Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Porosity”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 271 records · Page 15Linked to original sources
PubMed1999

Effect of nitinol implant porosity on cranial bone ingrowth and apposition after 6 weeks.

The present study addresses two aspects of the use of nitinol in cranial bone defect repair. The first is to verify that there is substantial bone ingrowth into the implant after 6 weeks; the second is to determine the effect of pore size on the ability of bone to grow into the implant during the early (6-week) postoperative period. Porous equiatomic (equal atomic masses of titanium and nickel) nickel-titanium (nitinol) implants with three different morphologies (differing in pore size and percent porosity) were implanted for 6 weeks in the parietal bones of New Zealand White rabbits. Ingrowth of bone into the implants and apposition of bone along the exterior and interior implant surfaces were calculated. The mean pore size (MPS) of implant type #1 (353 +/- 74 microm) differed considerably from implant types #2 (218 +/- 28 microm) and #3 (178 +/- 31 microm). There was no significant difference among implant types in the percentages of bone and void/soft tissue composition of the aggregate implants. The amount of bone ingrowth also was not significantly different among the implant types. Implant #1 was significantly higher in pore volume and thus had a significantly higher volume of ingrown bone (2.59 +/- 0.60 mm3) than implant #3 (1. 52 +/- 0.66 mm3) and a greater amount, but not significantly greater, than implant #2 (1.76 +/- 0.47 mm3). Pore size does not appear to affect bone ingrowth during the cartilaginous period of bone growth in the implant. This implies that within the commonly accepted range of implant porosities (150-400 microm), at 6 weeks bone ingrowth near the interface of nitinol implants is similar.

Alloys↗
PubMed2007

Stem-cement porosity may explain early loosening of cemented femoral hip components: experimental-computational in vitro study.

A combination of laboratory experiment and computational simulation was performed to assess the role of interface porosity on stem migration. The early motion of in vitro prepared cemented femoral components was measured during application of cyclic stair climbing loads. Following testing, transverse sections were obtained and the distribution of pores at the stem-cement interface was determined. Finite element models of cemented stem constructs were developed and a scheme was implemented to randomly assign pores to the stem-cement interface. For a series of 14 in vitro prepared components, pore fractions at the stem-cement interface ranged from 23% to 67%. The majority of pores at the stem-cement interface were less than 1 mm in length with a mean length of 1.27 +/- 2.7 mm and thickness of 0.12 +/- 0.11 mm. For stems with large pore fractions, pores tended to coalesce in longer extended gaps over the stem surface. Finite element and experimental models both revealed strong positive correlations (r(2) = 0.55-0.72; p < 0.0001) between stem-cement pore fraction and stem internal rotation, suggesting that the presence and extent of pores could explain the early motion of the stems. There was an increased volume of cement at risk of fatigue failure with increasing stem migration. Pore fractions greater than 30% resulted in large increases in stem internal rotation, suggesting that attempts to maintain surface porosity at or below this level may be desirable to minimize the risk of clinical loosening.

Aged↗
PubMed2000

Alternative blood conduits: assessment of whether the porosity of synthetic prostheses is the key to long-term biofunctionality.

The paper examines the effects of water permeability on solid particle (platelet) adhesion and lipid transport through the wall of a blood conduit. Also tested is the capacity of external supports to reduce lipid infiltration into venous grafts. The results indicate that water permeability not only facilitates particle adhesion, but also affects the spatial distribution of the adhesion. The presence of filtration flow leads to a concentration polarisation of atherogenic lipids at the blood/wall interface, with increased lipid concentration from the bulk value towards the interface, thus enhancing the drive potential for lipid infiltration into the vessel wall. An external support to a venous graft guards against excessive distention and significantly reduces lipid infiltration into the venous wall. These results strongly suggest that too high a water permeability or porosity can lead to the late failure of arterial grafting by affecting blood cell interaction with the graft and lipid infiltration into the wall. Therefore the pore structure of an arterial prosthesis is crucial to its long-term biofunctionality. Ideally, a synthetic prosthesis should display pores of adequate size and a structural network that promotes tissue ingrowth, while maintaining water porosity at a physiological level.

Blood Platelets↗
PubMed2004

Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixing.

The field of tissue engineering continues to advance with the discovery of new biomaterials, growth factors and scaffold fabrication techniques. However, for the ultimate success of a tissue engineered construct the issue of nutrient transport to the scaffold interior needs to be addressed. Often, the requirements for adequate nutrient supply are at odds with other scaffold design parameters such as mechanical properties as well as scaffold fabrication techniques, leading to incongruities in finding optimal solutions. The goal of this review article is to provide an overview of the various engineering design factors that promote movement of nutrients, waste and other biomolecules in scaffolds for musculoskeletal tissue engineering applications. The importance of diffusion in scaffolds and how it is influenced by porosity, permeability, architecture, and nutrient mixing has been emphasized. Methods for measuring porosity and permeability have also been outlined. The different types of biomaterials used, scaffold fabrication techniques implemented and the pore sizes/porosities obtained over the past 5 years have also been addressed.

Animals↗
PubMed2005

Location-dependent analysis of porosity and pore direction in tablets.

PURPOSE: Several phenomena in tablets indicate that an inhomogeneous pore distribution is formed during the compaction process. Examples are lamination and the capping of corners. In order to gain an understanding of the relation between structure and compact properties, analyzing the structure in a location dependent manner would be extremely useful. Our aim was to visualize and to quantitatively analyze the pore distribution in compacts. METHODS: This was done by embedding a cubic (sodium chloride) compact with polymer, allowing the compact to be cut without disrupting the structure. By doing so, it was possible to make scanning electron microscopic images from different angles at different locations in the compact. These images were made binary with a two-means cluster algorithm (Isodata) after which the porosity could be calculated. Counting the number of transitions from the pixels in the pores to the pixels in the sodium chloride particles in two perpendicular directions allows us to construct a measure for the anisotropic connectivity of the particles. RESULTS: The results show an increase in porosity toward the bottom of the compact and showed a preferred orientation of the pores in the direction of compression. CONCLUSIONS: The proposed method is suitable for analyzing the pore distribution quantitatively and for evaluating anisotropy.

Anisotropy↗
PubMed1990

Ultrasound speed in equine cortical bone: effects of orientation, density, porosity and temperature.

Ultrasound speed, as measured by a transmission technique in equine cortical bone, was found to vary markedly with the direction of the ultrasound path through the bone. Using bone samples from the mid-site of the third metacarpus of 20 horses, the ultrasound speed was measured as 4125 m s-1 in the longitudinal direction, 3442 m s-1 in the circumferential or transverse direction, and 3428 m s-1 in the radial direction. These results confirm the anisotropic properties of compact bone. Ultrasound speed had a positive linear relationship when compared with bone specific gravity of cortical bone (r = 0.773, n = 35, p less than 0.0001), and an inverse linear relationship with porosity. Specific gravity has an inverse correlation with porosity (r = 0.857, n = 35, p less than 0.0001). Over the temperature range of 4-42 degrees C, ultrasound speed varied inversely according to temperature with a logarithmic function giving the best fit. These results have important implications for the clinical applications of ultrasound speed in assessing bone quality in racehorses and provide important basic information for the understanding of the passage of ultrasound through cortical bone, which has possible clinical applications in humans.

Age Factors↗
PubMed1995

Chemistry and sintering behaviour of thin hydroxyapatite ceramics with controlled porosity.

Hydroxyapatite ceramic tapes (several hundred micrometres thick), have been prepared at different porosity levels, using the tape casting technique. The reactions, which occur during processing and sintering of the tapes, have been characterized by power X-ray diffraction analysis, differential thermal analysis (DTA), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Volume changes have been measured during different stages of heat treatment. These can be attributed to phase transformations of the starting materials, which determine the sintering behaviour and final porosity of the samples. Measurements of the elastic modulus were performed by the resonant frequency method. A cubic dependence on the relative density is found. Finally, some possible improvements for the technique and selection of powders are suggested, based on the reported results.

Ceramics↗
PubMed1991

Relationship of viscosity to porosities in automixed elastomeric impressions.

Porosities commonly presenting as voids have been recognized as an inherent problem in elastomeric impressions. Automixing of the impression has been found to be effective in reducing voids. The purpose of this study was to compare formation of voids in medium-viscosity and putty-wash materials in four automixed addition silicone elastomers. Impressions of a master model were made according to manufacturers' recommendations on manipulation of materials. Voids presenting on a predetermined surface were counted under a binocular microscope at a magnification factor of 7x. Results showed that Express exhibited a significantly higher number of voids than other materials in both categories. Putty-wash impressions generated significantly less voids than medium-viscosity impressions for all materials except Reprosil. The findings of this study suggested that putty-wash impressions produced significantly less porosities than medium-viscosity impressions and, consequently, offer better tear strength for impressions.

Dental Impression Materials↗
PubMed2005

Significance of bed porosity, bran and specific surface area in solid-state cultivation of Aspergillus oryzae.

In this paper, the effects of bed porosity, bran and specific surface area on the oxygen uptake rate and alpha-amylase production during growth of Aspergillus oryzae on wheat grain and wheat-flour substrate are reported. The high oxygen uptake rate found during cultivation of A. oryzae on wheat-flour substrate was not reached on wheat grain. This is mainly due to the bran of the wheat grain. Using wheat-flour substrates, it was shown that extra bed porosity increased the alpha-amylase production and oxygen uptake rates. Furthermore, the peak oxygen uptake rate decreased with increasing surface area-volume ratio of the substrate particles, while the alpha-amylase production and the cumulative oxygen uptake per gram of initial substrate dry matter increased. The present work does not support a direct correlation between aerial mycelia and enzyme production. There is, however, a correlation between the alpha-amylase yield and the cumulative oxygen uptake (not the uptake rate). This implies that aerial mycelia could accelerate alpha-amylase production even if they do not increase the yield.

Aspergillus oryzae↗
PubMed2004

A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering.

Porous objects of carbonated apatite were prepared by mixing polyvinyl alcohol fibres (PVA) and sodium chloride as porogens with nanocrystalline carbonated apatite powder. After cold isostatic pressing (CIP) and dissolving the porogens, the bioceramic showed an interconnecting porosity with pore diameters in the range of 250-400 microm. The method can be transposed to any material that is insoluble in water (like many polymers). Such objects are promising for bone regeneration because the interconnecting porosity in carbonated apatite provides a good environment for bone attachment and ingrowth.

Biocompatible Materials↗
PubMed2005

Characterisation and evaluation of metal-loaded iminodiacetic acid-silica of different porosity for the selective enrichment of phosphopeptides.

Silica particles of different porosity were functionalised with iminodiacetic acid (IDA) and loaded with Fe(III) to yield immobilised metal affinity chromatography stationary phases (Fe(III)-IDA-silica) for phosphopeptide enrichment. The elution step of bound phosphopeptides was optimised with a 32P radioactive labelled peptide by a comprehensive study. Several elution systems, including phosphate buffers of different pH and concentration and ethylenediaminetetraacetic acid solutions were employed. Furthermore the effect of support porosity on elution behaviour was investigated. Under best conditions recoveries higher than 90% were achieved. A solid-phase extraction (SPE) protocol was developed for fractionation of phosphorylated and non-phosphorylated peptides and desalting of the fractions which is essential for subsequent mass spectrometric analysis by the combination of Fe(III)-IDA-silica and C18-silica particles. The pH of the loading buffer was found to be a critical parameter for the efficiency of the SPE protocol. As tryptic digests of alpha-lactalbumin, lysozyme and ribonuclease A mixed with three synthetic phosphopeptides were fractionated, pH 2.5 provided minimal proportion of unspecific bound peptides when comparing the fractions after mu-LC-electrospray ionization MS separation. The effect of a sample derivatisation reaction (methylation) on the efficiency of phosphopeptide enrichment was further investigated. Blocking carboxylate groups by methyl ester formation totally prevented unspecific interaction with the immobilised Fe(III) ions, but generated partially methylated phosphopeptides that increased the complexity of the phosphorylated fraction.

Chromatography, Affinity↗
PubMed2004

The effects of molecular weight and porosity on the degradation and drug release from polyglycolide.

This paper explores the influence of initial molecular weight and porosity on the release of the drug, theophylline, from polyglycolide (PGA). PGA was made by a variety of processes to vary the molecular weight and was blended with NaCl with different crystal sizes and in different proportions to vary the pore size and volume. Overall, results showed that decreasing the molecular weight and increasing the pore size and volume increased the rate of drug release. The exact variation of these trends agreed well with the previously established four-stage degradation mechanism for PGA, but was more complex than a simple linear behaviour. Because both the molecular weight and the porosity of PGA have a substantial influence on the polymer degradation, and can be varied in a controlled manner, these parameters can play an important role in developing PGA as a controlled drug delivery material with tailored drug release.

Bronchodilator Agents↗
PubMed2005

Evaluation of synchrotron X-ray computerized microtomography for the visualization of transport processes in low-porosity materials.

Synchrotron-source X-ray computerized microtomography (CMT) is evaluated as a method to visualize transport processes. We conclude that CMT is adequate for visualization of transport experiments if the right conditions exist. Namely, 1) not much more than one-order-of-magnitude range in concentration data is needed for the study, 2) the pore space in the samples are greater than approximately 2--50 mum, depending on the sample size and system setup; 3) the sample is fine-grained enough so that a representative elemental volume (REV) can be contained by a 2--10 mm diameter sample, and 4) the transport process is slow enough that significant changes do not occur within the 25--50 min (and possibly less in the future) needed to collect data for one three-dimensional image. Absorption edge difference imaging (AEDI) in association with CMT is introduced as a method to enhance pore-space visualization. We successfully imaged the pore space in a low-porosity granodiorite, diorite and fine-grained granite cores and a higher-porosity soil aggregate sample. We found that the pore space important to transport in the core samples was smaller than what we were able to visualize with CMT. We also made rudimentary associations of minerals with pore-space location.

Absorption↗
PubMed2003

Fluid pressure gradients, arising from oscillations in intramedullary pressure, is correlated with the formation of bone and inhibition of intracortical porosity.

Fluid flow that arises from the functional loading of bone tissue has been proposed to be a critical regulator of skeletal mass and morphology. To test this hypothesis, the bone adaptive response to a physiological fluid stimulus, driven by low magnitude, high frequency oscillations of intramedullary pressure (ImP), were examined, in which fluid pressures were achieved without deforming the bone tissue. The ulnae of adult turkeys were functionally isolated via transverse epiphyseal osteotomies, and the adaptive response to four weeks of disuse (n=5) was compared to disuse plus 10 min per day of a physiological sinusoidal fluid pressure signal (60 mmHg, 20Hz). Disuse alone resulted in significant bone loss (5.7+/-1.9%, p< or =0.05), achieved by thinning the cortex via endosteal resorption and an increase in intracortical porosity. By also subjecting bone to oscillatory fluid flow, a significant increase in bone mass at the mid-diaphysis (18.3+/-7.6%, p<0.05), was achieved by both periosteal and endosteal new bone formation. The spatial distribution of the transcortical fluid pressure gradients (inverted Delta P(r)), a parameter closely related to fluid velocity and fluid shear stress, was quantified in 12 equal sectors across a section at the mid-diaphyses. A strong correlation was found between the inverted Delta P(r) and total new bone formation (r=0.75, p=0.01); and an inverse correlation (r=-0.75, p=0.01) observed between inverted Delta P(r) and the area of increased intracortical porosity, indicating that fluid flow signals were necessary to maintain bone mass and/or inhibit bone loss against the challenge of disuse. By generating this fluid flow in the absence of matrix strain, these data suggest that anabolic fluid movement plays a regulatory role in the modeling and remodeling process. While ImP increases uniformly in the marrow cavity, the distinct parameters of fluid flow vary substantially due to the geometry and ultrastructure of bone, which ultimately defines the spatial non-uniformity of the adaptive process.

Animals↗
PubMed1993

The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties.

The relationship between the mechanical properties of bone in three-point bending and eight histocompositional variables was studied. Ultimate stress, ultimate strain, and elastic modulus were measured in 35 beams of cortical bone from bovine tibias using standard ASTM methods. Four elements of porosity were determined by point counting, mineralization by ashing, and wet and dry apparent density from weight and volume. Collagen fiber orientation was estimated using polarized light, and specimens were categorized as plexiform, mixed, or osteonal. Analysis of variance showed that ultimate stress was similar in the plexiform and osteonal specimens, but elastic modulus was reduced in the latter (18.6 +/- 1.2 vs 21.0 +/- 1.9 GPa), which were significantly less porous (by 24%) and less mineralized (by 3%) than the plexiform group. Stepwise multiple regression analysis showed that collagen fiber orientation ranked highly as a predictor of bending properties. The next best predictors were density and mineralization. In the plexiform group, 77% of the variability in elastic modulus was accounted for by wet and dry density and collagen fiber orientation. In the osteonal group, 88% of modulus variability was accounted for by percentage mineralization and collagen fiber orientation. When all the specimens were pooled, 62% of the variability in elastic modulus was attributable to variations in collagen fiber orientation, density, and porosity due to Haversian canals.

Animals↗
PubMed1995

Porosity and accuracy of multiple-unit titanium castings.

The objective of this investigation was to determine whether titanium could be used to cast reproducible multiple-unit dental restorations. A metal analog was machined to simulate preparations for a three-unit fixed partial denture. Castings were made with four different sprue designs at three temperatures. Marginal accuracy and porosity were evaluated. A total of 70 titanium castings were made with an argon/electric arc/vacuum/pressure casting machine. Ten castings were made in the conventional manner by use of gold-palladium alloy as a control to compare the marginal gap. The results revealed that the porosity was less when a large individual sprue (6-gauge) was used. It was also noted that the lower pattern burnout temperatures of 910 degrees C and 920 degrees C exhibited significantly smaller marginal gaps than did the higher temperature of 930 degrees C.

Analysis of Variance↗
PubMed1999

Investigation of the effect of three sprue designs on the porosity and the completeness of titanium cast removable partial denture frameworks.

STATEMENT OF PROBLEM: Although titanium has been used to cast removable partial denture frameworks, the casting process is arduous and requires specialized equipment. PURPOSE: This study evaluated the ability of 3 sprue designs (tree, ball, and circular) to produce complete, void-free castings of removable partial denture frameworks made from commercially pure titanium. METHODS AND MATERIAL: A cast with a Kennedy class III, modification 1, partially edentulous arch was used. The blocked-out cast was modified to facilitate assessment of the completeness of the casting of the clasp arms. Thirty refractory casts were made, and 10 wax patterns for each sprue design were fabricated and invested with ethyl silicate investment. Castings were made with an arc-type automatic casting machine in an argon atmosphere. Castings were examined with radiographic equipment to detect the presence of voids in the castings, and the completeness to each casting was visually verified. Data on porosities were tabulated and statistically analyzed with 1-way ANOVA followed by Student Newman-Keuls test. Chi-square analysis was used to identify statistically significant differences in casting defects among the 3 sprue designs. RESULTS: No statistically significant differences in the total number of porosities were found between the 3 sprue designs (P =.51). Results of completeness of castings evaluated by using chi-square test revealed a statistically significant deference among the 3 sprue designs (P =.008). CONCLUSION: The ball-sprue design produced the most complete castings for the removable partial denture titanium frameworks.

Analysis of Variance↗
PubMed2003

The relationship between porosity and fatigue characteristics of bone cements.

In this study, the fatigue strengths of acrylic cement prepared by various commercially available reduced pressure mixing systems were compared with the fatigue strength of cement mixed by hand (control) under atmospheric conditions. The following observations were made from this investigation. The mean fatigue strength of reduced pressure mixed acrylic bone cement is double that of cement mixed by hand using an open bowl, 11,354+/-6,441 cycles to failure for reduced pressure mixing in comparison with 5,938+/-3,199 cycles for mixing under atmospheric conditions. However, the variability in mean fatigue strengths of reduced pressure mixed bone cement is greater for some mixing devices. The variation in fatigue strengths for the different mixing techniques is explained by the different porosity distributions. The design of the reduced pressure mixing system and the technique employed during mixing strongly contribute to the porosity distribution within the acrylic bone cement. The level of reduced pressure applied during cement mixing has an effect on the fatigue strength of bone cement, but the mixing mechanism is significantly more influential.

Biocompatible Materials↗