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Sternal closure with resorbable synthetic suture material in children.

The use of resorbable sutures for sternal closure after median sternotomy in children has developed to a clinically routine procedure. Since there is no follow-up study so far about the influence of these synthetic sutures on sternal stability, wound healing, and compatibility in children, we evaluated the use of polydioxanon (PDS) cord in children particularly regarding those properties. In 59 children (weighing up to 30 kg) we could show that the use of synthetic resorbable materials (Vicryl 4/0, PDS) allows a complication-free stability of the sternum, good wound healing, and very good compatibility. It is concluded that the use of PDS cord is a suitable and reliable method for sternal closure with good clinical results.

Biocompatible Materials↗

An experimental comparison of suture materials for tracheal and bronchial anastomoses.

Tracheal anastomosis, after circumferential resection, and bronchial anastomosis, after sleeve resection, have become widely accepted procedures. Nevertheless, there appears to be no agreement as to the optimal suture material for these anastomoses. Fifty-two rabbits were operated on, and 10 cervical tracheal rings were resected in each animal. End-to-end anastomosis was performed using 5/0 silk, chronic catgut, Teflon-coated polyester, coated polyglactin 910, polypropylene, or polydioxanone sutures. Twelve rabbits died. Rabbits which survived the intended length of time were evaluated with respect to acute and chronic inflammation and stricture formation. The results suggest that polypropylene is the best suture material, whereas silk is the worst material. Monofilament sutures should be used with caution for bronchial anastomosis, as their bristly knots can perforate adjacent blood vessels.

Animals↗

[Capsular ligament surgery of the knee joint with resorbable materials. 5-year clinical experience with Vicryl and PDS ligaments].

Current methods of capsular ligament surgery of the knee joint are not sufficient stable. Tensions of unloaded movements of the knee joint are appropriate to destruct again the reconstructed capsular ligament mechanism. Immobilisation is required. Additional capsular ligament plastics produced out of absorbable materials (Polyglactin, Polydioxanon) protect safely the reconstructed capsular ligaments from destruction. Early functional treatment is practicable. The ligament plastics seem to stimulate the nature of origin of ligament-similar tissue. The plastic ligaments will be broken down to natural substances byx hydrolysis. An additional surgical excision is not required. Ligament plastics out of Vicryl are recommended.

Humans↗

Orbital floor reconstruction with flexible Ethisorb patches: a retrospective long-term follow-up study.

OBJECTIVE: The purpose of the study was to investigate whether a flexible, biodegradable material (Ethisorb) shows better long-term results with regard to diplopia, bulbus motility, and exophthalmos/enophthalmos compared to the use of lyophilized dura-patches and polydioxanone (PDS) foils. METHODS: During a period of 6 years 435 patients with an orbital fracture were investigated retrospectively. Inclusion criteria were patients with fractures of the orbital floor with a maximum size of 2 x 2 cm. Bulbus motility, exophthalmos, enophthalmos, and diplopia were investigated during a period of 2 years. RESULTS: One hundred twenty orbital floors were reconstructed by lyophilized dura-patches, 81 by PDS, and 136 by Ethisorb. An exploration without an implantation was performed in 91 patients. The long-term investigation 12 to 15 months after surgery showed an exophthalmos and enophthalmos incidence of 1%, whereas a reduced bulbus motility and diplopia were found in 5% and 4%, respectively. Fifteen to 24 months after surgery 2% of the patients had an exophthalmos and 1% had an enophthalmos. A reduction of bulbus motility was found in 4% of the patients, and diplopia was found in 3%. The use of Ethisorb resulted in a significantly lower incidence of exophthalmos 3 months after surgery compared to PDS. CONCLUSION: The low rate of acquired bulbus motility demonstrates acceptable results in using Ethisorb in the floor of the orbit.

Absorbable Implants↗

Experimental studies with absorbable and nonabsorbable sutures in infected canine arterial anastomoses.

Vascular anastomoses are usually performed with nonabsorbable synthetic suture material. In an infected wound suture material may have a negative effect on the healing of vascular anastomoses, leading to leakage and formation of false aneurysms. In a canine model 40 neck wounds and 40 groin wounds were contaminated with a standard suspension of Staphylococcus aureus. Subsequently 80 end-to-end anastomoses were performed in both carotid and femoral arteries with the absorbable polydioxanone (PDS) or the nonabsorbable polypropylene (PPL) suture material in one of either side. After wound infection or hemorrhage occurred, or at least 7 days to 6 months after vascular surgery, the dogs were put to death and the contaminated vessels were removed to determine the extent of infection with light and scanning electron microscopy. Macroscopic (presence of pus, anastomotic rupture, or aneurysm) and microscopic findings (absorption, tissue reaction) were compared statistically with the McNemar test. There was no difference in the incidence of wound infection between the sutures examined. Bacteriologic cultures revealed no other microorganism than the inoculated staphylococcus strain or occasional skin contaminants. In the PPL group hemorrhages occurred more frequently (n = 6) than in the PDS group (n = 2; p = 0.125). Anastomotic aneurysms (n = 5) were found only in the PPL group (p = 0.375). These differences, although statistically not significant (because of the small number of the studied anastomoses), suggest the use of monofilament absorbable suture material for autogenous anastomoses in a contaminated area.

Animals↗

Polyglactin 910/polydioxanone bicomponent totally resorbable vascular prostheses.

Previous studies from our laboratory have shown that bioresorbable vascular prostheses woven from lactide-glycolide copolymers and implanted into arteries of several animal models become replaced by cellular tissues; the rate of replacement parallels the kinetics of prosthetic resorption. This study evaluates the efficacy of bicomponent resorbable prostheses as a method of augmenting resistance to dilatation during the resorption period of the more rapidly resorbed component. Bicomponent prostheses (n = 37) were woven from compound yarns containing 74% polyglactin 910 (PG910) and 26% polydioxanone (PDS) and were interposed into adult white New Zealand rabbit infrarenal aortas. Resultant prosthesis-tissue complexes were harvested after 2 weeks to 12 months. Specimens were photographed and sectioned for light, scanning, and transmission electron microscopy. Randomly selected fresh explants at 1 and 3 months and control aortic segments from the same rabbits were simultaneously perfused with culture media (37 degrees C, 100/80 mm Hg, 60 ml/min) and perfusates assayed by means of tritiated radioimmunoassay techniques for the stable prostacyclin metabolite 6-keto-PGF1 alpha before and after the addition of sodium arachidonate (10 micrograms/ml) to the media. Results showed 100% patency, no aneurysms, and stenosis in 1 of 37 prostheses (3%). PG910 was totally resorbed by 2 months and PDS by 6 months. By 1 month inner capsule thickness was 303 +/- 30 microns. In contrast to previous reports this was significantly thicker than that within 100% PDS (230 +/- 40 microns) and significantly less thick than in 100% PG910 (530 +/- 62 microns). Inner capsules in all three groups stabilized at similar thicknesses (417 to 502 microns).(ABSTRACT TRUNCATED AT 250 WORDS)

6-Ketoprostaglandin F1 alpha↗

Intradermal buried vertical mattress suture as sole skin closure: evaluation of 149 cases.

Various buried suture techniques have been reported for dermatological surgery, but in most cases, superficial non-absorbable sutures are placed additionally. The aim of this study was to evaluate whether the intradermal buried vertical mattress suture can be safely used without additional skin suturing. Following 149 procedures in 126 patients, the colour and dehiscence of the scar and the presence of hypertrophy, granulomas or keloids were analysed. The cosmetic results were excellent to good in 78.5%, satisfactory in 19.5% and poor in 2%. Single additional superficial sutures had to be placed in only 14.7%. Suture marks were absent. Hypertrophic scarring was significantly more frequent in scars sutured with polyglactine than in scars sutured with polydioxanone. Early wound dehiscence, secondary wound healing and infection due to missing superficial skin sutures did not occur. This suture technique is safe, easy and fast to perform, and achieves good cosmetic results without leaving suture marks.

Adolescent↗

Primary mass closure of fascial incisions using a continuous absorbable suture.

Investigations with animal models and reported studies from the obstetric and gynecologic literature as well as the general surgical literature have suggested that a single mass closure is equal or superior to interrupted suture techniques. Over a 12-month period, 150 patients were operated on using a continuous mass technique for fascial closure with No.1 polydioxanone suture (PDS). One hundred thirty-five patients (90%) had risk factors that placed them at increased likelihood for wound complications. No fascial disruptions occurred. Wound complications were noted in 15 patients (10%). This technique merits wider use.

Abdomen↗

Absorbable and nonabsorbable buried sutures for primary cleft lip repair.

Absorbable and nonabsorbable buried sutures were studied in primary cleft lip repair. Group 1 (N = 56) consisted of patients repaired with buried nonabsorbable material (monofilament nylon). Group 2 (N = 47) consisted of patients repaired with absorbable materials (polyglyconate, polydioxanone). All patients were monitored for 12 months. There were stitch abscesses in Group 1 (14%). There were no abscesses in Group 2. This difference was significant (p = 0.007). Abscesses were located in the suture line with no identifiable distribution. There was no significant difference in the cosmetic appearance of the scars in Groups 1 and 2. These results support the view that absorbable sutures are preferable to nonabsorbable sutures for primary cleft lip repair.

Abscess↗

Performance of sliding knots in monofilament and multifilament suture material.

Three different sliding knots were tested using five recently developed monofilament and multifilament suture materials. The resorbable materials were polyglactin-910 (Vicryl), polyglycolic-acid (Dexon-Plus), polyglyconate (Maxon), and polydioxanone (PDS), and the nonresorbable material was polypropylene (Prolene). For each type of sliding knot, three or five throws of suture were tested. Knot strength was determined by the loop holding capacity, which was defined as the strength at which the knot broke, or at which slippage in the knot amounted to more than 2 mm. When the three kinds of sliding knots were compared, identical sliding knots with identical throws around a single suture were found to be the most unreliable. Nonidentical and parallel sliding knots differed little with respect to knot reliability. Five-throw knots were generally stronger than three-throw knots. However, the effect of adding two extra throws to three-throw sliding knots was only significant if monofilament suture material was used. Comparison of the different suture materials revealed major differences in knot holding ability. These findings indicate that knot strength is dependent on both the type of knot and the type of suture material, and surgeons should be cognizant of these variables.

Polydioxanone↗

New absorbable synthetic explants for the treatment of retinal detachment.

The synthetic absorbable materials polyglicolic acid, (PGA) polyglactin (PG910), and polydioxanone (PDS) were used in various combinations in the repair of 82 eyes with retinal detachments. The latter two substances were tested in rabbit eyes and compared with fascia lata, catgut, and silicodesiccated sclera. The absorbable implants were well tolerated in all eyes. The PDS lasted the longest and produced a significant buckling effect for at least 6 months.

Animals↗

Rigid fixation of the calvaria in craniosynostosis without using "rigid" fixation.

Early observations of intracranial translocation of metal wires, plates, and screws used for infant skull surgery have led some surgeons to investigate alternative forms of fixation. The purpose of this study was to review a series of infants and children in whom absorbable suture fixation was used as the sole method of fixation in cranial vault remodeling. Standard osteotomies were successfully modified to permit the use of this less rigid form of fixation. Over a 6-year period, 142 cranial vault procedures were performed, primarily for craniosynostosis, using absorbable sutures (2-0 polydioxanone). Patients who did not have absorbable suture fixation, or who had a combination of absorbable sutures with another form of fixation, were excluded from this review. Records were reviewed for results (assessed by both the treating surgeon and an independent anthropologist) and for complications. The average age of patients was 2 years, 7 months (range, 1 month to 16 years). The clinical results were judged as follows: grade I (excellent), 49 percent; grade II (minor imperfections), 48 percent; grade III (small surgical procedure needed), 2 percent; and grade IV (complete reoperation required), 1 percent. Anthropologic results were similarly distributed: excellent, 36 percent; good, 56 percent; fair, 8 percent; and poor, 0 percent. Those 3 to 8 percent of patients who were found to have the poorest results were all noted to have syndromes, and it appeared that an inherent lack of growth was the primary basis for the low score. There were no deaths or major complications in this series of patients. The smaller complications identified were infections [four cases (2.8 percent)] and transient cerebrospinal fluid leak [two cases (1.4 percent)]. The most important factor in determining whether absorbable suture fixation was sufficient was the size of a preexisting calvarial defect. Although concerns have been raised about a possible link between absorbable suture fixation and subsequent poor reossification, no such association was noted in this review. The primary disadvantage of using absorbable sutures was the lack of rigidity provided. Advantages included lower costs, speed of application, and the absence of observed intracranial translocation. In conclusion, the use of absorbable suture fixation (with modifications in osteotomy design) was associated with both acceptable aesthetic outcomes and low complication rates. Craniofacial surgeons may wish to consider the use of absorbable sutures as another option for bone fixation in treatment of craniosynostosis.

Absorption↗

Biodegradable fixation of physeal fractures in goat distal femur.

We compared the effectiveness of absorbable polylactic acid (PLA) screws and polydioxanone (PDS) pins with that of ASIF cannulated screws in stabilizing Salter-Harris IV fractures in goat distal femur. Eighteen juvenile goats were randomly divided into control (cannulated screw), PLA screw, and PDS pin groups. A Salter-Harris IV medial femoral condyle fracture was created and stabilized, and the goats were sacrificed 8 weeks postoperatively. Articular cartilage displacement < 1 mm was considered anatomic. All PLA screws were anatomic as compared with 83% (five of six) of the controls and 17% (one of six) of the pins. Absorbable PLA screws stabilized Salter-Harris IV fractures as well as cannulated screws and better than PDS pins.

Animals↗

Tonsillar fossa obliteration and post-operative pain.

Fifty consecutive patients over the age of 15 years undergoing tonsillectomy had one tonsillar fossa obliterated by 2/0 Polydioxanone (PDS II) suture. The opposite side was used as a control. Pain was assessed on a visual analogue scale from the first to tenth post-operative day. Although on the initial post-operative days the pain was more on the sutured side, 41 patients subsequently experienced significant pain relief on that side (P = 0.0001). No complications were encountered due to the tonsillar fossa obliteration. On the 10 day review, the 41 patients indicated in their questionnaire that tonsillar fossa obliteration is a useful procedure to reduce the post-operative pain and would have preferred both sides to be obliterated rather than left to heal by secondary intention.

Adolescent↗

How to repair an anal sphincter injury after vaginal delivery: results of a randomised controlled trial.

OBJECTIVE: To compare two surgical techniques and two types of suture material for anal sphincter repair after childbirth-related injury. DESIGN: Factorial randomised controlled trial. SETTING: Tertiary referral maternity unit. POPULATION: Women with an anal sphincter injury sustained during childbirth. METHOD: Women were randomised into four groups: overlap repair with polyglactin (Vicryl); end-to-end repair with polyglactin (Vicryl); overlap repair with polydioxanone (PDS); and end-to-end repair with PDS. All repairs were completed as a primary procedure by staff trained in both methods. MAIN OUTCOME MEASURES: Suture-related morbidity at six weeks. Bowel symptoms at 3, 6 and 12 months. Anorectal physiology at three months. Quality of life scores at 3 and 12 months. RESULTS: One hundred and fifty women (1.5% of deliveries) were eligible and 112 (75%) were randomised. One hundred and three (92%) attended follow up visit at 6 weeks, 89 (80%) at 3 months, 79 (71%) at 6 months and 60 (54%) at 12 months. At six weeks, there was no difference in suture-related morbidity between groups (P=0.11) and 70% patients were completely asymptomatic. Incidence of bowel symptoms and quality of life disturbances were low, with no differences between the four groups. CONCLUSION: Obstetric anal sphincter repair carried out by appropriately trained staff is associated with low morbidity, irrespective of the suture material and repair method used.

Adult↗

A method for constricting large veins for use in arterial vascular reconstruction.

A satisfactory biologic graft can be created if dilated, but otherwise unusable veins are wrapped with a constrictive mesh tube. The purpose of this study was to determine whether a resorbable constrictive tube creates an appropriately sized vascular graft by induction of neoarterial wall growth. In 8 sheep a 5 cm segment of the carotid artery was resected and the external jugular vein inserted as a tubular graft. The vein was either wrapped with a polydioxanon (PDS) reinforced polyglactin (Vicryl) mesh (n = 4), a Vicryl mesh (n = 4), or a Dacron mesh tube (n = 3) to achieve a diameter reduction to 7 mm. Or the vein was used without reinforcement (n = 3). At angiography after 6 months the unreinforced veins had a diameter of 19 mm (range 15-22). The Vicryl reinforced veins measured 9.4 (8.5-10) mm, but 3 of 4 developed aneurysmatic dilatations at sites of valve sinuses with a mean diameter of 19 (15-21) mm. PDS reinforced veins measured 7.4 mm (7.1-7.9). Two of 4 had minor aneurysms of 13 and 16 mm. The two remaining PDS reinforced grafts were indistinguishable from the native artery. Dacron tubes reduced the vein size reliably to 7.6 (7.5-7.9) mm, but showed narrowing at the proximal anastomoses (PDS 7.2 +/- 0.4, Dacron 6.1 +/- 0.4, p = 0.016). PDS wrapping reduced maximal graft diameter to 10.9 +/- 4 mm as compared to that of the native vein, 18.7 +/- 3.5 (p less than 0.05). Resorbable meshes can reduce the diameter of a venous graft by strengthening the vessel wall.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

A comparison of knot security of commonly used hand-tied laparoscopic slipknots.

OBJECTIVE: To compare the peak force required for failure of hand-tied laparoscopic slipknot ligatures. STUDY DESIGN: In vitro mechanical evaluation of suture material/knot combinations. SAMPLE POPULATION: Four hand-tied laparoscopic slipknots were studied. Three suture materials and 2 suture sizes were evaluated. Twenty samples of each group were tested, for a total of 400 samples. METHODS: The 4S modified Roeder, modified Roeder, and Weston and Brooks laparoscopic slipknots using 0 polyglyconate, 0 polyglycolic acid, 1 polyglyconate, and 1 polydioxanone (PDS) were tested. A vertical distracting force (5 mm/s) was applied until failure. Mean peak force to failure was obtained for each suture material, size, and knot combination. RESULTS: Mean (+/-SEM) peak force to failure of hand-tied ligatures ranged from 156.8+/-9.1 N to 4.8+/-.4 N. The 4S-modified Roeder had the highest mean peak force to failure. Ligatures tied with polyglyconate and size 1 suture had the highest mean peak force to failure. CONCLUSIONS: The 4S-modified Roeder was significantly and consistently stronger than the other slipknots. Polyglyconate was superior to other suture materials. The 1 polyglyconate had the highest mean peak force to failure followed by 0 polyglyconate that exceeded the 1PDS. CLINICAL RELEVANCE: The 4S-modified Roeder slipknot using 1 polyglyconate has the greatest breaking strength of sutures tested and should be considered when performing laparoscopic ligatures.

Animals↗