associated diseases, and familial carcinoma in patients who had one or more cutaneous lesions within the spectrum of sebaceous adenoma, epithelioma, or carcinoma. Our histopathology files contained tissue from 59 such cases. Overlap between the categories was common, often precluding precise histologic classification. Of the 59 patients, 25 (42%) had one or more primary visceral malignancies. These totaled at least 49, of which 25 were colonic, 9 urogenital, 5 hematologic, 4 breast, and 6 miscellaneous. Fifteen patients (25%) had colonic polyps, most often multiple; and at least one primary carcinoma of the colon appeared in 10 of these, initially or later. Other less common findings included uterine fibroids, thyroid adenomas, and benign renal cysts. A family history of carcinoma was found in 72% of cases with visceral malignancy, most often of the colon and stomach. We conclude that sebaceous neoplasms form a histologic continuum, and strong associations with colonic polyps, internal malignancy, and a family history of carcinoma are apparent.

Adenocarcinoma↗
PubMed1991

Histochemical detection of burn-induced lipid peroxidation in sebaceous glands of rat skin.

Increased lipid peroxide levels both in skin and serum have been reported after cutaneous thermal injury. However, it still remains unclear where lipid peroxides are produced at the site of burned skin. In the present study, a histochemical method using cold Schiff's reagent was applied in order to detect the localization of lipid peroxide. Schiff positivity was detected in sebaceous glands, and the extent of positivity seemed to correlate with the serum lipid peroxide levels. These results may suggest that lipid peroxides produced in sebaceous glands after thermal injury enter the blood stream and are partially responsible for the elevated serum lipid peroxide levels.

Animals↗
PubMed1987

Effect of androgenic and anabolic steroids on the sebaceous gland in power athletes.

The effect of androgenic and anabolic steroids on sebaceous gland activity and the composition of sebum was studied in power athletes. The subject self-administered large doses of androgenic and anabolic hormones during a 12-week-period of strength training. After 4 weeks of administration of hormones the sebum excretion rate increased significantly (p = 0.002) and it remained high throughout the period of exogenous steroid use. The amounts of cholesterol were significantly increased during that period. There were no differences in the amounts of the following lipid groups; free fatty acids, squalen, triglycerides, wax esters, diglycerides and paraffins. It was concluded that large doses of androgenic and anabolic steroids lead to an increase in sebum output in healthy young adult males.

Adult↗
PubMed1987

Immunohistochemical study of carbonic anhydrase in mixed tumours and adenomas of sweat and sebaceous glands.

Immunohistochemical distribution of carbonic anhydrase II (CA) in mixed tumours and adenomas of sweat gland origin and in sebaceous adenomas was demonstrated by the PAP method. Normal sweat glands, both eccrine and apocrine, clear cells of the secretory coils, and ductal epithelial cells all showed conspicuous staining for CA, and sebaceous glands were also positive. Mixed tumours of the skin indicated strongly positive staining for CA in the luminal cells of tubular and duct-like or cystic structures, while most of the other tumour cells were negative. In solid or massive foci, CA positive cells were found scattered among the cellular mass. Sebaceous adenomas were usually moderately positive for CA throughout the tumour.

Adenoma↗
PubMed1989

Differential effect of testosterone on pigmented spot, sebaceous glands and hair follicles in the Syrian hamster flank organ.

The androgen-dependent flank organ of the Golden Syrian hamster has been used as a model for acne and hair growth. 1-cm silastic capsules of testosterone (T) were implanted subcutaneously into female hamsters. Serum levels of T remained relatively constant after 1 week. Maximum growth of the pigmented spot occurred at 4 weeks but regressed by 6 weeks. In contrast, the growth of the pilosebaceous unit continued for 6 weeks. Total sebaceous area and number of sebaceous lobules increased by 3 weeks with a further increase in total area by 6 weeks. The distribution of lobule size shifted to more large lobules. Diameters of hair follicles increased at 3 and 6 weeks with a concomitant recruitment to large follicles. The density of hairs remained constant. The diminution in size of the pigmented spot between 4 and 6 weeks of T stimulation was not related to a reduction in serum T. In fact, there was persistent growth of the sebaceous glands and hair follicles at this time. The measurement of the pigmented spot of the flank organ is not a reliable indicator of the androgen responsiveness of sebaceous glands and/or hair follicles.

Animals↗
PubMed1989

A morphometric and histologic study of the scalp in psoriasis. Paradoxical sebaceous gland atrophy and decreased hair shaft diameters without alopecia.

A histologic study was designed to evaluate the pilosebaceous unit of the scalp in nonpustular patch- and plaque-stage psoriasis. Punch biopsy specimens from involved and uninvolved areas of 28 patients were sectioned in a horizontal plane for qualitative and quantitative study. All samples were evaluated in a blind mode, and data were analyzed for statistical significance. There was no evidence for alopecia of any type. Sebaceous gland atrophy was a frequent concomitant in the psoriatic lesion, with probable down-sizing of the hair follicle and thinner hair shafts. Paradoxical sebaceous gland atrophy and down-sized hair follicles in psoriasis may be due to possible inhibiting effects of yet unidentified factors produced by the epidermal lesion.

Adult↗
PubMed1982

Variability in the fatty acid composition of wax esters from vernix caseosa and its possible relation to sebaceous gland activity.

Wax ester/sterol ester (WE/SE) ratios were measured in samples of vernix caseosa lipid obtained from 21 full-term infants. The mean WE/SE ratio was twice as high in males as in females, suggesting higher average fetal sebum production rates in males, but individual values varied widely and there was considerable overlap between the sexes. Wax esters (a class of lipid produced only by the sebaceous glands) were isolated from 6 of the 21 samples of vernix caseosa lipid and analyzed for fatty acid composition. The percentages of iso and anteiso branched saturated fatty acids and of delta 9-type monounsaturated fatty acids were found to be correlated negatively with the WE/SE ratios of the original lipid samples. Values for the percentages of the major delta 9-type monounsaturates, plotted as a function of WE/SE ratios, fell near a curve of the shape which would be expected if a limited quantity of delta 9-type monounsaturates were available for sebum synthesis, and were diluted with varying amounts of delta 6-type monounsaturates, the amount of the delta 6-type monounsaturates being proportional to the amount of wax esters synthesized by the sebaceous glands. The results suggested that the rate of sebum production may be the sole determinant of the percentage of delta 9-type monounsaturates in sebaceous wax esters and a partial determinant of the percentage of iso and anteiso branched saturates.

Esters↗
PubMed1986

Effect of a new topically active antiandrogen (RU 38882) on the rat sebaceous gland: comparison with cyproterone acetate.

RU 38882 is a new antiandrogen. When given by subcutaneous or oral route, RU 38882 is about 25 times less potent than cyproterone acetate. However, when applied topically to the intact rat skin, RU 38882 (0.25-25 mg/rat/day for 5 days or 3 weeks) decreases, in a dose-related manner, the volume density of the smooth endoplasmic reticulum vesicles of the differentiating cells of the sebaceous gland, a structure directly involved in sebum lipid synthesis. Under these conditions RU 38882 is about 100 times more potent than cyproterone acetate and unlike cyproterone acetate, does not modify the prostate weight. The lack of efficacy of cyproterone acetate on the sebaceous gland could be due to its partial androgenic activity while RU 38882, under these conditions, acts as a pure antiandrogen which inhibits the nuclear androgen-receptor translocation.

Administration, Topical↗
PubMed1998

Immunohistochemical demonstration of beta-endorphin in guinea pig sebaceous glands of normal skin and during immune inflammation.

Very suggestive evidence for possible role of beta-endorphin (BE) in immune activity has been continuously accumulated in the literature in spite of contradictory results about the involvement of the opiate system in immunological response. The reversed passive Arthus reaction (RPAR) was performed in the dorsal area of the guinea pig skin and immunohistochemical PAP method was applied for visualisation of BE. The positive BE immunoreactivity was observed in sebaceous gland cells (SGC) , mainly localized in the middle layer of the glands, both in the normal and experimental skin. The maximal intensity of immunoreactivity to BE in SGC during RPAR was stronger than normal. In control skin, 50% of SGC revealed positive immunoreactivity comparing to 60-66% in the late phase of RPAR. Sebaceous glands (SGs) probably take part in local homeostasis in the skin, also during immune inflammation.

Animals↗
PubMed1981

On the influence of X-ray irradiation and photochemotherapy with 8-methoxypsoralen on the sebaceous gland of the Syrian hamster ear.

30 male Syrian hamsters were X-ray irradiated on 1 ear with 500 rad (Dermopan 2; setting 3; tissue half value thickness, 7.5 mm). 30 other animals were treated locally on one ear with an emulsion containing 0.15% 8-methoxypsoralen and then with UV A (10 treatments in 23 days; total UV A dose, 5.0 J/cm20. The other ear served as control. An in vivo double-labelling autoradiography with 3H- and 14C-thymidine was carried out on half of the animals of each group. The other half was administered 3H-thymidine and the number of labelled cells still in contact with the basal lamina of the sebaceous gland after 6 days was determined. The effects of X-ray irradiation and photochemotherapy are identical. Cell proliferation in the sebaceous gland was reduced, the length of the S phase was shortened, and the number of marked cells still in contact with the basal lamina after 6 days was decreased.

Animals↗
PubMed1983

[Modification of sebaceous gland secretion by the antiestrogen tamoxifen in female and male golden hamsters].

24 male and 24 female syrian hamsters were treated with antiestrogen Tamoxifen for 21 days (dosage 5, 50, 200 and 800 microgram/d, respectively). For control, 6 male and 6 female animals remained untreated. After having finished this treatment, we performed double-labelling autoradiography with 3H- and 14C-thymidine on all animals, under in vivo-conditions. The number of single labelled 3H-cells has been related to cell proliferation. The quotient " double labelled cells/single 3H-labelled cells " served as a measure for the duration of the S-phase. In addition, we measured the sebaceous gland volume. No essential influence on the parameters could be found. Therefore, we have to assume that the antiestrogen Tamoxifen does not have an essential effect on cell kinetics in the sebaceous gland.

Administration, Topical↗